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PMTCT Malaria Drugs

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Amodiaquine
Artesunate
 Atovaquone
Azithromycin
Chloroquine
Dapsone
Pyrimethamine
 Sulfadoxine/Pyrimethamine
 



 
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Last Update:  September 16, 2008 
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General Reports
 
       Journal Papers, Abstracts, and Commentaries
 
 
Drugs for treating uncomplicated malaria in pregnant women.
 Orton L, Garner P.  
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004912.
 Abstract
 
Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of
malaria during pregnancy in Mali.
Kayentao K, Kodio M, Newman RD, et al 
J Infect Dis. 2005 Jan 1;191(1):109-16.
 Abstract

Drugs for preventing malaria-related illness in pregnant women and death in the newborn
(Cochrane Review).
 Garner P, Gulmezoglu AM.
Cochrane Database Syst Rev 2003;(1):CD000169
 Abstract

Malaria prophylaxis and the reduction of anemia at childbirth.
Geelhoed DW, Visser LE, Addae V,et al  
Int J Gynaecol Obstet 2001 Aug;74(2):133-8
 Abstract
 
Safety, efficacy and determinants of effectiveness of antimalarial drugs during pregnancy:
implications for prevention programmes in Plasmodium falciparum-endemic sub-Saharan
Africa.
Newman RD, Parise ME, Slutsker L
Trop Med Int Health. 2003 Jun;8(6):488-506.
 Abstract
 
Drugs for preventing malaria-related illness in pregnant women and death in the newborn.
Garner P, Gulmezoglu AM.
Cochrane Database Syst Rev. 2000;(2):CD000169.
 Abstract
Amodiaquine
 
       Journal Papers, Abstracts, and Commentaries
 
  Can amodiaquine be used safely during pregnancy?
Thomas F, Erhart A, D'Alessandro U.
Lancet Infect Dis. 2004 Apr;4(4):235-9.
Abstract
Artesunate
 

        Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
A randomized controlled pilot trial of azithromycin or artesunate added to
sulfadoxine-pyrimethamine as treatment for malaria in pregnant women.
Kalilani L, Mofolo I, Chaponda M,et al
PLoS ONE. 2007 Nov 14;2(11):e1166.
Paper
 
FULL-TEXT ARTICLE
The safety of artemisinins during pregnancy: a pressing question.
Dellicour S, Hall S, Chandramohan D, Greenwood B.
Malar J. 2007 Feb 14;6:15.
Paper
 
The safety of the combination artesunate and pyrimethamine-sulfadoxine given
during pregnancy. 
Deen JL, von Seidlein L, Pinder M, et al.
Trans R Soc Trop Med Hyg. 2001 Jul-Aug;95(4):424-8.
 Abstract   
 
The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum
malaria.
McGready R, Stepniewska K, Edstein MD, et al
Eur J Clin Pharmacol. 2003 Oct;59(7):545-52
 Abstract   
 
Atovaquone
 

        Journal Papers, Abstracts, and Commentaries

 
The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the
treatment of uncomplicated falciparum malaria in third-trimester pregnant women.
 Na-Bangchang K, Manyando C, Ruengweerayut R, et al 
Eur J Clin Pharmacol. 2005 Jul 23;
Abstract   
 
The pharmacokinetics of atovaquone and proguanil in pregnant women with acute
falciparum malaria.
McGready R, Stepniewska K, Edstein MD, et al
Eur J Clin Pharmacol. 2003 Oct;59(7):545-52
 Abstract   
 
Azithromycin
 

        Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
A randomized controlled pilot trial of azithromycin or artesunate added to
sulfadoxine-pyrimethamine as treatment for malaria in pregnant women.
 Kalilani L, Mofolo I, Chaponda M,et al
PLoS ONE. 2007 Nov 14;2(11):e1166.
Paper
 
Chloroquine
 

        Journal Papers, Abstracts, and Commentaries

 
Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double-blind,
placebo-controlled trial.
Villegas L, McGready R, Htway M,et al
Trop Med Int Health. 2007 Feb;12(2):209-18.
 Abstract
Failure of a Chloroquine Chemoprophylaxis Program to Adequately Prevent Malaria
during Pregnancy in Koupela District, Burkina Faso.
 Sirima SB, Sawadogo R, Moran AC, et al.
Clin Infect Dis 2003 Jun 1;36(11):1374-82
 Abstract
 
