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Last Update: August 26, 2017
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General Reports

          Journal Papers, Abstracts, and Commentaries

Brief Report: Lopinavir Hair Concentrations are the Strongest Predictor of Viremia in HIV-infected Asian Children and Adolescents on Second-line Antiretroviral Therapy.
Pintye J, Bacchetti P, Teeraananchai S, et al
J Acquir Immune Defic Syndr. 2017 Aug 18
Abstract
FULL-TEXT ARTICLE
Early ART Results in Greater Immune Reconstitution Benefits in HIV-Infected Infants: Working with Data Missingness in a Longitudinal Dataset.
Azzoni L, Barbour R, Papasavvas E, et al
PLoS One. 2015 Dec 15;10(12):e0145320.
Paper

FULL-TEXT ARTICLE
Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection.
Mori M, Adland E, Paioni P, Swordy A, et al
PLoS One. 2015 Jul 7;10(7):e0131591
Paper

Establishment and replenishment of the viral reservoir in perinatally HIV-1-infected children initiating very early antiretroviral therapy.
Martínez-Bonet M, Puertas MC, et al
Clin Infect Dis. 2015 Jun 10.
Abstract

Very early combination antiretroviral therapy in infants: prospects for cure.
Rainwater-Lovett K, Luzuriaga K, Persaud D.
Curr Opin HIV AIDS. 2014 Nov 14.
Abstract

Correlates of age at attainment of developmental milestones in HIV-infected infants receiving early antiretroviral therapy.
Benki-Nugent S, Eshelman C, Wamalwa D, et al
Pediatr Infect Dis J. 2014 Aug 20
Abstract

Cognitive and language outcomes in HIV-uninfected infants exposed to combined antiretroviral therapy in utero and through extended breast-feeding.
Ngoma MS, Hunter JA, Harper JA, et al
AIDS. 2014 Jul;28 Suppl 3:S323-30
Abstract

Role of Three Lipoprotein Lipase Variants in Triglycerides in Children Receiving HAART.
Colombero C, Catano G, Rocco CA, et al
Pediatr Infect Dis J. 2014 Jul 1
Abstract

Antiretroviral therapy in HIV-infected children and adolescents: lessons learned in 30 years of the epidemic.
Bazin GR, Gaspar MC, Silva NC,
Cad Saude Publica. 2014 Apr;30(4):687-702
Abstract

The neurodevelopment of HIV-infected infants on HAART compared to HIV-exposed but uninfected infants.
Whitehead N, Potterton J, Coovadia A.
AIDS Care. 2013 Oct 14.
Abstract

FULL-TEXT ARTICLE
Clinically significant interactions between antiretroviral and co-prescribed drugs for HIV-infected children: profiling and comparison of two drug databases.
Oshikoya KA, Oreagba IA, Ogunleye OO, et al
Ther Clin Risk Manag. 2013;9:215-221
Paper

Antiretroviral Therapy in Children: Recent Advances.
Lodha R, Manglani M.
Indian J Pediatr. 2012 Nov 27
Abstract

Outcomes after reinitiating antiretroviral therapy in children randomized to planned treatment interruptions in the PENTA 11 Study.
Bunupuradah T, Duong T, Compagnucci A, et al
AIDS. 2012 Nov 6.
Abstract

Effectiveness of antiretroviral therapy in HIV-infected children under 2 years of age.
Penazzato M, Prendergast A, Tierney J, et al
Cochrane Database Syst Rev. 2012 Jul 11;7:CD004772.
Abstract

Recent advances in pharmacovigilance of antiretroviral therapy in HIV-infected and exposed children.
Kenny J, Musiime V, Judd A, Gibb D.
Curr Opin HIV AIDS. 2012 Jul;7(4):305-16.
Abstract

Dynamics of the resting CD4+ T cell latent HIV reservoir in infants initiating highly active antiretroviral therapy less than six months of age.
Persaud D, Palumbo PE, Ziemniak C, et al
AIDS. 2012 May 2.
Abstract

Adaptive trials in paediatric development: dealing with heterogeneity and uncertainty in pharmacokinetic differences in children.
Cella M, Danhof M, Della Pasqua O.
Br J Clin Pharmacol. 2012 Jan 18.
Abstract

Age and CD4 Count at Initiation of Antiretroviral Therapy in HIV-Infected Children: Effects on Long-term T-Cell Reconstitution.
Lewis J, Walker AS, Castro H, et al
J Infect Dis. 2011 Dec 28.
Abstract

Unresolved Antiretroviral Treatment Management Issues in HIV-Infected Children.
Heidari S, Mofenson LM, Hobbs CV, et al
J Acquir Immune Defic Syndr. 2011 Nov 30.
Abstract

Cellular immune responses in human immunodeficiency virus (HIV)-1-infected children: is immune restoration by highly active anti-retroviral therapy comparable to non-progression?}
Hainaut M, Verscheure V, Ducarme M, et al;
Clin Exp Immunol. 2011 Jul;165(1):77-84
Abstract

