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HIV/HCV
Coinfection
 
Clinical Variants

General Reports
Hepatopulmonary Syndrome
Liver Fibrosis
Hepatic Steatosis
Cirrhosis
Hepatocellular Carcinoma

Portal Hypertension



 


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Last Update:  October 06, 2009
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General Reports
 

          Journal Papers, Abstracts, and Commentaries

 
Drug Abuse and Hepatitis C Infection as Comorbid Features of HIV Associated Neurocognitive Disorder:
Neurocognitive and Neuroimaging Features.
Martin-Thormeyer EM, Paul RH
Neuropsychol Rev. 2009 May 27.
Abstract

Hepatitis C in HIV-positive Patients-Treatment and Liver Disease Outcomes.
Adeyemi OM.
J Clin Gastroenterol
. 2007 Jan;41(1):75-87.
Abstract
 

The influence of hepatitis C virus-human immunodeficiency virus co-infection on the appearance
of liver enzyme elevation in people on high activity antiretroviral treatment.
Olalla J, Rubio R, Costa JR, Del Palacio A, et al 
Eur J Intern Med. 2005 Oct;16(6):405-7.

Abstract

Liver histopathology in human immunodeficiency virus-hepatitis C virus co-infected patients
with fatal liver disease.
Lichterfeld M, Haas S, Fischer HP, et al
J Gastroenterol Hepatol. 2005 May;20(5):739-7
-9.45
Abstract
 

     Conference Reports, Abstracts, and Posters
 
 
POSTER
Insulin Resistance and Liver Stiffness in HIV/HCV-co-infected Patients: A New Guest in Liver Disease
Progression?

N Merchante, I De Los Santos-Gil, A Rivero, et al
(16th CROI)
PDF Poster     Abstract

POSTER
Hepatic Venous Pressure Gradient Is Lower in HIV/HCV-co-infected than in HCV-mono-infected
Cirrhotic Patients

O Lo Lacono, J Berenguer, D Rincon, et al
(15th CROI)

PDF Poster     Abstract


Hepatopulmonary Syndrome
 

          Journal Papers, Abstracts, and Commentaries

  Hepatopulmonary Syndrome in HIV-Hepatitis C Virus Coinfection: A Case Report and
Review of the Literature.
Torno MS, Witt MD, Sue DY.
Clin Infect Dis. 2004 Aug 1;39(3):E25-9.
Abstract

Liver Fibrosis
 

          Journal Papers, Abstracts, and Commentaries

 
HIV-HCV co-infected patients with low CD4+ cell nadirs are at risk for faster fibrosis
progression and portal hypertension.
Reiberger T, Ferlitsch A, Sieghart W, et al
J
Viral Hepat
. 2009 Sep 25.
Abstract

Rapid Development of Advanced Liver Fibrosis after Acquisition of Hepatitis C
Infection during Primary HIV Infection.
Osinusi A, Kleiner D, Wood B, et al 
AIDS Patient Care STDS
. 2009 Jun;23(6):403-6
Abstract

Influence of insulin resistance on Hepatic Fibrosis and Steatosis in HCV Monoinfected compared with HIV-HCV
co-infected patients.
Halfon P, Pénaranda G, Carrat F, et al 
Aliment Pharmacol Ther
. 2009 Mar 9.
Abstract
 

Validation and comparison of simple noninvasive indexes for predicting liver fibrosis in
HIV-HCV-coinfected patients: ANRS CO3 Aquitaine cohort.
Loko MA, Castera L, Dabis F, et al
Am J Gastroenterol.
2008 Aug;103(8):1973-80
Abstract
 
Diagnostic accuracy, reproducibility and robustness of fibrosis blood tests in chronic hepatitis C:
A meta-analysis with individual data.
Leroy V, Halfon P, Bacq Y, et al
Clin Biochem. 2008 Jul 11
Abstract
 
Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than
HIV-negative patients despite antiretroviral therapy.

de Lédinghen V, Barreiro P, Foucher J, et al
J Viral Hepat.
2008 Jan 22
Abstract
 
Systematic Review and Meta-Analysis of the Diagnostic Accuracy of Fibrosis Marker
Panels in Patients with HIV/Hepatitis C Coinfection.
Shaheen AA, Myers RP.
HIV Clin Trials. 2008 Jan-Feb;9(1):43-51
Abstract
 
There is no difference in hepatic fibrosis rates of patients infected with hepatitis C virus
and those co-infected with HIV.