Pattern of chloroquine-induced pruritus in antenatal patients at the University College
Hospital, Ibadan.
Olayemi O, Fehintola FA, Osungbade A, et al
Obstet Gynaecol. 2003 Sep;23(5):490-5.
Abstract
 
Dapsone
 

        Journal Papers, Abstracts, and Commentaries

  Dapsone therapy for malaria during pregnancy: maternal and fetal outcomes.
 Brabin BJ, Eggelte TA, Parise M, Verhoeff F.
Drug Saf. 2004;27(9):633-48.
 Abstract
Pyrimethamine
 
  FULL-TEXT PDF ARTICLE
 Plasmodium falciparum dihydrofolate reductase alleles and pyrimethamine use in
pregnant Ghanaian women.
Mockenhaupt FP, Eggelte TA, Bohme T, et al
Am J Trop Med Hyg 2001 Jul;65(1):21-6
 Paper		  
Sulfadoxine -Pyrimethamine
 

          Journal Papers, Abstracts, and Commentaries 

 
FULL-TEXT ARTICLE
A randomized controlled pilot trial of azithromycin or artesunate added to
sulfadoxine-pyrimethamine as treatment for malaria in pregnant women.
Kalilani L, Mofolo I, Chaponda M,et al
PLoS ONE. 2007 Nov 14;2(11):e1166.
Paper
 
Two-Dose versus Monthly Intermittent Preventive Treatment of Malaria with Sulfadoxine-
Pyrimethamine in HIV-Seropositive Pregnant Zambian Women.
 Hamer DH, Mwanakasale V, Macleod WB, et al 
J Infect Dis. 2007 Dec 1;196(11):1585-1594
 Abstract
 
Inferiority of Single-Dose Sulfadoxine-Pyrimethamine Intermittent Preventive Therapy for Malaria
during Pregnancy among HIV-Positive Zambian Women.
 Gill CJ, Macleod WB, Mwanakasale V, et al 
J Infect Dis. 2007 Dec 1;196(11):1577-1584.
 Abstract
 
Pharmacokinetics of Sulfadoxine-Pyrimethamine in HIV-Infected and Uninfected Pregnant
Women in Western Kenya.
 Green MD, van Eijk AM, van Ter Kuile FO, et al 
J Infect Dis. 2007 Nov 1;196(9):1403-8
 Abstract
 
Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive
therapy for malaria control during pregnancy: a systematic review.
 ter Kuile FO, van Eijk AM, Filler SJ. 
JAMA. 2007 Jun 20;297(23):2603-16.
 Abstract
 
Randomized Trial of 2-Dose versus Monthly Sulfadoxine-Pyrimethamine Intermittent Preventive
Treatment for Malaria in HIV-Positive and HIV-Negative Pregnant Women in Malawi.
Filler SJ, Kazembe P, Thigpen M 
J Infect Dis. 2006 Aug 1;194(3):286-93.
Abstract

Intermittent preventive sulfadoxine-pyrimethamine treatment of primigravidae reduces
levels of plasma immunoglobulin G, which protects against pregnancy-associated
Plasmodium falciparum malaria.
 Staalsoe T, Shulman CE, Dorman EK ,et al
 Infect Immun. 2004 Sep;72(9):5027-30
 Abstract
 
  Implementation of intermittent preventive treatment with sulphadoxine-pyrimethamine
for control of malaria in pregnancy in Kisumu, western Kenya.
 Eijk AM, Ayisi JG, Kuile FO, et al
Trop Med Int Health. 2004 May;9(5):630-7.
 Abstract
 
Effectiveness of intermittent preventive treatment with sulphadoxine-pyrimethamine
for control of malaria in pregnancy in western Kenya: a hospital-based study.
van Eijk AM, Ayisi JG, ter Kuile FO
 Trop Med Int Health. 2004 Mar;9(3):351-60.
 Abstract

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