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Nevirapine (Viramune)
 
Pediatric Treament
 
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D4T/NVP/3TC
D4T/NVP/RTV
 NVP/DDI/ZDV
Multiple Combinations
Drug Comparison Studies
 Therapeutic Strategies



 
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Last Update:  March 20, 2012
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General Reports
       

           Journal Papers, Abstracts, and Commentaries  

 
Virologic Suppression in Nevirapine-Exposed HIV-Infected Infants Initiating Antiretroviral Therapy in Rural Uganda.
 Kay J, Wanzira H, Sandison T,  et al
J Trop Pediatr. 2011 Sep 19
 Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Reuse of Nevirapine in Exposed HIV-Infected Children After Protease Inhibitor-Based
Viral Suppression: A Randomized Controlled Trial.
 Coovadia A, Abrams EJ, Stehlau R,  et al
AMA. 2010 Sep 8;304(10):1082-90.
 Abstract

Response to antiretroviral therapy in HIV-infected Ugandan children exposed
and not exposed to single-dose nevirapine at birth.
Musoke PM, Barlow-Mosha L, Bagenda D, et al
J Acquir Immune Defic Syndr. 2009 Dec;52(5):560-8.
 Abstract
 
           Conference Reports, Abstracts, and Posters
 
 
POSTER
 6 Weeks of Extended Nevirapine Is More Effective than sd-Nevirapine in Increasing HIV-free Survival among
Low-birth-weight Infants of HIV+ Mothers
N Gupte A Kinikar .M Khandave, et al
 (19 CROI)
PDF Poster       Abstract
 

HPTN 046: Efficacy of Extended Daily Infant NVP through Age 6 Months Compared to 6 Weeks for
Postnatal PMTCT of HIV through Breastfeeding
 H Coovadia, E Brown, Y Maldonado, et al
 (XVIII IAC)
 Abstract

Early impact of extended prophylaxis with Nevirapine on HIV acquisition among infants in
Rural Rakai, Uganda
J. Kagaayi, R.H. Gray, V. Ddungu, et al(
(XVIII IAC)
 Abstract

Evaluating the potential impact of previous exposure to single dose nevirapine on a large PMTCT
program in rural, Kericho Kenya
 L. Soo, F. Sawe, J. Mumbi, J. Maswai 
(XVIII IAC)
 Abstract
D4T/NVP/3TC
       

           Journal Papers, Abstracts, and Commentaries  
 
 
A WEEK-IN-REVIEW FEATURED REPORT
A Chewable Pediatric Fixed-Dose Combination Tablet of Stavudine, Lamivudine,
and Nevirapine: Pharmacokinetics and Safety Compared With the Individual
Liquid Formulations in Human Immunodeficiency Virus-Infected Children in Thailand.
 Vanprapar N, Cressey TR, Chokephaibulkit K,  et al 
Pediatr Infect Dis J. 2010 May 5.
 Abstract

Nevirapine, stavudine and lamivudine pharmacokinetics in African children on paediatric
fixed-dose combination tablets.
 L'homme RF, Kabamba D, Ewings FM, et al 
AIDS. 2008 Mar 12;22(5):557-65
 Abstract

Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination
of stavudine, lamivudine and nevirapine.
Chokephaibulkit K, Plipat N, Cressey TR, et al 
AIDS. 2005 Sep 23;19(14):1495-1499
 Abstract
D4T/NVP/RTV
       

           Journal Papers, Abstracts, and Commentaries  

  Stavudine, nevirapine and ritonavir in stable antiretroviral therapy-experienced
children with human immunodeficiency virus infection.
Yogev R, Lee S,  Wiznia A, et al.
Pediatr Infect Dis J 2002 Feb;21(2):119-125
 Abstract
NVP/DDI/ZDV
       