Souza AR, Tovo CV, Mattos AA, Chaves S. et al
Braz J Med Biol Res.
2007 Dec 20
Abstract
 
Noninvasive diagnosis of hepatic fibrosis in HIV/HCV-coinfected patients.
Larrousse M, Laguno M, Segarra M, et al
J Acquir Immune Defic Syndr. 2007 Nov 1;46(3):304-11.
Abstract
 
Identification of liver fibrosis in HIV/HCV-coinfected patients using a simple predictive model
based on routine laboratory data.

Berenguer J, Bellón JM, Miralles P, et al 
J Viral Hepat. 2007 Dec;14(12):859-69.
Abstract
 
Documented rapid course of hepatic fibrosis between two biopsies in patients coinfected by HIV
and HCV despite high CD4 cell count.

Bonnard P, Lescure FX, Amiel C, et al 
J Viral Hepa
t. 2007 Nov;14(11):806-11
Abstract
 
Liver Fibrosis Stage and HCV Genotype Distribution in HIV-HCV Coinfected Patients with
Persistently Normal Transaminases.

Maida I, Soriano V, Barreiro P, et al 
AIDS Res Hum Retroviruses.
2007 Jun;23(6):801-4.
Abstract
 
Influence of Liver Fibrosis Stage on Plasma Levels of Antiretroviral Drugs in HIV-Infected
Patients with Chronic Hepatitis C.

Barreiro P, Rodriguez-Novoa S, Labarga P, et al 
J Infect Dis.
2007 Apr 1;195(7):973-9
Abstract
 
Contributions to Hepatic Fibrosis in HIV-HCV Coinfected and HCV Monoinfected Patients.
Monto A, Kakar S, Dove LM, et al 
Am J Gastroenterol. 2006 Jul;101(7):1509-15.
Abstract
 
HAART attenuates liver fibrosis in patients with HIV/HCV co-infection: fact or fiction?
Verma S.
J Antimicrob Chemother. 2006 Jul 19;
Abstract
 
Usefulness of elastometry in evaluating the extents of liver fibrosis in hemophiliacs coinfected
with hepatitis C virus and human immunodeficiency virus.
Masaki N, Imamura M, Kikuchi Y, Oka S .
Hepatol Res. 2006 May 16
Abstract
 
Diagnosis of Hepatic Fibrosis and Cirrhosis by Transient Elastography in HIV/Hepatitis C Virus-
Coinfected Patients.
de Ledinghen V, Douvin C, Kettaneh A, et al 
J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):175-179.
Abstract
 
Liver Fibrosis in HIV-Positive Patients With Hepatitis C Virus: Role of Persistently Normal Alanine
Aminotransferase Levels.
Uberti-Foppa C, De Bona A, Galli L, et al
J Acquir Immune Defic Syndr. 2006 Jan 1;41(1):63-67
Abstract
 
Do type and duration of antiretroviral therapy attenuate liver fibrosis in HIV-hepatitis C
virus-coinfected patients?
Verma S, Wang CH, Govindarajan S, et al 
Clin Infect Dis. 2006 Jan 15;42(2):262-70.
Abstract
 
HIV Infection Does Not Affect the Performance of Noninvasive Markers of Fibrosis for the
Diagnosis of Hepatitis C Virus-Related Liver Disease.
Nunes D, Fleming C, Offner G, et al
J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):538-544
Abstract
 
Slower fibrosis progression in HIV/HCV-coinfected patients with successful HIV suppression
using antiretroviral therapy.
Brau N, Salvatore M, Rios-Bedoya CF, et al 
J Hepatol. 2005 Sep 20;
Abstract
 
Prediction of liver fibrosis in HIV/HCV-coinfected patients by simple noninvasive indexes.
Macias J, Giron-Gonzalez JA, Gonzalez-Serrano M, et al
Gut
. 2005 Aug 23;
Abstract
 
Influence of Liver Fibrosis on Highly Active Antiretroviral Therapy-Associated Hepatotoxicity
in Patients with HIV and Hepatitis C Virus Coinfection.
Aranzabal L, Casado JL, Moya J, et al 
Clin Infect Dis.
2005 Feb 15;40(4):588-93.

