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Nevirapine
(Viramune)
 
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Last Update:  December 15, 2017
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New and Noteworthy
 

December  2017
 

General Reports
 

   

     Journal Papers, Abstracts, and Commentaries

 
Prevention of Hiv-1 Transmission Through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding in Hiv-1-Infected Women with High Cd4 Cell Count (Impaact Promise): A Randomized, Open Label, Clinical Trial.
Flynn PM, Taha TE, Cababasay M,  et a'l
J Acquir Immune Defic Syndr
. 2017 Dec 11

Abstract

Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates.
Cressey TR, Punyawudho B, Le Coeur S,  et a
J Acquir Immune Defic Syndr
. 2017 May 9.
Abstract

Nevirapine Plasma Concentrations in Human Immunodeficiency Virus-Exposed Neonates Receiving High-Dose Nevirapine Prophylaxis as Part of 3-Drug Regimen.
Bolaris MA, Keller MA, Robbins BL,  et al
J Pediatric Infect Dis Soc
.
2016 Jan 23.
Abstract

Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy.
Gantt S, Leister E, Jacobson DL,  et al  
J Med Virol
. 2015 Oct 31
Abstract

FULL-TEXT ARTICLE
A cross-sectional study of the magnitude, barriers, and outcomes of HIV status disclosure among women participating in a perinatal HIV transmission study, "the Nevirapine Repeat Pregnancy study".
Kiweewa FM, Bakaki PM, McConnell MS, et al
BMC Public Health
. 2015 Sep 29;15(1):988.
Paper

FULL-TEXT ARTICLE
Nevirapine, Sodium Concentration and HIV-1 RNA in Breast Milk and Plasma among HIV-Infected Women Receiving Short-Course Antiretroviral Prophylaxis.
Salado-Rasmussen K, Theilgaard ZP, Chiduo MG. et al
PLoS One
. 2015 Mar 26;10(3):e0121111.
Paper

Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.
Baranyai D, Muro E, Gödtel-Armbrust U,  et al
J Antimicrob Chemother. 2014 Apr 2.
Abstract

FULL-TEXT PDF ARTICLE
Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis.
Permar SR, Salazar MG, Gao F,  et al
Retrovirology
. 2013 Aug 14;10(1):88.
Paper

Clinical and Genetic Determinants of Plasma Nevirapine Exposure following an Intrapartum Dose to Prevent Mother-to-Child Transmission.
Vardhanabhuti S, Acosta EP, Ribaudo HJ, et al
J Infect Dis. 2013 May 17
Abstract

Facilitators and barriers to cotrimoxazole and nevirapine prophylaxis among HIV exposed babies: a qualitative study from Harare, Zimbabwe.
Sibanda E, Weller I, Bernays S,et al .
J Int AIDS Soc
. 2012 Nov 11;15 Suppl 4:18061
Abstract

Nevirapine Inhibits Cell-Free Human Immunodeficiency Virus (HIV)-1 Infection In Vitro More Efficiently Than Cell-Cell HIV Infection at Concentrations Found in Human Breastmilk.
Dorosko SM, Housman ML, Connor RI.
Breastfeed Med
. 2012 Dec 18.
Abstract

FULL-TEXT ARTICLE
Maternal CD4+ Cell Count Decline after Interruption of Antiretroviral Prophylaxis for the Prevention of
Mother-to-Child Transmission of HIV.
Ekouevi D, Abrams EJ, Schlesinger M, et al
PLoS One
. 2012;7(8):e43750.
Paper

Population Pharmacokinetic Analysis of a Nevirapine-Based HIV-1 Prevention of Mother-to-Child Transmission
Program in Uganda to Assess the Impact of Different Dosing Regimens for Newborns.

