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Efavirenz (Sustiva/Strocrin)
 
Journal Citations: Adverse Events

Breast Disorders
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 Hypersensitivity
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Breast Disorders
       
  Efavirenz-associated gynecomastia: report of five cases and review of the literature.
 Jover F, Cuadrado JM, Roig P,et al  
Breast J. 2004 May-Jun;10(3):244-6.
 Abstract 
 
A case-control study of gynecomastia in HIV-1-infected patients receiving HAART
 Rahim S, Ortiz O, Maslow M, Holzman R. 
AIDS Read. 2004 Jan;14(1):23-4, 29-32, 35
 Abstract
 
  FULL-TEXT ARTICLE
Efavirenz-associated breast hypertrophy in HIV-infection patients.
Mercie P, Viallard JF, Thiebaut R, et al.
AIDS 2001 Jan 5;15(1):126-9
Paper
Cardiovascular Disorders
       
  FULL-TEXT ARTICLE
 Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral-
Therapy-Naive Patients Infected with HIV-1
van Leth F, Phanuphak P, Stroes E, et al
PLOS Vol2 Issue 9 Sep 2005
 Paper
Cutaneous Disorders
 
 
Rashes in HIV-infected patients undergoing therapy with nevirapine or efavirenz.
 Hartmann M, Brust J, Schuster D, et al 
Hautarzt. 2005 Feb 23
 Abstract 
 
Incidence and risk factors for rash in Thai patients randomized to regimens with
nevirapine, efavirenz or both drugs.
 Ananworanich J, Moor Z, Siangphoe U, et a;
AIDS. 2005 Jan 28;19(2):185-192
 Abstract 

Efavirenz-induced skin eruption and successful desensitization.
Phillips EJ, Kuriakose B, Knowles SR. 
Ann Pharmacother 2002 Mar;36(3):430-2
Abstract       

 
Hepatic Disorders
 
 
Hepatotoxicity in patients prescribed efavirenz or nevirapine.
 Brück S, Witte S, Brust J,  et al 
Eur J Med Res. 2008 Jul 28;13(7):343-8.
 Abstract   
 
Risk and determinants of developing severe liver toxicity during therapy with
nevirapine-and efavirenz-containing regimens in HIV-infected patients.
 Ena J, Amador C, Benito C, Fenoll V. et al 
Int J STD AIDS. 2003 Nov;14(11):776-81.
Abstract   

Incidence of Liver Injury After Beginning Antiretroviral Therapy with  Efavirenz or
Nevirapine.
Martin-Carbonero L, Nunez M, Gonzalez-Lahoz J, Soriano V
 HIV Clin Trials 2003 Mar-Apr;4(2):115-120
Abstract   

NNRTI hepatotoxicity: efavirenz versus nevirapine.
Pulido F, Torralba M.
J HIV Ther 2002 Nov;7(Suppl 2):S3-S9
 Abstract

Fulminant hepatic failure after the start of an efavirenz-based HAART regimen in a
treatment-naive female AIDS patient without hepatitis virus co-infection.
Abrescia N, D'Abbraccio M, Figoni M, et al.
Antimicrob Chemother 2002 Nov;50(5):763-5
 Abstract

Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy:
Role of hepatitis C and B infections.
Sulkowski MS, Thomas DL, Mehta SH, et al.
Hepatology 2002 Jan;35(1):182-9
Abstract

  
Hypersensitivity
 
 
Efavirenz-Induced Hypersensitivity Reaction Manifesting in Rash and Hepatitis in a Latino Male
(March).
 Leung JM, O'Brien JG, Wong HK, Winslow DL.
Ann Pharmacother. 2008 Feb 5
Abstract
 
Association of Efavirenz Hypersusceptibility with Virologic Response in ACTG 368, a Randomized
Trial of Abacavir (ABC) in Combination with Efavirenz (EFV) and Indinavir (IDV) in HIV-Infected Subjects
with Prior Nucleoside Analog Experience.
 Demeter LM, Degruttola V, Lustgarten S, et al
HIV Clin Trials. 2008 Jan-Feb;9(1):11-25
 Abstract
 
Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure.
 Angel-Moreno-Maroto A, Suarez-Castellano L, Hernandez-Cabrera M, Perez-Arellano JL.
 J Infect. 2005 Jul 1;
 Abstract

Pulmonary hypersensitivity reaction induced by efavirenz.
Behrens GM, Stoll M, Schmidt RE.
 Lancet 2001 May 12;357(9267):1503-4
 Abstract

  
Metabolic Disorders
 
 
A WEEK-IN-REVIEW FEATURED REPORT
Insulin resistance in HIV-infected patients receiving long-term therapy with efavirenz,
lopinavir/ritonavir and atazanavir.
 Bernal E, Masiá M, Padilla S, et al 
Med Clin (Barc). 2007 Jul 14;129(7):252-4.
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Long-Term Body Fat Outcomes in Antiretroviral-Naive Participants Randomized to Nelfinavir
or Efavirenz or Both Plus Dual Nucleosides: Dual X-Ray Absorptiometry Results From A5005s,
a Substudy of Adult Clinical Trials Group 384.
 Dubé MP, Komarow L, Mulligan K, et al 
J Acquir Immune Defic Syndr. 2007 Jun 21;
 Abstract
 
Body Fat and Other Metabolic Effects of Atazanavir and Efavirenz, Each Administered in Combination
with Zidovudine plus Lamivudine, in Antiretroviral-Naive HIV-Infected Patients.
Jemsek JG, Arathoon E, Arlotti M, et al
Clin Infect Dis. 2006 Jan 15;42(2):273-80.
 Abstract
 
Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir
or efavirenz plus dual nucleosides.
Dube MP, Parker RA, Tebas P, et al
AIDS. 2005 Nov 4;19(16):1807-1818.
Abstract

Long-term metabolic consequences of switching from protease  inhibitors to efavirenz in
therapy for human immunodeficiency virus-infected patients with lipoatrophy.
Estrada V, De Villar NG, Larrad MT, et al.
Clin Infect Dis 2002 Jul 1;35(1):69-76
 Abstract
Mental Disorders
 
 
A WEEK-IN-REVIEW FEATURED REPORT
Neuropsychiatric side effects of efavirenz therapy.
 Arendt G, de Nocker D, von Giesen HJ, Nolting T.
Expert Opin Drug Saf. 2007 Mar;6(2):147-54.
 Abstract 
 
Quality of life and depression among HIV-infected patients receiving efavirenz- or protease
inhibitor-based therapy in Senegal.
 Poupard M, Ngom Gueye N, Thiam D, et al
HIV Med. 2007 Mar;8(2):92-5.
 Abstract 
 
Efavirenz and chronic neuropsychiatric symptoms: a cross-sectional case control study.
 Rihs TA, Begley K, Smith DE, et al  
 HIV Med. 2006 Nov;7(8):544-548.
Abstract 
 
Use of Efavirenz Is Not Associated with a Higher Risk of Depressive Disorders: A Substudy
of the Randomized Clinical Trial ALIZE-ANRS 099.
 Journot V, Chene G, Castro ND, et al   
Clin Infect Dis. 2006 Jun 15;42(12):1790-9.
 Abstract 
 
Neuropsychiatric adverse events after switching from an antiretroviral regimen containing
efavirenz withouttenofovir to an efavirenz regimen containing tenofovir: a report of nine cases.
 Allavena C, Le Moal G, Michau C, et ak 
Antivir Ther. 2006;11(2):263-5
 Abstract 
 
Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using
plasma drug level monitoring.
 Gutierrez F, Navarro A, Padilla S, et al  
Clin Infect Dis. 2005 Dec 1;41(11):1648-53.
Abstract 
 
Long-Term Neuropsychiatric Disorders on Efavirenz-Based Approaches: Quality of Life,
Psychologic Issues, and Adherence.
 Fumaz CR, Munoz-Moreno JA, et al  
J Acquir Immune Defic Syndr. 2005 Apr 15;38(5):560-565.
Abstract 
 
Efavirenz intoxication due to slow hepatic metabolism.
 Hasse B, Gunthard HF, Bleiber G, Krause M. 
Clin Infect Dis. 2005 Feb 1;40(3):e22-3.
Abstract
 
