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A WEEK-IN-REVIEW FEATURED REPORT
POSTER
Safety and efficacy of maraviroc-raltegravir combination following 6 months
induction with maraviroc-raltegravir-tenofovir-emtricitabine in naïve
HIV-1-infected patients with CCR5 virus: interim analysis of the No Nuc No
Boost study
L. Cotte1, J. Durant, C. Brochier, P. André
Poster
Abstract
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Safety and efficacy of
maraviroc in CCR5-tropic HIV-1-infected children aged 2 to < 18 years
C. Giaquinto, L. Keet, C. Fortuny, et al
Abstract
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Maraviroc (MVC)
intensification can activate NFkB through CCR5 and the expression of its
target genes in resting CD4+ T cells in suppressed HIV-1-infected patients
N. Madrid-Elena, B. Hernandez-Novoa, L. Garcia-Bermejo, S. Moreno
Abstract
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Update from Study
A4001031: maraviroc pharmacokinetics in CCR5-tropic HIV-1-infected children
aged 2 to < 18 years
M. Vourvahis, L. McFadyen, T. Checchio, et al
Abstract
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Modelling HIV PrEP in
humanized mice: pharmacokinetic studies on antiretroviral drugs raltegravir,
tenofovir and maraviroc
R. Akkina, M. Veselinovic C.P. Ne et al
Abstract
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XIX International AIDS Conference
|
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Horizontal
transmission of HIV-1 exhibiting resistance to four antiretroviral drug
classes, including integrase inhibitors
C. Walworth, D. Ward, L. Napolitano, et al
Abstract
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Sustained release tenofovir and maraviroc from intravaginal ring in sheep
T.J. Smith
6th IAS Conference on HIV Pathogenesis,
Treatment
and Prevention |
|
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POSTER
Clinical validation of standard population-based and deep sequencing
genotypic tropism tests using virological
response to a short-term monotherapy maraviroc exposure
A. Gonzalez-Serna, R.A. McGovern, R. Harrigan, et al
Poster
Abstract
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POSTER
Natural resistance to Maraviroc in
HIV-infected patients: study by genetic forms and co-receptors usage
Y. Vega, A. Fernandez-García, E. Delgado, et al
Poster
Abstract
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POSTER
Immunological efficacy of maraviroc (MVC)
as intensification strategy in HIV-infected patients (pts) failing CD4
recovery on virologically-suppressive HAART
S. Rusconi, E. Colella, F. Adorni, et al
Poster
Abstract
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POSTER
Study of the immunomodulant effect of darunavir and maraviroc on apoptosis of
PBMC
I. Sauzullo, F. Mengoni, A. Ermocida, et al
Poster
Abstract
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POSTER
Maraviroc 150 mg QD plus lopinavir/ritonavir, a NRTIs-sparing regimen for
naïve patients: preliminary 48-weeks
results
S. Nozza, L. Galli, A. Antinori, M.
et al
Poster
Abstract
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POSTER
Persistence of antiretroviral regimens including raltegravir, maraviroc,
darunavir and/or etravirine in clinical practice
I. Castillo Romera, N. Trovato López, S. Plata Paniagua, et al
Poster
Abstract
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POSTER
No maraviroc (MVC) concentration exposure-response relationship identified for
48-week efficacy (< 50 copies/mL) in treatment-experienced patients in the
MOTIVATE studies when undetectable MVC concentrations were accounted for
separately from MVC concentrations
L. McFadyen P. Jacqmin, B. Weatherley, et al
Poster
Abstract
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POSTER
Maraviroc (MVC) pharmacokinetics (PK) in CCR5-tropic HIV-1-infected children
aged 2-< 18 years: preliminary results from study A4001031
M. Vourvahis, L. McFadyen, B. Duncan, et al
Poster
Abstract
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POSTER
Safety and efficacy of maraviroc (MVC) in CCR5-tropic HIV-1-infected children
aged 2 to < 18 years
C. Giaquinto, J. Fourie, I. Mitha, et al
Poster
Abstract
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POSTER
Efficacy of maraviroc (MVC) administered once daily (QD) or twice daily (BID)
with boosted protease inhibitors (bPIs) to treatment-experienced patients
S. Taylor, J. Arribas, C.-F. Perno, et al
Poster
Abstract
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48-week results
of a dual-therapy regimen of once-daily maraviroc (MVC) 150 mg in
combination with
ritonavir-boosted atazanavir (ATV/r) compared to emtricitabine/tenofovir
(FTC/TDF) + ATV/r in
|treatment-naïve (TN) patients infected with CCR5-tropic H
S. Portsmouth, C. Craig, A. Mills,
et al
Abstract
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Maraviroc (MVC) reduces liver stiffness (LS) in HIV-hepatitis C (HCV)
