Nevirapine Pediatric Data

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Nevirapine (Viramune)

Pediatric Treatment

General Reports
D4T/NVP/3TC
D4T/NVP/RTV
NVP/DDI/ZDV
Multiple Combinations
Drug Comparison Studies
Therapeutic Strategies

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Last Update: May 18, 2017
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General Reports

Journal Papers, Abstracts, and Commentaries

Virologic Response to First-line Efavirenz- or Nevirapine-based Antiretroviral Therapy in HIV-infected African Children.
Kekitiinwa A, Szubert AJ, Spyer M, et al
Pediatr Infect Dis J. 2017 Jun;36(6):588-59
Abstract
Determinants of virological outcome and adverse events in African children treated with paediatric nevirapine fixed-dose-combination tablets.
Bienczak A, Denti P, Cook A, Wiesner L, et al
AIDS. 2017 Jan 4.
Abstract

FULL-TEXT ARTICLE
Efficacy of Six-Week Extended-Dose Nevirapine Varies by Infant Birth Weight with Greatest Relative Efficacy in Low Birth Weight Infants.
Gupte N, Kinikar A, McIntire KN, et al
PLoS One. 2016 Sep 30;11(9):e016297
Paper

Evaluation of adherence measures of antiretroviral prophylaxis in HIV exposed infants in the first 6 weeks of life.
Desmond AC, Moodley D, Conolly CA, et al
BMC Pediatr. 2015 Mar 19;15(1):23.
Abstract

Steady-State Pharmacokinetics of Nevirapine Extended-Release Tablets in HIV-1 Infected Children and Adolescents: An Open-Label, Multiple Dose, Cross-Over Study.
Giaquinto C, Anabwani G, Feiterna-Sperling C, et al
Pediatr Infect Dis J. 2013 Dec 30.
Abstract

Virologic Suppression in Nevirapine-Exposed HIV-Infected Infants Initiating Antiretroviral Therapy in Rural Uganda.
Kay J, Wanzira H, Sandison T, et al
J Trop Pediatr. 2011 Sep 19
Abstract

Reuse of Nevirapine in Exposed HIV-Infected Children After Protease Inhibitor-Based
Viral Suppression: A Randomized Controlled Trial.
Coovadia A, Abrams EJ, Stehlau R, et al
JAMA. 2010 Sep 8;304(10):1082-90.
Abstract

Response to antiretroviral therapy in HIV-infected Ugandan children exposed
and not exposed to single-dose nevirapine at birth.
Musoke PM, Barlow-Mosha L, Bagenda D, et al
J Acquir Immune Defic Syndr. 2009 Dec;52(5):560-8.
Abstract

D4T/NVP/3TC

           Journal Papers, Abstracts, and Commentaries

A Chewable Pediatric Fixed-Dose Combination Tablet of Stavudine, Lamivudine,
and Nevirapine: Pharmacokinetics and Safety Compared With the Individual
Liquid Formulations in Human Immunodeficiency Virus-Infected Children in Thailand.
Vanprapar N, Cressey TR, Chokephaibulkit K, et al
Pediatr Infect Dis J. 2010 May 5.
Abstract

Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric
fixed-dose combination tablets.
L'homme RF, Kabamba D, Ewings FM, et al
AIDS. 2008 Mar 12;22(5):557-65
Abstract

Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination
of stavudine, lamivudine and nevirapine.
Chokephaibulkit K, Plipat N, Cressey TR, et al
AIDS. 2005 Sep 23;19(14):1495-1499
Abstract

D4T/NVP/RTV

           Journal Papers, Abstracts, and Commentaries

Stavudine, nevirapine and ritonavir in stable antiretroviral therapy-experienced
children with human immunodeficiency virus infection.
Yogev R, Lee S, Wiznia A, et al.
Pediatr Infect Dis J 2002 Feb;21(2):119-125
Abstract

NVP/DDI/ZDV

  Journal Papers, Abstracts, and Commentaries

Combination treatment with zidovudine, didanosine, and nevirapine in infants with
human immunodeficiency virus type 1 infection.
Luzuriaga K, Bryson Y, Krogstad P et al.
New England Journal of Medicine 1997; 336(19): 1343-1349.
Abstract

Multiple Combinations

              Journal Papers, Abstracts, and Commentaries

Pooled Individual Data Analysis of Five Randomized Trials of Infant Nevirapine Prophylaxis to Prevent Breast-Milk HIV-1 Transmission.
Hudgens MG, Taha TE, Omer SB, et al
Clin Infect Dis. 2012 Sep 20
Abstract
Antiretroviral Therapy in HIV-1 Infected Children.
Lodha R, Upadhyay A, Kabra SK.
Indian Pediatr. 2005 Aug 7;42(8):789-796.
Abstract

Nevirapine use in HIV-1-infected children.
Verweel G, Sharland M, Lyall H, et al
AIDS. 2003 Jul 25;17(11):1639-47.
Abstract

Nucleoside-analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or
ritonavir for pretreated children infected with human mmunodeficiency virus type 1.
Krogstad P, Lee S, Johnson G, Stanley K,. et al.
Clin Infect Dis 2002 Apr 1;34(7):991-1001
Abstract

Combination nucleoside analog reverse transcriptase inhibitor(s) plus nevirapine,
nelfinavir, or ritonavir in stable antiretroviral therapy- experienced HIV-infected
children: week 24 results of a randomized controlled trial--PACTG 377.
Pediatric AIDS Clinical Trials Group 377 Study Team.
AIDS Research and Human Retroviruses 2000; 16(12): 1113-1121.
Abstract


Drug Comparison Studies/Strategies

Nevirapine vs Efavirenz

              Journal Papers, Abstracts, and Commentaries

Efficacy and tolerability of nevirapine- versus efavirenz-containing regimens in HIV-infected Thai children.
Lapphra K, Vanprapar N, Chearskul S, et al
Int J Infect Dis. 2008 Jun 21.
Abstract

Nevirapine vs Lopinavir

             Journal Papers, Abstracts, and Commentaries

Nevirapine- vs Lopinavir/Ritonavir-based Antiretroviral Therapy in HIV-infected Infants and Young Children: Long-term Follow-up of the IMPAACT P1060 Randomized Trial.
Barlow-Mosha L, Angelidou K, Lindsey J, et al
Clin Infect Dis. 2016 Jul 20.
Abstract
Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children.
Violari A, Lindsey JC, Hughes MD, et al
N Engl J Med. 2012 Jun 21;366(25):2380
Abstract



Therapeutic Strategies

             Journal Papers, Abstracts, and Commentaries

Nevirapine-related adverse events among children switched from efavirenz to nevirapine as compared to children who were started on
nevirapine-based antiretroviral therapy directly.
Sanjeeva GN, Sukanya V, Pavithra HB, et al
AIDS Care. 2014 Dec 17:1-5.
Abstract

Is nevirapine dose escalation appropriate in young, African, HIV-infected children?
Fillekes Q, Mulenga V, Kabamba D, et al
AIDS. 2013 Apr 16.
Abstract
Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with
|a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial.
Kuhn L, Coovadia A, Strehlau R, et al
Lancet Infect Dis. 2012 Mar 15.
Abstract

FULL-TEXT PDF ARTICLE
Outcome of protease inhibitor substitution with nevirapine in HIV-1 infected children.
Gonzalez-Tome MI, Ramos Amador JT, et al
BMC Infect Dis. 2008 O
ct 22;8(1):144
Paper

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