Medical Advocates
Lopinavir/Ritonavir (Kaletra/Aluvia)
 
Adolescent/Adult Journal Citations
Drug Comparison Trials

LPV/RTV vs  Atazanavir          
LPV/RTV vs  Efavirenz
LPV/RTV vs  Fosamprenavir
LPV/RTV vs  Indinavir
LPV/RTV vs  Nelfinavir  
LPV/RTV vs  Saquinavir 
LPV/RTV vs  Tenofovir


 
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Last Update: July 22, 2008
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LPV/RTV vs Atazanavir
 
 
A WEEK IN REVIEW FEATURED REPORT
 Atazanavir and lopinavir with ritonavir alone or in combination: analysis of pharmacokinetic
interaction and predictors of drug exposure.
 Di Giambenedetto S, De Luca A, Villani P, et al
HIV Med. 2008 Apr;9(4):239-45.
 Abstract

Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease
inhibitor failure: a randomized multinational trial.
 Cohen C, Nieto-Cisneros L, Zala C, et al   
 Curr Med Res Opin. 2005 Oct;21(10):1683-92.
 Abstract

LPV/RTV vs Efavirenz
 
 
A 96-Week Comparison of Lopinavir-Ritonavir Combination Therapy Followed by Lopinavir-Ritonavir
Monotherapy versus Efavirenz Combination Therapy.
Cameron DW, da Silva BA, Arribas JR, et al
J Infect Dis. 2008 Jun 9.
 Abstract
 
A WEEK IN REVIEW FEATURED REPORT
First-line antiretroviral therapy with efavirenz or lopinavir/ritonavir plus two nucleoside
analogues: the SUSKA study, a non-randomized comparison from the VACH cohort.
Domingo P, Suárez-Lozano I, Torres F, et al 
Antimicrob Chemother. 2008 Mar 20
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and safety of an anti-retroviral combination regimen including either efavirenz or
lopinavir-ritonavi rwith a backbone of two nucleoside reverse transcriptase inhibitors.
Panagopoulos P, Tsiodras S, Antoniadou A, et al 
Clin Microbiol Infect. 2006 May;12(5):486-9.
 Abstract
 
Exploratory analysis for the evaluation of lopinavir/ritonavir-versus efavirenz-based
HAART regimens in antiretroviral-naive HIV-positive patients: results from the Italian
MASTER Cohort.
Torti C, Maggiolo F, Patroni A, et al
 J Antimicrob Chemother. 2005 May 25
 Abstract

First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy
for naive patients.
Manfredi R, Calza L, Chiodo F.
AIDS. 2004 Nov 19;18(17):2331-3.
 Abstract

LPV/RTV vs Fosamprenavir
 
  A WEEK-IN-REVIEW FEATURED REPORT
The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in
combination with abacavir-lamivudine, for initial treatment of HIV infection over
48 weeks: a randomised non-inferiority trial.
Eron J Jr, Yeni P, Gathe J Jr, et al 
Lancet. 2006 Aug 5;368(9534):476-82.
Abstract

LPV/RTV vs Indinavir
 
 
Pharmacokinetics of Two Randomized Trials Evaluating the Safety and Efficacy of
Indinavir, Saquinavir and Lopinavir in Combination with Low-Dose Ritonavir: The
MaxCmin1 and 2 Trials.
Justesen US, Fox Z, Pedersen C, et al
Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):339-44.
 Abstract

Lopinavir/ritonavir vs. indinavir/ritonavir in antiretroviral naive HIV-infected
patients: immunovirological outcome and side effects.
Bongiovanni M, Bini T, Chiesa E, et al  
Antiviral Res. 2004 Apr;62(1):53-6
 Abstract

LPV/RTV vs Nelfinavir
 
  Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
Walmsley S, Bernstein B, King M, et al.
N Engl J Med 2002 Jun 27;346(26):2039-46
 Abstract  		 

LPV/RTV vs Saquinavir
 
A WEEK-IN-REVIEW FEATURED REPORT
Abstract
  Pharmacokinetics of Two Randomized Trials Evaluating the Safety and Efficacy of
Indinavir, Saquinavir and Lopinavir in Combination with Low-Dose Ritonavir: The
MaxCmin1 and 2 Trials.
Justesen US, Fox Z, Pedersen C, et al
Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):339-44.
 Abstract
 

LPV/RTV vs Tenofovir
 
A WEEK-IN-REVIEW FEATURED REPORT
Abstract
  Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive
HIV-1-infected patients at week 48.
 Ortiz R, Dejesus E, Khanlou H, et al 
AIDS. 2008 Jul 31;22(12):1389-97.
 Abstract

 
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Lopinavir/Ritonavir
Journal Papers/Abstracts/Commentaries:
Adolescent/Adult Drug Comparison Strategies