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Zidovudine/Lamivudine (Combivir)
 
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Combivir PI
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Last updated:  July 06, 2015
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New and Noteworthy
     
June 2014
 
Drug Alerts
 
  • Ziagen/Combivir Alert
    GlaxoSmithKline and FDA
    March 2007
Pediatric Data
       
USPHS Pediatric Antiretroviral Drug Information

 US Treatment Guidelines
 
Efficacy
 
ZDV/3TC
 
    Journal Papers, Abstracts, and Commentaries
 
  Development of fixed dose combination tablets containing zidovudine and lamivudine
for paediatric applications.
Kayitare E, Vervaet C, Ntawukulilyayo JD,
Int J Pharm. 2008 Nov 18.
Abstract
 
ZDV/3TC/NVP
 
    Journal Papers, Abstracts, and Commentaries
 
  Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine
 in HIV-infected children.
Chokephaibulkit K, Cressey TR, Capparelli E, et al
Antivir Ther. 2011;16(8):1287-1295.
 Abstract
 
      Conference Reports, Abstracts, and Posters
 
  POSTER
The pediatric dispersible tablet with a FDC of 3TC/NVP/AZT is bioequivalent to the combination of Retrovir® syrup, Epivir® solution and Viramune® suspension providing simplified adaptable dosing for pediatric patients
T Bhushan, A. Deshmukh, S. Chakraborty, et al
(7th IAS Conference)
Poster      Abstract(

ZDV/3TC vs DDI

    Journal Papers, Abstracts, and Commentaries

  A randomized study of combined zidovudine-lamivudine versus didanosine monotherapy
in children with symptomatic therapy-naïve HIV-1 infection.
The Pediatric AIDS Clinical Trials Group Protocol 300 Study Team.
McKinney RE,Johnson GM, Stanley K et al.
Journal of Pediatrics 1998; 133(4): 500-508.
Abstract
   
  Zidovudine, didanosine, or both as the initial treatment for symptomatic HIV-infected
children.
AIDS Clinical Trials Group (ACTG) Study 152 Team. 
Englund JA, Baker CJ, Raskino C et al.
New England Journal of Medicine 1997; 336(24): 1704-1712.
Abstract

ZDV/3TC/ABC vs ZDV/ 3TC

     Journal Papers, Abstracts, and Commentaries

  A randomized, double-blind study of triple nucleoside therapy of abacavir, lamivudine,
and zidovudine versus lamivudine and zidovudine in previously treated human
immunodeficiency virus type 1-infected children.
Saez-Llorens X, Nelson RP, Emmanuel P et al
Pediatrics. 2001 Jan;107(1):E4.
Abstract

 

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