Medical Advocates
HIV Infection/Disease
  Lipodystrophy Drugs
General Reports
Androgen Therapy
Bezafibrate
Gemfibrozil
Growth Hormone
Metformin
 Oxymetholone
Pioglitazone
Rosiglitazone

 
Lipodystrophy Treatment   Main New/Newsworthy Home Page  
Last Update: September 29, 2006
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General Reports
 

       Journal Papers, Abstracts, and Commentaries

 
Hypolipidemic therapy under special conditions: acquired immune deficiency syndrome.
Yu PC, Calderaro D, Lima EM, Caramelli B. 
Arq Bras Cardiol. 2005 Oct;85 Suppl 4:58-61. Epub 2006 Jan 2.
 Abstract

Pharmacologic Therapy for HIV-Associated Lipodystrophy.
Benavides S, Nahata MC.
Ann Pharmacother. 2004 Jan 30
 Abstract
Androgen Therapy
 
General Reports

       Journal Papers, Abstracts, and Commentaries
 
  Use of androgens in patients who have HIV/AIDS: what we know about the effect of
androgens on wasting and lipodystrophy.
Abrams D.
AIDS Read. 2001 Mar;11(3):149-56.
Abstract
 		  
DHEA

     Conference Reports, Abstracts, and Posters
 
  Dehydroepiandrosterone (DHEA) does not improve HAART-associated
lipodystrophy syndrome
 JC Wasmuth, I Oosterhaar, E Voigt, et al
 (15IAC)
 Abstract
Bezafibrate
 

       Journal Papers, Abstracts, and Commentaries

  Bezafibrate-induced improvement in glucose uptake and endothelial function in
protease inhibitor-associated insulin resistance.
Nystrom T, Bratt G, Sjoholm A.
J Intern Med 2002 Dec;252(6):570-4
 Abstract		  
DHEA
 

 

Gemfibrozil
 

   Conference Reports, Abstracts, and Posters

  PDF POSTER
 A Randomized, Double-Blind, Placebo-Controlled, Comparative Study on the
Effects of Metformin or Gemfibrozil in Lipodystrophic HIV-1-Infected Patients
Receiving Protease Inhibitors (PI)
E. Martínez, P. Domingo, J. B. Pérez-Cuevas, et al
(9 CROI)
 PDF Poster   Abstract		  
Metformin
 

       Journal Papers, Abstracts, and Commentaries

 
Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte
chemoattractant protein-1 in human immunodeficiency virus-infected patients with lipodystrophy.
Coll B, van Wijk JP, Parra S, rt al
 Eur J Pharmacol. 2006 Jun 16;
 Abstract
 
Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving
protease inhibitor containing HAART.
Tomazic J, Karner P, Vidmar L, Maticic M,
Pharmacol Ther. 2005 Oct 15;22(8):685-700.
Abstract
 
Comparison of rosiglitazone and metformin for treating HIV lipodystrophy: a randomized trial.
 van Wijk JP, de Koning EJ, Cabezas MC, et al
Ann Intern Med. 2005 Sep 6;143(5):337-46.
Abstract

FULL-TEXT PDF ARTICLE
Increased PAI-1 and tPA Antigen Levels Are Reduced with Metformin Therapy in
HIV-Infected Patients with Fat Redistribution and Insulin Resistance
Hadigan, JB Meigs JB,  Rabe J, et al.
J Clin Endocrinol Metab. 2001 86: 939-943.
 PSD Paper

Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled
trial.
Hadigan C, Corcoran C, Basgoz N, et al
JAMA 2000 Jul 26;284(4):472-7
 Abstract

  

       Conference Reports, Abstracts, and Posters

 
Rosiglitazone and Metformin for the Treatment of HIV-Lipodystrophy: a Randomized Trial
J.P.H. VanA  WijkI, M. Castro CavezasA, E. J P. De Koning , et al
 (45 ICAAC)
 Abstract

PDF POSTER
 A Randomized, Double-Blind, Placebo-Controlled, Comparative Study on the Effects
of Metformin or Gemfibrozil in Lipodystrophic HIV-1-Infected Patients Receiving
Protease Inhibitors (PI)
E Martínez, P Domingo, JB Pérez-Cuevas, et al
(9 CROI)
 PDF Poster   Abstract

  
Oxymetholone
 

    Conference Reports, Abstracts, and Posters

 

