Medical Advocates

Nevirapine
(Viramune)
 
Perinatal/Neonate Safety/Resistance/
Viral Dynamics

Safety
Resistance
Viral Dynamics





 


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Last Update:  October 01, 2016
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Safety
 

        Journal Papers, Abstracts, and Commentaries

 
Safety of nevirapine in HIV-infected pregnant women initiating antiretroviral therapy at higher CD4 counts:
A systematic review and meta-analysis.
Bera E, Mia R. S Afr Med J. 2012 Oct 8;102(11):855-9.
Abstract

Safety of nevirapine in pregnancy.
Natarajan U, Pym A, McDonald C, et al
HIV Med. 2007 Jan;8(1):64-9
Abstract
 

Safety of nevirapine-containing antiretroviral triple therapy regimens to prevent vertical
transmission in an African cohort of HIV-1-infected pregnant women.
Marazzi MC, Germano P, Liotta G, Guidotti G, et
HIV Med. 2006 Jul;7(5):338-44.
Abstract

Safety and trough concentrations of nevirapine prophylaxis given daily, twice weekly,
or weekly in breast-feeding infants from birth to 6 months.
Shetty AK, Coovadia HM, Mirochnick MM, et al
 
J Acquir Immune Defic Syndr.
2003 Dec 15;34(5):482-90
Abstract


Resistance
 

      Journal Papers, Abstracts, and Commentaries

 
Frequent nevirapine resistance in infants infected by HIV-1 via breastfeeding while on nevirapine prophylaxis: results of the Breastfeeding, Antiretrovirals and Nutrition study.
Nelson JA, Fokar A, Hudgens MG,  et al
AIDS. 2015 Jul 17.
Abstract

Breast milk transmission of nevirapine-resistant HIV-1 to infants after single-dose nevirapine in Beira, Mozambique.
Micek MA, Dross S, Blanco AJ,  et al
J Infect Dis
. 2
014 Ma
r 4
Abstract

Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine.
Micek MA, Blanco AJ, Carlsson J,  et al
J Infect Dis
. 2012 Apr 5.
Abstract

A Comparison of 3 Regimens to Prevent Nevirapine Resistance Mutations in HIV-Infected Pregnant Women Receiving a Single Intrapartum Dose of Nevirapine.
Van Dyke RB, Ngo-Giang-Huong N, Shapiro DE,  et al
Clin Infect Dis
.
2011 Dec 5.

Abstract

FULL-TEXT ARTICLE
Emergence and Persistence of Minor Drug-Resistant HIV-1 Variants in Ugandan Women after Nevirapine Single-Dose Prophylaxis.
Hauser A, Mugenyi K, Kabasinguzi R, et al  
PLoS One
. 2011;6(5):e20357.
Paper

FULL-TEXT ARTICLE
Detection of HIV drug resistance mutations in pregnant women receiving single dose
Nevirapine in south India.

Jacob MS, Durairaj A, Vijayakumari J, et al
Indian J Pathol Microbiol
. 2011 April-June;54(2):359-361.
Paper

Analysis of nevirapine resistance in HIV-infected infants who received extended nevirapine or
nevirapine/zidovudine prophylaxis.
Fogel J, Hoover DR, Sun J, et al
AIDS
. 2011 Apr 24;25(7):911-917.
Abstract

Minor drug-resistant HIV type-1 variants in breast milk and plasma of HIV type-1-infected Ugandan women
after nevirapine single-dose prophylaxis.
Pilger D, Hauser A, Kuecherer C, Mugenyi K,  et al

Antivir Ther
. 2011;16(1):109-13.
Abstract

Slower Clearance of Nevirapine Resistant Virus in Infants Failing Extended Nevirapine Prophylaxis
for Prevention of Mother-to Child HIV-Transmission.
Persaud D, Bedri A, Ziemniak C,  et al
AIDS Res Hum Retroviruses
. 2011 Jan 18.
Abstract

