MEDICAL ADVOCATES
WOMEN AND HIV RESOURCE CENTER
  Pregnancy ARV Adverse Events:
General Studies*

General Adverse Events       Neutropenia
 Fetal Death                          Pre-eclampsia
 Birth Defects
 Anemia
 Decreased Birth Weight
 Febrile Seizures
 Hepatic Disorders
 Immune Reconstitution
 Insulin Resistance
 Lactic Acidemia
 Mitochondrial Damage
 *Drug-specific adverse events are listed under the applicable drug
HIV Pregnancy Main Page Women Main Page  
Last Update:  November 11, 2008
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General Adverse Events
 
       Journal Papers, Abstracts, and Commentaries
 
 
Side effects of antiretroviral treatment for transmission prophylaxis in preterm and near-term
infants.
 Schlösser R, Linde R, Dunsch D, et al 
Z Geburtshilfe Neonatol. 2007 Dec;211(6):230-5.
 Abstract
 
Declines in Low Birth Weight and Preterm Birth Among Infants Who Were Born to
HIV-Infected Women During an Era of Increased Use of Maternal Antiretroviral Drugs:
Pediatric Spectrum of HIV Disease, 1989-2004.
Schulte J, Dominguez K, Sukalac T, et al
Pediatrics. 2007 Mar 12;
Abstract
 
Antiretroviral agents during pregnancy: Consequences on hematologic parameters in
HIV-exposed, uninfected newborn infant.
El Beitune P, Duarte G. Eur J
bstet Gynecol Reprod Biol. 2006 Jul 27;
 Abstract

Maternal toxicity and pregnancy complications in human immunodeficiency
virus-infected women receiving antiretroviral therapy: PACTG 316.
Watts DH, Balasubramanian R, Maupin RT Jr, et al  
Am J Obstet Gynecol. 2004 Feb;190(2):506-516.
 Abstract
 
           Conference Reports, Abstracts, and Posters
 
  Antiretroviral Pregnancy Registry (APR) at 10,000 prospective reports
KP Beckerman, D Covington, K Dominguez, et al
 ( Ninth International Congress on Drug Therapy in HIV Infection)
 PDF Abstract
Fetal Death
 
           Journal Papers, Abstracts, and Commentaries
 
  Increased risk of pre-eclampsia and fetal death in HIV-infected pregnant women r
eceiving highly active antiretroviral therapy.
 Suy A, Martinez E, Coll O, Lonca M, et al 
AIDS. 2006 Jan 2;20(1):59-66.
Abstract
 		  

           Conference Reports, Abstracts, and Posters

 
Increased risk of pre-eclampsia and fetal death in HIV-infected pregnant
women receiving highly active antiretroviral therapy
A Suy, O Coll, E Martinez, M Lonca,  et al
 (15IAC)
 Abstract
 
Birth Defects
 

          Journal Papers, Abstracts, and Commentaries
 
Teratogenicity risk of antiretroviral therapy in pregnancy.
 Watts DH.
Curr HIV/AIDS Rep. 2007 Aug;4(3):135-40.
 Abstract

Prenatal zidovudine use and congenital anomalies in a medicaid population.
Newschaffer CJ, Cocroft J, Anderson CE, Hauck WW, Turner BJ
J Acquir Immune Defic Syndr 2000 Jul 1;24(3):249-56
Abstract

  
Anemia
 

     Journal Papers, Abstracts, and Commentaries

  Life-Threatening Maternal and Fetal Macrocytic Anemia From Antiretroviral Therapy.
 Myers SA, Torrente S, Hinthorn D, Clark PL.
Obstet Gynecol. 2005 Nov;106(5):1189-1191
 Abstract		  
Decreased Birth Weight
 

     Journal Papers, Abstracts, and Commentaries

  Protease Inhibitors and Decreased Birth Weight in HIV-Infected Pregnant Women
With Impaired Glucose Tolerance
Chmait R, Franklin P, Spector SA, et al .
J Perinatol 2002 Jul-Aug;22(5):370-3
 Abstract		  
Febrile Seizures
 

          Journal Papers, Abstracts, and Commentaries

  Risk of early febrile seizure with perinatal exposure to nucleoside analogues.
Landreau-Mascaro A, Barret B, et al.
 Lancet 2002 Feb 16;359(9306):583-4
 Abstract		  
Hepatic Disorders
 
General Reports

             Conference Reports, Abstracts, and Posters

  Hepatic Toxicity of Antiretrovirals in HIV-infected Pregnant Women: A Review of the
FDA's Adverse Event Reporting System
 M Baylor, M Truffa, N Gibbs
(11 CROI)
 Abstract

