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Pegylated Interferon alfa-2
b (PEG-INTRON)
    HCV Journal Citations: Efficacy

Acute HCV
Chronic HCV
HCV/Hemophilia
HCV Cirrhosis
Post-Transplant Hepatitis
Non-Responders
Hemodialysis


 
 

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Last Update:  January 26, 2015

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Acute HCV
 

Peg Interferon alfa-2b Monotherapy
 
  A short course of pegylated interferon-alpha in acute HCV hepatitis.
Calleri G, Cariti G, Gaiottino F, et al  
J Viral Hepat.
2007 Feb;14(2):116-121.

Abstract
 

Peg Interferon alfa-2b Monotherapy vs Peg Interferon alfa-2b/Ribavirin
 
 
Prediction of efficacy to pegylated interferon-α-2b plus ribavirin in patients with genotype 2 hepatitis C virus using viral response within 2 weeks.
Wada Y, Tamai H, Uno A, Kawashima A,  et al
Hepatol Res
. 2013 Feb 25.
Abstract

Peginterferon alfa-2a relapse rates depend on weight-based ribavirin dosage in HCV-infected patients
with genotype 1: Results of a retrospective evaluation.
Zopf S, Herold C, Hahn EG, Ganslmayer M.  
Scand J Gastroenterol
. 2008 Dec 31:1-5.
Abstract

Hepatic HCV RNA before and after treatment with interferon alone or combined
with ribavirin.
McHutchison JG, Poynard T, Esteban-Mur R, et al.
Hepatology 2002 Mar;35(3):688-93
Abstract

 

Peg Interferon alfa-2b/Ribavirin
 
 
Acute hepatitis C: A 24 week-course of Peg-Interferon alpha-2b versus a 12 week-course of Peg-Interferon alpha-2b alone or with ribavirin.
Santantonio T, Fasano M, Sagnelli E,  et al
Hepatology
. 2014 Jan 18.

Abstract

Pegylated interferon alpha2b versus pegylated interferon alpha2a for chronic hepatitis C:
The unreached goal of superiority.

Rumi MG.
J Hepatol
. 2009 Oct 2
Abstract

Eradication of hepatitis C virus after a 5-week treatment
Gaundong Mbéthé GL, Foucher J, Deledinghen V, Couzigou VP.
Rev Med Interne
. 2009 May 18.

Abstract


Chronic HCV
 

Peg Interferon alfa-2b/Ribavirin
 
 
Peginterferon alpha-2b plus ribavirin for chronic hepatitis C virus mixed genotype infection.
C
hing-Chung L, Chia-Hsien W, Huan-Lin C,  et al 
Ann Hepatol. 2014 Jul-Aug;13(4):350-
Abstract

Pegylated Interferon-α2a and Ribavirin versus Pegylated Interferon-α2b and Ribavirin in Chronic Hepatitis C : A Meta-Analysis.
Flori N, Funakoshi N, Duny Y,et al
Drugs. 2013 Feb 23.
0(9):581-5.
Abstract

Virologic response to treatment with Pegylated Interferon alfa-2b and Ribavirin for chronic hepatitis C in children.
Pawlowska M, Pilarczyk M, Halota W.
Med Sci Monit
. 2010 Nov 30;16(12):CR616-621
Abstract

Efficacy and tolerability of peginterferon alfa-2a or alfa-2b plus ribavirin in the daily routine treatment of patients with chronic hepatitis C in Germany:
The PRACTICE Study.
Witthoeft T, Hueppe D, John C,  et al
J Viral Hepat
. 2010 Jul;17(7):459-68.
Abstract

FULL-TEXT PDF ARTICLE
Retreatment of hepatitis C patients with pegylated interferon combined with ribavirin in non-responders to interferon plus ribavirin. Is it different in real life?
Goncales FL Jr, Moma CA, Vigani AG,  et al
BMC Infect Dis
. 2010 Jul 20;10(1):212
Paper

Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C.
Honda T, Katano Y, Shimizu J, et al |
Liver Int
. 2010 Apr;30(4):527-37.
Abstract

High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin.
Wirth S, Ribes-Koninckx C, Calzado MA, et al
J Hepatol
. 2010 Feb 4.
Abstract

Pegylated Interferons for the Treatment of Chronic Hepatitis C: Pharmacological and Clinical Differences between Peginterferon-alpha-2a and Peginterferon-alpha-2b.
Foster GR. 
Drugs
. 2010;70(2):147-65.
Abstract

On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula.
Saito H, Ebinuma H, Ojiro K, et al
World J Gastroenterol
. 2010 Jan 7;16(1):89-97.
Abstract

Management of chronic hepatitis C patients who have relapsed or not responded to pegylated interferon alfa plus ribavirin.
Dieterich DT, Rizzetto M, Manns MP.
J Viral Hepat
. 2009 Dec;16(12):833-43.
Abstract

