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Efavirenz (Sustiva/Strocrin)
 
Pediatric Data

General Reports
 Pharmacokinetics
 Viral Dynamics
Adverse Events
Monitoring
 Efficacy
Treatment Strategies
 US Treatment Guidelines


 
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Last Update:  August 23, 2008
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General Reports
 

Journal Papers, Abstracts, and Commentaries

  High Prevalence of Subtherapeutic Plasma Concentrations of Efavirenz in Children.
 Ren Y, Nuttall JJ, Egbers C, et al  
J Acquir Immune Defic Syndr. 2007 Apr 5;
Abstract
Pharmacokinetics
 
Journal Papers, Abstracts, and Commentaries
 
  Pharmacokinetics and Pharmacodynamics of Efavirenz and Nelfinavir in HIV-infected Children
Participating in an Area-under-the-curve Controlled Trial.
 Fletcher CV, Brundage RC, Fenton T, et al 
Clin Pharmacol Ther. 2007 Jul 4;
Abstract

Conference Reports, Abstracts, and Posters

  CYP2B6-G516T Polymorphisms Influence Plasma Concentrations of Efavirenz in HIV-
1-infected Children Receiving HAART
 A Saitoh, C Fletcher, R Brundage, et al
(13  CROI)
 Abstract
Viral Dynamics
 

Journal Papers, Abstracts, Letters, and Commentaries

  Patterns of plasma human immunodeficiency virus type 1 RNA response to
highly active antiretroviral therapy in infected children.
Spector SA, Yong FH, Cabral S et al.
Journal of Infectious Disease 2000; 182(6): 1769-1773.
Abstract
Adverse Events
 

Journal Papers, Abstracts, Letters, and Commentaries

  Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.
 Lowenhaupt EA, Matson K, Qureishi B,et al  
Clin Infect Dis. 2007 Nov 15;45(10):e128-30.
Abstract
Efficacy
 

Journal Papers, Abstracts, Letters, and Commentaries

 
Efficacy and tolerability of nevirapine- versus efavirenz-containing regimens in HIV-infected Thai children.
 Lapphra K, Vanprapar N, Chearskul S, et al
Int J Infect Dis. 2008 Jun 21.
 Abstract
 
Antiviral efficacy, tolerability and pharmacokinetics of efavirenz in an unselected cohort of
HIV-infected children.
 Wintergerst U, Hoffmann F, Jansson A, et al 
J Antimicrob Chemother. 2008 Mar 13
Abstract
 
Once-Daily Highly Active Antiretroviral Therapy for HIV-Infected Children: Safety and Efficacy
of an Efavirenz-Containing Regimen.
 Scherpbier HJ, Bekker V, Pajkrt D, et al 
Pediatrics. 2007 Feb 16;
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Effect of First Line Therapy Including Efavirenz and Two Nucleoside Reverse Transcriptase
Inhibitors in HIV-infected Children.
 Funk MB, Notheis G, Schuster T, et al 
Eur J Med Res. 2005 Dec 7;10(12):503-8.
 Abstract
 
Safety and efficacy of a NRTI-sparing HAART regimen of efavirenz and
lopinavir/ritonavir in HIV-1-infected children.
 Fraaij PL, Neubert J, Bergshoeff AS
Antivir Ther. 2004 Apr;9(2):297-9
 Letter

FULL-TEXT ARTICLE
Impact of Protease Inhibitor Substitution With Efavirenz in HIV-Infected Children:
Results of the First Pediatric Switch Study.
McComsey G, Bhumbra N, Ma JF, et al 
Pediatrics 2003 Mar;111(3):E275-E281
Paper

Combination therapy with efavirenz, nelfinavir, and nucleoside reverse- transcriptase
inhibitors in children infected with human immunodeficiency virus type 1.
Pediatric AIDS Clinical Trials Group 382 Team. Starr SE, Fletcher CV, et al.
New England Journal of Medicine 1999; 341(25): 1874-881.
Abstract
 

  
Conference Reports, Abstracts, and Posters
 
 
POWERPOINT POSTER PRESENTATION
Once-a-day pediatric HAART with DDI+3TC+EFV in Burkina Faso - a phase II Trial (ANRS 12103 trial)
 P. Msellati
(XVII International AIDS Conference)
 Poster  Presentaion
 
Long-term effectiveness of NNRTI-based HAART in antiretroviral-naive HIV-infected children
participating in Thailand´s National Access Program: 192-week result
Aurpibul L, Puthanakit T, Oberdorfer P, et al
 (4th IAS Conference)
 Abstract
 
TREC Response in P1021: A Once-daily Regimen of Emtricitabine, Didanosine, and Efavirenz
in Previously Naive Children
R Dickover, D Smith, P Britto, et al
 (13 CROI)
 Abstract

Potency of efavirenz as part of a first-line antiretroviral therapy (ART) regimen in antiretroviral naïve
children in a public hospital in Soweto, South Africa
T  Meyers, HJ  Moultrie, S Mtshizana, H Gous
 (15IAC)
 Abstract
 
  Effect of first line therapy including efavirenz and two nucleoside reverse transcriptase inhibitors
in previously untreated HIV-infected children
MB Funk, Z Elanjikal, G Notheis,  et al
 (15IAC)
Antiretroviral efficacy and tolerability of Abacavir (ABC) based regimens in a clinical cohort of
HIV-infected children
 F Hoffmann, T Niehues, B Buchholz, et al
 (14IAC)
 Abstract
Monitoring
 
Conference Reports, Abstracts, and Posters
 
 
Exploring the feasibility of dried blood spots for quantification of lopinavir, nevirapine and efavirenz
concentrations
L Else, L Dickinson, M Schellenberger, et al
 (8th Int Congress on Drug Therapy in HIV Infection )
Abstract

TDM of efavirenz as a tool of adherence in HIV-infected children
 R Rosso, A Di Biagio, C Dentone, et al
(8th Int Congress on Drug Therapy in HIV Infection )
Abstract
Treatment Strategies
 

Switching Therapies

Conference Reports, Abstracts, and Posters

  Switching Stavudine to Tenofovir and Protease Inhibitor to Efavirenz  Results in a
Favorable Clinical Outcome in HIV-infected Children
 A Viganò , V Giacomet , S Beretta , et al
(!2  CROI)
 Abstract
 
HIV/TB Coinfection

 Conference Reports, Abstracts, and Posters
 
  Plasma Concentrations of Efavirenz and Lopinavir in Children with and without Rifampicin-
based Anti-TB Treatment
 Y Ren, J Nuttall, C Egbers, et al
 (!4  CROI)
 Abstract

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