Frank M, Harms G, Kunz A, Kloft C.
J Clin Pharmacol. 2012 May 25.
Abstract

FULL-TEXT PDF LETTER
Transplacental passage of nevirapine, nelfinavir and lopinavir.
van Hoog S, Boer K, Nellen J, et al
J Med
. 2012 Mar;70(2):102-103.
Commentary

Kinetics of nevirapine and its impact on HIV-1 RNA levels in maternal plasma and breast milk over time
after perinatal single dose nevirapine.
Aizire J, McConnell MS, Mudiope P, et al
J Acquir Immune Defic Syndr. 2012 Jan 1
Abstract

FULL-TEXT ARTICLE
Effectiveness of Non-nucleoside Reverse-Transcriptase Inhibitor-Based Antiretroviral
Therapy in Women Previously Exposed to a Single Intrapartum Dose of Nevirapine:
A Multi-country, Prospective Cohort Study.

Stringer JS, McConnell MS, Kiarie J,  et al
PLoS Med
. 2010 Feb 16;7(2):e1000233.
Paper

Temporal reduction of HIV type 1 viral load in breast milk by single-dose nevirapine
during prevention of MTCT.
Rossenkhan R, Ndung'u T, Sebunya TK, et al .
AIDS Res Hum Retroviruses.
2009 Dec;25(12):1261-4.
Abstract

Tolerance and viral resistance after single-dose nevirapine with tenofovir and emtricitabine to prevent
vertical transmission of HIV-1.
The TEmAA ANRS 12109 Study group.
AIDS. 2009 Mar 19.
Abstract
 

Persistence of nevirapine in breast milk and plasma of mothers and their children after single-dose
administration.
Kunz A, Frank M, Mugenyi K, et al
J Antimicrob Chemother. 2008 Oct 30.
Abstract

Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding
in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials.
Six Week Extended-Dose Nevirapine (SWEN) Study Team.
Lancet. 2008 Jul 26;372(9635):300-313.
Abstract
 
Nevirapine concentrations in newborns receiving an extended prophylactic regimen.
Mirochnick M, Nielsen-Saines K, Pilotto JH, et al 
J Acquir Immune Defic Syndr.
2008 Mar 1;47(3):334-7.
Abstract
 
Transmission Rates in Consecutive Pregnancies Exposed to Single-Dose Nevirapine in
Soweto, South Africa and Abidjan, Cote d'Ivoire.
Martinson NA, Ekouevi DK, Dabis F, et al

J Acquir Immune Defic Syndr.
2007 Apr 12
Abstract
 
Stability of Nevirapine Suspension in Prefilled Oral Syringes Used for Reduction of Mother-
to-Child HIV Transmission.
Rexroad VE, Parsons TL, Hamzeh FM,et al 
J Acquir Immune Defic Syndr. 2006 Sep 21;
Abstract
 
Enzyme Inducers Reduce Elimination Half-Life After a Single Dose of Nevirapine in Healthy
Women.
L'homme RF, Dijkema T, van der Ven AJ, Burger DM 
J Acquir Immune Defic Syndr
. 2006 Aug 24;
Abstract
 
Controversies in the use of nevirapine for prevention of mother-to-child transmission of HIV.
McIntyre JA. 
Expert Opin Pharmacother.
2006 Apr;7(6):677-85.
Abstract
 
Transmission of Human Immunodeficiency Virus Type 1 Nevirapine Resistance Mutaton
K103Nfrom a Treatment-Naive Mother to her Child
Schmitz T, Kleinkauf N, Klempa B, et al 
Pediatr Infect Dis J. 2006 Mar;25(3):275-276
Abstract
 
 
Should nevirapine be used to prevent mother-to-child transmission of HIV among
women of unknown serostatus?
Sint TT, Dabis F, Kamenga C, et al 
Bull World Health Organ
. 2005 Mar;83(3):224-228.
Abstract

Constraints of implementing on a larger scale the protocol of prevention of HIV/AIDS from
mother to child by Nevirapine intake
Adeothy-Koumakpai S, Monnykosso CN,  D'almeida M, et al 
Arch Pediatr.
2004 Dec;11(12):1425-1429.
Abstract

Intrapartum Exposure to Nevirapine and Subsequent Maternal Responses to
Nevirapine-Based Antiretroviral Therapy.
Jourdain G, Ngo-Giang-Huong N, Le Coeur S, et al
N Engl J Med.
2004 Jul 9
Abstract
 
  Nevirapine: a review of its use in the prevention and treatment of paediatric
HIV infection
.