Addition of 7 days of zidovudine plus lamivudine to peripartum single-dose nevirapine effectively
reduces nevirapine resistance postpartum in HIV-infected mothers in Malawi.
Farr SL, Nelson JA, Ng'ombe TJ,, et al
J Acquir Immune Defic Syn
dr
. 2010 Aug 15;54(5):515-23
Abstract

FULL-TEXT ARTICLE
Minor resistant variants in nevirapine-exposed infants may predict virologic failure
on nevirapine-containing ART.
Macleod IJ, Rowley CF, Thior I, Wester C, et al
J Clin Virol. 2010 Apr 26.
Abstract

Nevirapine Resistance by Timing of HIV Type 1 Infection in Infants Treated with
Single-Dose Nevirapine.
Micek MA, Blanco AJ, Beck IA, et al
Clin Infect Dis
. 2010 Apr 12
Abstract

Detection of HIV-1-Drug-Resistance in Women Following Single-Dose-Nevirapine:
Comparison of Plasma RNA versus Cellular DNA by Consensus Sequencing and by
Oligonucleotide Ligation Assay.
Wagner TA, Kress CM, Beck I,  et al
J Clin Microbiol
. 2010 Feb 24
Abstract

Addition of extended zidovudine to extended nevirapine prophylaxis reduces nevirapine
resistance in infants who were HIV-infected in utero.
Lidström J, Li Q, Hoover DR, Kafulafula G, et al
AIDS. 2010 Jan 28;24(3):381-6.
Abstract

Tolerance and viral resistance after single-dose nevirapine with tenofovir and emtricitabine to prevent
vertical transmission of HIV-1.
The TEmAA ANRS 12109 Study group.
AIDS
. 2009 Mar 19.
Abstract

Addition of extended zidovudine to extended nevirapine prophylaxis reduces nevirapine resistance
in infants who were HIV-infected in utero.
Lidström J, Li Q, Hoover DR, et al
AIDS
. 2009 Dec 5.
Abstract

Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited
antiretroviral therapy.
Paredes R, Cheng I, Kuritzkes DR,  et al
AIDS.2009 Nov 12
Abstract

FULL TEXT  ARTICLE
Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child
HIV transmission: a randomized clinical trial.
McIntyre JA, Hopley M, Moodley D, et al
PLoS Med. 2009 Oct;6(10):e1000172.
Paper

Lower Risk of Resistance After Short-Course HAART Compared With Zidovudine/Single-Dose Nevirapine
Used for Prevention of HIV-1 Mother-to-Child Transmission.
Lehman DA, Chung MH, Mabuka JM, et al
J Acquir Immune Defic Syndr. 2009 Jun 4
Abstract

Identification of Nevirapine-Resistant HIV-1 in the Latent Reservoir after Single-Dose Nevirapine
to Prevent Mother-to-Child Transmission of HIV-1.
Wind-Rotolo M, Durand C, Cranmer L, et al 
J Infect Di
s
. 2009 Apr 1.
Abstract
 

Tolerance and viral resistance after single-dose nevirapine with tenofovir and emtricitabine to prevent
vertical transmission of HIV-1.
The TEmAA ANRS 12109 Study group. 
AIDS
. 2009 Mar 19.
Abstract
 
FULL-TEXT ARTICLE
Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine
prophylaxis in subtype C HIV-infected infants.

