MedICAL ADVOCATES
Children
  ARV Drug Classes
Protease Inhibitors
Nucleoside Reverse Transcriptase Inhibitors
 NNRTIs
Integrase Inhibitor
         






 
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Last Update:  December 11, 2016
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Protease Inhibitors
       

General Reports

          Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
 Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.
Hobbs CV, Gabriel EE, Kamthunzi P,  et al
 PLoS One. 2016 Dec 9;11(12):e0165140.
 Paper

FULL-TEXT ARTICLE
 Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.
 Rossouw TM, Feucht UD, Melikian G, et al
PLoS One. 2015 Jul 21;10(7):e0133452.
Paper

Genetic Changes in HIV-1 Gag-Protease Associated with Protease Inhibitor-Based Therapy Failure in Paediatric Patients.
Giandhari J, Basson AE, Coovadia A, et al
AIDS Res Hum Retroviruses. 2015 Apr 28.
 Abstract

Treatment Failure in HIV-infected Children on Second-line Protease Inhibitor-based Antiretroviral Therapy.
Suaysod R, Ngo-Giang-Huong N, Salvadori N, et al
Clin Infect Dis. 2015 Apr 1. pii: civ271.
 Abstract

No Differences of Immune Activation and Microbial Translocation Among HIV-infected Children Receiving Combined Antiretroviral Therapy or Protease Inhibitor Monotherapy.
Falcon-Neyra L, Benmarzouk-Hidalgo OJ,  et al
Medicine (Baltimore). 2015 Mar;94(11):e521
Abstract

Adherence and Viral Suppression among Infants and Young Children Initiating Protease Inhibitor-Based Antiretroviral Therapy.
 Teasdale CA, Abrams EJ, Coovadia A,  et al
Pediatr Infect Dis J. 2012 Dec 17
 Abstract

Boosted protease inhibitors as a therapeutic option in the treatment of HIV-infected children.
Ramos J.
HIV Med. 2009 Oct;10(9):536-47.
 Abstract

FULL-TEXT PDF ARTICLE
 Outcome of protease inhibitor substitution with nevirapine in HIV-1 infected children.
 Gonzalez-Tome MI, Ramos Amador JT, et al
BMC Infect Dis. 2008 Oct 22;8(1):144
 Paper
 
Two-Year Outcomes of Children on Non-Nucleoside Reverse Transcriptase Inhibitor and
Protease Inhibitor Regimens in a South African Pediatric Antiretroviral Program.
 Jaspan HB, Berrisford AE, Boulle AM.   
Pediatr Infect Dis J. 2008 Sep 24.
 Abstract
 
Neurodevelopmental Functioning in HIV-Infected Infants and Young Children Before and After the
Introduction of Protease Inhibitor-Based Highly Active Antiretroviral Therapy.
 Lindsey JC, Malee KM, Brouwers P, Hughes MD.
Pediatrics. 2007 Feb 12;
 Abstract
 
Protease Inhibitor Combination Therapy, Severity of Illness, and Quality of Life Among
Children With Perinatally Acquired HIV-1 Infection.
Storm DS, Boland MG, Gortmaker SL, et al
 Pediatrics. 2005 Jan 3
 Abstract

Endocrinologic and immunologic factors associated with recovery of growth in children
with human immunodeficiency virus type 1infection treated withprotease inhibitors.
Van Rossum AM, Gaakeer MI, Verweel S , et al 
 Pediatr Infect Dis J 2003 Jan;22(1):70-6
Abstract		  
     
  Protease inhibitor therapy in HIV-infected children.
Feingold AR, Rutstein RM, Meislich D, et al.
AIDS Patient Care STDS 2000 Nov;14(11):589-93
 Abstract		  

Efficacy

          Journal Papers, Abstracts, and Commentaries

  Effectiveness and safety of protease inhibitor-based regimens in HIV-infected Thai children failing first-line treatment.
Wattanutchariya N, Sirisanthana V, Oberdorfer P.
HIV Med. 2012 Oct 24.
Abstract

Antiretroviral Regimens Containing a Single Protease Inhibitor Increase Risk of Virologic Failure in Young HIV-Infected Children.
 Walters E, Reichmuth K, Dramowski A, et al
Pediatr Infect Dis J. 2012 Oct 30.
 Abstract

Long-term protease inhibitor-containing therapy results in limited improvement in T cell
function but not restoration of interleukin-12 production in pediatric patients with aids.
Chougnet C Jankelevich S, Fowke K , et al
J Infect Dis 2001 Jul 15;184(2):201-5
Abstract

Adverse Events

         Journal Papers, Abstracts, and Commentaries

  Endocrinologic and immunologic factors associated with recovery of growth in children
with human immunodeficiency virus type 1infection treated with protease inhibitors.
Van Rossum AM, Gaakeer MI, Verweel S , et al 
 Pediatr Infect Dis J 2003 Jan;22(1):70-6
Abstract

