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  ARV Treatment Strategies

 General Reports
 Starting Therapy
Alternating Therapy
 Switching Therapy
Treatment Interruption
 Treatment  Simplification
 Adherence
 Salvage Therapy


 
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Last Update:  November 11, 2008  
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General Reports
 
     Journal Papers, Abstracts, and Commentaries
 
 
A WEEK IN REVIEW FEATURED REPORT
Plasma drug concentrations and virologic evaluations after stopping treatment with nonnucleoside
reverse-transcriptase inhibitors in HIV type 1-infected children.
 Cressey TR, Green H, Khoo S, et al
Clin Infect Dis. 2008 May 15;46(10):1601-8
 Abstract
 
Planned Multiple Exposures to Autologous Virus in HIV Type 1-Infected Pediatric Populations
Increases HIV-Specific Immunity and Reduces HIV Viremia.
 Borkowsky W, Yogev R, Muresan P, et al 
AIDS Res Hum Retroviruses. 2008 Mar 7
 Abstract
 

Treatment of Pediatric HIV Infection.
 d’Oulx EA, Chiappini E, de Martino M, Tovo PA.
Curr Infect Dis Rep. 2007 Sep;9(5):425-33.
 Abstract
 
     Conference Reports, Abstracts, and Posters 
 
  Formulation, dosing and ART strategies for children with HIV infection
D Gibb
[8th Int Congress on Drug Therapy in HIV Infection]
 Abstract
Starting Therapy
 

     Journal Papers, Abstracts, and Commentaries
 
 
Delayed early antiretroviral treatment is associated with an HIV-specific long-term cellular response
in HIV-1 vertically infected infants.
 Palma P, Romiti ML, Cancrini C, et al
Vaccine. 2008 Apr 15
Abstract

A WEEK IN REVIEW FEATURED REPORT
FULL TEXT ARTICLE
When Should Children with HIV Infection Be Started on Antiretroviral Therapy?
 Welch SB, Gibb D 
PLoS Med. 2008 Mar 25;5(3):e73.
 Paper
 
Effect of First Line Therapy Including Efavirenz and Two Nucleoside Reverse Transcriptase
Inhibitors in HIV-infected Children.
 Funk MB, Notheis G, Schuster T, et al 
Eur J Med Res. 2005 Dec 7;10(12):503-8.
 Abstract
 
Use of total lymphocyte count for informing when to start antiretroviral therapy in
HIV-infected children: a meta-analysis of longitudinal data.
HIV Paediatric Prognostic Markers Collaborative Study. 
Lancet. 2005 Nov 26;366(9500):1868-74.
Abstract

Early versus Deferred Antiretroviral Multidrug Therapy in Infants Infected with
HIV Type 1.
 Faye A, Le Chenadec J, Dollfus C, et al 
Clin Infect Dis. 2004 Dec 1;39(11):1692-8.
 Abstract

     Conference Reports, Abstracts, and Posters 

  Antiretroviral therapy initiated before 12 weeks of age reduces early mortality in
young HIV-infected infants: evidence from the Children with HIV Early Antiretroviral
Therapy (CHER) Study
 Violari A., Cotton M, Gibb D, et al
(4th IAS Conference)
 Abstract
Alternating Therapy
 

     Journal Papers, Abstracts, and Commentaries

  Alternation of antiretroviral drug regimens for HIV infection. A randomized,
controlled trial.
Martinez-Picado J, Negredo E, Ruiz L, et al.
Ann Intern Med. 2003 Jul 15;139(2):81-9.
Abstract
Treatment Interruption
 

     Journal Papers, Abstracts, and Commentaries

 
Structured treatment interruptions (STIs) in HIV-1 infected pediatric populations increases interferon
gamma production and reduces viremia.
 Borkowsky W, Yogev R, Muresan P, et al 
Vaccine. 2008 Jan 4
 Abstract
 
A WEEK IN REVIEW FEATURED REPORT
Clinical Outcomes After an Unstructured Treatment Interruption in Children and Adolescents
With Perinatally Acquired HIV Infection.
 Saitoh A, Foca M, Viani RM, et al 
Pediatrics. 2008 Mar;121(3):e513-21.
 Abstract
 
Partial treatment interruption of protease inhibitors augments HIV-specific immune
responses in vertically infected pediatric patients.
Legrand FA, Abadi J, Jordan KA, et al 
AIDS. 2005 Oct 14;19(15):1575-1585.
 Abstract
 
Treatment interruption for virological failure or as sparing regimen in children
with chronic HIV-1 infection.
 Monpoux F, Tricoire J, Lalande M, et al 
AIDS. 2004 Dec 3;18(18):2401-2409.
 Abstract

Immunologic Changes During Unplanned Treatment Interruptions of Highly
Active Antiretroviral Therapy in Children With Human Immunodeficiency Virus
Type 1 Infection.
The Collaborative HIV Paediatric Study Steering Committee Sophia Children’s
Hospital Rotterdam the Netherlands.
Pediatr Infect Dis J. 2004 May;23(5):446-450.
 Abstract

     Conference Reports, Abstracts, and Posters 

 
PDF CONFERENCE PRESENTATION
Treatment interruption in children with chronic HIV-infection: the results of the paediatric
European network for treatment of AIDS (PENTA) 11 trial
 DM Gibb, A Compagnucci, H Green, et al  
(Ninth International Congress on Drug Therapy in HIV Infection)
PDF Abstract
 