Antiretroviral Drugs in Pediatric HIV-Infected Patients: Pharmacokinetic and Practical Challenges.
Phelps BR, Rakhmanina N.
Paediatr Drugs. 2011 Jun 1;13(3):175-92.
Abstract

Paediatric Antiretroviral Drug Targets.
Slogrove A, Rabie H, Cotton M.
Infect Disord Drug Targets. 2011 Mar 15
Abstract

Antiretroviral Drugs in HIV-infected Children.
Viganò A, Manfredini V, Penagini F, et al
Pharmacol Res. 2011 Jan 18. [
Abstract

Viral Load Predicts New World Health Organization Stage 3 and 4 Events in HIV-Infected Children Receiving Highly Active Antiretroviral Therapy, Independent of CD4 T Lymphocyte Value.
Oliveira R, Krauss M, Essama-Bibi S, et al
Clin Infect Dis. 2010 Dec 1;51(11):1325-1333
Abstract

          Conference Reports, Abstracts, and Posters

Selecting optimal paediatric ARV medicines through a structured formulary review process
N. Sugandhi, A. Ojoo, D. Jamieson, M. Gauval
(XX International AIDS Conference)
Abstract

          Videos

ART (Anti-Retroviral Therapy) Support Programme - Giving Hope To Children With HIV

Post-Exposure Prophylaxis

          Journal Papers, Abstracts, and Commentaries

A pilot study of health beliefs and attitudes concerning measures of antiretroviral adherence among prisoners receiving directly observed antiretroviral therapy.
White BL, Wohl DA, Hays RD, et al;
AIDS Patient Care STDS. 2006 Jun;20(6):408-17.

Postexposure prophylaxis in children and adolescents for nonoccupational exposure to human immunodeficiency virus.
Havens PL
Pediatrics. 2003 Jun;111(6 Pt 1):1475-89.
Abstract

Safety

          Journal Papers, Abstracts, and Commentaries

Drug safety during pregnancy and in infants. Lack of mortality related to mitochondrial dysfunction among perinatally HIV-exposed children in pediatric
HIV surveillance.
Lindegren ML, Rhodes P, Gordon L, et al.
Ann N Y Acad Sci 2000 Nov;918:222-35
Abstract

Tolerability

          Journal Papers, Abstracts, and Commentaries

Tolerabilities of Antiretrovirals in Paediatric HIV Infection.
Avi Lemberg D, Palasanthiran P, Goode M, Ziegler JB.
Drug Saf 2002;25(14):973-91
Abstract

Pharmacokinetics

          Journal Papers, Abstracts, and Commentaries

Antiretroviral Drugs in Pediatric HIV-Infected Patients: Pharmacokinetic and Practical Challenges.
Phelps BR, Rakhmanina N.
Paediatr Drugs. 2011 Jun 1;13(3):175-92.
Abstract
Pharmacokinetics of Antiretroviral Therapy in HIV-1-Infected Children
Fraaij PL, van Kampen JJ, Burger DM, de Groot R.
Clin Pharmacokinet. 2005;44(9):935-956.
Abstract

Resistance

          Journal Papers, Abstracts, and Commentaries

HIV-1 Drug Resistance and Second-Line Treatment in Children Randomized to Switch at Low Versus Higher RNA Thresholds.
Harrison L, Melvin A, Fiscus S, et al
J Acquir Immune Defic Syndr. 2015 Sep 1;70(1):42-53.
Abstract
Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure.
Fisher RG, Smith DM, Murrell B, et al
J Clin Virol. 2015 Jan;62:48-53.
Abstract

Drug resistance in the HIV-1-infected paediatric population worldwide: a systematic review.
Rojas Sánchez P, Holguín A.
J Antimicrob Chemother. 2014 Apr 30
Abstract

FULL-TEXT PDF ARTICLE
Antiviral Resistance and Correlates of Virologic Failure in the first Cohort of HIV-Infected Children Gaining Access to Structured Antiretroviral Therapy in Lima, Peru: A Cross-Sectional Analysis.
Rath BA, von Kleist M, Castillo ME, et al
BMC Infect Dis. 2013 Jan 2;13(1):1.
Paper

Impact of Maternal and Infant Antiretroviral Drug Regimens on Drug Resistance in HIV-Infected Breastfeeding Infants.
Fogel JM, Mwatha A, Richardson P, et al
Pediatr Infect Dis J. 2012 Dec 17.|
Abstract

Management of paediatric HIV-1 resistance.
Gupta RK, Gibb DM, Pillay D.
Curr Opin Infect Dis. 2009 Jun;22(3):256-63.
Abstract

FULL-TEXT ARTICLE
Emergency of primary NNRTI resistance mutations without antiretroviral selective pressure in a HAART-treated child.
Machado ES, Afonso AO, Nissley DV, et al
PLoS ONE. 2009;4(3):e4806
Paper