Abstract
 
Impact of antiretroviral treatment on progression of hepatic fibrosis in HIV/hepatitis C virus
co-infected patients.
Marine-Barjoan E, Saint-Paul MC, Pradier C, et al
AIDS. 2004 Nov 5;18(16):2163-2170.
Abstract

Fibrosis is worse in HIV-HCV patients with low-level immunodepression referred for HCV
treatment than in HCV-matched patients.
Rullier A, Trimoulet P, Neau D, et al 
Hum Pathol.
2004 Sep;35(9):1088-94.
Abstract
 
Incidence and predictors of severe liver fibrosis in human immunodeficiency virus-infected
patients with chronic hepatitis C: a European collaborative study.
Martin-Carbonero L, Benhamou Y, Puoti M, et al
Clin Infect Dis.
2004 Jan 1;38(1):128-33
Abstract

Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with
hepatitis C virus and human immunodeficiency virus.
Martinez-Sierra C, Arizcorreta A, Diaz F, et al.
Clin Infect Dis 2003 Feb 15;36(4):49
Abstract

 

     Conference Reports, Abstracts, and Posters

 
POSTER
Prevalence and Factors Associated with Significant Liver Fibrosis Measured by Transient Elastometry
in HIV/HCV-co-infected Patients

J Pineda, C Tural, E Ortega, et al
(16th CROI)
PDF Poster     Abstract
 
POSTER
Prevalence of Fibrosis Similar in Those with HIV/HCV Compared to HCV Alone

M Jain, E Neak, M Limerick, et al

PDF Poster     Abstract

 
Increased Rates of Fibrosis Progression between Sequential Liver Biopsies in HIV/HCV-
co-infected Patients

J Macias, J Berenguer, A Arizcorreta, et al
(15th CROI)
Abstract
 
POSTER
Prospective Validation of Simple Biological Markers in Assessing Liver Fibrosis in HIV/HCV/
co-infected Patients

J Tor, C Tural, R Muga, et al
(15th CROI)
PDF Poster     Abstract

 
POSTER
Improving the Differentiation of Mild from Significant Liver Fibrosis in HIV/HCV-co-infected Patients
Using Transient Elastometry
J del Valle, J Macias, P Barreiro, et al
(15th CROI)
PDF Poster     Abstract
 
Blood markers to assess the degree of liver fibrosis in HIV-HCV co-infected patients might have
a high diagnostic performance

Batisse D, Perré P, Fouchart-Hubert I, et al
(4th IAS Conference)
Abstract
 
POSTER
Low Prevalence of Moderate-severe Liver Fibrosis Assessed by Transient Hepatic Elastography
in HIV-infected Patients without HBV or HCV Co-infection

N Merchante, E Recio,
J Mira, et al
(14 CROI)
PDF Poster
     Abstract
 
POSTER
Soluble TNF Receptor II Levels Are Elevated in HCV/HIV Co-infection and Are Associated with
Advanced Liver Fibrosis Stage

M Shuhart, M Chung, D Paschal, et al
(14 CROI)
PDF Poster
     Abstract
 
Independent Assessment of Non-invasive Liver Fibrosis Biomarkers in HIV/HCV-co-infected |
Patients: The Fibrovic Study-ANRS HC 02 RIBAVIC

P Cacoub, F Carrat, P Bedossa, et al
(14 CROI)
Abstract
 
Failure of Transient Elastometry (Fibroscan) to Differentiate Mild from Significant Liver Fibrosis
in HIV/HCV-co-infected Patients

S Vergara, J Macías, A Rivero, et al
(14 CROI)
Abstract
 
Biological Non-invasive Tests for Prediction of Liver Fibrosis in HIV-infected Patients with Chronic
Hepatitis C: ANRS CO3 Aquitaine Cohort