Bardsley-Elliot A, Perry CM.
Paediatr Drugs 2
000 Sep-Oct;2(5):373-407

Abstract
 
 

Pharmacokinetics
               

       Journal Papers, Abstracts, and Commentaries

 
Nevirapine Pharmacokinetics and Safety in Neonates Receiving Combination Antiretroviral Therapy for Prevention of Vertical HIV Transmission
Lau E, Brophy J, Samson L, Kakkar F,
J Acquir Immune Defic Syndr. 2017 Jan 20.
Abstract

Nevirapine prophylaxis to prevent HIV-1 mother-to-child transmission: pharmacokinetic considerations in preterm infants.
Capretti MG, Marsico C, Conti M, et al
New Microbiol
. 2016 Jun 10;39(3).
Abstract

Pharmacokinetics of Injectable, Long-acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants.
Cortez JM Jr, Quintero R, Moss JA, et al
Antimicrob Agents Chemother
. 2014 Oct 13
Abstract

Population Pharmacokinetic Analysis of a Nevirapine-Based HIV-1 Prevention of Mother-to-Child Transmission Program in Uganda to Assess the Impact of Different Dosing Regimens for Newborns.
Frank M, Harms G, Kunz A, Kloft C.
J Clin Pharmacol
. 2013 Mar;53(3):294-304
Abstract 

Chronic administration of nevirapine during pregnancy: impact of pregnancy on
pharmacokinetics.
Capparelli EV, Aweeka F, Hitti J, et al 
HIV Med.
2008 Apr;9(4):214-220.
Abstract 
 

Steady-state nevirapine plasma concentrations are influenced by pregnancy.
Nellen JF, Damming M, Godfried MH 
HIV Med. 2008 Apr;9(4):234-8.
Abstract 

Nevirapine: pharmacokinetic considerations in children and pregnant women.
Mirochnick M, Clarke DF, Dorenbaum A.
Clin Pharmacokinet 2000 Oct;39(4):281-93

Abstract
 

Pharmacokinetics of nevirapine in human immunodeficiency virus type 1-infected
pregnant women and their neonates. Pediatric AIDS Clinical Trials Group Protocol 250
Team
.

Mirochnick M, Fenton T, Gagnier et al .
J Infect Dis 1998 Aug;178(2):368-74
Abstract

A phase I/II study of the safety and pharmacokinetics of nevirapine in HIV-1-infected
pregnant Ugandan women and their neonates (HIVNET006)
.

Musoke P, Guay LA, Bagenda D, et al,
AIDS
1999 Mar 11;13(4):479-86  

Abstract

 

Adherence
 

      Journal Papers, Abstracts, and Commentaries

 
Predictors of Nonadherence to Single-Dose Nevirapine Therapy for the Prevention of
Mother-to-Child HIV Transmission.
Albrecht S, Semrau K, Kasonde P, et al
J Acquir Immune Defic Syndr. 2006 Jan 1;41(1):114-118
Abstract
 

Adverse Events
 

         Journal Papers, Abstracts, and Commentaries

 
Hepatotoxicity in healthy infants exposed to nevirapine during pregnancy.
Iveli P, Noguera-Julian A, Soler-Palacín P,  et al
Enferm Infecc Microbiol Clin
. 2014 Dec 5. pii: S0213-005X(14)00354-1.
Abstract

Adverse events associated with nevirapine use in pregnancy: a systematic review and meta-analysis.
Ford N, Calmy A, Andrieux-Meyer I,  et al
AIDS. 2013 Jan 5.
Abstract

FULL-TEXT ARTICLE
Adverse Events in a Cohort of HIV Infected Pregnant and Non-Pregnant Women
Treated with Nevirapine versus Non-Nevirapine Antiretroviral Medication.

