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Zidovudine (Retrovir)
 
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Last Update:  March 12, 2008  
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General Reports
       

    Journal Papers, Abstracts, and Commentaries

 
Growth of Human Immunodeficiency Virus-Uninfected Children Exposed to Perinatal Zidovudine for
the Prevention of Mother-to-Child Human Immunodeficiency Virus Transmission.
Briand N, Le Coeur S, Traisathit P, et al;
 Pediatr Infect Dis J. 2006 Apr;25(4):325-332
 Abstract

Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and
Perinatally Exposed to Zidovudine.
 Tardieu M, Brunelle F, Raybaud C, et al 
AJNR Am J Neuroradiol. 2005 Apr;26(4):695-701.
Abstract

       Conference Reports, Abstracts, and Posters   

  Impact of prophylactic treatment of mother-to-child HIV transmission by zidovudine (AZT) on the
growth of HIV-uninfected children, in Thailand.
N Briand, S Le Coeur, G Jourdain, et al
 (15IAC)
 Abstract
 
Perinatal zidovudine (AZT) exposure in PACTG 076 and long-term effect on hematologic parameters
in HIV-exposed but uninfected children
D Shapiro, P Muresan, L M Mofenson, et al
 (15IAC)
 Abstract
Drug/Drug Interactions
 

       Journal Papers, Abstracts, and Commentaries

  FULL TEXT ARTICLE
Pharmacokinetic interaction between zidovudine and trimethoprim/sulphamethoxazole in HIV-1
infected children.
Dallas S, E Read S, King S, Koren G, Bendayan R
Can J Infect Dis. 2000 Sep;11(5):254-8.
Paper		  
Monotherapy
       

    Journal Papers, Abstracts, and Commentaries

 
Disease Progression Among HIV-Infected Children Who Receive Perinatal Zidovudine Prophylaxis.
Berk DR, Falkovitz-Halpern MS, et al  
J Acquir Immune Defic Syndr. 2006 Oct 30;
Abstract
 
Plasma levels of zidovudine twice daily compared with three times daily in six HIV-1-
infected children.
 Bergshoeff AS, Fraaij PL, Verweij C 
J Antimicrob Chemother. 2004 Nov 10
Abstract

Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral
therapy or idovudine monotherapy: a meta-analysis.
 Dunn D; HIV Paediatric Prognostic Markers Collaborative Study Group.
Lancet. 2003 Nov 15;362(9396):1605-1
 Abstract
   
  A multicenter trial of oral zidovudine in children with advanced human immunodeficiency
virus disease.
The Protocol 043 Study Group. McKinney RE, Maha MA, Connor EM, et al
New England Journal of Medicine 1991; 324(15): 1018-1025.
Abstract
   
  The pharmacokinetics of zidovudine administered by continuous infusion in children.
Balis FM, Pizzo PA, Murphy RF et al.
Annals of Internal Medicine 1989; 110(4): 279-285.
Abstract
   
  Effect of continuous intravenous infusion zidovudine (AZT) in children with symptomatic
HIV infection.
Pizzo PA, Eddy J, Falloon J et al.
New England Journal of Medicine 1988; 319:889-896.
Abstract
Combination Therapies
       

ZDV/DDI

    Journal Papers, Abstracts, and Commentaries

  Pharmacokinetics of Didanosine and Drug Resistance Mutations in Infants Exposed to
Zidovudine During Gestation or Postnatally and Treated With Didanosine or Zidovudine
in the First Three Months of Life.
 Kovacs A, Cowles MK, Britto P, et al
Pediatr Infect Dis J. 2005 Jun;24(6):503-509
 Abstract

       Conference Reports, Abstracts, and Posters   

 
Comparison of Pediatric Drug Dosing of Zidovudine and Didanosine from a Dose Chart
based on Weight to Dose Recommendations based on Body-Surface Area for Children in
Resource-limited Settings.
 Weidle P.J., Abrams E.J., Gvetadze R., et al
(3rd IAS)
Abstract

POTENTIAL OF CHLOROQUINE IN COMBINATION THERAPY WITH ZIDOVUDINE AND
DIDANOSINE IN HIV-1 INFECTED CHILDREN
C. Engchanil, P. Kosalaraksa, P. Lumbiganon, et al
 (2nd IAS)
 Abstract

ZDV/3TC/IND

    Journal Papers, Abstracts, and Commentaries

  Long-term virologic and immunologic responses in human  immunodeficiency virus type 1-infected
children treated with indinavir, zidovudine, and lamivudine.
Jankelevich S, Mueller BU, Mackall CL et al.
Journal of Infectious Disease 2001; 183(7): 1116-1120. 
Abstract
ZDV/3TC   

Pharmacokinetics/Safety

        Journal Papers, Abstracts, and Commentaries

 
A pilot study to evaluate the safety and feasibility of the administration of AZT/3TC f
ixed dose combination to HIV infected pregnant women and their infants in Rio de
Janeiro, Brazil.
Lambert JS, Nogueira SA, Abreu T, et al.
Sex Transm Infect. 2003 Dec;79(6):448-52.
 Abstract 

Pharmacokinetics of zidovudine and lamivudine in neonates following coadministration of
oral doses every 12 hours.
Moodley D, Pillay K, Naidoo K,  et al.
J Clin Pharmacol 2001 Jul;41(7):732-41
Abstract 

  

Efficacy

        Journal Papers, Abstracts, and Commentaries

 
A pilot study to evaluate the safety and feasibility of the administration of AZT/3TC
fixed dose combination to HIV infected pregnant women and their infants in Rio de
Janeiro, Brazil.
Lambert JS, Nogueira SA, Abreu T, et al.
Sex Transm Infect. 2003 Dec;79(6):448-52.
Abstract 

Short-course therapy with zidovudine plus lamivudine for prevention of mother-to-child
 transmission of human immunodeficiency virus type 1 in Thailand.
Chaisilwattana P, Chokephaibulkit K, Chalermchockcharoenkit A, et al.
Clin Infect Dis 2002 Dec 1;35(11):1405-13
 Abstract
ZDV/3TC/NFV

        Conference Reports, Abstracts, and Posters
  Experience with the Zidovudine (ZVD), Lamivudine (3TC) and Nelfinavir
(NFV) regime in HIV pediatric patients with no previous treatment
J Quian, A Galli, S Gutiérrez, A González
 (2nd IAS)
 Abstract
Therapeutic Strategies
 

       Journal Papers, Abstracts, and Commentaries

  Haematological changes after switching from stavudine to zidovudine in HIV-infected children
receiving highly active antiretroviral therapy.
Aurpibul L, Puthanakit T, Sirisanthana T, Sirisanthana V. 
HIV Med. 2008 Mar 10
Abstract		  

Zidovudine Pediatric Data