Randomized Study of Peginterferon-alpha2a Plus Ribavirin Versus Peginterferon-alpha2b Plus Ribavirin in Chronic Hepatitis C.
Rumi M, Aghemo A, Prati GM, et al 
Gastroenterology. 2009 Sep 17

Abstract

Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection.
McHutchison JG, Lawitz EJ, Shiffman ML, et al 
N Engl J Med. 2009 Aug 6;361(6):580-93.
Abstract

Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin.
Hiramatsu N, Oze T, Yakushijin T, et al
J  Viral Hepat
. 2009 Jun 22.
Abstract

Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C.
Honda T, Katano Y, Shimizu J, et al
Liver Int. 2009 Jun 12
Abstract

Clinical effectiveness and cost effectiveness of tailoring chronic hepatitis C treatment with peginterferon alpha-2b plus ribavirin to HCV genotype and early viral response: a decision analysis based on german guidelines.
Siebert U, Sroczynski G, Aidelsburger P,  et al 
Pharmacoeconomics. 2009;27(4):341-54. doi: 10.2165/00019053-200927040-00006.
Abstract

Effective prediction of outcome of combination therapy with pegylated interferon alpha 2b plus ribavirin in Japanese patients with genotype-1 chronic hepatitis C using early viral kinetics and new indices.
Nomura H, Miyagi Y, Tanimoto H, Higashi M, Ishibashi H. 
J Gastroenterol
. 2009 Mar 10.
Abstract
 

Treatment Outcomes With Pegylated Interferon and Ribavirin for Male Prisoners With Chronic  Hepatitis C.
Chew KW, Allen SA, Taylor LE, Rich JD, Feller E.

J Clin Gastroenterol
. 2009 Mar 17.
Abstract

 
FULL-TEXT ARTICLE
Pegylated interferon 2a and 2b in combination with ribavirin for the treatment of chronic hepatitis C in HIV infected patients.
Dhillon R, Rossi S, Herrine SK.
Ther Clin Risk Manag. 2008 Aug;4(4):789-96.
Paper

Pegylated interferon-alpha2b plus ribavirin: an efficacious and well-tolerated treatment regimen for patients with hepatitis C virus related histologically proven cirrhosis.
Roffi L, Colloredo G, Pioltelli P, et al  
Antivir Ther
. 2008;13(5):663-73.
Abstract

Pegylated alpha-interferon-2a plus ribavirin compared with pegylated alpha-interferon-2b plus ribavirin for initial treatment of chronic hepatitis C virus: Prospective, non-randomized study.
Escudero A, Rodríguez F, Serra MA, et al 
J Gastroenterol Hepatol. 2008 Apr 19
Abstract
 
Impact of weight-based ribavirin with peginterferon alfa-2b in african americans with hepatitis C virus genotype 1.
Jacobson IM, Brown RS Jr, McCone J, et al  
Hepatology
. 2007 Sep 25;46(4):982-990
Abstract
 
FULL TEXT ARTICLE
Using pegylated interferon alfa-2b and ribavirin to treat chronic hepatitis patients infected with hepatitis c virus genotype 1: are nonresponders and relapsers different populations?
Silva GF, Polônio RJ, Pardini MI, et al

Braz J Infect Dis. 2007 Dec;11(6):554-60.
Paper
 
Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: A randomized trial.
Jacobson IM, Brown RS Jr, Freilich B, et al 
Hepatology.
2007 Sep 25;46(4):971-981
Abstract
 
Effect of treatment with interferon alpha-2b and ribavirin in patients infected with genotype 2 hepatitis C virus.
Nagase Y, Yotsuyanagi H, Okuse C, et al
Hepatol Res.
2007 Sep 6;
Abstract
 
Pharmacodynamics of peginterferon alfa-2a and peginterferon alfa-2b in interferon-naïve patients with chronic hepatitis C: a randomized, controlled study.
Bruno R, Sacchi P, Scagnolari C. et al  
Aliment Pharmacol Ther.
2007 Aug 1;26(3):369-76.
Abstract
Pegylated interferon and ribavirin combination therapy for chronic hepatitis C in patients with congenital bleeding disorders: a single-centre experience.
Posthouwer D, Fischer K, DE Heusden N, et al
Haemophilia.
2007 Jan;13(1):98-103.
Abstract
 
Pegylated interferon and ribavirin in re-treatment of responder-relapser HCV patients.
Basso M, Torre F, Grasso A, et al
Dig Liver Dis
. 2006 Oct 30;
Abstract
 
Hepatitis C virus survival curve analysis in naive patients treated with peginterferon alpha-2b plus ribavirin. A randomized controlled trial for induction with high doses of peginterferon and
predictability of sustained viral response from early virologic data.
Mimidis K, Papadopoulos VP, Elefsiniotis I, et al   
J Gastrointestin Liver Dis. 2006 Sep;15(3):213-9.
Abstract
 