Aaron E, Kempf MC, Criniti S,  et al
PLoS One
. 2010 Sep 7;5(9).
Paper

Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure.
Ouyang DW, Shapiro DE, Lu M, et al 
AIDS
. 2009 Jul 15.
Abstract

Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared
with other antiretrovirals.
Ouyang DW, Brogly SB, Lu M, et al
AIDS. 2009 Nov 18.
Abstract

Plasma lipid profile in pregnant women with HIV receiving nevirapine.
Floridia M, Tamburrini E, Anzidei G, et al
AIDS Patient Care STDS. 2009 Mar;23(3):147-52.
Abstract

Plasma Lipid Profile in Pregnant Women with HIV Receiving Nevirapine.
Floridia M, Tamburrini E, Anzidei G, et al
AIDS Patient Care STDS
. 2009 Feb 3.
Abstract
 

Serious toxicity associated with continuous nevirapine-based HAART in pregnancy.
van Schalkwyk JE, Alimenti A, Khoo D, et al
BJOG
. 2008 Sep;115(10):1297-302.
Abstract
 
Nevirapine-induced side effects in pregnant women: experience of a Brazilian university
hospital.
Kondo W, Carraro EA, Prandel E, et al
Braz J Infect Dis. 2007 Dec;11(6):544-8.
Abstract
 
Nevirapine-associated toxicity in HIV-infected Thai men and women, including pregnant
women.
Phanuphak N, Apornpong T, Teeratakulpisarn S, et al
HIV Med. 2007 Sep;8(6):357-66.
Abstract
 
Effects of Nevirapine, Compared with Lamivudine, on Lipids and Lipoproteins in HIV-1-
Uninfected Newborns: The Stopping Infection from Mother-to-Child via Breast-Feeding
in Africa Lipid Substudy.
Sankatsing RR, Wit FW, Pakker N, et al
J Infect Dis. 2007 Jul 1;196(1):15-22.
Abstract
 
Antiretroviral-Associated Toxicity Among HIV-1-Seropositive Pregnant Women in
Mozambique Receiving Nevirapine-Based Regimens.
Jamisse L, Balkus J, Hitti J, et al
J Acquir Immune Defic Syndr. 2007 Jan 25;
Abstract
 
Maternal hepatotoxicity with nevirapine as part of combination antiretroviral therapy
in pregnancy.
Lyons F, Hopkins S, Kelleher B, et al  
HIV Med. 2006 May;7(4):255-60.
Abstract
 
Nevirapine toxicity in a cohort of HIV-1-infected pregnant women.
Joao EC, Calvet GA, Menezes JA, et al 
Am J Obstet Gynecol.
2006 Jan;194(1):199-202
Abstract

Third-Trimester Maternal Toxicity With Nevirapine Use in Pregnancy.
Joy S, Poi M, Hughes L, Brady MT,
Obstet Gynecol
. 2005 Nov;106(5):1032-1038.
Abstract
 

Nelfinavir and nevirapine side effects during pregnancy.
Timmermans S, Tempelman C, Godfried MH 
AIDS. 2005 May 20;19(8):795-799.
Abstract
 
Maternal Toxicity With Continuous Nevirapine in Pregnancy: Results From PACTG
1022.

For the PACTG 1022 Study Team .
J Acquir Immune Defic Syndr.
2004 Jul 1;36(3):772-776.
Abstract

Effect of nevirapine toxicity on choice of perinatal HIV prevention strategies.
Stringer JS, Sinkala M,  Rouse DJ, et al.
Am J Public Health
2002 Mar;92(3):365-6
Abstract
 

 

Diagnostics/Monitoring
 

         Journal Papers, Abstracts, and Commentaries
 
  Good performance of an immunoassay based method for nevirapine measurements in human breast milk.
Salado-Rasmussen K, Theilgaard ZP, Chiduo M,  et a
Clin Chem Lab Med. 2011 Apr 20.

Abstract

Sensitive Drug-Resistance Assays Reveal Long-Term Persistence of HIV-1 Variants with the
K103N Nevirapine (NVP) Resistance Mutation in Some Women and Infants after the
Administration of Single-Dose NVP: HIVNET 012.
Flys T, Nissley DV, Claasen CW,
J Infect Dis. 2005 Jul 1;192(1):24-9.
Abstract


Economics
 

         Journal Papers, Abstracts, and Commentaries
 
  Cost-effectiveness of nevirapine to prevent mother-to-child HIV transmission in eight
African countries.
Sweat MD, O'Reilly KR, Schmid GP, et al   
AIDS. 2004 Aug 20;18(12):1661-71
Abstract
 


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