Pharmacokinetics of ampreavir and lopinavir in combo with NVP


Medical Advocates for Social Justice
Journal Papers, Abstracts and Commentaries
		Abstract Pharmacokinetics of amprenavir and lopinavir in combination with nevirapine in highly pretreated HIV-infected patients. Gerd Fãtkenheuer^a, Katja Römer^a, Robert Kamps^a, Bernt Salzberger^a, David Berger^b AIDS, 2001:Vol 15, No 17 2334-2355

A pharmacokinetic study on the combination of amprenavir, lopinavir, and nevirapine was conducted on five patients. The results of the study are charted in a Table in the paper. Although the authors found that the amprenavir concentrations were within the expected range, the lopinavir concentrations were highly variable (40-60% lower than predicted by the manufacturer]. There was no basis for this variability reflected in the data. The authors theorize that this variability may be due in to the interaction with nevirapine which may decrease the
the lopinavir concentrations by induction of the cytochrome P450 system and by the interaction with amprenavir.
The authors recommended that therapeutic drug monitoring be performed when this combination is used.

^aDepartment of Internal Medicine, University of Cologne, Germany
^bDepartment of Clinical Pharmacology, University of Nijmegen, The Netherlands

Abstract by Gordon Nary

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Pharmacokinetics of amprenavir and lopinavir in combination with
nevirapine in highly pretreated HIV-infected patients.
© 2002 Medical Advocates for Social Justice