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General Reports
 Amodiaquine
Artemotil
Artemether-Lumefantrine
Artesunate
Atovaquone
Chloramphenicol
Choroquine
Co-trimoxazole 		Diazepam
Dihydroartemisinin
Fosmidomycin
Halofantrine
Lorazepam  
Mefloquine
Quinine
Sulfadoxine

 
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Last Update:  January 03, 2009    
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General Reports
 

          Journal Papers, Abstracts, and Commentaries

 
Effect Of Antiretroviral Therapy On Asymptomatic Malaria Parasitaemia In HIV-1 Infected Children.
Adetifa IM, Akinsulie AO, Temiye EO, et al
Niger Postgrad Med J. 2008 Sep;15(3):141-5.
 Abstract
 
FULL TEXT ARTICLE
A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal
intermittent preventive treatment for malaria in Senegalese children.
 Sokhna C, Cissé B, Bâ el H, et al
PLoS ONE. 2008 Jan 23;3(1):e1471.
 Paper

Comparative efficacy of antimalarial drugs including ACTs in the treatment of
uncomplicated malaria among children under 5 years in Ghana.
Koram KA, Abuaku B, Duah N, Quashie N.
Acta Trop. 2005 Sep;95(3):194-203.
 Abstract

Pediatric Malaria Drugs
Imbert P, Laurent C.
Med Trop (Mars) 2002;62(5):554-60
 Abstract
Amodiaquine
 
         Journal Papers, Abstracts, and Commentaries
 
 
FULL-TEXT ARTICLE
Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated
infections treatedwith amodiaquine.
 Sowunmi A, Balogun ST, Gbotosho GO, Happi CT, et al  
Malar J. 2008 Sep 2;7:169.
Paper
 
Effect of concomitant artesunate administration and CYP2C8 polymorphisms on the pharmacokinetics
of amodiaquine in Ghanaian children with uncomplicated malaria.
 Adjei GO, Kristensen K, Goka BQ, et al  
Antimicrob Agents Chemother. 2008 Sep 8.
 Abstract
 
Combination therapy for uncomplicated falciparum malaria in Ugandan children:
a randomized trial.
Dorsey G, Staedke S, Clark TD, et al
JAMA. 2007 May 23;297(20):2210-9.
 Abstract

Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria
in children in Guinea-Bissau: implications for future treatment recommendations.
Kofoed PE, Ursing J, Poulsen A, et al
Trans R Soc Trop Med Hyg. 2006 Aug 10;
 Abstract

High reinfection rate and treatment failures in children treated with amodiaquine for falciparum
malaria in Muheza villages, Northeastern Tanzania.
Lemnge M, Alifrangis M, Kafuye MY
Am J Trop Med Hyg. 2006 Aug;75(2):188-93
 Abstract
 
Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-
pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in
Central African children with noncomplicated malaria
Menard D, Madji N, Manirakiza A, et al
Am J Trop Med Hyg. 2005 May;72(5):581-5
 Abstract
 
Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and
artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm
randomised effectiveness trial.
Mutabingwa TK, Anthony D, Heller A, et al
Lancet. 2005 Apr 23-29;365(9469):1474-80
 Abstract
Artemotil
 

          Journal Papers, Abstracts, and Commentaries

  A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral
malaria.
Thuma PE, Bhat GJ, Mabeza GF, et al.
Am J Trop Med Hyg 2000 Apr;62(4):524-9
Abstract		  
Artemether-Lumefantrine
 

          Journal Papers, Abstracts, and Commentaries

 
A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus
artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in
children in western Kenya.
Juma EA, Obonyo CO, Akhwale WS, Ogutu BR.  
Malar J. 2008 Dec 22;7(1):262.
 Abstract
 
FULL-TEXT ARTICLE
Paediatric malaria case-management with artemether-lumefantrine in Zambia: a repeat
cross-sectional study.
Zurovac D, Ndhlovu M, Sipilanyambe N, et al
Malar J. 2007 Mar 16;6:31.
Paper

FULL-TEXT ARTICLE
Assessment of the therapeutic efficacy of a paediatric formulation of  artemether-lumefantrine
(Coartesiane) for the treatment of uncomplicated Plasmodium falciparum in children in Zambia.
Chanda P, Hawela M, Kango M, Sipilanyambe N.
Malar J. 2006 Aug 28;5:75.
Paper 

