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Saquinavir (Fortovase/Invirase)
 
Pediatric Index

Guidelines
 Pharmacokinetics
 Combination Therapy







 
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Last Update:  August 18, 2006
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Prevention/Treatment Guidelines and Recommendations
United States      

USPHS Pediatric Antiretroviral Drug Information
 (Effective March 24, 2005)
Clinical Pharmacology
Pharmacokinetics Combination Therapy       

Pharmacokinetics

    Journal Papers, Abstracts, and Commentaries  

  Pharmacokinetics and pharmacodynamics of saquinavir in pediatric patients with 
human immunodeficiency virus infection.
Grub S, Delora P, Ludin E, et al.
Clin Pharmacol Ther 2002 Mar;71(3):122-30
 Abstract

     Conference Reports, Abstracts, and Posters  

  Pharmacokinetics of saquinavir (SQV) with nelfinavir (NFV) or ritonavir (RTV) in
HIV-infected children.   
 (8 CROI)
 Abstract
Combination Therapy
       

    Journal Papers, Abstracts, and Commentaries

 
Pharmacokinetics and 24-Week Efficacy/Safety of Dual Boosted Saquinavir/Lopinavir/Ritonavir
in Nucleoside-Pretreated Children.
Ananworanich J, Kosalaraksa P, Hill A, et al
Pediatr Infect Dis J. 2005 Oct;24(10):874-87
Abstract

Combination therapy with saquinavir soft gelatin capsules in children with human
immunodeficiency virus infection.
Kline MW, Brundage RC, Fletcher CV, et al. 
Pediatric Infectious Disease Journal 2001; 20:666- 671.
Abstract
   
  Comparison of ritonavir plus saquinavir- and nelfinavir plus saquinavir-containing
regimens as salvage therapy in children with human immunodeficiency virus type 1
infection.
Hoffmann F, Notheis G, Wintergerst U, et al.
Pediatric Infectious Disease Journal 2000; 19:47-51.
 Abstract

     Conference Reports, Abstracts, and Posters

 
Lack of PI resistance in children failing double boosted saquinavir (SQV)/lopinavir/ritonavir
(LPV/r) combination
 Bunupuradah T., Kosalaraksa P., Engchanil C., et al
 (XVI International AIDS Conference)
 Abstract
 
Efficacy and safety of double boosted saquinavir (SQV)/lopinavir/ritonavir (LPV/r) in nucleoside
pre-treated children at 48 weeks
Kosalaraksa P., Bunupuradah T., Engchanil C., et al
(XVI International AIDS Conference)
 Abstract
 
Pharmacokinetics and 24-Week Efficacy and Safety of Saquinavir/Lopinavir/Ritonavir
in RTI-pre-treated Children
 J Ananworanich , P Kosalaraksa , U Siangphoe. et al
(12 CROI)
Abstract

A randomized trial of combination therapy with saquinavir soft gel capsules (SQV) in
HIV-infected children .
 (8 CROI)
Abstract

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