Moorthy A, Gupta A, Bhosale R, et al  
PLoS ONE
. 2009;4(1):e4096.
Paper
 
Prevalence of Nevirapine-Associated Resistance Mutations after Single Dose Prophylactic
Treatment among Antenatal Clinic Attendees in North Rift Kenya.
Kiptoo M, Ichimura H, Wembe RL,  et al  
AIDS Res Hum Retroviruse
s
. 2008 Dec;24(12):1555-9.
Abstract
 
Analysis of Nevirapine (NVP) Resistance in Ugandan Infants Who Were HIV Infected Despite Receiving
Single-Dose (SD) NVP versus SD NVP Plus Daily NVP Up to 6 Weeks of Age to Prevent HIV Vertical
Transmission.
Church JD, Omer SB, Guay LA, et al 
J Infect Dis.
2008 Aug 6.
Abstract
 
Nevirapine Resistance in Women and Infants after First versus Repeated Use of Single-Dose Nevirapine
for Prevention of HIV-1 Vertical Transmission.
Flys TS, McConnell MS, Matovu F, et al
J Infect Dis.
2008 Jun 26.
Abstract
 
Low rate of emergence of nevirapine and lamivudine resistance after post-partum interruption of a
triple-drug regimen.
Pérez H, Vignoles M, Laufer N
Abstract
 
Use of single-dose nevirapine for the prevention of mother-to-child transmission of HIV-1: does
development of resistance matter?

McConnell MS, Stringer JS, Kourtis AP, et al
Am J Obstet Gynecol.
2007 Sep;197(3 Suppl):S56-6
Abstract
 
Drug Resistance in Plasma and Breast Milk after Single-Dose Nevirapine in Subtype C
HIV Type 1: Population and Clonal Sequence Analysis.
Kassaye S, Lee E, Kantor R, et al 
AIDS Res Hum Retroviruses.
2007 Aug;23(8):1055-61

Abstract
 
Prevalence of resistance to nevirapine in mothers and children after single-dose exposure
to prevent vertical transmission of HIV-1: a meta-analysis.
Arrive E, Newell ML, Ekouevi DK, et al 
Int J Epidemiol. 2007 May 28;
Abstract
 
Persistence of K103N-Containing HIV-1 Variants after Single-Dose Nevirapine for
Prevention of HIV-1 Mother-to-Child Transmission.
Flys TS, Donnell D, Mwatha A, et al 
J Infect Dis.
2007 Mar 1;195(5):711-5
Abstract
 
Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine.
Lockman S, Shapiro RL, Smeaton LM, et al 
N Engl J Med. 2007 Jan 11;356(2):135-147.
Abstract
 
Impact of NVP plasma concentration on selection of resistant virus in mothers who
received single dose NVP to prevent perinatal HIV-1 transmission and persistence of
resistant virus in their infected children.

Chaix ML, Ekouevi DK, Peytavin G, et al
Antimicrob Agents Chemother.
2006 Dec 18;
Abstract
 
Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy
for prevention of maternal-to-fetal HIV-1 transmission.
Palmer S, Boltz V, Martinson, et al 
Proc Natl Acad Sci
U S A. 2006 Apr 25;
Abstract
 
Transmission of Human Immunodeficiency Virus Type 1 Nevirapine Resistance Mutaton
K103Nfrom a Treatment-Naive Mother to her Child
Schmitz T, Kleinkauf N, Klempa B, et al 
Pediatr Infect Dis J. 2006 Mar;25(3):275-276
Abstract
 
Low Risk of Nevirapine Resistance Mutations in the Prevention of Mother-to-Child Transmission
of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus, Abidjan, Cote d'Ivoire.
Chaix ML, Ekouevi DK, Rouet F, et al   
J Infect Dis.
2006 Feb 15;193(4):482-7.
Abstract
 
Development of Nevirapine Resistance in Infants Is Reduced by Use of Infant-Only
Single-Dose Nevirapine plus Zidovudine Postexposure Prophylaxis for the Prevention
of Mother-to-Child Transmission of HIV-1.
Eshleman SH, Hoover DR, Hudelson SE
J Infect Dis.
2006 Feb 15;193(4):479-81.
Abstract
 
Characterization of Nevirapine (NVP) Resistance Mutations and HIV Type 1 Subtype in
Women from Abidjan (Cote d'Ivoire) After NVP Single-Dose Prophylaxis of HIV Type 1
Mother-to-Child Transmission.
Toni TD, Masquelier B, Lazaro E, et al
AIDS Res Hum Retroviruses. 2005 Dec;21(12):1031-4.
Abstract
 