Feasibility and acceptability of the use of artemether-lumefantrine in the home management
of uncomplicated malaria in children 6-59 months old in Ghana.
Chinbuah AM, Gyapong JO, Pagnoni F, et al
Trop Med Int Health. 2006 Jul;11(7):1003-16.
Abstract
 
Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the
treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.
Martensson A, Stromberg J, Sisowath C, et al
Clin Infect Dis. 2005 Oct 15;41(8):1079-86.
 Abstract
 
Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and
artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm
randomised effectiveness trial.
Mutabingwa TK, Anthony D, Heller A, et al
Lancet. 2005 Apr 23-29;365(9469):1474-80
 Abstract
 
Efficacy and safety of artemether-lumefantrine (Coartem) tablets (six-dose regimen) in African
infants and children with acute, uncomplicated falciparum malaria.
Falade C, Makanga M, Premji Z, et al
Trans R Soc Trop Med Hyg. 2005 Jun;99(6):459-67.
 Abstract
 
Artesunate
 

          Journal Papers, Abstracts, and Commentaries

 
FULL TEXT PDF ARTICLE
Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in
children with uncomplicated falciparum malaria on the coast of Benin, West Africa
Nahum A, Erhart A, D Gazard D, et al  
Malaria Journal 2007, 6:170
Paper

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated
falciparum malaria among children under 5 years in Kailahun, Sierra Leone.
Grandesso F, Hagerman A, Kamara S, et al
 Trop Med Int Health. 2006 Jul;11(7):1017-21.
Abstract

Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-
sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in
Nigerian children.
Sowunmi A, Fehintola FA, Adedeji AA, et al
Trop Med Int Health. 2005 Nov;10(11):1161-70.
 Abstract
 
Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the
treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.
Martensson A, Stromberg J, Sisowath C, et al
Clin Infect Dis. 2005 Oct 15;41(8):1079-86.
 Abstract
 
FULL-TEXT  ARTICLE
5-day nonobserved artesunate monotherapy for treating uncomplicated Falciparum malaria
in young Gabonese children.
Schwarz NG, Oyakhirome S, Potschke M, et al
Am J Trop Med Hyg. 2005 Oct;73(4):705-9.
 Paper
 
Life-saving rectal artesunate for complicated malaria in children.
Pengsaa K, Sirivichayakul C, Na-Bangchang K, et al
Southeast Asian J Trop Med Public Health. 2005 May;36(3):597-601.
 Abstract
 
 
          Conference Reports, Abstracts, and Posters 
 
  CONFERENCE PDF POSTER
 High Risk of Neutropenia in HIV-infected Children following Treatment with Artesunate +
Amodiaquine for Uncomplicated Malaria in Uganda
 M Kamya, A Gasasira, J Achan, et al
 (15th CROI)
 PDF Poster     Abstract
Atovaquone
 

          Journal Papers, Abstracts, and Commentaries

  Efficacy of atovaquone/proguanil for malaria prophylaxis in children and its effect on the
immunogenicity of live oral typhoid and cholera vaccines.
Faucher JF, Binder R, Missinou MA, et al.
Clin Infect Dis 2002 Nov 15;35(10):1147-54
Abstract
 
Combination atovaquone and proguanil hydrochloride vs. halofantrine for treatment of
acute Plasmodium falciparum malaria in children.
Anabwani G, Canfield CJ, Hutchinson DB. et al
Pediatr Infect Dis J. 1999 May;18(5):456-61
Abstract
 
Chloramphenicol
 

          Journal Papers, Abstracts, and Commentaries

  Chloramphenicol pharmacokinetics in African children with severe malaria.
Kokwaro GO, Muchohi SN, Ogutu BR, Newton CR.
J Trop Pediatr. 2006 Aug;52(4):239-43.
 Abstract
Choroquine
 

          Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT  ARTICLE
Use of pre-packaged chloroquine for the home management of presumed malaria in Malagasy
children.
Ratsimbasoa A, Randrianarivelojosia M, Millet P, et al
Malar J. 2006 Sep 14;5:79
Paper
 
Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria
 in children in Guinea-Bissau: implications for future treatment recommendations.
Kofoed PE, Ursing J, Poulsen A, et al
Trans R Soc Trop Med Hyg. 2006 Aug 10;
 Abstract
 
FULL-TEXT ARTICLE
 Randomised Trial of Chloroquine/Sulphadoxine-Pyrimethamine in Gambian Children with
Malaria: Impact against Multidrug-Resistant P. falciparum.
Dunyo S, Ord R, Hallett R, Jawara M, et al
PLoS Clin Trials. 2006 Jul 21;1(3):e14
Paper
 
