Medical Advocates

Nevirapine
(Viramune)
 
Perinatal/Neonate Safety/Resistance/
Viral Dynamics

Safety
Resistance
Viral Dynamics





 


Perinatal NVP Main Page  Main New/Newsworthy

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Last Update:  January 03, 2009 
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Safety
 

        Journal Papers, Abstracts, and Commentaries

 
Safety of nevirapine in pregnancy.
Natarajan U, Pym A, McDonald C, et al
HIV Med. 2007 Jan;8(1):64-9
Abstract
 
Safety of nevirapine-containing antiretroviral triple therapy regimens to prevent vertical
transmission in an African cohort of HIV-1-infected pregnant women.
Marazzi MC, Germano P, Liotta G, Guidotti G, et
HIV Med. 2006 Jul;7(5):338-44.
Abstract

Safety and trough concentrations of nevirapine prophylaxis given daily, twice weekly,
or weekly in breast-feeding infants from birth to 6 months.
Shetty AK, Coovadia HM, Mirochnick MM, et al
 
J Acquir Immune Defic Syndr.
2003 Dec 15;34(5):482-90
Abstract

        Conference Reports, Abstracts, and Posters

  Maternal and fetal safety of nevirapine-containing HAART regimens during pregnancy
Coll O, Lonca M, Ocaña I,  et al
(4th IAS Conference)
Abstract

Resistance
 

      Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine
prophylaxis in subtype C HIV-infected infants.

Moorthy A, Gupta A, Bhosale R, et al  
PLoS ONE
. 2009;4(1):e4096.
Paper
 
Prevalence of Nevirapine-Associated Resistance Mutations after Single Dose Prophylactic
Treatment among Antenatal Clinic Attendees in North Rift Kenya.
Kiptoo M, Ichimura H, Wembe RL,  et al  
AIDS Res Hum Retroviruse
s
. 2008 Dec;24(12):1555-9.
Abstract
 
Analysis of Nevirapine (NVP) Resistance in Ugandan Infants Who Were HIV Infected Despite Receiving
Single-Dose (SD) NVP versus SD NVP Plus Daily NVP Up to 6 Weeks of Age to Prevent HIV Vertical
Transmission.
Church JD, Omer SB, Guay LA, et al 
J Infect Dis.
2008 Aug 6.
Abstract
 
Nevirapine Resistance in Women and Infants after First versus Repeated Use of Single-Dose Nevirapine
for Prevention of HIV-1 Vertical Transmission.
Flys TS, McConnell MS, Matovu F, et al
J Infect Dis.
2008 Jun 26.
Abstract
 
Low rate of emergence of nevirapine and lamivudine resistance after post-partum interruption of a
triple-drug regimen.
Pérez H, Vignoles M, Laufer N
Abstract
 
Use of single-dose nevirapine for the prevention of mother-to-child transmission of HIV-1: does
development of resistance matter?

McConnell MS, Stringer JS, Kourtis AP, et al
Am J Obstet Gynecol.
2007 Sep;197(3 Suppl):S56-6
Abstract
 
Drug Resistance in Plasma and Breast Milk after Single-Dose Nevirapine in Subtype C
HIV Type 1: Population and Clonal Sequence Analysis.
Kassaye S, Lee E, Kantor R, et al 
AIDS Res Hum Retroviruses.
2007 Aug;23(8):1055-61

Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Prevalence of resistance to nevirapine in mothers and children after single-dose exposure
to prevent vertical transmission of HIV-1: a meta-analysis.
Arrive E, Newell ML, Ekouevi DK, et al 
Int J Epidemiol. 2007 May 28;
Abstract
 
Persistence of K103N-Containing HIV-1 Variants after Single-Dose Nevirapine for
Prevention of HIV-1 Mother-to-Child Transmission.
Flys TS, Donnell D, Mwatha A, et al 
J Infect Dis.
2007 Mar 1;195(5):711-5
Abstract
 
Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine.
Lockman S, Shapiro RL, Smeaton LM, et al 
N Engl J Med. 2007 Jan 11;356(2):135-147.
Abstract
 
Impact of NVP plasma concentration on selection of resistant virus in mothers who
received single dose NVP to prevent perinatal HIV-1 transmission and persistence of
resistant virus in their infected children.

