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Zidovudine (Retrovir)
 
Perinatal Efficacy
General Reports
 ZDV Monotherapy
 ZDV/NVP
ZDV/DDI
ZDV/LPV/'RTV
ZDV Followed by ART
ZDV vs HAART



 






 
Perinatal ZDV Main New/Newsworthy  Home Page

Last Update:  August 05, 2011  
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General Reports
 

        Conference Reports, Abstracts, and Posters
 
  Risk factors for HIV vertical transmission - when should be considered more than one drug
to an HIV vertically exposed newborn: results from a Brazilian cohort study
C. Sepulveda, E. Santos, P. Vianna
 (6th IAS)
 Abstract
ZDV Monotherapy
 

   Journal Papers, Abstracts, and Commentaries
 
Disease Progression Among HIV-Infected Children Who Receive Perinatal Zidovudine
Prophylaxis.
 Berk DR, Falkovitz-Halpern MS, et al  
J Acquir Immune Defic Syndr. 2006 Oct 30;
Abstract
 
Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant
zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized
trial: the Mashi Study.
Thior I, Lockman S, Smeaton LM,et al 
JAMA. 2006 Aug 16;296(7):794-805.
 Abstract

Effectiveness of Short-Term and Long-Term Zidovudine Prophylaxis on Detection of HIV-1
Subtype Ein Human Placenta and Vertical Transmission.
 Bhoopat L, Khunamornpong S, Lerdsrimongkol PSirivatanapa P,et al   
 J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):545-550
 Abstract

      Conference Reports, Abstracts, and Posters   

  POSTER
 Prevention of the vertical transmission of HIV, experience of the Pediatric University Hospital of Rabat in Morocco
S. Benchekroun M. Chrahbili, M. Adnaou, et al|
 (6th IAS Conference)
Poster     Abstract

Baseline maternal characteristics associated with "early" and "late" HIV-1 vertical
transmission to non-breastfed infants despite zidovudine (ZDV) prophylaxis, in Thailand
G Jourdain, J Y Mary, S Le Coeur, et al
 (15IAC)
 Abstract

EFFECT OF PERINATAL ZIDOVUDINE TREATMENT ON THE EVOLUTION OF
CELL-FREE HIV-1 IN BREAST MILK ON POSTNATAL TRANSMISSION, ANRS 049
DITRAME-VIRO STUDY
O. Manigart, M. Crépin, V. Leroy, et al
 (2cd IAS)
 Abstract
 
Efficacy of perinatal Zidovudine administration using a modified PACTG 076 protocol, for
reduction of mother to child transmission of HIV: A historically case controlled longitudinal
study from Barbados
A Kumar, M A St. John
 (14IAC)
 Abstract
 
Superiority of An “Ultra short” Zidovudine (ZDV) regimen in the prevention of perinatal HIV
transmission in rural Zimbabwe
M S Silverman, P Thistle, G Arbess,  et al
 (14IAC)
 Abstract          
 
High post-partum morbidity in replacement fed infants born to HIV-infected women
in India, receiving short-course zidovudine
M A Phadke, K E Bharucha, A N Shrotri, et al
 (14IAC)
 Abstract
 
Impact of short-course zidovudine regimen on transmission risk and risk factors for
perinatal HIV transmission, Bangkok, Thailand
T Chotpitayasunondh, N Vanprapa, N Waranawat, et al
 (14IAC)
 Abstract
 
Acceptance of and adherence to zidovudine and infant formula for preventing
mother-child HIV transmission, Bangkok, Thailand
U Chaovarindr, A Chalermchokcharoenkit, S Asavapiriyanont, et al
 (14IAC)
 Abstract
 
Barriers to implementing a short-course zidovudine program in two Bangkok hospitals,
1999-2001
S Chearskul, T Chotpitayasunondh, N Vanprapa, et al
 (14IAC)
 Abstract
 
Adherence to maternal and infant zidovudine in a pilot study to prevent mother to child HIV
transmission associated with breastfeeding, Botswana
S Lockman, R L Shapiro, I Thior, et al
 (14IAC)
 Abstract

Successful of Zidovudine prophylaxis to prevent mother to child transmission
J Contarelli, G Alberich, A Cucchetti, et al
 (14IAC)
 Abstract

ZDV NVP Studies
         
 
Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces
nevirapine resistance in mothers from the Western Cape, South Africa.
 van Zyl GU, Claassen M, Engelbrecht S, et al 
J Med Virol. 2008 Apr 21;80(6):942-946
 Abstract
 
Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing
mother-to-child transmission of HIV in Africa?
 Leroy V, Sakarovitch C, Cortina-Borja M,
AIDS. 2005 Nov 4;19(16):1865-1875.
Abstract
 
Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent
peripartum HIV transmission.
 ANRS 1201/1202 DITRAME PLUS Study Group    
AIDS. 2005 Feb 18;19(3):309-318
 Abstract

Intrapartum and Neonatal Single-Dose Nevirapine Compared with Zidovudine for
Prevention of Mother-to-Child Transmission of HIV-1 in Kampala, Uganda:
Randomized Trial (HIVNET 012)
Guay LA, Musoke P, Fleming T, et al.
 Lancet 1999 Sep 4;354(9181):795-802  
Abstract
  Alternating nevirapine and zidovudine treatment of human  immunodeficiency virus
type 1-infected persons does not prolong nevirapine activity
de Jong MD, Loewenthal M, Boucher CA et al  
 J Infect Dis 1994 Jun;169(6):1346-50
Abstract		  