PDF POSTER
Oxymetholone for the Treatment of HIV Wasting: A Double-blind, Randomized,
Placebo-controlled Phase 3 Trial in Eugonadal Men and Women
UR Hengge, K Stocks, S Faulkner, et al
 (11 CROI)
 PDF Poster       Abstract

Randomized Phase III Trial of Oxymetholone for the Treatment of HIV Wasting
and Lipodystrophy
UR Hengge, K Stocks, S Unger. et al.
 (9 CROI)
 Abstract

  
Pioglitazone
 

       Conference Reports, Abstracts, and Posters

  Clinical efficacy of pioglitazone in patients with HIV-associated lipodystrophy
W Prasithsirikul, W Muennooch, S Puttawong, et al
(15IAC)
 Abstract
Rosiglitazone
 
     Internet Documents
 
  LETTER
 Rosiglitazone . Adverse Events Warning Letter
GSK
December 2005
PDF Letter

     Journal Papers, Abstracts, and Commentaries

 
Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant
protein-1 in human immunodeficiency virus-infected patients with lipodystrophy.
Coll B, van Wijk JP, Parra S, rt al 
Eur J Pharmacol. 2006 Jun 16;
Abstract
 
Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving
protease inhibitor containing HAART.
Tomazic J, Karner P, Vidmar L, Maticic M,
Pharmacol Ther. 2005 Oct 15;22(8):685-700.
Abstract
 
Comparison of rosiglitazone and metformin for treating HIV lipodystrophy: a randomized trial.
 van Wijk JP, de Koning EJ, Cabezas MC, et al
Ann Intern Med. 2005 Sep 6;143(5):337-46.
Abstract
 
Impact of rosiglitazone treatment on the bioavailability of antiretroviral compounds in
HIV-positive patients.
Oette M, Kurowski M, Feldt T, et al
J Antimicrob Chemother. 2005 Jun 27;
 Abstract
 
Influence of rosiglitazone on flow-mediated dilation and other markers of cardiovascular
risk in HIV-infected patients with lipoatrophy.
Kovacic JC, Martin A, Carey D, et aL
Antivir Ther. 2005;10(1):135-43.
Abstract
 
Resistin Levels in HIV-infected Patients with Lipoatrophy Decrease in Response
to Rosiglitazone.
Kamin D, Hadigan C, Lehrke M, et al
J Clin Endocrinol Metab. 2005 Mar 1;
 Abstract

FULL-TEXT PDF ARTICLE
Metabolic Effects of Rosiglitazone in HIV Lipodystrophy: A Randomized,
Controlled Trial.
Hadigan C, Yawetz S, Thomas A,et al.
Ann Intern Med. 2004 May 18;140(10):786-794
 PDF Paper

No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind,
placebo-controlled trial.
Carr A, Workman C, Carey D,
Lancet. 2004 Feb 7;363(9407):429-38.
 Abstract
 
Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly
active antiretroviral therapy-associated lipodystrophy.
Sutinen J, Kannisto K, Korsheninnikova E, et al
Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E941-9.
 Abstract
 
FULL-TEXT ARTICLE
Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy
duringrosiglitazone therapy.
Yki-Jarvinen H, Sutinen J, Silveira A, et al
Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):688-94
Paper
 
Improved insulin sensitivity and body fat distribution in HIV-infected patients treated
with rosiglitazone: a pilot study.
Gelato MC, Mynarcik DC, Quick JL, et al
J Acquir Immune Defic Syndr. 2002 Oct 1;31(2):163-70.

    Conference Reports, Abstracts, and Posters

 
Rosiglitazone and Metformin for the Treatment of HIV-Lipodystrophy: a Randomized Trial
J.P.H. VanA  WijkI, M. Castro CavezasA, E. J P. De Koning , et al
 (45 ICAAC)
 Abstract
 
A Randomized Placebo Controlled Trial of Rosiglitazone for the Treatment of HIV
Lipodystrophy
R Cavalcanti , K Kain, S Shen, et al
 (12 CROI)
 Abstract

Evaluation of safety and efficacy of rosiglitazone in the treatment of HIV-associated
lipodystrophy
T Feldt, M Oette, K Goebels, et al
 (15IAC)
 Abstract

Lipodystrophy Treatment   Main New/Newsworthy Home Page  

Lipodystrophy Drugs