co-infected patients
P. Nasta, F.
Gatti, F. Borghi, et al
Abstract
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Maraviroc-resistant subtype B primary HIV-1 induced in vitro selection
became highly sensitive to anti-gp120
neutralizing antibodies and
autologous plasma IgG under high concentrations of the CCR5 inhibitor
K. Yoshimura, S. Harada, A. Hamaji, S. Matsushita
Abstract
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HIV-1 escape from
the CCR5 antagonist maraviroc associated with an altered and less
efficient mechanism
of gp120-CCR5
engagement that attenuates macrophage tropism
M. Roche, M.R. Jakobsen, J. Sterjovski, et al
Abstract
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Next generation
deep sequencing to evaluate viral tropism in HIV-1 patients exposed to
maraviroc add-on therapy
for eight days
R.A. McGovern, A.F.Y. Poon,
et al
Abstract
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Plasma viral load underestimates the antiviral efficacy of maraviroc
V. Kramer, S. Schader, M. Oliviera, et al
Abstract
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Effect of maraviroc
treatment in a patient with a dual-tropic viral population
L. Mainetti, A. Galli, A. Pignataro, et al
Abstract
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Pharmacokinetics of
maraviroc administered at 150 mg QD in association with lopinavir/ritonavir as a
part of a
novel NRTI-sparing regimen in naïve patients
S. Bonora, S. Nozza, D. Gonzalez de Requena, et al
Abstract
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Prevalence of X4-tropic
viruses in HIV-1-infected patients according to CD4 counts, viral load and
antiretroviral
exposure
E. Seclén, V. Soriano, M.M. Gonzalez, et al
Abstract
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Human primary
macrophages and lymphocytes are differently infected by HIV-1 dual/mixed
variants: study of
susceptibility to CCR5- and CXCR4-inhibitors
E. Balestra, M. Surdo, P. Saccomandi, et al
Abstract
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Maraviroc-resistant
subtype B primary HIV-1 induced in vitro selection became highly sensitive to
anti-gp120 neutralizing antibodies and autologous plasma IgG under high
concentrations of the CCR5 inhibitor
K. Yoshimura, S. Harada, A.
Hamaji, et al
Abstract
XVIII International AIDS Conference
|
|
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POSTER
Maraviroc in treatment-experienced patients
G. Sterrantino, M. Trotta, P.G. Rogasi, et al
PDF Poster
Abstract
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POSTER
Duration of antiretroviral regimens
including Raltegravir, Maraviroc, Darunavir and/or Etravirine in
clinical practice
I. Castillo Romera, A. Ais Larisgoitia, V. Escudero Vilaplana, et al
PDF Poster
Abstract
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POSTER
Low risk of malignancy with maraviroc in treatment-experienced (TE) and
treatment-naïve (TN)
patients across the maraviroc clinical development program
S. Walmsley, R. Campo, J. Goodrich, et al
PDF Poster
Abstract
-
POSTER
Duration of antiretroviral regimens including
Raltegravir, Maraviroc, Darunavir and/or Etravirine in
clinical practice
I. Castillo Romera, A. Ais Larisgoitia, V. Escudero Vilaplana, et al
PDF Poster
Abstract
- POSTER
Efficacy and safety of MVC in treatment-experienced over-sixty patients
G. Sterrantino, B. Borchi, M. Trotta, et al
PDF Poster
Abstract
- POSTER
Virologic outcome by V3 loop genotypic population sequencing and 454 ‘deep
sequencing’ in clade B
and non-B virus in MERIT at 48 and 96 weeks
S. Portsmouth1, D. Chapman1, M. Lewis, et al
PDF Poster
Abstract
- POSTER
Use of genotypic and maraviroc (MVC) clinical trial data to develop
statistical models for predicting r
esponse in a treatment-experienced (TE) population