MA Loko, L Castera, F Dabis, et al
(14 CROI)
Abstract
 
Markers of Liver Fibrosis Predict Adverse Liver Outcomes in a Population of HCV+ Individuals
with and without HIV Co-infection

D Nunes, D Nunes, G Offner, et al
(14 CROI)
Abstract
 
Insulin Resistance and Progression to Liver Fibrosis in HIV/HCV-co-infected Patients
Participating to the Prospective ANRS Co13 French Cohort Study

D Salmon, M A Loko, S Dominguez, et al
(14 CROI)
Abstract
 
Risk Factors for Advanced Liver Fibrosis and High Level of Necroinflammatory
Activity in HIV/HCV Co-infected Patients Receiving ART

J Pascual-Pareja, A Caminoa, J Arribas,  et al
(14 CROI)
Abstract
 

POSTER
Fibrosis progression in HIV/HCV co-infected patients with paired liver biopsies:
evaluation of risk factors
M Schiavini, E Ange1, A Mainini, et al
(2nd International Workshop on HIV and Hepatitis Co-infection)
PDF Poster

 

POSTER
Fibrosis progression in HIV/HCV co-infected patients with paired liver biopsies: evaluation
of risk factors

M Schiavini, E Angeli, A Mainini, et al  
(2nd International Workshop on HIV/HCV Coinfection)
PDF Poster

Liver Fibrosis Stage in HIV/HCV-Coinfected Patients with Persistently Normal Transaminases
Levels

I. MAIDA, V. SORIANO  J. GONZALEZ-LAHOZ , et al 
(45 ICAAC)

Abstract
 

Noninvasive Diagnostic to Evaluate the Grading and Staging of Hepatic Fibrosis in HIV/HCV
Co-Infected Patients
M. LARROUSSE, M. LAGUNO, M. SEGARRA, et al
(45 ICAAC)
Abstract
 
Influence of Antiretroviral Drugs on Liver Fibrosis in HIV-infected Patients with Chronic Hepatitis C
J Macias, V Castellano, N Merchante, et al
[11 CROI}
Abstract
 
Serum Markers of Liver Fibrosis in HIV/HCV-infected Adults
S Mehta, K Bhaskar, M Sulkowski, et al
(11 CROI}
Abstract
 

Hepatic Steatosis
 

     Journal Papers, Abstracts, and Commentaries
 

 
Influence of insulin resistance on Hepatic Fibrosis and Steatosis in HCV Monoinfected compared with HIV-HCV
co-infected patients.
Halfon P, Pénaranda G, Carrat F, et al 
Aliment Pharmacol Ther
. 2009 Mar 9.
Abstract
 
HIV coinfection and antiretroviral therapy enhances liver steatosis in patients with hepatitis C,
but only in those infected by HCV genotype other than 3.
Borghi V, Puoti M, Mussini C, et al 
Antivir Ther
. 2008;13(8):1057-65.
Abstract
 
FULL-TEXT PDF ARTICLE
Hepatic steatosis in patients with HIV-Hepatitis C Virus coinfection: is it associated with antiretroviral therapy and
more advanced hepatic fibrosis?

Verma S, Goldin RD, Main J., et al
BMC Res Notes. 2008 Jul 15;1(1):46
Paper
 
Prevalence of and Factors Associated With Hepatic Steatosis in Patients Coinfected
With Hepatitis C Virus and HIV: Agence Nationale pour la Recherche contre le SIDA
et les hépatites virales CO3 Aquitaine Cohort.

Neau D, Winnock M, Castéra L
J Acquir Immune Defic Syndr. 2007 Jun 1;45(2):168-173
Abstract
 
Histological Findings and Clinical Characteristics Associated with Hepatic Steatosis in Patients
Coinfected with HIV and Hepatitis C Virus.
Marks KM, Petrovic LM, Talal AH, et al 
J Infect Dis. 2005 Dec 1;192(11):1943-9.
Abstract

Hepatic steatosis in HIV/hepatitis C coinfection: Prevalence and significance compared
with hepatitis C monoinfection.
Monto A, Dove LM, Bostrom A,  et al   
Hepatology.
2005 Jul 15;42(2):310-316
Abstract
 

     Conference Reports, Abstracts, and Posters
 
 
HIV-HCV coinfected patients have to be screened for hepatic steatosis
Poizot-Martin I, Benhaim S, Drogoul-Vey M-P, et al
(4th IAS Conference)
Abstract

POSTER
Hepatic Steatosis and Associated Histological Findings in HIV/HCV Co-infected Patients
KM Marks, LM Petrovic, A  Talal, et al.

