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Last Update:  March 16, 2018
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New and Noteworthy
       
March 2018
 
General Reports
 

      Journal Papers, Abstracts, and Commentaries

 
Single-dose nevirapine exposure does not affect response to antiretroviral therapy in HIV-infected African children aged below 3 years.
 Musoke P, Szubert AJ, Musiime V, et al
AIDS. 2015 Jul 17.
 Abstract

Efficacy and Safety of an Extended Nevirapine Regimen in Infants of Breastfeeding Mothers With HIV-1 Infection for Prevention of HIV-1 Transmission (HPTN 046):
18-Month Results of a Randomized, Double-Blind, Placebo-Controlled Trial.
 Fowler MG, Coovadia H, Herron CM,  et al
J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):366-74.
Abstract

Nevirapine Inhibits Cell-Free Human Immunodeficiency Virus (HIV)-1 Infection In Vitro More Efficiently Than Cell-Cell HIV Infection at Concentrations Found in Human Breastmilk.
 Dorosko SM, Housman ML, Connor RI.
Breastfeed Med. 2012 Dec 18.
 Abstract
Factors influencing plasma nevirapine levels: a study in HIV-infected children on generic antiretroviral
treatment in India.
 Swaminathan S, Ramachandran G, Agibothu Kupparam HK, et al
 J Antimicrob Chemother. 2011 Mar 9.
Abstract

Response to Nonnucleoside Reverse Transcriptase Inhibitor-Based Therapy in HIV-Infected
Children with Perinatal Exposure to Single-Dose Nevirapine.
Musiime V, Ssali F, Kayiwa J, Namala W, et al
AIDS Res Hum Retroviruses. 2009 Sep 24.
Abstract

Nevirapine: a review of its use in the prevention and treatment of  paediatric HIV  infection.
Bardsley-Elliot A, Perry CM. 
Paediatric Drugs 2000;Sept-Oct (5): 373-407.
Abstract

  
Dosing
 
              Journal Papers, Abstracts, and Commentaries
 
  Nevirapine Extended-Release Formulation Tablets in HIV-1 Infected Children - Long-term Follow-up.
 Anabwani G, Königs C, Giaquinto C,  et al
Clin Infect Dis. 2015 Apr 26.
Abstract

Nevirapine Concentrations in Preterm and Low Birth Weight HIV-Exposed Infants: Implications for Dosing Recommendations.
 de Waal R, Kroon SM, Holgate SL, et al
Pediatr Infect Dis J. 2014 Jun 18
 Abstract


 Evaluation of Nevirapine Dosing Recommendations in HIV-infected Children.
 Foissac F, Bouazza N, Frange P, et al
 Br J Clin Pharmacol. 2012 Dec 28.  
 Abstract

Nevirapine Exposure with WHO Pediatric Weight Band Dosing - Enhanced Therapeutic Concentrations Predicted Based on Extensive International Pharmacokinetic Experience.
Nikanjam M, Kabamba D, Cressey TR, et al
Antimicrob Agents Chemother. 2012 Aug 6.
Abstract
 
Pharmacokinetics
       
      Journal Papers, Abstracts, and Commentaries
 
 
The Effect of Malnutrition on the Pharmacokinetics and Virologic Outcomes of Lopinavir, Efavirenz and Nevirapine in Food Insecure HIV-infected Children in Tororo, Uganda.
Bartelink IH, Savic RM, Dorsey G,  et al
Pediatr Infect Dis J. 2015 Mar;34(3):e63-e70.
 Abstract

Pharmacokinetics of Injectable, Long-acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants.
Cortez JM Jr, Quintero R, Moss JA, et al
Antimicrob Agents Chemother. 2014 Oct 13
 Abstract

Pharmacokinetics of nevirapine in HIV-infected 3-<6 kg infants taking paediatric fixed dose combination tablets.
 Fillekes Q, Mulenga V, Kabamba D,  et al
AIDS. 2012 Jun 27.
 Abstract

Population Pharmacokinetic Analysis of a Nevirapine-Based HIV-1 Prevention of Mother-to-Child Transmission Program in Uganda to Assess the Impact of Different Dosing Regimens for Newborns.
 Frank M, Harms G, Kunz A, Kloft C.
J Clin Pharmacol. 2012 May 25.
Abstract

Pharmacokinetics of nevirapine in HIV-infected children under 3 years on rifampicin-based
antituberculosis treatment.
Oudijk JM, McIlleron H, Mulenga V,  et al
AIDS. 2012 Apr 26
 Abstract

Limited Sampling Models to Predict the Pharmacokinetics of Nevirapine, Stavudine,
and Lamivudine in HIV-Infected Children Treated With Pediatric Fixed-Dose
Combination Tablets.
 Burger D, Ewings F, Kabamba D, et al  
Ther Drug Monit. 2010 Apr 8.
 Abstract