Recurrence of post-traumatic stress disorder symptoms after initiation of  antiretrovirals
including efavirenz: a report of two cases.
Moreno A, Labelle C, Samet JH.
HIV Med. 2003 Jul;4(3):302-304.
Abstract

Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz.
Lochet P, Peyriere H, Lotthe A, et al.
HIV Med 2003 Jan;4(1):62-66
 Abstract

Central nervous system adverse effects with efavirenz: case report and review.
Puzantian T.
Pharmacotherapy 2002 Jul;22(7):930-3
 Abstract

  
Neurological Disorders
 
 
Status epilepticus resulting from severe efavirenz toxicity in an HIV-infected patient.
 Nijhawan AE, Zachary KC, Kwara A, Venna N.
AIDS Read. 2008 Jul;18(7):386-8,
Abstract 
 
No Observable Correlation between Central Nervous System Side Effects and EFV Plasma
Concentrations in Japanese HIV Type 1-Infected Patients Treated with EFV Containing HAART.
 Takahashi M, Ibe S, Kudaka Y, et al 
AIDS Res Hum Retroviruses. 2007 Aug;23(8):983-987.
 Abstract 
 
Efavirenz-induced neurological symptoms in rare homozygote CYP2B6 *2/*2 (C64T).
 Usami O, Ashino Y, Komaki Y, et al 
Int J STD AIDS. 2007 Aug;18(8):575-6.
 Abstract 
 
A WEEK-IN-REVIEW FEATURED REPORT
Neuropsychiatric side effects of efavirenz therapy.
 Arendt G, de Nocker D, von Giesen HJ, Nolting T.
Expert Opin Drug Saf. 2007 Mar;6(2):147-54.
 Abstract 
 
Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using
plasma drug level monitoring.
 Gutierrez F, Navarro A, Padilla S, et al  
Clin Infect Dis. 2005 Dec 1;41(11):1648-53.
Abstract 
 
Pharmacogenetics of efavirenz and central nervous system side effects: an Adult
AIDS Clinical Trials Group study.
 Haas DW, Ribaudo HJ, Kim RB, et al
AIDS. 2004 Dec 3;18(18):2391-2400.
 Abstract

Central nervous system adverse effects with efavirenz: case report and review.
Puzantian T.
Pharmacotherapy 2002 Jul;22(7):930-3
 Abstract

Efavirenz plasma levels can predict treatment failure and central nervous system side
 effects in HIV-1-infected patients.
Marzolini C, Telenti A, Decosterd LA,  et al.   
AIDS 2001 Jan 5;15(1):71-5
 Abstract

  
Pulmonary Disorders
 
  Pulmonary hypersensitivity reaction induced by efavirenz.
Behrens GM, Stoll M, Schmidt RE.
 Lancet 2001 May 12;357(9267):1503-4
 Abstract		  
Renal/Urinary Tract Disorders
 
 
A WEEK-IN-REVIEW FEATURED REPORT
Efavirenz-induced urolithiasis.
 Wirth GJ, Teuscher J, Graf JD, Iselin CE.
Urol Res. 2006 Apr 20;
 Abstract
 
Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure.
 Angel-Moreno-Maroto A, Suarez-Castellano L, Hernandez-Cabrera M, Perez-Arellano JL.
 J Infect. 2005 Jul 1;
 Abstract
 
Sleep Disorders
 
 
Changes in sleep quality and brain wave patterns following initiation of an efavirenz-containing
triple antiretroviral regimen.
 Moyle G, Fletcher C, Brown H, et al  
 HIV Med. 2006 May;7(4):243-7
 Abstract

Analyzing Sleep Abnormalities in HIV-Infected Patients Treated with Efavirenz.
 Gallego L, Barreiro P, Rio Rd R, et al
Clin Infect Dis. 2004 Feb 1; 38(3): 430-2.
Abstract
Quality of Life
 
 
Quality of life and depression among HIV-infected patients receiving efavirenz- or protease
inhibitor-based therapy in Senegal.
 Poupard M, Ngom Gueye N, Thiam D, et al
HIV Med. 2007 Mar;8(2):92-5.
 Abstract

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Adverse Events