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Last Update:  November 25, 2011
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New and Noteworthy
       
November 2011
 
General Reports
 

      Journal Papers, Abstracts, and Commentaries

 
Factors influencing plasma nevirapine levels: a study in HIV-infected children on generic antiretroviral
treatment in India.
 Swaminathan S, Ramachandran G, Agibothu Kupparam HK, et al
 J Antimicrob Chemother. 2011 Mar 9.
Abstract

Response to Nonnucleoside Reverse Transcriptase Inhibitor-Based Therapy in HIV-Infected
Children with Perinatal Exposure to Single-Dose Nevirapine.
Musiime V, Ssali F, Kayiwa J, Namala W, et al
AIDS Res Hum Retroviruses. 2009 Sep 24.
Abstract

Nevirapine: a review of its use in the prevention and treatment of  paediatric HIV  infection.
Bardsley-Elliot A, Perry CM. 
Paediatric Drugs 2000;Sept-Oct (5): 373-407.
Abstract
 

  
             Conference Reports, Abstracts, and Posters
 
 
Factors Influencing Plasma NVP Levels: A Study in HIV-infected Children on Generic ART in India
 AK Hemanth Kumar, G Ramachandran, M Vasantha, et al
 (19 CROI)
 Abstract

Nevirapine Concentrations in HIV-infected Ugandan Children on Adult Fixed-dose Combination Tablet ART,
with and without Rifampicin-based Treatment for Active M. tuberculosis Infection
L Barlow-Mosha, P Musoke, T Parsons, et al 
(16 CROI)
 Abstract

Nevirapine Exposure with WHO Pediatric Weight Band Dosing--Enhanced Therapeutic Concentrations
Predicted Based on Extensive International Pharmacokinetic Experience
 E Capparelli, D Kabamba, T Cressey,  D Burger
(15th CROI)
 Abstract
Pharmacokinetics
       
      Journal Papers, Abstracts, and Commentaries
 
 
Limited Sampling Models to Predict the Pharmacokinetics of Nevirapine, Stavudine,
and Lamivudine in HIV-Infected Children Treated With Pediatric Fixed-Dose
Combination Tablets.
 Burger D, Ewings F, Kabamba D, et al  
Ther Drug Monit. 2010 Apr 8.
 Abstract

Pharmacokinetics of nevirapine in HIV-infected children with and without malnutrition
receiving divided adult fixed-dose combination tablets.
 Pollock L, Else L, Poerksen G, et al
J Antimicrob Chemother. 2009 Dec;64(6):1251-9.
Abstract

Pharmacokinetics of nevirapine in HIV-infected children with and without malnutrition
receiving divided adult fixed-dose combination tablets
Pollock L, Else L, Poerksen G, et al  
J Antimicrob Chemother. 2009 Oct 6.
 Abstract

CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical
response in HIV-1-infected children.
 Saitoh A, Sarles E, Capparelli E, et al 
AIDS. 2007 Oct 18;21(16):2191-9.
 Abstract

Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination
of stavudine, lamivudine and nevirapine.
Chokephaibulkit K, Plipat N, Cressey TR, et al 
AIDS. 2005 Sep 23;19(14):1495-1499
 Abstract
 
             Conference Reports, Abstracts, and Posters
 
 
Steady-state Pharmacokinetics of NVP Extended-release Formulation in Children with HIV-1 Infection
 C Giaquinto, G Anabwani, C Feiterna-Sperling
(18 CROI)
 Abstract

POSTER
 Pharmacokinetics of Nevirapine in 3- to 6-kg, HIV-infected Infants Taking Pediatric Fixed-dose Combination
Tablets
 V Mulenga, Q Fillekes, D Kabamba, et al 
(16 CROI)
 PDF Poster     Abstract

POSTER
 Pharmacokinetics of Nevirapine, Stavudine, and Lamivudine in HIV-infected Children in
Zambia Treated with Pediatric Fixed-dose Combination Tablets
 D Kabamba, R L'homme, F Ewings, et al 
(14 CROI)
 PDF Poster    Abstract
Resistance
 
