Aspergillosis

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Last Update: June 13, 2008

Prevention/Treatment Guidelines

Journal Papers, Abstracts, and Commentaries

FULL-TEXT ARTICLE
Treating opportunistic infections among HIV-exposed and infected children:
recommendations from CDC, the National Institutes of Health, and the Infectious
Diseases Society of America.
Mofenson LM, Oleske J, Serchuck L, et al
MMWR Dec 3, 2004 / 53(RR14);1-63
Paper

General Reports

Journal Papers, Abstracts, and Commentaries

Aspergillosis in children after liver transplantation: Single center experience.
Teisseyre J, Kaliciński P, Markiewicz-Kijewska M, et al
Pediatr Transplant. 2007 Dec;11(8):868-7
Abstract

Allergic bronchopulmonary aspergillosis in paediatric cystic fibrosis patients.
de Almeida MB, Bussamra MH, Rodrigues JC. er ak
Paediatr Respir Rev. 2006 Mar;7(1):67-72.
Abstract

Invasive aspergillosis in children with hematologic malignancies.
Hasan RA, Abuhammour W.
Paediatr Drugs. 2006;8(1):15-24
Abstract

Prolonged survival after invasive aspergillosis: a single-institution review of 11 cases.
Wright JA, Bradfield SM, Park JR, Hawkins DS.
J Pediatr Hematol Oncol 2003 Apr;25(4):286-91
Abstract

Current approaches to diagnosis and treatment of fungal infections in children infected
with human immuno deficiency virus.
Muller FM, Groll AH, Walsh TJ
Eur J Pediatr 1999 Mar;158(3):187-99
Abstract

Diagnosis/Monitoring

Journal Papers, Abstracts, and Commentaries

Assessment of the lightcycler PCR assay for diagnosis of invasive aspergillosis in paediatric
patients with onco-haematological diseases.
Cesaro S, Stenghele C, Calore E, et al
Cancer. 2008 Mar 13
Abstract

The radiological spectrum of invasive aspergillosis in children: a 10-year review.
Thomas KE, Owens CM, Veys PA, et al.
Pediatr Radiol 2003 May 9
Abstract

Clinical manifestations and diagnosis of invasive aspergillosis in immunocompromised children.
Muller FM, Trusen A, Weig M.
Eur J Pediatr 2002 Nov;161(11):563-74
Abstract

Value of antigen detection using an enzyme immunoassay in the diagnosis and prediction
of invasive aspergillosis in two adult and pediatric hematology units during a 4-year
prospective study.
Sulahian A, Boutboul F, Ribaud P, et al.
Cancer 2001 Jan 15;91(2):311-8
Abstract

Current approaches to diagnosis and treatment of fungal infections in children
infected with human immuno deficiency virus.
Muller FM, Groll AH, Walsh TJ
Eur J Pediatr 1999 Mar;158(3):187-99
Abstract

Clinical Management

Journal Papers, Abstracts, and Commentaries

Atypical invasive aspergillosis in a neutropenic child.
Nyman AG, Peters M, Jaffe A, Sonnappa S.
Pediatr Pulmonol. 2008 Jul;43(7):717-20.
Abstract

Allergic bronchopulmonary aspergillosis: a unique presentation in a pediatric patient.
Huppmann MV, Monson M.
Pediatr Radiol. 2008 May 27
Abstract

Invasive aspergillosis and allogeneic hematopoietic stem cell transplantation in children:
a 15-year experience.
Crassard N, Hadden H, Pondarré C, et al
Transpl Infect Dis. 2008 Mar 4
Abstract

Successful Combination Antifungal Agents and Surgical Resection for Pulmonary
Aspergillosis in a Child with Hodgkin Disease: Review of the Literature.
Doganis D, Baka M, Pourtsidis A, et al
Pediatr Hematol Oncol. 2007 Dec;24(8):631-8.
Abstract

Diagnostic and therapeutic implications of neurological complications following paediatric
haematopoietic stem cell transplantation.
Weber C, Schaper J, Tibussek D, et al
Bone Marrow Transplant. 2007 Nov 5
Abstract

Results of a multicenter retrospective study of a combined medical and surgical approach
to pulmonary aspergillosis in pediatric neutropenic patients.
Cesaro S, Cecchetto G, Corti FD, et al
Pediatr Blood Cancer. 2006 Dec 7
Abstract

Treatment of invasive aspergillosis in children with hematologic malignancies.
Abuhammour W, Hasan RA.
Indian J Pediatr. 2004 Sep;71(9):837-43.
Abstract

Drugs

Amphotericin B

Journal Papers, Abstracts, and Commentaries

Amphotericin B-induced partial nephrogenic diabetes insipidus in a child.
Hopp L, Bernardi J, Reeves G.
Pediatr Nephrol 2001 Jul;16(7):594-7
Abstract

Caspofungin

Journal Papers, Abstracts, and Commentaries

FULL TEXT ARTICLE
Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or
probable aspergillosis in pediatric hematological patients.
Cesaro S, Giacchino M, Locatelli F, et al
BMC Infect Dis. 2007 Apr 18;7:28
Paper

Efficacy and safety of caspofungin therapy in children with invasive fungal infections.
Merlin E, Galambrun C, Ribaud P, et al
Pediatr Infect Dis J. 2006 Dec;25(12):1186-8.
Abstract

