Medical Advocates for Social Justice

Ritonavir
(Norvir)
 
Journal: Adolescent/Adult
Treatment Citations

Guidelines
RTV/AMP Data
RTV IND Data
RTV NFV Data
RTV SQV Data
RTV/ZDV/3TC Data
Therapeutic Strategies


 


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Last Update:  December 22, 2005
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Guidelines and Recommendations
 

FULL-TEXT PDF ARTICLE
Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIV.
MMWR Morb Mortal Wkly Rep. 2002 May 17;51(RR-7):1-55.
PDF Pape
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RTV/AMP Data
 

Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients.
Marcelin AG, Lamotte C, Delaugerre C, et al.
Antimicrob Agents Chemother 2003 Feb;47(2):594-600
Abstract
FULL-TEXT PDF ARTICLE
Salvage therapy with amprenavir and ritonavir: Prospective study in 17 heavily
pretreated patients.

Arvieux C, Tattevin P, Souala FM, et al .
HIV Clin Trials
2002 Mar-Apr;3(2):125-32

PDF Paper

RTV/IND Data
 

RTV vs IND

        RTV vs IND Efficacy

A randomized trial comparing the introduction of ritonavir or indinavir in 1251 nucleoside-experienced patients with advanced HIV infection.
ISS-IP1 Clinical Investigators. Floridia M, Tomino C, Bucciardini R, et al.
AIDS Res Hum Retroviruses 2000 Nov 20;16(17):1809-20

Abstract

RTV/IND 

         Efficacy

  Efficacy of a twice-daily antiretroviral regimen containing 100 mg ritonavir/400 mg indinavir in HIV-infected patients.
Ghosn J, Lamotte C, Ait-Mohand H, et al.
AIDS 2003 Jan 24;17(2):209-14
Abstract
 
     
  Dose-finding study of a once-daily indinavir/ritonavir regimen.
Hugen PW, Burger DM, ter Hofstede HJ, et al. 
J Acquir Immune Defic Syndr 2000 Nov 1;25(3):236-45 

Abstract
 
     
  Dose-finding study of a once-daily indinavir/ritonavir regimen.
Hugen PW, Burger DM, ter Hofstede HJ, et al. 
J Acquir Immune Defic
Syndr 2000 Nov 1;25(3):236-45 
Abstract
 
     
  Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of
low-dose ritonavir
.
v
an Praag RM, Weverling GJ, Portegies P, et al.  
AIDS
2000 Jun 16;14(9):1187-94
 
Abstract
 

RTV/IND/Double  Nucleosides

        Efficacy and Safety

Efficacy and safety of twice daily first-line ritonavir/indinavir plus double nucleoside combination therapy in HIV-infected individuals.
German Ritonavir/Indinavir Study Group. Rockstroh JK, Bergmann F, Wiesel W, et al. 
AIDS 2000 Jun 16;14(9):1181-5  
Abstract

RTV/IND/DVD/NRTIs

        Switching Therapy

  FULL-TEXT PDF ARTICLE
Combination therapy with indinavir, ritonavir, and delavirdine and nucleoside reverse  transcriptase inhibitors in patients with hiv/aids who have failed multiple antiretroviral combinations.
G
rodesky M, Acosta EP, Fujita N et al
HIV Clin Trials 2001 May-Jun;2(3):193-9

PDF Paper

                    

RTV/IND/ZDV/3TC

          Dose Finding Study

Dose-finding study of once-daily indinavir/ritonavir plus zidovudine and lamivudine in HIV-infected patients.
Mallolas J, Blanco JL, Sarasa M, et al..
 
J Acquir Immune Defic Syndr
2000 Nov 1;25(3):229-35
 
Abstract


RTV/NFV Data
 

RTV NFV 

        Safety/Tolerability

Safety, tolerability, and antiretroviral effects of ritonavir-nelfinavir combination therapy
administered for 48 weeks
.
Raines CP, Flexner C, Sun E, et al.
J Acquir Immune Defic Syndr 2000 Dec 1;25(4):322-8 

Abstract 

                           
RTV vs NFV vs EFV + one protease inhibitor

Comparison of initial combination antiretroviral therapy with a single protease inhibitor, ritonavir and saquinavir,or efavirenz.
Lucas GM, Chaisson RE, Moore RD.

AIDS
2001 Sep 7;15(13):1679-1686

Abstract


RTV SQV Data
 

RTV/SQV

          Drug Interactions

              RTV/SQV/fusidic acid

A drug interaction between fusidic acid and a combination of ritonavir and saquinavir.
Khaliq Y, Gallicano K, Leger R, Foster B, et al.

Br J Clin Pharmacol
2000 Jul;50(1):82-3
Abstract 

             RTV/SQV/sildenafil

Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir.
Muirhead GJ, Wulff MB, Fielding A, Kleinermans D, Buss N
Br J Clin Pharmacol 2000 Aug;50(2):99-107
Abstract

        Viral Dynamics/Response

Cerebrospinal fluid HIV RNA and drug levels with combination ritonavir and saquinavir.
Kravcik S, Gallicano K, Roth V, et al.