Chaix ML, Ekouevi DK, Peytavin G, et al
Antimicrob Agents Chemother.
2006 Dec 18;
Abstract
 
Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy
for prevention of maternal-to-fetal HIV-1 transmission.
Palmer S, Boltz V, Martinson, et al 
Proc Natl Acad Sci
U S A. 2006 Apr 25;
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Transmission of Human Immunodeficiency Virus Type 1 Nevirapine Resistance Mutaton
K103Nfrom a Treatment-Naive Mother to her Child
Schmitz T, Kleinkauf N, Klempa B, et al 
Pediatr Infect Dis J. 2006 Mar;25(3):275-276
Abstract
 
Low Risk of Nevirapine Resistance Mutations in the Prevention of Mother-to-Child Transmission
of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus, Abidjan, Cote d’Ivoire.
Chaix ML, Ekouevi DK, Rouet F, et al   
J Infect Dis.
2006 Feb 15;193(4):482-7.
Abstract
 
Development of Nevirapine Resistance in Infants Is Reduced by Use of Infant-Only
Single-Dose Nevirapine plus Zidovudine Postexposure Prophylaxis for the Prevention
of Mother-to-Child Transmission of HIV-1.
Eshleman SH, Hoover DR, Hudelson SE
J Infect Dis.
2006 Feb 15;193(4):479-81.
Abstract
 
Characterization of Nevirapine (NVP) Resistance Mutations and HIV Type 1 Subtype in
Women from Abidjan (Cote d’Ivoire) After NVP Single-Dose Prophylaxis of HIV Type 1
Mother-to-Child Transmission.
Toni TD, Masquelier B, Lazaro E, et al
AIDS Res Hum Retroviruses. 2005 Dec;21(12):1031-4.
Abstract
 
Distinct Patterns of Emergence and Fading of K103N and Y181C in Women With Subtype
A vs. D After Single-Dose Nevirapine: HIVNET 012.
Eshleman SH, Guay LA, Wang J, et al 
J Acquir Immune Defic Syndr
. 2005 Sep 1;40(1):24-29.
Abstract
 
Breast-Milk Shedding of Drug-Resistant HIV-1 Subtype C in Women Exposed to
Single-Dose Nevirapine.
Lee EJ, Kantor R, Zijenah L, et al
J Infect Dis. 2005 Oct 1;192(7):1260-4.

Emergence of Drug-Resistant HIV-1 after Intrapartum Administration of Single-Dose
Nevirapine Is Substantially Underestimated.
Johnson JA, Li JF, Morris L, et al 
J Infect Dis.
2005 Jul 1;192(1):16-23.
Abstract
 
Sensitive Drug-Resistance Assays Reveal Long-Term Persistence of HIV-1 Variants with
the K103N Nevirapine (NVP) Resistance Mutation in Some Women and Infants after the
Administration of Single-Dose NVP: HIVNET 012.
Flys T, Nissley DV, Claasen CW,
J Infect Dis. 2005 Jul 1;192(1):24-9.
Abstract
 
Nevirapine (NVP) Resistance in Women with HIV-1 Subtype C, Compared with Subtypes
 A and D, after the Administration of Single-Dose NVP.
Eshleman SH, Hoover DR, Chen S, et 
J Infect Dis. 2005 Jul 1;192(1):30-6
Abstract
 
Persistence of Nevirapine Exposure During the Postpartum Period After Intrapartum Single-
Dose Nevirapine in Addition to Zidovudine Prophylaxis for the Prevention of Mother-to-Child
Transmission of HIV-1.
Cressey TR, Jourdain G, Lallemant MJ, et al  
J Acquir Immune Defic Syndr.
2005 Mar 1;38(3):283-288.
Abstract
 
Characterization of Nevirapine Resistance Mutations in Women With Subtype A Vs.
D HIV-1 6-8 Weeks After Single-Dose Nevirapine (HIVNET 012)
.

Eshleman SH, Guay LA, Mwatha A, et al 
J Acquir Immune Defic Syndr. 2004 Feb 1; 35(2): 126-130.
Abstract

Development of resistance mutations in women receiving standard antiretroviral therapy
who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus
type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316.
Cunningham CK, Chaix ML, Rekacewicz C, et al
J Infect Dis 2002 Jul 15;186(2):181-8
Abstract

Identification of the K103N resistance mutation in Ugandan women receiving nevirapine to
prevent HIV-1 vertical transmission
.
Jackson JB, Becker-Pergola G, Guay LA,  et al
A
IDS 2000 Jul 28;14(11):F111-5  
Abstract

Pharmacological implications of lengthened in-utero exposure to nevirapine.
Taylor GP, Lyall EG, Back D, Ward C, Tudor-Williams G.
Lancet 2000 Jun 17;355(9221):2134-5  
Abstract