Caspofungin therapy for Aspergillus lung infection in a boy with chronic ganulomatous
disease.
Sallmann S, Heilmann A, Heinke F, et al.
Pediatr Infect Dis J 2003 Feb;22(2):199-200
Abstract

Voriconazole

          Journal Papers, Abstracts, and Commentaries

Topical voriconazole solution for cutaneous aspergillosis in a pediatric patient
after bone marrow transplant.
Klein KC, Blackwood RA.
Pediatrics. 2006 Aug;118(2):e506-8.
Abstract

Resolution of Orbitocerebral Aspergillosis During Combination Treatment With
Voriconazole and Amphotericin Plus Adjunctive Cytokine Therapy.
Bethell D, Hall G, Goodman TR, Klein N, Pollard AJ.
Pediatr Hematol Oncol. 2004 May;26(5):304-307
Abstract

Voriconazole for invasive aspergillosis in oncohematological patients: a single-center
pediatric experience.
Cesaro S, Strugo L, Alaggio R,
Support Care Cancer. 2003 Sep 13
Abstract

Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal
infections in children.
Walsh TJ, Lutsar I, Driscoll T, et al.
Pediatr Infect Dis J 2002 Mar;21(3):240-8
Abstract

Case Studies/Literature Reviews

Journal Papers, Abstracts, and Commentaries

Aspergillus fumigatus endocarditis in a pediatric liver transplant recipient: Favorable outcome
without cardiac surgery.
Mourier O, Durand P, Lambert V, et al
Pediatr Transplant. 2008 Apr 6
Abstract

Invasive nosocomial aspergillosis associated with heart failure and complete heart block
following recovery from dengue shock syndrome.
Kohli U, Sahu J, Lodha R, et al
Pediatr Crit Care Med. 2007 Jul;8(4):389-91.
Abstract

FULL TEXT PDF ARTICLE
Two children with invasive gastrointestinal aspergillosis.
Kayiran P, Urganci N, Cetinkaya F, Tanik C.
Indian Pediatr. 2007 May;44(5):375-7.
Paper

Central nervous system aspergillosis in children: a systematic review of reported cases.
Dotis J, Iosifidis E, Roilides E.
Int J Infect Dis. 2007 May 15;
Abstract

Primary cutaneous aspergillosis in a leukemic child
Torrelo A, Hernández-Martín A, Scaglione C, et al
Actas Dermosifiliogr. 2007 May;98(4):276-8.
Abstract

Severe Aspergillus endophthalmitis occurring after liver transplantation in an 8-month-old
baby.
Pollack K, Naeke A, Fischer R, et al
Ophthalmologe. 2007 Apr 21;
Abstract

Intrathecal aspergillosis and fusiform arterial aneurysms in an immunocompromised
child: a clinico-pathological case report
Laurencikas E, Sandstedt B, Soderman M.
Childs Nerv Syst. 2006 Sep 2;
Abstract

Primary intestinal aspergillosis after high-dose chemotherapy and autologous stem
cell rescue.
Lehrnbecher T, Becker M, Schwabe D, et al
Pediatr Infect Dis J. 2006 May;25(5):465-6.
Abstract

Intracranial aspergillosis in children successfully treated with antifungal therapy
and surgical intervention.
Giacchino M, Chiapello N, Riva C, et al
Pediatr Infect Dis J. 2006 Apr;25(4):379-81
Abstract

Pneumonia with marked pleural effusion caused by Aspergillus infection.
Miyake F, Yoshikawa T, Fujita A, et al
Pediatr Infect Dis J. 2006 Feb;25(2):186-7.
Abstract

Cerebellar aspergillosis in an infant: case report.
Mohindra S, Gupta R, Mohindra S, et al
Neurosurgery. 2006 Mar;58(3):E587;
Abstract

Improved survival in central nervous system aspergillosis: a series of immunocompromised
children with leukemia undergoing stereotactic resection of aspergillomas. Report of four
cases.
Middelhof CA, Loudon WG, Muhonen MD, et al
J Neurosurg. 2005 Oct;103(4 Suppl):374-8.
Abstract

Resolution of Orbitocerebral Aspergillosis During Combination Treatment With Voriconazole
and Amphotericin Plus Adjunctive Cytokine Therapy.
Bethell D, Hall G, Goodman TR, Klein N, Pollard AJ.
Pediatr Hematol Oncol. 2004 May;26(5):304-307
Abstract

Cerebral aspergillosis in an infant with corticosteroid-resistant nephrotic syndrome.
Roilides E, Pavlidou E, Papadopoulos F, et al
Pediatr Nephrol 2003 May;18(5):450-3
Abstract

Clinical and radiological findings in two cases of aspergillosis of the central nervous
system in children
Blazicevich Carrillo L, Cabrales Camacho LM
Rev Neurol 2003 Apr 1-15;36(7):632-5
Abstract

Neonatal primary cutaneous aspergillosis: case report and review of the literature.
Woodruff CA, Hebert AA.
Pediatr Dermatol 2002 Sep-Oct;19(5):439-44
Abstract

National Challenges

North America

United States

Journal Papers, Abstracts, and Commentaries

Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases.
Burgos A, Zaoutis TE, Dvorak CC, et al
Pediatrics. 2008 May;121(5):e1286-94
Abstract

Epidemiology, Outcomes, and Costs of Invasive Aspergillosis in Immunocompromised
Children in the United States, 2000.
Zaoutis TE, Heydon K, Chu JH, et al
Pediatrics. 2006 Mar 13;
Abstract

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Aspergillosis