FULL-TEXT ARTICLE
Chloroquine/Sulphadoxine-Pyrimethamine for Gambian Children with Malaria: Transmission
to Mosquitoes of Multidrug-Resistant Plasmodium falciparum.
Hallett RL, Dunyo S, Ord R, et al
PLoS Clin Trials. 2006 Jul 21;1(3):e15
 Paper
 
Pre-treatment with chloroquine and parasite chloroquine resistance in Ghanaian children
with severe malaria.
Evans JA, May J, Tominski D, et al
QJM. 2005 Nov;98(11):789-96.
 Abstract
 
Plasmodium falciparum malaria in Nigerian children during high and low transmission seasons:
gametocyte carriage and response to oral chloroquine.
Adedeji AA, Fehintola FA, Fateye BA, et al
J Trop Pediatr. 2005 Oct;51(5):288-94.
 Abstract
 
Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-
pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in
Central African children with noncomplicated malaria
Menard D, Madji N, Manirakiza A, et al
Am J Trop Med Hyg. 2005 May;72(5):581-5
 Abstract
 
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of
uncomplicated falciparum malaria in young African children: double-blind randomised
controlled trial.
Alloueche A, Bailey W, Barton S,et al
Lancet. 2004 Jun 5;363(9424):1843-8
 Abstract

FULL-TEXT PDF ARTICLE
 Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in
southern, central Vietnam using an extended 28-day in vivo test and polymerase chain
reaction genotyping.
Taylor WR, Doan HN, Nguyen DT 
Am J Trop Med Hyg. 2000 Jun;62(6):693-7.
Paper
Co-trimoxazole
 

          Journal Papers, Abstracts, and Commentaries

  Effects of antifolates--co-trimoxazole and pyrimethamine-sulfadoxine--on gametocytes
in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria.
Sowunmi A, Fateye BA, Adedeji AA
 Mem Inst Oswaldo Cruz. 2005 Jul;100(4):451-5.
 Abstract
Diazepam
 

          Journal Papers, Abstracts, and Commentaries

  Response to diazepam in children with malaria induced seizures.
 Ikumi ML, Muchohi SN, Ohuma EO, et al  
Epilepsy Res. 2008 Sep 18.
Abstract
Dihydroartemisinin
 

          Journal Papers, Abstracts, and Commentaries

  Dihydroartemisinin suppository in moderately severe malaria: comparative efficacy of
dihydroartemisinin suppository versus intramuscular artemeter followed by oral
sulfadoxine-pyrimethamine in the management of moderately severe malaria in nigerian children.
 Falade CO, Fadero FF, Happi CT, et al  
Am J Trop Med Hyg. 2007 Jan;76(1):1-6.
Abstract
Fosmidomycin
 

          Journal Papers, Abstracts, and Commentaries

  Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with
Plasmodium falciparum malaria.
Borrmann S, Lundgren I, Oyakhirome S, ET AL
 Antimicrob Agents Chemother. 2006 Aug;50(8):2713-8.
 Abstract
Halofantrine
 

          Journal Papers, Abstracts, and Commentaries

 
Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M, et al
 Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71
Abstract
 
Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M,et al
Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71.
 Abstract
 
Halofantrine efficacy in non-immune children with imported acute Plasmodium falciparum
malaria Infection.
Hau I, Seringe S, Aberrane S, De La Rocque F
Eur J Pediatr. 2003 Nov 28
 Abstract
 
FULL-TEXT PDF ARTICLE
Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern,
central Vietnam using an extended 28-day in vivo test and polymerase chain reaction
genotyping.
Taylor WR, Doan HN, Nguyen DT 
Am J Trop Med Hyg. 2000 Jun;62(6):693-7.
Paper
 
Mechanism of cardiotoxicity of halofantrine.
Wesche DL, Schuster BG, Wang WX, Woosley RL.
Clin Pharmacol Ther. 2000 May;67(5):521-9.
Abstract
 
Lorazepam
 

          Journal Papers, Abstracts, and Commentaries

  Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and
convulsions.
Muchohi SN, Obiero K, Newton CR, et al
 Br J Clin Pharmacol. 2007 Jul 17;
Abstract
Mefloquine
 

          Journal Papers, Abstracts, and Commentaries

 
Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M, et al
Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71
 Abstract
 
Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M,et al
Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71.
 Abstract