 

          Conference Reports, Abstracts, and Posters

 
Nevirapine metabolism and association with drug resistance in breast milk and plasma
S. Kassaye , E. Lee  , D. Holland, et al
(XVII International AIDS Conference)
Abstract

 
Detection of minor drug-resistant populations in plasma of HIV-infected children and their mothers after
single-dose nevirapine

A. Kunz, A. Hauser, K. Mugenyi, et al
(XVII International AIDS Conference)
Abstract
 
Intrapartum Tenofovir and Emtricitabine Reduces Development of Low-level NNRTI Resistance
following Ingestion of Single-dose Nevirapine for Perinatal HIV Prevention

B Chi, L Frenkel, G Aldrovandi, et al
(15th CROI)
Abstract
 
The TEmAA ANRS 12109 Phase II Trial, Step 1: Tolerance and Viral Resistance after Single-dose
Nevirapine and Short-course of Tenofovir Disoproxil Fumarate and Emtricitabine to Prevent

Mother-to-Child Transmission of HIV-1

E Arrive, M  Chaix E Nerriene, et al
(15th CROI)
Abstract
 
Emergence and Fading of Nevirapine Resistance after First versus Repeated Use of Single-dose
Nevirapine for Prevention of Mother-to-Child HIV Transmission: Women and Infants in the Repeat
Pregnancy Study in Uganda

S Eshleman T Flys, M McConnell
(15th CROI)
Abstract
 
Analysis of NVP Resistance in Ugandan Infants Who Were HIV-infected despite Receiving
Single-dose Nevirapine vs Single-dose NVP Plus up to 6 Weeks of Daily NVP to Prevent HIV
Vertical Transmission

J Church, S Omer, L Guay, et al   
(15th CROI)
Abstract
 
Low emergence of nevirapine (NVP) and lamivudine (3TC) resistance after post-partum
interruption of a triple drug regimen for prevention of HIV mother to child transmission
(MTCT)
Pérez H, Vignoles M, Laufer N, et al
(4th IAS  Conference)
Abstract
 
Development of phenotypic HIV-1 drug resistance following exposure to single dose nevirapine
Basson A, Ntsala M, Tlale E, et al
(4th IAS  Conference)
Abstract
 
Detection of the onset of drug resistant mutations in pregnant women receiving single dose
nevirapine in Namakkal, Tamilnadu, using oligonucleotide ligation assay

Jacob SM, Durairaj A, Vijayakumari JJ, et al
(4th IAS  Conference)
Abstract
 
Nevirapine-resistant HIV-1 among Mozambican Infants Infected in Utero vs Intra-partum
or Early Postpartum

M Micek, A Blanco, A Blanco, et al 
(14 CROI)
Abstract
 
Clonal analysis of the diversity in drug resistant subtype C HIV-1 after single dose nevirapine
Kassaye S., Lee E., Johnston B., Kantor R., Katzenstein D.
(XVI International AIDS Conference)
Abstract
 
Resistance induced by the use of single dose nevirapine (sdNVP) for prevention of
mother-to-child transmission of HIV (PMTCT): debate and reality, experience in Nigeria
Mandala J., Abutu A., Anomnachi L
(XVI International AIDS Conference)
Abstract

 
POSTER
Analysis of K103N-containing HIV-1 Variants in Women with HIV-1 Subtypes A, C, and D
after Single-dose Nevirapine Using a Sensitive and Quantitative Point Mutation Assay

T S. Flys, S Chen, D Jones, et al 
(13 CROI)

PDF Poster   Abstract

 
Selection of Resistance Mutations in Children Receiving Prophylaxis with Lamivudine or
Nevirapine for the Prevention of Postnatal Transmission of HIV
M  Giuliano, C Galluzzo, E Germinario, et al
(12 CROI)
Abstract
 
Clonal Analysis of Drug-resistant Mutations in Plasma and Breast Milk following
Single-dose Nevirapine
E Lee, R Kantor, E Johnston,  et al
(12 CROI)
Abstract
 
Controversies in the Use of Nevirapine for Prevention of Mother-to-Child Transmission
J McIntyre
(12 CROI)
Abstract
 
Infant Zidovudine Prophylaxis and Emergence of Nevirapine Resistance at 6 Weeks in
Perinatally HIV-infected Infants Exposed to Intra-partum or Newborn Nevirapine
N Ngo-Giang-Huong, G Jourdain, P Tungyai, et al
(12 CROI)
Abstract
 