    Journal Papers, Abstracts, and Commentaries
 
 
HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.
Hunt GM, Coovadia A, Abrams EJ, et al
AIDS. 2011 May 30
 Abstract

A WEEK-IN-REVIEW FEATURED REPORT
 Analysis of nevirapine resistance in HIV-infected infants who received extended nevirapine or
nevirapine/zidovudine prophylaxis.
Fogel J, Hoover DR, Sun J, et al
AIDS. 2011 Apr 24;25(7):911-917.
 Abstract

FULL-TEXT PDF ARTICLE
 Induction Therapy with Protease-Inhibitors Modifies the Effect of Nevirapine Resistance on Virologic
Response to Nevirapine-based HAART in Children.
Moorthy A, Kuhn L, Coovadia A, et al
Clin Infect Dis. 2011 Feb;52(4):514-21.
Paper

Minor resistant variants in nevirapine-exposed infants may predict virologic failure
on nevirapine-containing ART.
MacLeod IJ, Rowley CF, Thior I,  et al
J Clin Virol. 2010 Jul;48(3):162-7.
 Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine.
Micek MA, Blanco AJ, Beck IA, et al 
Clin Infect Dis. 2010 May 15;50(10):1405-14
 Abstract

A WEEK-IN-REVIEW FEATURED REPORT
 Minor resistant variants in nevirapine-exposed infants may predict virologic failure
on nevirapine-containing ART.
 Macleod IJ, Rowley CF, Thior I, Wester C, et al 
J Clin Virol. 2010 Apr 26.
 Abstract

High rate of mutation K103N causing resistance to nevirapine in Indian children with acquired
immunodeficiency syndrome.
Sehgal S, Pasricha N, Singh S.
Indian J Med Microbiol. 2008 Oct-Dec;26(4):372-4.
 Abstract
 
Impact of NVP plasma concentration on selection of resistant virus in mothers who
received single dose NVP to prevent perinatal HIV-1 transmission and persistence of
resistant virus in their infected children.
 Chaix ML, Ekouevi DK, Peytavin G, et al
Antimicrob Agents Chemother. 2006 Dec 18;
 Abstract
 
Selection and Persistence of Viral Resistance in HIV-Infected Children After Exposure to
Single-Dose Nevirapine
 Martinson NA, Morris L, Gray G, et al 
J Acquir Immune Defic Syndr. 2006 Nov 16;
Abstract

Need for Therapeutic Drug Monitoring in HIV-1 Infected Children Receiving Efavirenz Doses
according to International Guidelines.
von Hentig N, Koenigs C, Elanjikal S, et al
Eur J Med Res. 2006 Sep 29;11(9):377-80.
 Abstract
   

             Conference Reports, Abstracts, and Posters

 
POSTER
 Antiretroviral Drug Resistance Mutations in HIV-1-infected Ugandan Children
Perinatally Exposed to Single-dose Nevirapine following Virologic Failure to
an NNRTI-based Regimen
V Musiime, F Ssali, I Nankya,  et al
(17th CROI)
 PDF Poster     Abstract

POSTER
 Predictors of Nevirapine Resistance in Ugandan Infants Who Were HIV-infected despite
Single-dose Nevirapine Prophylaxis
 J Church, A Mwath, L Guay, et al
(16 CROI)
 PDF Poster     Abstract
 
Analysis of NVP Resistance in Ugandan Infants Who Were HIV-infected despite Receiving
Single-dose Nevirapine vs Single-dose NVP Plus up to 6 Weeks of Daily NVP to Prevent HIV
Vertical Transmission
 J Church, S Omer, L Guay, et al   
(15th CROI)
 Abstract

Selection of Resistance Mutations in Children Receiving Prophylaxis with Lamivudine or
Nevirapine for the Prevention of Postnatal Transmission of HIV
 M  Giuliano, C Galluzzo, E Germinario, et al  
 (12 CROI)
 Abstract

Genotypic resistance profiles in HIV-1 reverse transcriptase after 24-week therapy with
nevirapine-based HAART in antiretroviral naïve Thai HIV-infected children
T Puthanakit, V Sirisanthana, S Sirivichayakul, et al
 (15IAC)
 Abstract
 