Metabolic abnormalities in HIV type 1-infected children treated and not treated with
protease inhibitors.
Melvin AJ, Lennon S, Mohan KM, Purnell JQ.
AIDS Res Hum Retroviruses 2001 Aug 10;17(12):1117-23
Abstract

  

Viral Dynamics

         Journal Papers, Abstracts, and Commentaries

  Antiretroviral Regimens Containing a Single Protease Inhibitor Increase Risk of Virologic Failure in Young HIV-Infected Children.
 Walters E, Reichmuth K, Dramowski A, et al
Pediatr Infect Dis J. 2012 Oct 30.
 Abstract

Long-term protease inhibitor-containing therapy results in limited improvement in
T cell function but not restoration of interleukin-12 production in pediatric patients
with AIDS.
Chougnet C, Jankelevich S, Fowke, et al
 J Infect Dis 2001 Jul 15;184(2):201-5        
Abstract
Nucleoside Reverse Transcriptase Inhibitors
       

General Reports

          Journal Papers, Abstracts, and Commentaries
 
 
Role of Non-Nucleoside Reverse Transcriptase Inhibitors in Treating HIV-Infected Children.
Penazzato M, Giaquinto C.
Drugs. 2011 Nov 12;71(16):2131-49
 Abstract

FULL-TEXT PDF ARTICLE
Immunologic and virologic failure after first-line NNRTI-based antiretroviral therapy in Thai HIV-infected children.
Bunupuradah T, Puthanakit T, Kosalaraksa P, et al
AIDS Res Ther. 2011 Oct 26;8(1):40
 Paper

Response to Nonnucleoside Reverse Transcriptase Inhibitor-Based Therapy in HIV-Infected
Children with Perinatal Exposure to Single-Dose Nevirapine.
 Musiime V, Ssali F, Kayiwa J, Namala W, et al
AIDS Res Hum Retroviruses. 2009 Sep 24.
Abstract

Pattern and predictors of immunologic recovery in human immunodeficiency virus-infected children receiving
non-nucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy.
Puthanakit T, Kerr S, Ananworanich J, et al
Pediatr Infect Dis J. 2009 Jun;28(6):488-92.
 Abstract

FULL TEXT PDF ARTICLE
 Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic
response to combination therapy in children (PACTG 338).
 Fiscus SA, Kovacs A, Petch LA, et al  
AIDS Res Ther. 2007 Feb 6;4(1):2
Paper

Mutations linked to drug resistance, human immunodeficiency virus type 1
biologic phenotype and their association with disease progression in children
receiving nucleoside reverse transcriptase inhibitors.
Englund JA, Raskino C, Vavro C, et al.
Pediatr Infect Dis J. 2004 Jan;23(1):15-22
 Abstract
 
Resistance

         Journal Papers, Abstracts, and Commentaries

  Resistance to dual nucleoside reverse-transcriptase inhibitors in children
infected with HIV clade A/E.
Lolekha R, Sirivichayakul S, Siangphoe U,et al 
Clin Infect Dis. 2005 Jan 15;40(2):309-12.
 Abstract
Non-Nucleoside Reverse Transcriptase Inhibitors
       

General Reports

          Journal Papers, Abstracts, and Commentaries
 
 
FULL-TEXT ARTICLE
 Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.
Hobbs CV, Gabriel EE, Kamthunzi P,  et al
 PLoS One. 2016 Dec 9;11(12):e0165140.
 Paper

Role of Non-Nucleoside Reverse Transcriptase Inhibitors in Treating HIV-Infected Children.
Penazzato M, Giaquinto C.
Drugs. 2011 Nov 12;71(16):2131-49.
Abstract

Response to Nonnucleoside Reverse Transcriptase Inhibitor-Based Therapy in HIV-Infected Children with Perinatal Exposure to Single-Dose Nevirapine.
Musiime V, Ssali F, Kayiwa J, Namala W, et al
AIDS Res Hum Retroviruses. 2009 Sep 24.
Abstract

Pattern and Predictors of Immunologic Recovery in Human Immunodeficiency Virus-Infected Children
Receiving Non-Nucleoside Reverse Transcriptase Inhibitor-Based Highly Active Antiretroviral Therapy.
 Puthanakit T, Kerr SJ, Ananworanich J,   et al 
Pediatr Infect Dis J. 2009 Apr 28.
 Abstract

Two-Year Outcomes of Children on Non-Nucleoside Reverse Transcriptase Inhibitor and
Protease Inhibitor Regimens in a South African Pediatric Antiretroviral Program.
 Jaspan HB, Berrisford AE, Boulle AM.   
Pediatr Infect Dis J. 2008 Sep 24.
 Abstract
Integrase Inhibitors
       

          Journal Papers, Abstracts, and Commentaries

  Use of Integrase Inhibitors in HIV-Infected Children and Adolescents.
Dehority W, Abadi J, Wiznia A, Viani RM.
Drugs. 2015 Aug 5.
 Abstract

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Pediatric HIV Drug Classes