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Last Update:  August 02, 2011
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Treatment Guidelines and Recommendations
United States      
USPHS Pediatric Antiretroviral Drug Information
 (Effective March 24, 2005)

Nucleoside and Nucleotide Analogue Reverse Transcriptase Inhibitor Data
Stavudine Data
General Reports
       

    Journal Papers, Abstracts, and Commentaries

 
Possible Mitochondrial Dysfunction and Its Association with Antiretroviral Therapy Use in |
Children Perinatally Infected with HIV.
Crain MJ, Chernoff MC, Oleske JM,  et al
J Infect Dis. 2010 Jun 9.
Abstract

Effects of the change from Stavudine to tenofovir in human immunodeficiency virus-infected
children treated with highly active antiretroviral therapy: studies on mitochondrial toxicity and
thymic function.
 Rosso R, Nasi M, Di Biagio A, et al
Pediatr Infect Dis J. 2008 Jan;27(1):17-21.
 Abstract
Monotherapy
       

    Journal Papers, Abstracts, and Commentaries

  A phase I/II evaluation of stavudine (d4T) in children with human immunodeficiency
virus infection.
Kline MW, Dunkle LM, Church JA et al
Pediatrics 1995; 96:2 Pt 1 (Aug): 247-252.
 Abstract
   
  A randomized comparative trial of stavudine (d4T) versus zidovudine (ZDV, AZT) in children
with human immunodeficiency virus infection.
Kline MW, Van Dyke RB, Lindsey JC et al
Pediatrics 1998; 101(2): 214-220.
Abstract
D4T/DDI
       

    Journal Papers, Abstracts, and Commentaries

  FULL-TEXT PDF ARTICLE
Efficacy and safety of stavudine plus didanosine in asymptomatic HIV-infected children
with plasma HIV RNA below 50,000 copies per milliliter.
Mendoza C, Ramos JT, Ciria L, et al. 
HIV Clin Trials 2002 Jan-Feb;3(1):9-16 
 PDF Paper
   
  Combination therapy with stavudine (d4T) plus didanosine (ddI) in children with human
immunodeficiency virus infection.
Kline MW, Van Dyke RB, Lindsey JC et al.
Pediatrics 1999; 103(5): e62.
Abstract
   
  Combination Therapy with Stavudine and Didanosine in Children With Advanced
Human Immunodeficiency virus Infection: Pharmacokinetic Properties, Safety,
and Immunologic and Virologic Effects.
Kline MW, Fletcher CV, Federici ME et al.
Pediatrics 1996; 97(6): 886-890
Abstract
D4T/ZDV
       

    Conference Reports, Abstracts and Posters

  Substitution of stavudine with zidovudine in HIV-infected children receiving HAART does NOT
result in clinically significant hematologic changes
Aurpibul L, Puthanakit T, Sirisanthana T, Sirisanthana V
(4th CROI)
 Abstract
D4T/NVP/3TC
       

    Journal Papers, Abstracts, and Commentaries

 
A WEEK-IN-REVIEW FEATURED REPORT
A Chewable Pediatric Fixed-Dose Combination Tablet of Stavudine, Lamivudine,
and Nevirapine: Pharmacokinetics and Safety Compared With the Individual
Liquid Formulations in Human Immunodeficiency Virus-Infected Children in Thailand.
Vanprapar N, Cressey TR, Chokephaibulkit K,  et al 
Pediatr Infect Dis J. 2010 May 5.
 Abstract

Limited Sampling Models to Predict the Pharmacokinetics of Nevirapine, Stavudine,
and Lamivudine in HIV-Infected Children Treated With Pediatric Fixed-Dose
Combination Tablets.
 Burger D, Ewings F, Kabamba D, et al  
Ther Drug Monit. 2010 Apr 8.
 Abstract

Fixed Dose Combination of Lamivudine, Stavudine and Nevirapine in the Treatment of
Pediatric HIVInfection: A Preliminary Report.
 Pensi T  
 Indian Pediatr. 2007 Jul;44(7):519-21
 Abstract

Stavudine, nevirapine and ritonavir in stable antiretroviral therapy-experienced children with
human immunodeficiency virus infection.
Yogev R, Lee S,  Wiznia A, et al.
Pediatr Infect Dis J 2002 Feb;21(2):119-125
 Abstract
D4T/NVP/RTV
       

    Journal Papers, Abstracts, and Commentaries

  Stavudine, nevirapine and ritonavir in stable antiretroviral therapy-experienced children with
human immunodeficiency virus infection.
Yogev R, Lee S,  Wiznia A, et al.
Pediatr Infect Dis J 2002 Feb;21(2):119-125
 Abstract
D4T/DDI/IND
       

    Journal Papers, Abstracts, and Commentaries

  A pilot study of combination therapy with indinavir, stavudine (d4T), and didanosine (ddI) in
children infected with the human immunodeficiency virus.
Kline MW, Fletcher CV, Harris AT et al 
Journal of Pediatrics 1998; 132(3 Pt 1): 543-546.
Abstract
Treatment Strategies
       
    Conference Reports, Abstracts and Posters
 
  POSTER
 Improvement of lipodystrophy in children after substitution of stavudine with zidovudine in
NNRTI-based antiretroviral therapy
L. Aurpibul, T. Puthanakit, S. Taejaroenkul, et al
 (6th IAS Conference)
 Poster     Abstract

 
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