(11 CROI)
PDF Poster       Abstract


Cirrhosis
 


     Journal Papers, Abstracts, and Commentaries
 
 
Natural history of compensated viral cirrhosis in a cohort of patients with HIV infection.
Bruno R, Sacchi P, Puoti M, et al 
J Acquir Immune Defic Syndr. 2007 Nov 1;46(3):297-303
Abstract
 
Diagnosis and management of cirrhosis in coinfected patients.
Bonacini M.
J Acquir Immune Defic Syndr.
2007 Jul 1;45 Suppl 2:S38-46;
Abstract
 
HIV coinfection shortens the survival of patients with hepatitis C virus-related
decompensated cirrhosis.
Pineda JA, Romero-Gomez M, Diaz-Garcia F, et al
Hepatology. 2005 Mar 30;41(4):779-789
Abstract
 
  Factors Associated with Survival and First Hepatic Decompensation in a Large Prospective Cohort
of HIV/HCV-co-infected Patients with Liver Cirrhosis

M Lopez-Dieguez, M Montes, C Quereda, et al
Abstract
 
     Conference Reports, Abstracts, and Posters
 
 
POSTER
Cytokines and Liver Fibrosis in HIV/HCV Co-infection
M Ragni, M Nalesnik, L Qin, et al
(16th CROI)

PDF Poster     Abstract
 
POSTER
Liver Stiffness as a Predictor of Lack of Esophageal Varices Requiring Therapy in HIV/HCV-co-infected Patients
with Cirrhosis

J Pineda, E Recio, Á Camacho, et al
(16th CROI)
PDF Poster     Abstract

Survival of HIV/HCV-co-infected Patients with Compensated Liver Cirrhosis: Effect of HCV Therapy
ML Montes, J Pascual, M Lopez-Dieguez, et al
(16th CROI)
Abstract


Liver Failure
 

 

Hepatocellular Carcinoma
 

     Journal Papers, Abstracts, and Commentaries

 
Unusual presentation of metastatic hepatocellular carcinoma in an HIV/HCV coinfected patient:
case report and review of the literature.
Berretta M, Zanet E, Di Benedetto F,et al 
Tumori.
2008 Jul-Aug;94(4):589-91.
Abstract
 
Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era.
Macdonald DC, Nelson M, Bower M, Powles T
World J Gastroenterol
. 2008 Mar 21;14(11):1657-1663.
Abstract

Hepatocellular Carcinoma and Non-Hodgkin’s Lymphoma: The Roles of HIV, Hepatitis C Infection,
and Alcohol Abuse.
McGinnis KA, Fultz SL, Skanderson M, et al  
J Clin Oncol. 2006 Nov 1;24(31):5005-9
Abstract

Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with
hepatitis C virus and human immunodeficiency virus.
Martinez-Sierra C, Arizcorreta A, Diaz F, et al.
Clin Infect Dis 2003 Feb 15;36(4):49
Abstract
 

 
  Conference Reports, Abstracts, and Posters
 
POSTER

Clinical Presentation and Outcome of Hepatocellular Carcinoma in HIV-infected Patients
M Puoti, R Bruno, V Soriano, et al
(11 CROI)
PDF Poster       Abstract

Portal Hypertension
 

          Journal Papers, Abstracts, and Commentaries

  HIV-HCV co-infected patients with low CD4+ cell nadirs are at risk for faster fibrosis
progression and portal hypertension.
Reiberger T, Ferlitsch A, Sieghart W, et al
J
Viral Hepat
. 2009 Sep 25.

Abstract

 


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HIV/HCV Clinical Variants