Hepatotoxicity

          Journal Papers, Abstracts, and Commentaries

  Hepatotoxicity with antiretroviral treatment of pregnant women.
Hill JB, Sheffield JS, Zeeman GG, Wendel GD Jr.
 Obstet Gynecol 2001 Nov;98(5 Pt 2):909-11
 Abstract

Effect of HIV-1 antiretroviral prophylaxis on hepatic and hematological parameters
of African infants.
Taha TE, Kumwenda N, Gibbons A, et al.
AIDS 2002 Apr 12;16(6):851-8
 Abstract

Hepatotoxicity with antiretroviral treatment of pregnant women.
Hill JB, Sheffield JS, Zeeman GG,   Wendel GD.  
Obstet Gynecol 2001 Nov;98(5 Pt 2):909-11
Abstract

 
Immune Reconstitution
 
       Journal Papers, Abstracts, and Commentaries
 
  Pregnancy may be followed by an inflexion of the immune reconstitution in
HIV-infected women who receive antiretroviral drugs before conception.
Le Moing V, Taïeb A, Longuet P, et al 
HIV Med. 2008 Sep 14
 Abstract
Insulin Resistance
 
       Journal Papers, Abstracts, and Commentaries
 
  Insulin resistance complicating pregnancy in a human immunodeficiency virus-
infected patient treated with protease inhibitors and corticosteroids.
Aschkenazi S, Rochelson B, Bernasko J, Kaplan J.
Obstet Gynecol. 2003 Nov;102(5 Suppl):1210-2.
Abstract
Lactic Acidemia/Acidosis
 
         Journal Papers, Abstracts, and Commentaries
 
  Risk of early febrile seizure with perinatal exposure to nucleoside.analogues.
 Landreau-Mascaro A, Barret B, et al.
Lancet 2002 Feb 16;359(9306):583-4
 Abstract		  

           Conference Reports, Abstracts, and Posters

 
Lack of Hyperlactatemia and Impaired Mitochondrial DNA Content in CD4+ Cells
of HIV-uninfected Infants Exposed to Perinatal Antiretroviral Therapy
 A Vigano, R Bianchi, L Schneider, et al
(11 CROI)
 Abstract
 
Lactic Acid Levels in Infants Exposed to ART during Fetal Life
C Giaquinto, O Rampon, S Torresan, et al
 (11 CROI)
 Abstract
 
Mitochondrial Damage
 
              Journal Papers, Abstracts, and Commentaries
 
  Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral
nucleoside analogues.
Blanche S, Tardieu M, Rustin P, et al
Lancet 1999 Sep 25;354(9184):1084-9
Abstract
 
              Conference Reports, Abstracts, and Posters   
 
  Lack of mitochondrial toxicity in adipose tissue from HIV-infected women as
measured at delivery: results from the Italian prospective cohort on antiretroviral
therapy in pregnancy: efficacy and toxicity (TARGET) study
Nasi M, Chiesa E, Rocco G, et al
 (4th IAS Conference)
 Abstract
 
  Lack of Hyperlactatemia and Impaired Mitochondrial DNA Content in CD4+ Cells
of HIV-uninfected Infants Exposed to Perinatal Antiretroviral Therapy
 A Vigano, R Bianchi, L Schneider, et al
 (11 CROI)
 Abstract
Neutropenia
 

           Conference Reports, Abstracts, and Posters

 
Severe neutropenia among HIV-1-exposed infants according to maternal antiretroviral
prophylaxis regimen
 M Jacob, P Srijayanth, S Dharmarajan, et al
 (8th Int Congress on Drug Therapy in HIV Infection)
 Abstract 
 
Pre-eclampsia
 
           Journal Papers, Abstracts, and Commentaries
 
  A WEEK-IN-REVIEW FEATURED REPORT
Increased risk of pre-eclampsia and fetal death in HIV-infected pregnant women r
eceiving highly active antiretroviral therapy.
 Suy A, Martinez E, Coll O, Lonca M, et al 
AIDS. 2006 Jan 2;20(1):59-66.
Abstract
 		  

           Conference Reports, Abstracts, and Posters

 
Increased risk of pre-eclampsia and fetal death in HIV-infected pregnant
women receiving highly active antiretroviral therapy
A Suy, O Coll, E Martinez, M Lonca,  et al
 (15IAC)
 Abstract
 

 

HIV Pregnancy Main Page Women Main Page  

Pregnancy: General ARV Adverse Events