Sensitive Drug Resistance Assays Reveal Long-term Persistence of HIV-1 Variants with
the K103N Nevirapine-resistance Mutation in Some Women and Infants after Single-dose
NVP: HIVNET 012
S Eshleman, D Nissley, C Claasen, et al
(12 CROI)
Abstract
 
Nevirapine Resistance and Survival of Women Receiving HAART Subsequent to Prevention
of Mother-to-Child Transmission: A Population-based Stochastic Model
D Westreich , A Van Rie, F Behets, et al
(12 CROI)
Abstract
 
Persistence of NNRTI-r Resistant Variants after Single-dose Nevirapine in HIV-1 Subtype-
C-infected Women
S Palmer , V Boltz , F Maldarelli, et al  
(12 CROI)
Abstract
 
Resistance Emerges in the Majority of Women Provided Intrapartum Single-dose Nevirapine
J Johnson, J  F Li, L Morris, et al
(12 CROI)
Abstract
 
Nevirapine resistance mutations among HIV-1 infected infants following single dose nevirapine
CCN Pillay, G Gray, C Chezzi,  et al
(15IAC)
Abstract
 
Resistance patterns in mother-infant pairs following single dose nevirapine (NVP) for the
prevention of mother-to-child transmission (MTCT) of HIV-1.
M Gordon, N Graham, R Bland, et al
(15IAC)
Abstract
 
Comparison of genotypic and phenotypic assays for measuring nevirapine resistance
among women participating in mother-to-child prevention programs
M Ntsala, C Pillay, E Tlale, et al
(15IAC)
Abstract
 
Persistence of nevirapine resistance mutations 6 months following single dose nevirapine
L Morris, N Martinson, C Pillay,et al
(15IAC)
Abstract
 
Profile of NNRI associated mutations in women exposed to a single dose of nevirapine
during delivery in Thailand
N Ngo-Giang-Huong, P Tungyai, A Kummee
(15IAC)
Abstract

Modeling the sexual transmission of HIV-1 strains resistant to nevirapine from MTCT programs
A Medley, K O’Reilly, G Schmid, M D Sweat
(15IAC)
Abstract 

HIV-1 GENOTYPIC RESISTANCE TO ANTIRETROVIRAL TREATMENT IN CAMEROON,
IN POPULATIONS TREATED BY HAART AND BY SINGLE-DOSE NEVIRAPINE TO
PREVENT MTCT
C. Kouanfack, L. Vergne, M. Tardy, et al

(2nd IAS)
Abstract
 
POSTER
Nevirapine Plasma Concentrations Are Still Detectable after More than 2 Weeks in the
Majority of Women Receiving Single-dose NVP: Implications for Intervention Studies

E Muro, J Droste, H ter Hofstede, et al
(11 CROI
PDF Poster    Abstract

 
POSTER
Rapid flux in non-nucleoside reverse transcriptase inhibitor resistance mutations among
subtype C HIV-1-infected women after single dose nevirapine
D Katzenstein, et al.
(XII International HIV Drug Resistance Workshop)
PDF Poster
 
POSTER
HIV-1 pol gene diversity and archived Nevirapine resistance mutation in pregnant women
in Rwanda
J Servais, C Lambert , E Karita, et al
(Ist Euro Conference)
PDF Poster

Selection of Nevirapine Resistance (NVPR) Mutations in Ugandan Women and Infants
Receiving NVP Prophylaxis To Prevent HIV-1 Vertical Transmission (HIVNET-012
)
.
(8 CROI) 
Abstract

 

Viral Dynamics
 

      Journal Papers, Abstracts, and Commentaries

 
Nevirapine Plasma Concentrations are Still Detectable After More Than 2 Weeks in the Majority of
Women Receiving Single-Dose Nevirapine: Implications for Intervention Studies.
Muro E, Droste JA, Hofstede HT 
J Acquir Immune Defic Syndr.
2005 Aug 1;39(4):419-421.
Abstract

FULL-TEXT ARTICLE
Intrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-
Based Antiretroviral Therapy.
Jourdain G, Ngo-Giang-Huong N, Le Coeur S, et al 
N Engl J Med.
2004 Jul 9
Abstract
 

 
          Conference Reports, Abstracts, and Posters
 
  Receipt of single dose nevirapine in labor may defer rather than blunt the postpartum breast
milk HIV viral load rebound seen after the discontinuation of ZDV

Rossenkhan R, Ndung’u T, Sebunya TK, et al
(4th IAS  Conference)
Abstract


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