Pharmacokinetics of nevirapine in HIV-infected children with and without malnutrition
receiving divided adult fixed-dose combination tablets.
 Pollock L, Else L, Poerksen G, et al
J Antimicrob Chemother. 2009 Dec;64(6):1251-9.
Abstract

Pharmacokinetics of nevirapine in HIV-infected children with and without malnutrition
receiving divided adult fixed-dose combination tablets
Pollock L, Else L, Poerksen G, et al  
J Antimicrob Chemother. 2009 Oct 6.
 Abstract

CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical
response in HIV-1-infected children.
 Saitoh A, Sarles E, Capparelli E, et al 
AIDS. 2007 Oct 18;21(16):2191-9.
 Abstract

Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination
of stavudine, lamivudine and nevirapine.
Chokephaibulkit K, Plipat N, Cressey TR, et al 
AIDS. 2005 Sep 23;19(14):1495-1499
 Abstract
Virology
 

              Journal Papers, Abstracts, and Commentaries

  Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-Experienced HIV-Infected Children.
 Moholisa RR, Schomaker M, Kuhn L, et al
Pediatr Infect Dis J. 2016 Aug 31.
 Abstract

The Effect of Malnutrition on the Pharmacokinetics and Virologic Outcomes of Lopinavir, Efavirenz and Nevirapine in Food Insecure HIV-infected Children in Tororo, Uganda.
Bartelink IH, Savic RM, Dorsey G,  et al
Pediatr Infect Dis J. 2015 Mar;34(3):e63-e70.
 Abstract
Resistance
 
    Journal Papers, Abstracts, and Commentaries
 
 
.Persistence of HIV-drug-resistance among South African Children given Nevirapine to Prevent Mother-to-Child-Transmission.
 Kanthula R, Rossouw T, Feucht UD, et al
AIDS. 2017 Mar 15.
Abstract

FULL-TEXT ARTICLE
 Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique.
 Antunes F, Zindoga P, Gomes P, et al
PLoS One. 2015 Jul 10;10(7):e0131994.
Paper

Nevirapine Resistance in Previously Nevirapine-Unexposed HIV-1-Infected Kenyan Infants Initiating Early Antiretroviral Therapy.
 Chohan BH, Tapia K, Benki-Nugent S, et al
AIDS Res Hum Retroviruses. 2015 Apr 22.
Abstract

Nevirapine resistance in previously nevirapine-unexposed HIV-1 infected Kenyan infants initiating early antiretroviral therapy.
 Chohan B, Tapia K, Benki-Nugent S, et al 
AIDS Res Hum Retroviruses. 2015 Mar 28.
Abstract

HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.
Hunt GM, Coovadia A, Abrams EJ, et al
AIDS. 2011 May 30
 Abstract

Analysis of nevirapine resistance in HIV-infected infants who received extended nevirapine or
nevirapine/zidovudine prophylaxis.
Fogel J, Hoover DR, Sun J, et al
AIDS. 2011 Apr 24;25(7):911-917.
 Abstract

FULL-TEXT PDF ARTICLE
 Induction Therapy with Protease-Inhibitors Modifies the Effect of Nevirapine Resistance on Virologic
Response to Nevirapine-based HAART in Children.
Moorthy A, Kuhn L, Coovadia A, et al
Clin Infect Dis. 2011 Feb;52(4):514-21.
Paper

Minor resistant variants in nevirapine-exposed infants may predict virologic failure
on nevirapine-containing ART.
MacLeod IJ, Rowley CF, Thior I,  et al
J Clin Virol. 2010 Jul;48(3):162-7.
 Abstract

Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine.
Micek MA, Blanco AJ, Beck IA, et al 
Clin Infect Dis. 2010 May 15;50(10):1405-14
 Abstract

Minor resistant variants in nevirapine-exposed infants may predict virologic failure
on nevirapine-containing ART.
 Macleod IJ, Rowley CF, Thior I, Wester C, et al 
J Clin Virol. 2010 Apr 26.
 Abstract

High rate of mutation K103N causing resistance to nevirapine in Indian children with acquired
immunodeficiency syndrome.
Sehgal S, Pasricha N, Singh S.
Indian J Med Microbiol. 2008 Oct-Dec;26(4):372-4.
 Abstract
 
Impact of NVP plasma concentration on selection of resistant virus in mothers who
received single dose NVP to prevent perinatal HIV-1 transmission and persistence of
resistant virus in their infected children.
 Chaix ML, Ekouevi DK, Peytavin G, et al
Antimicrob Agents Chemother. 2006 Dec 18;
 Abstract
 
Selection and Persistence of Viral Resistance in HIV-Infected Children After Exposure to
Single-Dose Nevirapine
 Martinson NA, Morris L, Gray G, et al 
J Acquir Immune Defic Syndr. 2006 Nov 16;
Abstract