HIV-1 DRUG RESISTANCE IN HIV-1-INFECTED CHILDREN IN THE UNITED KINGDOM FROM 1998 TO 2004.
Chakraborty R, Smith CJ, Dunn D, et al
Pediatr Infect Dis J. 2008 Mar 27
Abstract

Prevalence and risk factors associated with antiretroviral resistance in HIV-1-infected children.
Delaugerre C, Warszawski J, Chaix ML, et al
J Med Virol. 2007 Jul 2;79(9):1261-1269
Abstract

Emergence of human immunodeficiency virus type 1 variants containing the Q151M complex in children receiving long-term antiretroviral chemotherapy.
Harada S, Hazra R, Tamiya S, et al
Antiviral Res. 2007 Mar 21;
Abstract

HIV-1 drug resistance in French infected-children: from newborn to adolescent.
Delaugerre C, Chaix ML, Warszawski J, et al
Arch Pediatr. 2007 Feb 5
Abstract

Antiretroviral drug resistance among HIV-1 infected children failing treatment.
Mullen J, Leech S, O'Shea S, et al. J
Med Virol 2002 Nov;68(3):299-304
Abstract

Impact of Human Immunodeficiency Virus Type 1 Subtypes on Virologic Response and Emergence of Drug Resistance among Children in the Paediatric
European Network for Treatment of AIDS (PENTA) 5 Trial.
Pillay D, Walker AS, Gibb DM,
J Infect Dis 2002 Sep 1;186(5):617-25
Abstract

Effect of combination antiretroviral therapy on cerebrospinal fluid HIV RNA, HIV resistance, and clinical manifestations of encephalopathy.
McCoig C, Castrejon MM, Castano E, et al
J Pediatr 2002 Jul;141(1):36-44
Abstract

Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine,
nelfinavir, or ritonavir
(Pediatric AIDS Clinical Trials Group 377).Eshleman SH, et al
J Infect Dis 2001 Jun 15;183(12):1732-8
Abstract

Adherence

          Journal Papers, Abstracts, and Commentaries

Impact of HIV-Status Disclosure on Adherence to Antiretroviral Therapy Among HIV-Infected Children in Resource-Limited Settings: A Systematic Review.
Nichols J, Steinmetz A, Paintsil E.
AIDS Behav. 2016 Jul 9.
Abstract
Children and Adolescents with Perinatal HIV-1 Infection: Factors Associated with Adherence to Treatment in the Brazilian Context.
Cruz ML, Cardoso CA, Darmont MQ, et al
Int J Environ Res Public Health. 2016 Jun 21;13
Abstract

Adherence to antiretroviral therapy and its determinants in children with HIV infection - Experience from Paediatric Centre of Excellence in HIV Care in North India.
Seth A, Gupta R, Chandra J, et al
AIDS Care. 2013 Nov 22
Abstract

Adherence to Antiretroviral Therapy and Acceptability of Planned Treatment Interruptions in HIV-Infected Children.
Harrison L, Ananworanich J, Hamadache D, et al
AIDS Behav. 2012 May 15.
Abstract

Efficacy

        Journal Papers, Abstracts, and Commentaries

Early Combination Antiretroviral Therapy Limits HIV-1 Persistence in Children.
Luzuriaga K.
Annu Rev Med. 2016 Jan 14;67:201-13.
Abstract
No Differences of Immune Activation and Microbial Translocation Among HIV-infected Children Receiving Combined Antiretroviral Therapy or Protease Inhibitor Monotherapy.
Falcon-Neyra L, Benmarzouk-Hidalgo OJ, et al
Medicine (Baltimore). 2015 Mar;94(11):e521
Abstract

Long-term response to combination antiretroviral therapy in HIV-infected children in the Netherlands registered from 1996-2012.
Cohen S, Smit C, van Rossum AM, Fraaij PL, et al
AIDS. 2013 Jul 9
Abstract

Maternal and infant antiretroviral regimens to prevent postnatal HIV-1 transmission: 48-week follow-up of the BAN randomised controlled trial.
Jamieson DJ, Chasela CS, Hudgens MG, et al
Lancet. 2012 Apr 25.
Abstract

Treatment Failure

Journal Papers, Abstracts, and Commentaries

A novel pharmacokinetic approach to predict virologic failure in HIV-1-infected paediatric patients.
Bouazza N, Tréluyer JM, Msellati P, et al
AIDS. 2013 Mar 13;27(5):761-8.
Abstract

Increased Gut Microbial Translocation in Human Immunodeficiency Virus-Infected Children Persists in Virologic Responders and Virologic Failures Following Antiretroviral Therapy.
Pilakka-Kanthikeel S, Huang S, Fenton T, et al
Pediatr Infect Dis J. 2012 Feb 10.
Abstract

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