The association of HIV-specific T cell responses and drug-resistance in chronic paediatric
infection before and during antiretroviral therapy (continuous and structured treatment
interruption)
 Reddy S.
 (4th IAS Conference)
 Abstract
 
Persistence of PI-resistance Mutations among Children Undergoing a PI-targeted Partial
Treatment Interruption
 U Phillips, M Rosenberg, J Dobroszyci. et al
 (14 CROI)
Abstract
 
Programmed Treatment Interruption in HIV-infected Children with Optimal Virological Response
to First-line HAART: A 3-Year Follow-up
 A Noguera, L Alsina, C Muñoz-Almagro, et al
(14 CROI)
Abstract
 
HIV-specific T cell responses in chronic paediatric infection during antiretroviral therapy (continuous
and structured treatment interruption)
Reddy S.
(XVI International AIDS Conference)
Abstract
 
Structured treatment interruption in HIV-infected children and adolescents: risks and benefits
Rubini N.P.M., Llerena C.L.A., Brindeiro P., et al
 (XVI International AIDS Conference)
Abstract
 
Repeated Supervised Treatment Interruption with Progressive Increases in "Off-Treatment"
Duration Results in Enhanced Virologic Control in a Subset of Pediatric Individuals
W Borkowsky, E McFarland, R Yogev,  et al
(13 CROI)
Abstract
 
Clinical and Laboratory Consequences of Unplanned Treatment Interruptions in
Perinatally HIV-infected Children and Adolescents
S Heffernan-Vacca, M Foca, B Na, A Jurgrau,  P LaRussa
(12 CROI)
 Abstract
 
CD8+ and CD4+ T-cell Responses in HIV-1 Clade C Acutely Infected Infants
Receiving HAART and Structured Treatment Interruption
C Thobakgale, D Ramduth, P Rathnavalu, et al
(12 CROI)
 Abstract
 
POSTER
 Virologic and Clinical Outcomes of a Progressively Increasing Structured
Treatment Interruption Study in Chronically Infected Children
R Yogev, B Borkowsky, P Muresan, et al
 (11 CROI)
 PDF Poster      Abstract
 
POSTER
Partial Treatment Interruption of PI-based HAART Regimens in HIV-infected
Children
J Abadi, E Sprecher, M Rosenberg, et al
 (11 CROI)
PDF Poster         Abstract
 
Increases in HIV-specific Interferon-gamma and Proliferative Responses in Children
Undergoing Structured Treatment Interruption
 EJ McFarland, W Borkowsky, P Muresan, et al.
(11 CROI)
 Abstract
 
Controlled Interruption of Highly Active Antiretroviral Therapy in HIV-infected Children
C Fortuny, A Noguera, E Sánchez,  et al
 (11 CROI)
 Abstract
 
Outcomes of Treatment Interruption in HIV-infected Children
 A Alimenti, D Burdge, D Khoo, et al
(11 CROI)
 Abstract
 
Switching Therapy
 
     Journal Papers, Abstracts, and Commentaries
 
  A WEEK-IN-REVIEW FEATURED REPORT
Switching from protease inhibitor-based-HAART to a protease inhibitor-sparing regimen
is associated with improved specific HIV-immune responses in HIV-infected children.
Pensieroso S, Romiti ML, Palma P, et al
AIDS. 2006 Sep 11;20(14):1893-1896.
 Abstract
 
     Conference Reports, Abstracts, and Posters 
 
 
POWERPOINT POSTER PRESENTATION
Use of antiretroviral therapy in resource-limited countries in 2007: up-take of 2nd-line and paediatric
treatment stagnant
F Renaud-Théry
 (XVII International  AIDS Conference)
 Poster Presentation

Wide disparity in switch to second-line therapy in HIV-infected children in CHIPS
KJ Lee, H Lyall, AS Walker, et al
 [8th Int Congress on Drug Therapy in HIV Infection]
 Abstract
Treatment Simplification
 
     Journal Papers, Abstracts, and Commentaries
 
  Successful simplification of protease inhibitor-based HAART with triple nucleoside
regimens in children vertically infected with HIV.
 Palma P, Romiti ML, Cancrini C, et al 
AIDS. 2007 Nov 30;21(18):2465-2472.
 Abstract
 
     Conference Reports, Abstracts, and Posters 
 
  3-NRTI HAART Simplification in Children Is Effective in Maintaining Virological and
Immunological Control after 108 Weeks
G Castelli-Gattinara, M Amicosante, P Palma, et al
 (13 CROI)
 Abstract
Stopping Therapy
 
     Journal Papers, Abstracts, and Commentaries
 
  Long-Term Effects of Highly Active Antiretroviral Therapy on CD4(+) Cell Evolution among
Children and Adolescents Infected with HIV: 5 Years and Counting.
 Patel K, Hernán MA, Williams PL, et al
Clin Infect Dis. 2008 Apr 2
 Abstract
Salvage Therapy
 
     Journal Papers, Abstracts, and Commentaries
 
  A WEEK-IN-REVIEW FEATURED REPORT
FULL TEXT PDF ARTICLE
 Predictive factors of virological success to salvage regimens in HIV-1 infected children.
Larru B, De Mendoza C, Bellon JM, et al
 BMC Infect Dis. 2007 Jun 10;7(1):55
Paper

   

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