P. Biswas, D. Chapman, X. Zhong, et al
PDF Poster
Abstract
- POSTER
Effect of 24 weeks intensificaction with a CCR5-antagonist on the decay of
the HIV-1 latent reservoir
L. Díaz, C. Gutierrez, C. Page, et al
PDF Poster
Abstract
- POSTER
Effect of a CCR5 antagonist in immune activation in highly suppressed
HIV-1 infected patients
A. Vallejo1, L. Diaz, M. Abad, et al
PDF Poster
Abstract
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Maraviroc
containing regimen suppress cerebrospinal fluid HIV replication in HIV-1
infected patients
with neurological symptoms
G. Melica, A. Canestri, G. Peytavin, et al
Abstract
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Clinical
outcome of HIV tropism testing and Maraviroc regimens – 48 weeks follow-up
H. Knechten, F. Wiesmann, E. Wolf, et al
Abstract
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Hard rescue:
prospective study of effectiveness and safety of new drugs (Darunavir-DRV,
Etravirina-ETR,
Raltegravir-RTG andMaraviroc-MVC) in the last four years (2006-2009)
H. Azkune Galparsoro,.A. Iribarren Loyarte, M.J. Aramburu Bengoechea, et
al
Abstract
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In vivo
synergistic activity of maraviroc and raltegravir in the reduction of HIV
proviral burden in
circulating reservoirs
C. Tommasi, E. Nicastri, I. Abbate, et al
Abstract
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mDAPTA, a
potent CCR5 receptor blocker, prevents viral recovery from CD8-depleted
patient PBMCs
with VL< 50 background
L. Agrawal, O. Ducoudret, N. Baichoo, et al
Abstract
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Detection of
CXCR4-using variants in circulating and proviral HIV quasispecies from
patients treated
with CCR5
antagonist by ultra-deep pyrosequencing
I. Abbate, G. Rozera, C. Tommasi, et al
Abstract
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Maternal-fetal
pharmacokinetics of a single intrapartum dose of maraviroc in rhesus
macaques
M. Winters1,, K. Van Rompay, A. Kashuba,,et al
Abstract
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Safety and
immunovirological activity of once daily maraviroc (MVC) in combination
with
ritonavir-boosted atazanavir (ATV/r) compared to emtricitabine
200mg/tenofovir 300mg QD
(TDF/FTC) +
ATV/r in treatment-naïve patients infected with CCR5-tropic HIV-1 (Study
A4001078):
A week 24
planned interim analysis
A. Mills, D. Mildvan, D. Podzamczer, et al
Abstract
|
5th IAS Conference on HIV Pathogenesis,
Treatment
and Prevention |
|
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The MERIT study
of maraviroc in antiretroviral-naive patients with R5 HIV-1: 96-week results
J. Heera, P. Ive, M. Botes, et al
Abstract
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Incidence of
malignancies in treatment-experienced (TE) patients in the MOTIVATE studies
of maraviroc (MVC) + optimized background therapy (OBT): 96 week follow-up
A. Ayoub, S. Walmsley, R. Campo, et al
Abstract
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Concurrent use of
statins does not influence efficacy of maraviroc in MOTIVATE studies
G. Moyle, N. Rajicic, H. Valdez, et al
Abstract
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Virologic
suppression on maraviroc in treatment-naïve patients with R5 HIV-1 is similar
to efavirenz at
high baseline viral load, and maraviroc discontinuations for adverse events
are less likely to show drug resistance: 48-week results from the MERI
M. Nelson, A. Lazzarin, G. Di Perri, et al
Abstract
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Anti-HIV activity
of the candidate microbicide maraviroc, a CCR5 receptor antagonist
P.S. Fletcher, C. Herrera, N. Armanasco, et al
Abstract
|
Ninth International Congress on Drug Therapy in HIV Infection
|
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