| A pharmacokinetic study on
the combination of amprenavir, lopinavir, and nevirapine was conducted on
five patients. The results of the study are charted in a Table in the
paper. Although the authors found that the amprenavir concentrations were
within the expected range, the lopinavir concentrations were highly
variable (40-60% lower than predicted by the manufacturer]. There was no
basis for this variability reflected in the data. The authors theorize
that this variability may be due in to the interaction with nevirapine
which may decrease the the lopinavir concentrations by induction of the cytochrome P450 system and by the interaction with amprenavir. The authors recommended that therapeutic drug monitoring be performed when this combination is used. |
|
a Department of Internal Medicine,
University of Cologne, Germany b Department of Clinical Pharmacology, University of Nijmegen, The Netherlands Abstract by Gordon Nary |
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Pharmacokinetics of amprenavir and lopinavir in combination with |