Adverse Events
 
           Journal Papers, Abstracts, and Commentaries  
 
  Nevirapine-Associated Rash With Eosinophilia and Systemic Symptoms in a Child With
Human Immunodeficiency Virus Infection.
Santos RP, Ramilo O, Barton T.
Pediatr Infect Dis J. 2007 Nov;26(11):1053-1056.
Abstract

          Conference Reports, Abstracts, and Posters

 
POSTER
 Incidence and risk factors for nevirapine related toxicities among HIV-infected Asian children randomized to
starting ART at different CD4%
C. Kea, T. Puthanakit, T. Apornpong, et al
(6th IAS Conference)
Poster     Abstract

POSTER
 Neutropenia, anemia and skin-rash among HIV exposed infants receiving nevirapine and
cotrimoxazole compared to cotrimoxazole prophylaxis alone
J. Aizire, M.G. Fowler. Wang, et al
 (XVIII IAC)
PDF Poster     Abstract

Stevens-Johnson syndrome (SJS) following switch to Nevirapine based regimen
at Baylor-Uganda´s Paediatric Infectious Diseases Clinic, Mulago Hospital
 P. Kasirye Gitta, S. Bakeera-Kitaka, A. Kekitiinwa, et al
(XVIII IAC)
 Abstract

POSTER
 2-Year Evolution of Triglycerides and Cholesterol in Thai HIV-1-infected Children Receiving
First-line NVP or Efavirenz EFV-based Regimen
S Kanjanavanit, R Hansudewechakul, S Kim, et al
(17th CROI)
PDF Poster     Abstract

POSTER
 Hepatotoxicity Associated with Nevirapine Use in HIV-infected Children
 M Baylor, O Ayime, M Truffa,  et al
 (12 CROI)
PDF Poster   Abstract

  
Diagnostics/Monitoring
 

              Journal Papers, Abstracts, and Commentaries

  Nevirapine Concentration in Nonstimulated Saliva: An Alternative to Plasma Sampling in
Children with Human Immunodeficiency Virus Infection.
 Rakhmanina NY, Capparelli EV, van den Anker JN. et al 
Ther Drug Monit. 2007 Feb;29(1):110-117
 Abstract
 
  Need for Therapeutic Drug Monitoring in HIV-1 Infected Children Receiving Efavirenz Doses
according to International Guidelines.
 von Hentig N, Koenigs C, Elanjikal S, et al
 Eur J Med Res. 2006 Sep 29;11(9):377-80.
 Abstract		  
Prevention
 
              Journal Papers, Abstracts, and Commentaries
 
  Extended prophylaxis with nevirapine and cotrimoxazole among HIV-exposed uninfected infants is well tolerated.
 Aizire J, Fowler MG, Wang J,  et al
AIDS. 2011 Nov 22.
 Abstract

Quantifying the impact of nevirapine-based prophylaxis strategies to prevent mother-to-child transmission of HIV-1: A combined pharmacokinetic, pharmaco- and viral dynamic analysis to predict clinical outcomes.
 Frank M, von Kleist M, Kunz A, et al
Antimicrob Agents Chemother. 2011 Sep 26.
Abstract
HIV/TB Coinfection
 
              Journal Papers, Abstracts, and Commentaries
 
  Serum Nevirapine and Efavirenz Concentrations and Effect of Concomitant Use of Rifampicin in HIV Infected Children on Antiretroviral Therapy.
 Shah I, Swaminathan S, Ramachandran G, et al
Indian Pediatr. 2011 Mar 15.
 Abstract

     Conference Reports, Abstracts, and Posters
 
  Immunological and virological response to fixed dose nevirapine based highly active
antiretroviral therapy (HAART) in HIV-infected Ugandan children with concurrent active
tuberculosis (TB) infection on rifampicin based anti-TB treatment
M. Kamateeka, L. Barlow Mosha, P. Mudiope, et al 
(5th IAS Conference_
 Abstract		  

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