Pedatric Malaria Drugs
Imbert P, Laurent C.
 Med Trop (Mars) 2002;62(5):554-60
 Abstract

  
Phenobarbital
 

          Journal Papers, Abstracts, and Commentaries

  Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum
malaria and convulsions.
Kokwaro GO, Ogutu BR, Muchohi SN, et al
Br J Clin Pharmacol. 2003 Oct;56(4):453-457
 Abstract
Quinine
 

          Journal Papers, Abstracts, and Commentaries

 
Ventricular fibrillation in a 5-year-old child on therapeutic dose of quinine dihydrochloride infusion
for acute malaria.
 Busari O, Busari O. 
J Natl Med Assoc. 2008 Aug;100(8):945-7.
 Abstract
 
Changes in laboratory features of 192 children with imported falciparum malaria
treated with quinine.
Ladhani S, Patel VS, El Bashir H, Shingadia D.
Pediatr Infect Dis J. 2005 Nov;24(11):1017-20.
Abstract
 
FULL-TEXT ARTICLE
Quinine pharmacokinetics and pharmacodynamics in children with malaria caused by
Plasmodium falciparum.
Le Jouan M, Jullien V, Tetanye E, et al
Antimicrob Agents Chemother. 2005 Sep;49(9):3658-62.
 Papers

The effect of quinine on the electroretinograms of children with pediatric cerebral malaria.
Lochhead J, Movaffaghy A, Falsini B,  et al.
J Infect Dis 2003 Apr 15;187(8):1342-5
 Abstract

Tolerance of quinine administered as an intrarectal solution in children in French-
speaking Africa.
Barennes H, Mahaman Sani A, Kahia Tani F, et al.
Med Trop (Mars) 1999;59(4):383-8
Abstract

  
Sulfadoxine
 

          Journal Papers, Abstracts, and Commentaries

 
FULL TEXT PDF ARTICLE
Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in
children with uncomplicated falciparum malaria on the coast of Benin, West Africa
Nahum A, Erhart A, D Gazard D, et al  
Malaria Journal 2007, 6:170
Paper
 
FULL TEXT PDF ARTICLE
Varying efficacy of intermittent preventive treatment for malaria in infants in two similar
trials: public health implications.
 Menendez C, Schellenberg D, Macete E, et al  
Malar J. 2007 Sep 26;6(1):132
 Paper
 
Intermittent preventive treatment in infants as a means of malaria control: a randomized,
double-blind, placebo-controlled trial in northern ghana.
Mockenhaupt FP, Reither K, Zanger P, et al 
Antimicrob Agents Chemother. 2007 Sep;51(9):3273-81
 Abstract
 
A randomized controlled trial of extended intermittent preventive antimalarial treatment in
infants.
Kobbe R, Kreuzberg C, Adjei S, et al
Clin Infect Dis. 2007 Jul 1;45(1):26-8.
Abstract
 
Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications.
Barnes KI, Little F, Smith PJ
Clin Pharmacol Ther. 2006 Dec;80(6):582-96
 Abstract
.
FULL-TEXT ARTICLE
Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with
uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.
Lemnge MM, Ali AS, Malecela EK, et al
Am J Trop Med Hyg. 2005 Oct;73(4):681-5.
Paper
 
FULL-TEXT ARTICLE
Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-
pyrimethamine in Malawian children.
pyrimethamine in Malawian children.
Dzinjalamala FK, Macheso A, Kublin JG, et al
Antimicrob Agents Chemother. 2005 Sep;49(9):3601-6
 Paper
 
Effects of antifolates--co-trimoxazole and pyrimethamine-sulfadoxine--on gametocytes
in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria.
Sowunmi A, Fateye BA, Adedeji AA
 Mem Inst Oswaldo Cruz. 2005 Jul;100(4):451-5.
 Abstract
 
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum
malaria: a randomized, multisite trial to guide national policy in Uganda.
Bakyaita N, Dorsey G, Yeka A, et al
Am J Trop Med Hyg. 2005 May;72(5):573-80.
 Abstract
 
The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the
treatment of severe falciparum malaria in children.
Ogutu BR, Nzila AM, Ochong E,
Trop Med Int Health. 2005 May;10(5):484-8.
 Abstract

Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the
treatment of uncomplicated falciparum malaria in young African children: double-blind
randomised controlled trial.
Alloueche A, Bailey W, Barton S,et al
Lancet. 2004 Jun 5;363(9424):1843-8
 Abstract

 
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