Acquir Immune Defic Syndr
1999 Aug 15;21(5):371-5

Abstract

       Efficacy

  FULL-TEXT ARTICLE
Ritonavir-saquinavir dual protease inhibitor compared to ritonavir alone in human
immunodeficiency virus-infected patients.
Michelet C, Ruffault A, Sebille V,  et al.  
Antimicrob Agents Chemother
2001 Dec;45(12):3393-402

Paper
   
  FULL-TEXT ARTICLE
Ritonavir-saquinavir dual protease inhibitor compared to ritonavir alone in human
immunodeficiency virus-infected patients.
Michelet C, Ruffault A, Sebille V,  et al.  
Antimicrob Agents Chemother 2001 Dec;45(12):3393-402

Paper
   
  Safety and Efficacy of Reduced Doses of Ritonavir (RTV) Plus Saquinavir (SQV) in the
Treatment of AIDS Patients in Brazil
.
Brites C, Alcantara AP, Mosqueira B, et al. 
Braz J Infect Dis 1999 Jun;3(3):91-96

Abstract
   
  Ritonavir and saquinavir combination therapy for the treatment of HIV infection.
Cameron DW, Japour AJ, Xu Y,  et al. 
AIDS 1999 Feb 4;13(2):213-24
 
Abstract

         Resistance

HIV-1 genotypic resistance patterns predict response to saquinavir-ritonavir
therapy in patients in whom previous inhibitor therapy had failed
.
Zolopa AR, Shafer RW, Warford A,  et al.  
Ann Intern Med 1999 Dec 7;131(11):813-21
Abstract 

         Adverse Events

               Hepatitis/Hepatotoxicity

Risk Factors for Hepatotoxicity in HIV-1-Infected Patients Receiving Ritonavir and Saquinavir with or without Stavudine
Gisolf EH, Dreezen C, Danner SA, et al. 
Clin Infect Dis 2000 Nov;31(5):1234-1239

Abstract

        Clinical Management Strategies

             First-Line Therapy           

Efficacy and safety of twice daily first-line ritonavir/indinavir plus double nucleoside combination therapy in HIV-infected individuals. German Ritonavir/Indinavir Study Group.
Rockstroh JK, Bergmann F, Wiesel W, et al.
AIDS 2000 Jun 16;14(9):1181-5

Abstract

              Intensification Therapy      

The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine.
Prometheus Study Group. Gisolf EH, Jurriaans S, Pelgrom J, et al

AIDS
2000 Mar 10;14(4):405-13

Abstract

              Salvage Therapy   

HIV-1 genotypic resistance patterns predict response to saquinavir-ritonavir therapy in
patients in whom previous protease inhibitor therapy had failed.

Zolopa AR, Shafer RW, Warford A, et al. 
Ann Intern Med 1999 Dec 7;131(11):813-21
 
Abstract

        Quality of Life

Quality of life in asymptomatic- and symptomatic HIV infected patients in a trial of ritonavir/saquinavir therapy.
The Prometheus Study Group. Nieuwkerk PT, Gisolf EH, Colebunders R, et al. 

A
IDS
2000 Jan 28;14(2):181-7  
Abstract
 

RTV/SQV vs RTV

FULL-TEXT ARTICLE
Ritonavir-saquinavir dual protease inhibitor compared to ritonavir alone in human immunodeficiency virus-infected patients.
Michelet C, Ruffault A, Sebille V, et al.
Antimicrob Agents Chemother 2001Dec;45(12):3393-402
Paper


RTV/SQV vs RTV/SQV/D4T

        Efficacy

The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/and ritonavir/saquinavir/stavudine.
Prometheus Study Group. Gisolf EH, Jurriaans S, Pelgrom J, et al.
AIDS 2000 Mar 10;14(4):405-13
 
Abstract


RTV/ZDV/3TC
 

 Efficacy

Assessing efficacy by measuring CD(4) counts and quality of life of AIDS patients treated with ritonavir, AZT and 3TC.
de Andrade JL Neto, Focaccia Siciliano R

Braz J Infect Dis 2000 Aug;4(4):173-82
 
Abstract

 Resistance

Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315
ACTG Protocol 315 Team. Kuritzkes DR, Sevin A, Young B, et al.
J Infect Dis
2000 Feb;181(2):491-7  
Abstract
 

Clinical Management Strategies

Assessing efficacy by measuring CD(4) counts and quality of life of AIDS patients treated with ritonavir, AZT and 3TC.
de Andrade JL Neto, Focaccia Siciliano R

Braz J Infect Dis 2000 Aug;4(4):173-82  
Abstract


Therapeutic Strategies
 

HIV/HCV Coinfection
 

  Switch from indinavir to ritonavir-indinavir regimen in patients treated with highly active antiretroviral therapy co-infected with hepatitis C is not associated with alteration of liver function tests.
Vora S, Michon C, Junet C, et al
AIDS
2000 Dec 1;14(17):2795-7

Abstract
 

Kaposi’s Sarcoma
 

  The efficacy of ritonavir in the prevention of AIDS-related Kaposi’s sarcoma.
Stebbing J, Portsmouth S, Nelson M,et al. 
Int J Cancer. 2004 Feb 10;108(4):631-3.
Abstract 

 


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Adolescent /Adult Therapeutic Indications