  Journal Papers, Abstracts, and Commentaries        

  Combination treatment with zidovudine, didanosine, and nevirapine in infants with
human  immunodeficiency virus type 1 infection.
 Luzuriaga K, Bryson Y, Krogstad P et al.
New England Journal of Medicine 1997; 336(19): 1343-1349.
Abstract
Multiple Combinations
       

              Journal Papers, Abstracts, and Commentaries

 
Antiretroviral Therapy in HIV-1 Infected Children.
Lodha R, Upadhyay A, Kabra SK.
Indian Pediatr. 2005 Aug 7;42(8):789-796.
 Abstract
 
Nevirapine use in HIV-1-infected children.
Verweel G, Sharland M, Lyall H, et al
AIDS. 2003 Jul 25;17(11):1639-47.
Abstract

Nucleoside-analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or
ritonavir for pretreated children infected with human mmunodeficiency virus type 1.
Krogstad P, Lee S, Johnson G, Stanley K,. et al.
 Clin Infect Dis 2002 Apr 1;34(7):991-1001
 Abstract 

Combination nucleoside analog reverse transcriptase inhibitor(s) plus nevirapine,
nelfinavir, or ritonavir in stable antiretroviral therapy- experienced HIV-infected
children: week 24 results of a randomized controlled trial--PACTG 377.
Pediatric AIDS Clinical Trials Group 377 Study Team.
AIDS Research and Human Retroviruses 2000; 16(12): 1113-1121. 
Abstract 
  

             Conference Reports, Abstracts, and Posters
 
 
POSTER
 Virologic Outcomes in Children Receiving Efavirenz-based and Nevirapine-based cART
in a Large African Cohort
 E Lowenthal, J Ellenberg, T David, et al
(19 CROI)
 PDF Poster     Abstract

Efficacy and safety of Nevirapine based HAART in a cohort of Thai children
K Frederix, C Fontaine, F Breitenecker
 (15IAC)
 Abstract
Drug Comparison Studies/Strategies
       
Nevirapine vs Efavirenz
 
              Journal Papers, Abstracts, and Commentaries
 
  Efficacy and tolerability of nevirapine- versus efavirenz-containing regimens in HIV-infected Thai children.
 Lapphra K, Vanprapar N, Chearskul S, et al
Int J Infect Dis. 2008 Jun 21.
 Abstract
 
             Conference Reports, Abstracts, and Posters
 
  Efficacy and tolerability of nevirapine-based regimen VS efavirenz-based regimen in HIV-infected
Thai children
 Lapphra K., Vanprapar N., Chearskul S , et al;
(XVII  International AIDS Conference )
 Abstract
 

Nevirapine vs Lopinavir
 
             Conference Reports, Abstracts, and Posters
 
  NVP- vs LPV/r-based ART among HIV+ Infants in Resource-limited Settings: T
he IMPAACT P1060 Trial
 P Palumbo, A Violari, J Lindsey, et al 
(18 CROI)
 Abstract
Therapeutic Strategies
       
             Journal Papers, Abstracts, and Commentaries  
 
 
Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with
|a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial.
 Kuhn L, Coovadia A, Strehlau R, et al
Lancet Infect Dis. 2012 Mar 15.
 Abstract

A WEEK IN REVIEW FEATURED REPORT
FULL-TEXT PDF ARTICLE
 Outcome of protease inhibitor substitution with nevirapine in HIV-1 infected children.
 Gonzalez-Tome MI, Ramos Amador JT, et al 
BMC Infect Dis. 2008 O
ct 22;8(1):144
 Paper

 
             Conference Reports, Abstracts, and Posters
 
  Long-term Outcomes of Switching Children to NVP-based Therapy after Initial Suppression with
a PI-basedRegimen
 L Kuhn, A Coovadia, R Strehlau, et al
(16 CROI)
 Abstract

Changes in lipid profiles after switching young children from a suppressive lopinavir/ritonavir-based
regimen to a nevirapine-based regimen
R. Strehlau, A. Coovadia, L. Martens, et al 
(5th IAS Conference)
 Abstract

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