Medical Advocates
Ritonavir (Norvir)
 
Journal Citations: Drug
Interactions 

Acenocoumarol
 Alprazolam
 Amprenavir
 Bupropion
 Buspirone
 Carbamazepine
 Digoxin
 Enfuvirtide
Fentanyl
 Fluoxetine
Fosamprenavir		 Fusidic Acid          Zaleplon
Ketoconazole       Zolpidem
Meperidine          Zopiclone      
Nelfinavir             Multi Combos   
Normeperidine
 Prednisone
 Risperidone 
 Sildenafil
Trazodone
 Triazolam
Ritonavir Main Page Drugs Main Page   Home Page    

Last Update:  April 13, 2006

RTV/Acenocoumarol

Severe interaction between ritonavir and acenocoumarol.
Llibre JM, Romeu J, Lopez E, Sirera G.
Ann Pharmacother 2002 Apr;36(4):621-3
 Abstract

RTV/Alprazolam

Alprazolam-ritonavir interaction: implications for product labeling.
Greenblatt DJ,von Moltke LL, Harmatz JS, et al.
Clin Pharmacol Ther 2000 Apr;67(4):335-41  
Abstract 

Extensive impairment of triazolam and alprazolam clearance by short-term
low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction.
Greenblatt DJ, von Moltke LL, Daily JP,  et al.
J Clin Psychopharmacol 1999 Aug;19(4):293-6
Abstract 

RTV/Amprenavir

 
Ritonavir Increases Plasma Amprenavir (APV) Exposure to a Similar Extent when Coadministered with
either Fosamprenavir or APV.
 Wire MB, Baker KL, Jones LS, et al 
Antimicrob Agents Chemother. 2006 Apr;50(4):1578-80.
 Abstract 

Genotypic inhibitory quotient as predictor of virological response to ritonavir-
amprenavir in human immunodeficiency virus type 1protease inhibitor-experien
ced patients.
Marcelin AG, Lamotte C, Delaugerre C, et al.  
 Antimicrob Agents Chemother 2003 Feb;47(2):594-600
 Abstract

  

FULL-TEXT ARTICLE
Pharmacokinetic modeling and simulations of interaction of amprenavir and ritonavir.
 Sale M, Sadler BM, Stein DS.
Antimicrob Agents Chemother 2002 Mar;46(3):746-54
 Paper

FULL-TEXT ARTICLE
Low level of cross-resistance to amprenavir (141W94) in samples from patients
pretreated with other protease inhibitors.
Schmidt B, Korn K, Moschik B, et al.
Antimicrob Agents Chemother 2000 Nov;44(11):3213-6  
Paper

RTV/Bupropion

Ritonavir, Efavirenz, and Nelfinavir Inhibit CYP2B6 Activity in Vitro: Potential Drug
Interactions with Bupropion.
Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ 
Drug Metab Dispos 2001 Feb 1;29(2):100-102
Abstract

RTV/Buspirone

  Pseudo-Parkinson disease secondary to ritonavir-buspirone interaction.
 Clay PG, Adams MM. 
Ann Pharmacother 2003 Feb;37(2):202-5
 Abstract		  

RTV/Carbamazepine

Protease inhibitor-induced carbamazepine toxicity.
Berbel Garcia A, Latorre Ibarra A, Porta Etessam J, M., et al.
Clin Neuropharmacol 2000 Jul-Aug;23(4):216-8  
 Abstract


RTV/Digoxin
 
  Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy
volunteers.
 Ding R, Tayrouz Y, Riedel KD, et al 
Clin Pharmacol Ther. 2004 Jul;76(1):73-84.
Abstract
 
RTV/Enfuvirtide
 
  Lack of Interaction between Enfuvirtide and Ritonavir or Ritonavir-Boosted Saquinavir in
HIV-1-Infected Patients.
 Ruxrungtham K, Boyd M, Bellibas SE, et al    
 J Clin Pharmacol. 2004 Jul;44(7):793-803.
 Abstract

RTV/Fentanyl

Ritonavir’s role in reducing fentanyl clearance and prolonging its half-life.
Olkkola KT, Palkama VJ, Neuvonen PJ
Anesthesiology 1999 Sep;91(3):681-5  
Abstract

RTV/Fluoxetine

  FULL-TEXT ARTICLE
Effect of fluoxetine on pharmacokinetics of ritonavir.
Ouellet D, Hsu A, Qian J, Lamm JE, et al.
Antimicrob Agents Chemother 1998 Dec;42(12):3107-12
 Paper
 		  
RTV/Fosamprenavir
 
  Ritonavir Increases Plasma Amprenavir (APV) Exposure to a Similar Extent when Coadministered with
either Fosamprenavir or APV.
 Wire MB, Baker KL, Jones LS, et al 
Antimicrob Agents Chemother. 2006 Apr;50(4):1578-80.
 Abstract 