Need for Therapeutic Drug Monitoring in HIV-1 Infected Children Receiving Efavirenz Doses
according to International Guidelines.
von Hentig N, Koenigs C, Elanjikal S, et al
Eur J Med Res. 2006 Sep 29;11(9):377-80.
 Abstract
   
Adverse Events
 
           Journal Papers, Abstracts, and Commentaries  
 
  Nevirapine-related adverse events among children switched from efavirenz to nevirapine as compared to children who were started on nevirapine-based antiretroviral therapy directly.
 Sanjeeva GN, Sukanya V, Pavithra HB, et al
AIDS Care. 2014 Dec 17:1-5.
Abstract

Hepatotoxicity in healthy infants exposed to nevirapine during pregnancy.
 Iveli P, Noguera-Julian A, Soler-Palacín P, et al  
Enferm Infecc Microbiol Clin. 2014 Dec 5. pii: S0213-005X(14)00354-1.
 Abstract

Stevens-Johnson Syndrome and HIV in Children in Swaziland.
 Dziuban EJ, Hughey AB, Stewart DA, et al
Pediatr Infect Dis J. 2013 Jun 5.
 Abstract

Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapy.
 Arpadi S, Shiau S, Strehlau R,  et al  
Arch Dis Child. 2012 Dec 5
Abstract

FULL-TEXT PDF ARTICLE
 Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India.
Ram M, Gupte N, Nayak U,   et al
BMC Infect Dis. 2012 Oct 31;12(1):282.
 Paper

Nevirapine-Associated Rash With Eosinophilia and Systemic Symptoms in a Child With
Human Immunodeficiency Virus Infection.
Santos RP, Ramilo O, Barton T.
Pediatr Infect Dis J. 2007 Nov;26(11):1053-1056.
Abstract

          Conference Reports, Abstracts, and Posters

     
Diagnostics/Monitoring
 

              Journal Papers, Abstracts, and Commentaries

  Nevirapine Concentration in Nonstimulated Saliva: An Alternative to Plasma Sampling in
Children with Human Immunodeficiency Virus Infection.
 Rakhmanina NY, Capparelli EV, van den Anker JN. et al 
Ther Drug Monit. 2007 Feb;29(1):110-117
 Abstract
 
  Need for Therapeutic Drug Monitoring in HIV-1 Infected Children Receiving Efavirenz Doses
according to International Guidelines.
 von Hentig N, Koenigs C, Elanjikal S, et al
 Eur J Med Res. 2006 Sep 29;11(9):377-80.
 Abstract		  
Therapeutic Strategies
 

              Journal Papers, Abstracts, and Commentaries

  Nevirapine-related adverse events among children switched from efavirenz to nevirapine as compared to children who were started on
nevirapine-based antiretroviral therapy directly.
 Sanjeeva GN, Sukanya V, Pavithra HB, et al
AIDS Care. 2014 Dec 17:1-5.
Abstract
 

              Conference Reports, Abstracts, and Posters

 

Lipid profile in children randomized to immediate versus deferred nevirapine-based antiretroviral therapy
in the PREDICT study
 S. Kanjanavanit, T. Puthanakit, P. Kosalaraksa, et al
 (XIX IAC)
 Abstract
Prevention
 
              Journal Papers, Abstracts, and Commentaries
 
  Efficacy and safety of an extended nevirapine regimen in infants of breastfeeding mothers with HIV-1 infection for prevention of HIV-1 transmission (HPTN 046): 18-month results of a randomized, double-blind, placebo-controlled trial.
 Fowler MG, Coovadia H, Herron CM, Maldonado Y, et al
J Acquir Immune Defic Syndr. 2013 Nov 1
 Abstract

Extended prophylaxis with nevirapine and cotrimoxazole among HIV-exposed uninfected infants is well tolerated.
 Aizire J, Fowler MG, Wang J,  et al
AIDS. 2011 Nov 22.
 Abstract

Quantifying the impact of nevirapine-based prophylaxis strategies to prevent mother-to-child transmission of HIV-1: A combined pharmacokinetic, pharmaco- and viral dynamic analysis to predict clinical outcomes.
 Frank M, von Kleist M, Kunz A, et al
Antimicrob Agents Chemother. 2011 Sep 26.
Abstract
HIV/TB Coinfection
 
              Journal Papers, Abstracts, and Commentaries
 
  Pharmacokinetics of nevirapine in HIV-infected children under 3 years on rifampicin-based
antituberculosis treatment.
Oudijk JM, McIlleron H, Mulenga V,  et al
AIDS. 2012 Apr 26
 Abstract

Serum Nevirapine and Efavirenz Concentrations and Effect of Concomitant Use of Rifampicin in HIV Infected Children on Antiretroviral Therapy.
 Shah I, Swaminathan S, Ramachandran G, et al
Indian Pediatr. 2011 Mar 15.
 Abstract
 

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