Medical Advocates
Zidovudine (Retrovir)
 
Perinatal Efficacy
ZDV Monotherapy
 ZDV NVP
ZDV DDI
ZDV/3TC
ZDV Followed by ART




 






 
Perinatal ZDV Main New/Newsworthy Home Page

Last Update:  October 18, 2008  
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ZDV Monotherapy
 

   Journal Papers, Abstracts, and Commentaries
 
Disease Progression Among HIV-Infected Children Who Receive Perinatal Zidovudine
Prophylaxis.
 Berk DR, Falkovitz-Halpern MS, et al  
J Acquir Immune Defic Syndr. 2006 Oct 30;
Abstract
 
Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant
zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized
trial: the Mashi Study.
Thior I, Lockman S, Smeaton LM,et al 
JAMA. 2006 Aug 16;296(7):794-805.
 Abstract

Effectiveness of Short-Term and Long-Term Zidovudine Prophylaxis on Detection of HIV-1
Subtype Ein Human Placenta and Vertical Transmission.
 Bhoopat L, Khunamornpong S, Lerdsrimongkol PSirivatanapa P,et al   
 J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):545-550
 Abstract

      Conference Reports, Abstracts, and Posters   

  Baseline maternal characteristics associated with "early" and "late" HIV-1 vertical
transmission to non-breastfed infants despite zidovudine (ZDV) prophylaxis, in Thailand
G Jourdain, J Y Mary, S Le Coeur, et al
 (15IAC)
 Abstract
 
EFFECT OF PERINATAL ZIDOVUDINE TREATMENT ON THE EVOLUTION OF
CELL-FREE HIV-1 IN BREAST MILK ON POSTNATAL TRANSMISSION, ANRS 049
DITRAME-VIRO STUDY
O. Manigart, M. Crépin, V. Leroy, et al
 (2cd IAS)
 Abstract
 
Efficacy of perinatal Zidovudine administration using a modified PACTG 076 protocol, for
reduction of mother to child transmission of HIV: A historically case controlled longitudinal
study from Barbados
A Kumar, M A St. John
 (14IAC)
 Abstract
 
Superiority of An “Ultra short” Zidovudine (ZDV) regimen in the prevention of perinatal HIV
transmission in rural Zimbabwe
M S Silverman, P Thistle, G Arbess,  et al
 (14IAC)
 Abstract          
High post-partum morbidity in replacement fed infants born to HIV-infected women
in India, receiving short-course zidovudine
M A Phadke, K E Bharucha, A N Shrotri, et al
 (14IAC)
 Abstract
 
Impact of short-course zidovudine regimen on transmission risk and risk factors for
perinatal HIV transmission, Bangkok, Thailand
T Chotpitayasunondh, N Vanprapa, N Waranawat, et al
 (14IAC)
 Abstract
 
Acceptance of and adherence to zidovudine and infant formula for preventing
mother-child HIV transmission, Bangkok, Thailand
U Chaovarindr, A Chalermchokcharoenkit, S Asavapiriyanont, et al
 (14IAC)
 Abstract
 
Barriers to implementing a short-course zidovudine program in two Bangkok hospitals,
1999-2001
S Chearskul, T Chotpitayasunondh, N Vanprapa, et al
 (14IAC)
 Abstract
 
Adherence to maternal and infant zidovudine in a pilot study to prevent mother to child HIV
transmission associated with breastfeeding, Botswana
S Lockman, R L Shapiro, I Thior, et al
 (14IAC)
 Abstract

Successful of Zidovudine prophylaxis to prevent mother to child transmission
J Contarelli, G Alberich, A Cucchetti, et al
 (14IAC)
 Abstract

ZDV NVP Studies
         
 
Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces
nevirapine resistance in mothers from the Western Cape, South Africa.
 van Zyl GU, Claassen M, Engelbrecht S, et al 
J Med Virol. 2008 Apr 21;80(6):942-946
 Abstract
 
Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing
mother-to-child transmission of HIV in Africa?
 Leroy V, Sakarovitch C, Cortina-Borja M,
AIDS. 2005 Nov 4;19(16):1865-1875.
Abstract
 
Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent
peripartum HIV transmission.
 ANRS 1201/1202 DITRAME PLUS Study Group    
AIDS. 2005 Feb 18;19(3):309-318
 Abstract