Distinct Patterns of Emergence and Fading of K103N and Y181C in Women With Subtype
A vs. D After Single-Dose Nevirapine: HIVNET 012.
Eshleman SH, Guay LA, Wang J, et al 
J Acquir Immune Defic Syndr
. 2005 Sep 1;40(1):24-29.
Abstract
 
Breast-Milk Shedding of Drug-Resistant HIV-1 Subtype C in Women Exposed to
Single-Dose Nevirapine.
Lee EJ, Kantor R, Zijenah L, et al
J Infect Dis. 2005 Oct 1;192(7):1260-4.

Emergence of Drug-Resistant HIV-1 after Intrapartum Administration of Single-Dose
Nevirapine Is Substantially Underestimated.
Johnson JA, Li JF, Morris L, et al 
J Infect Dis.
2005 Jul 1;192(1):16-23.
Abstract
 
Sensitive Drug-Resistance Assays Reveal Long-Term Persistence of HIV-1 Variants with
the K103N Nevirapine (NVP) Resistance Mutation in Some Women and Infants after the
Administration of Single-Dose NVP: HIVNET 012.
Flys T, Nissley DV, Claasen CW,
J Infect Dis. 2005 Jul 1;192(1):24-9.
Abstract
 
Nevirapine (NVP) Resistance in Women with HIV-1 Subtype C, Compared with Subtypes
 A and D, after the Administration of Single-Dose NVP.
Eshleman SH, Hoover DR, Chen S, et 
J Infect Dis. 2005 Jul 1;192(1):30-6
Abstract
 
Persistence of Nevirapine Exposure During the Postpartum Period After Intrapartum Single-
Dose Nevirapine in Addition to Zidovudine Prophylaxis for the Prevention of Mother-to-Child
Transmission of HIV-1.
Cressey TR, Jourdain G, Lallemant MJ, et al  
J Acquir Immune Defic Syndr.
2005 Mar 1;38(3):283-288.
Abstract
 
Characterization of Nevirapine Resistance Mutations in Women With Subtype A Vs.
D HIV-1 6-8 Weeks After Single-Dose Nevirapine (HIVNET 012)
.

Eshleman SH, Guay LA, Mwatha A, et al 
J Acquir Immune Defic Syndr. 2004 Feb 1; 35(2): 126-130.
Abstract

Development of resistance mutations in women receiving standard antiretroviral therapy
who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus
type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316.
Cunningham CK, Chaix ML, Rekacewicz C, et al
J Infect Dis 2002 Jul 15;186(2):181-8
Abstract

Identification of the K103N resistance mutation in Ugandan women receiving nevirapine to
prevent HIV-1 vertical transmission
.
Jackson JB, Becker-Pergola G, Guay LA,  et al
A
IDS 2000 Jul 28;14(11):F111-5  
Abstract

Pharmacological implications of lengthened in-utero exposure to nevirapine.
Taylor GP, Lyall EG, Back D, Ward C, Tudor-Williams G.
Lancet 2000 Jun 17;355(9221):2134-5  
Abstract

 

Viral Dynamics
 

      Journal Papers, Abstracts, and Commentaries

 
Nevirapine Plasma Concentrations are Still Detectable After More Than 2 Weeks in the Majority of
Women Receiving Single-Dose Nevirapine: Implications for Intervention Studies.
Muro E, Droste JA, Hofstede HT 
J Acquir Immune Defic Syndr.
2005 Aug 1;39(4):419-421.
Abstract

FULL-TEXT ARTICLE
Intrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-
Based Antiretroviral Therapy.
Jourdain G, Ngo-Giang-Huong N, Le Coeur S, et al 
N Engl J Med.
2004 Jul 9
Abstract
 

 


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