        Conference Reports, Abstracts, and Posters   

 
The efficacy of triple antiretroviral treatment during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1: hospital setting experience from Tanzania
M. Diese, N. Kikumbih, P. Perchal, et al
 (3rd IAS)
 Abstract

Routine use of combined zidovudine and nevirapine regimen in MTCT-Plus program
 O Marcy ,  A Mafoua ,  G Halembokaka  
(3rd IAS)
 Abstract
 
97% Progression-free Survival of HIV+ Pregnant Women 33 Months Post-delivery
 F Martin, L Navaratne , W Khan, et al
(12 CROI)
Abstract

Infant Zidovudine Prophylaxis and Emergence of Nevirapine Resistance at 6 Weeks in
Perinatally HIV-infected Infants Exposed to Intra-partum or Newborn Nevirapine
 N Ngo-Giang-Huong, G Jourdain, P Tungyai, et al
(12 CROI)
Abstract
 
Prevention of vertical HIV-1 transmission by Zidovudine and Nevirapine
S N Kurle, S P Tripathy, P L Joshi, et al
 (15IAC)
 Abstract
 
Effect of short course zidovudine plus single dose nevirapine on plasma viral load and
intrapartum prevention of mother to child HIV transmission (MTCT) in Thailand
A Teeraratkul, A Chalermchokcharoenkit, S Asavapiriyanont, et al
 (15IAC)
 
Infant ARV prophylaxis failures from a study of a short-course zidovudine plus 2-dose
nevirapine regimen for prevention of mother-to-child HIV transmission in Thailand
N Vanprapar, T Chotpitayasunondh, M Culnane, et al
 (15IAC)
 Abstract
 
Multicentre, Randomized Controlled Trial, Assessing the Safety and Efficacy of
Nevirapine in Addition to Zidovudine for the Prevention of Perinatal HIV In Thailand:
PHPT-2 Update
 M Lallemant, G Jourdain, S Le Coeur, et al.
(2cd IAS)
 Abstract
 
Effectiveness of a short course of zidovudine + nevirapine to prevent mother-to-
child transmission (PMTCT) of HIV-1: The Ditrame Plus ANRS 1201 Project in
Abidjan, Cote d’Ivoire
F Dabis, V Leroy, L Bequet, et al
 (14IAC)
 Abstract
 
Effectiveness of nevirapine and zidovudine use in the prevention of perinatal
transmission of HIV in Uganda
F Bajunirwe, S Asiimwe, M Kamya, et al
 (14IAC)
 Abstract
 
Neonatal post-exposure prophylaxis with nevirapine and zidovudine reduces
mother-to-child transmission of HIV
T E Taha, N Kumwenda, A Gibbons, et al
 (14IAC)
 Abstract
 
Addition of neonatal zidovudine to a standard single dose nevirapine to
the mother and newborn to increase reduction of mother-to-child transmission
of HIV
T E Taha, N Kumwenda, A Gibbons, et al
 (14IAC)
 Abstract

ZDV DDI Studies
ZDV/DDI vs ZDV/DDI/NVP
ZDV/DDI vs ZDV/DDI/NVP

Efficacy

     Journal Papers, Abstracts, and Commentaries

  Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in
patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial.
Basgoz N, Niu M, Hirsch MS, et al.  
 Ann Intern Med 1996 Jun 15;124(12):1019-30
Abstract 
 
ZDV/DDI/NVP vs ZDV/DDI

Efficacy

      Journal Papers, Abstracts, and Commentaries

  Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in
patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial.  
 D'Aquila RT, Hughes MD, Johnson VA,  et al.  
 Ann Intern Med 1996 Jun 15;124(12):1019-30  
Abstract 		  

 
ZDV/LPV/RTV Studies
Z
Efficacy

     Journal Papers, Abstracts, and Commentaries
 
  Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during
the third trimester of pregnancy.
 Cressey TR, Jourdain G, Rawangban B,  et al
AIDS. 2010 Jul 9
 Abstract 
ZDV Followed by ART
 

        Conference Reports, Abstracts, and Posters
 
  POSTER
Community-based Generic ART following Single-dose Nevirapine or Short-course Zidovudine
in Zimbabwe
L Zijenah, G Kadzirange, S Rusakaniko, et al
(13 CROI)
 PDF Poster     Abstract
ZDV vs HAART
 
      Journal Papers, Abstracts, and Commentaries
 
 
Highly Active Antiretroviral Therapy versus Zidovudine for Prevention of Mother-to-Child Transmission
in a Programmatic Setting, Botswana.
 Dryden-Peterson S, Jayeoba O, Hughes MD, et al
J Acquir Immune Defic Syndr. 2011 Jul 22

Use of Zidovudine-sparing HAART in pregnant HIV-infected women in Europe: 2000-2009.
Tariq S, Townsend CL, Cortina-Borja M, et al
J Acquir Immune Defic Syndr. 2011 Apr 14
Abstract

        Conference Reports, Abstracts, and Posters
 
  POSTER
 Effectiveness of Maternal HAART vs ZDV to Prevent MTCT in a Programmatic Setting: Botswana
 S Dryden-Peterson, O Jayeoba, H Jibril, et al
 (18 CROI)
 PDF Poster     Abstract

A Phase III Randomized, Partially Double-blind and Placebo-controlled Trial Comparing the Efficacy and
Safety of Maternal and Infant NVP vs Infant only NVP, or Maternal LPV/r, in Addition to Standard ZDV
Prophylaxis to Prevent Perinatal HIV Transmission: Thailand, PHPT-5
 M Lallemant, G Jourdain, N Ngo-Giang-Huong, et al
(18 CROI)
 Abstract

 

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Zidovudine Perinatal Efficacy