Intrapartum and Neonatal Single-Dose Nevirapine Compared with Zidovudine for
Prevention of Mother-to-Child Transmission of HIV-1 in Kampala, Uganda:
Randomized Trial (HIVNET 012)
Guay LA, Musoke P, Fleming T, et al.
 Lancet 1999 Sep 4;354(9181):795-802  
Abstract
  Alternating nevirapine and zidovudine treatment of human  immunodeficiency virus
type 1-infected persons does not prolong nevirapine activity
de Jong MD, Loewenthal M, Boucher CA et al  
 J Infect Dis 1994 Jun;169(6):1346-50
Abstract		  

        Conference Reports, Abstracts, and Posters   

 
Routine use of combined zidovudine and nevirapine regimen in MTCT-Plus program
 O Marcy ,  A Mafoua ,  G Halembokaka  
(3rd IAS)
 Abstract
 
97% Progression-free Survival of HIV+ Pregnant Women 33 Months Post-delivery
 F Martin, L Navaratne , W Khan, et al
(12 CROI)
Abstract

Infant Zidovudine Prophylaxis and Emergence of Nevirapine Resistance at 6 Weeks in
Perinatally HIV-infected Infants Exposed to Intra-partum or Newborn Nevirapine
 N Ngo-Giang-Huong, G Jourdain, P Tungyai, et al
(12 CROI)
Abstract
 
Prevention of vertical HIV-1 transmission by Zidovudine and Nevirapine
S N Kurle, S P Tripathy, P L Joshi, et al
 (15IAC)
 Abstract
 
Effect of short course zidovudine plus single dose nevirapine on plasma viral load and
intrapartum prevention of mother to child HIV transmission (MTCT) in Thailand
A Teeraratkul, A Chalermchokcharoenkit, S Asavapiriyanont, et al
 (15IAC)
 
Infant ARV prophylaxis failures from a study of a short-course zidovudine plus 2-dose
nevirapine regimen for prevention of mother-to-child HIV transmission in Thailand
N Vanprapar, T Chotpitayasunondh, M Culnane, et al
 (15IAC)
 Abstract
 
Multicentre, Randomized Controlled Trial, Assessing the Safety and Efficacy of
Nevirapine in Addition to Zidovudine for the Prevention of Perinatal HIV In Thailand:
PHPT-2 Update
 M Lallemant, G Jourdain, S Le Coeur, et al.
(2cd IAS)
 Abstract
 
Effectiveness of a short course of zidovudine + nevirapine to prevent mother-to-
child transmission (PMTCT) of HIV-1: The Ditrame Plus ANRS 1201 Project in
Abidjan, Cote d’Ivoire
F Dabis, V Leroy, L Bequet, et al
 (14IAC)
 Abstract
 
Effectiveness of nevirapine and zidovudine use in the prevention of perinatal
transmission of HIV in Uganda
F Bajunirwe, S Asiimwe, M Kamya, et al
 (14IAC)
 Abstract
 
Neonatal post-exposure prophylaxis with nevirapine and zidovudine reduces
mother-to-child transmission of HIV
T E Taha, N Kumwenda, A Gibbons, et al
 (14IAC)
 Abstract
 
Addition of neonatal zidovudine to a standard single dose nevirapine to
the mother and newborn to increase reduction of mother-to-child transmission
of HIV
T E Taha, N Kumwenda, A Gibbons, et al
 (14IAC)
 Abstract

ZDV DDI Studies
ZDV/DDI vs ZDV/DDI/NVP
ZDV/DDI vs ZDV/DDI/NVP

Efficacy

     Journal Papers, Abstracts, and Commentaries

  Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in
patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial.
Basgoz N, Niu M, Hirsch MS, et al.  
 Ann Intern Med 1996 Jun 15;124(12):1019-30
Abstract 
 
ZDV/DDI/NVP vs ZDV/DDI

Efficacy

      Journal Papers, Abstracts, and Commentaries

  Nevirapine, zidovudine, and didanosine compared with zidovudine and didanosine in
patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial.  
 D’Aquila RT, Hughes MD, Johnson VA,  et al.  
 Ann Intern Med 1996 Jun 15;124(12):1019-30  
Abstract 		  

 
ZDV Followed by ART
 

        Conference Reports, Abstracts, and Posters
 
  POSTER
Community-based Generic ART following Single-dose Nevirapine or Short-course Zidovudine
in Zimbabwe
L Zijenah, G Kadzirange, S Rusakaniko, et al
(13 CROI)
 PDF Poster     Abstract
 

Perinatal ZDV Main New/Newsworthy Home Page

Zidovudine Perinatal Efficacy