Sustained Viral Response to Pegylated Interferon alpha-2b and Ribavirin in Chronic Hepatitis C Refractory to Prior Treatment.
Mathew A, Peiffer LP, Rhoades K, McGarrity T.  
Dig Dis Sci. 2006 Sep 27;
Abstract
Efficacy and Safety of Pegylated Interferon-alpha2b Plus Ribavirin for the Treatment of Chronic Hepatitis C in HIV-Infected Patients.
Santin M, Shaw E, Garcia MJ, et al 
AIDS Res Hum Retroviruse
s. 2006 Apr;22(4):315-20.
Abstract
 
Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection in HIV-Infected Patients.
Torriani FJ, Rodriguez-Torres M, Rockstroh, et al 
N Engl J Med. 2004 Jul 29;351(5):438-450.
Abstract
 
Treatment of chronic hepatitis C infection with peginterferons plus ribavirin.
Fried MW, Hadziyannis SJ.
Semin Liver Dis. 2004 May;24 Suppl 2:47-54.
Abstract
 
Response to combination therapy of interferon alfa-2b plus ribavirin in Hispanics with chronic hepatitis C.
Munoz H, Arroyo J, Torres EA, De Jesus-Monge, et al
P R Health Sci J. 2004 Jun;23(2 Suppl):61-7.
Abstract
 
Peg Interferon alfa-2b Monotherapy
 
  A short course of pegylated interferon-alpha in acute HCV hepatitis.
Calleri G, Cariti G, Gaiottino F, et a
J Viral Hepat.
2007 Feb;14(2):116-121.
Abstract
 

Peg Interferon alfa-2b Monotherapy vs Peg Interferon alfa-2b/Ribavirin
 
 
Efficacy and safety of pegylated IFN alfa 2b alone or in combination with ribavirin in thalassemia major with chronic hepatitis C.
Sood A, Sobti P, Midha V,
Indian J Gastroenterol. 2010 Mar;29(2):62-5.
Abstract

High sustained response rate in patients with histologically mild (low grade and stage) chronic hepatitis C infection. A randomized, double blind, placebo controlled trial of interferon alpha-2b
with and without ribavirin.
Verbaan HP, Widell HE, Bondeson TL    
Eur J Gastroenterol Hepatol 2002 Jun;14(6):627-33
Abstract
 

  Daily or three times a week interferon alfa-2b in combination with ribavirin or interferon alone for the treatment of patients with chronic hepatitis C.
de Ledinghen V, Trimoulet P, Winnock M, et al
J Hepatol 2002 May;36(5):672-80
Abstract
 

Peg Interferon alfa-2b Monotherapy vs Standard Interferons
 
  Peginterferon vs. standard interferon in the treatment of chronic hepatitis C.
Zaman A, Fennerty MB, Keeffe EB.
Aliment Pharmacol Ther. 2003 Oct;18(7):661-70.
Abstract

HCV/Cirrhosis
 

Peg Interferon alfa-2b/Ribavirin

  Pegylated interferon-alpha2b plus ribavirin: an efficacious and well-tolerated treatment regimen for patients with hepatitis C virus related histologically proven cirrhosis.
Roffi L, Colloredo G, Pioltelli P, et al 
Antivir Ther
. 2008;13(5):663-73
Abstract

HCV/Hemophilia
 

Peg Interferon alfa-2b/Ribavirin
 

High efficacy of combined therapy with pegylated interferon plus ribavirin in patients  with hemophilia and chronic hepatitis C.
Mancuso ME, Rumi MG, Santagostino E, et al 
Haematologica. 2006 Oct;91(10):1367-71.

Abstract

Post-Transplant Hepatitis
 

Peg Interferon alfa-2b/Ribavirin
 

Limited Benefit of Biochemical Response to Combination Therapy for Patients With Recurrent Hepatitis C After Living-Donor Liver Transplantation.
Ueda Y, Takada Y, Haga H,et al  
Transplantation.
2008 Mar 27;85(6):855-862.
Abstract

Treatment With Pegylated Interferon and Ribavirin for Hepatitis C Virus-associated Severe  Cryoglobulinemia in a Liver/Kidney Transplant Recipient.
Montalbano M, Pasulo L, Sonzogni A, et al 
J Clin Gastroenterol.
2007 Feb;41(2):216-220.

Abstract


Non-Responders
 

Peg Interferon alfa-2b/Ribavirin/Merimempodib
 

Phase 2 study of the combination of merimempodib with peginterferon-alpha2b, and ribavirin in  nonresponders to previous therapy for chronic hepatitis C.
Marcellin P, Horsmans Y, Nevens F, et al 
J Hepatol.
2007 Jun 21;

Abstract

Hemodialysis
 

Safety and efficacy of an escalating dose regimen of pegylated interferon alpha-2b in the treatment of haemodialysis patients with chronic hepatitis C.
Tan SS, Abu Hassan MR, Abdullah A, et al
J Viral Hepat
. 2009 Sep

Abstract


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Peginterferon alfa-2b HCV Efficacy