RTV/Meperidine

The effect of ritonavir on the pharmacokinetics of meperidine and normeperidine.
Piscitelli SC, Kress DR, Bertz RJ, et al.
Pharmacotherapy 2000 May;20(5):549-53
Abstract 

RTV/Indinavir

  Effects of Ritonavir on Indinavir Pharmacokinetics in Cerebrospinal Fluid
and Plasma.
 Haas DW, Johnson B, Nicotera J, et al
Antimicrob Agents Chemother. 2003 Jul;47(7):2131-2137.
 Abstract 

RTV/Nelfinavir
  Low-dose ritonavir moderately enhances nelfinavir exposure.
 Kurowski M, Kaeser B, Sawyer A, et al.
 Clin Pharmacol Ther 2002 Aug;72(2):123-32
 Abstract 

RTV/Normeperidine

The effect of ritonavir on the pharmacokinetics of meperidine and
normeperidine.
 Piscitelli SC, Kress DR, Bertz RJ, et al.
Pharmacotherapy 2000 May;20(5):549-53 
Abstract 

RTV/Olanzapine
  Influence of Ritonavir on Olanzapine Pharmacokinetics in Healthy
Volunteers.
Penzak SR, Hon YY, Lawhorn WD, et al.
 J Clin Psychopharmacol 2002 Aug;22(4):366-370
 Abstract 		  
RTV/Prednisone
 
  Prednisolone Pharmacokinetics in the Presence and Absence of Ritonavir After Oral
Prednisone Administration to Healthy Volunteers.
Penzak SR, Formentini E, Alfaro RM, et al
J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):573-580
 Abstract 

RTV/Risperidone
  Reversible coma caused by risperidone-ritonavir interaction.
Jover F, Cuadrado JM, Andreu L, Merino J.  
 Clin Neuropharmacol 2002 Sep-Oct;25(5):251-3
 Abstract 

Extrapyramidal Symptoms with Ritonavir/Indinavir plus Risperidone.
Kelly DV, Beique LC, Bowmer MI..
Ann Pharmacother 2002 May;36(5):827-30
 Abstract 

  

RTV/Sildenafil

Interaction of sildenafil and indinavir when co-administered to HIV-positive
patients. 
 Merry C, Barry MG, Ryan M, et al.
AIDS 1999 Oct 22;13(15):F101-7
Abstract

RTV/Trazodone

  Short-term exposure to low-dose ritonavir impairs clearance and enhances
adverse effects of trazodone.
 Greenblatt DJ, von Moltke LL, Harmatz JS
Clin Pharmacol 2003 Apr;43(4):414-22
 Abstract

RTV/Triazolam

Differential impairment of triazolam and zolpidem clearance by ritonavir.
Greenblatt DJ, von Moltke LL, Harmatz JS, et al.
J Acquir Immune Defic Syndr 2000 Jun 1;24(2):129-36  
Abstract 

Differential impairment of triazolam and zolpidem clearance by ritonavir.
Greenblatt DJ, von Moltke LL, Harmatz JS, et al
J Acquir Immune Defic Syndr 2000 Jun 1;24(2):129-36  
Abstract 
 
RTV/Zaleplon
 
  Clinically important drug interactions with zopiclone, zolpidem and
zaleplon.
 Hesse L, Von Moltke L, Greenblatt D.
CNS Drugs 2003;17(7):513-32
 Abstract 

RTV/Zolpidem

Differential impairment of triazolam and zolpidem clearance by ritonavir.
Greenblatt DJ, von Moltke LL, Harmatz JS, et al
J Acquir Immune Defic Syndr 2000 Jun 1;24(2):129-36  
Abstract 
 

  Clinically important drug interactions with zopiclone, zolpidem and
zaleplon.
 Hesse L, Von Moltke L, Greenblatt D.
CNS Drugs 2003;17(7):513-32
 Abstract 

RTV/Zopiclone
 
Clinically important drug interactions with zopiclone, zolpidem and
zaleplon.
 Hesse L, Von Moltke L, Greenblatt D.
CNS Drugs 2003;17(7):513-32
 Abstract 

RTV/SQV/Fusidic acid

A drug interaction between fusidic acid and a combination of ritonavir and saquinavir.
Khaliq Y, Gallicano K, Leger R, et al.
Br J Clin Pharmacol 2000 Jul;50(1):82-3
Letter/Citation only

RTV/SQV/Ketoconazole

Effect of ketoconazole on ritonavir and saquinavir concentrations in plasma and
cerebrospinal fluid from patients infected with human immunodeficiency virus.
Khaliq Y, Gallicano K, Venance S,et al.
Clin Pharmacol Ther 2000 Dec;68(6):637-46
Abstract

RTV/Multiple pediatric drugs

Competing drug-drug interactions among multidrug antiretroviral regimens used in the
treatment of HIV- infected subjects: ACTG 884. PACTG 884 Protocol Team. AIDS
Clinical Trials Group.
Fletcher CV, Acosta EP, Cheng H, et al. 
AIDS 2000 Nov 10;14(16):2495-501
Abstract 

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