Medical Advocates

Tipranavir (
Aptivus)
Conference Citations

XVII International AIDS Conference
15th CROI
11th European AIDS Conference
4th IAS Conference

14th CROI
XVI International AIDS Conference
13th CROI

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Tipranavir Main Page New/Noteworthy Home Page      

Last Update:  September 14, 2008 
 
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XVII International AIDS Conference
 

 


5th IAS Conference on HIV Pathogenesis, Treatment
and Prevention

  • POSTER
    Pharmacokinetic Interaction between Tipranavir/Ritonavir and Rosuvastatin
    P Pham, L Lee, E Fuchs, P Barditch-Crovo
    PDF Poster     Abstract

11th European AIDS Conference
 

 
POSTER
Tipranavir displays similar in vitro antiviral activity against non-subtype B clinical
isolates of HIV-1 compared with isolates from subtype B
PR Bonneau, Y Lie, R Bethell 
PDF Poster

 
POSTER
Linear modeling to estimate the contribution of each drug component of the regimens
of highly treatment-experienced patients in RESIST
DB Hall, JD Baxter, J Schapiro, et al
PDF Poster
 
POSTER
Patients who responded to tipranavir/r (500/200 mg BID) plus new enfuvirtide (ENF)
at Week 16 of RESIST studies maintain superior virologic and immunologic outcomes
through Week 96
G Pierone Jr, B Clotet, D Jayaweera, et al
PDF Poster
 
POSTER
Genotypic tipranavir scores as predictors of response
J Schapiro, J Scherer, R Vinisko, et al  
PDF Poster
 

POSTER
Improving the prediction of virologic response to tipranavir: the development of a
tipranavir weighted score
J Scherer, CA Boucher, JD Baxter, et al 
PDF Poster
 

POSTER
Tipranavir/r (TPV/r) maintains long term virological suppression – Three year follow-up
of RESIST
C Hicks, P Cahn, D Ward, et al  
11th European AIDS Conference
PDF Poster

NEWS RELEASE
New three-year data confirms Aptivus (tipranavir) as effective and durable treatment
option for treatment-experienced patients
(also see PowerPoint Gemini presentation below)

Boehringer Ingelheim
October 25, 2007
 

  POWERPOINT PRESENTATION
The Gemini Study: Saquinavir/r (SQV/r) vs lopinavir/r (LPV/r) plus emtricitabine/tenofovir
(FTC/TDF) as initial therapy in HIV-1 infected patients
Walmsley S, Ruxrungtham K ,Slim J, et al
Oral/Slide Presentation

4th IAS Conference on HIV Pathogenesis, Treatment
and Prevention

  NEWS RELEASE
Aptivus (tipranavir) demonstrates potent and durable treatment response in HIV-positive women
Boehringer Ingelheim
July 24, 2007
News
 
  NEWS RELEASE
Boehringer Ingelheim announces first international head-to-head trial of Aptivus (tipranavir)
versus darunavir in treatment-experienced HIV-positive patients

Boehringer Ingelheim
July 24, 2007

News
 
  A WEEK-IN-REVIEW FEATURED REPORT
Effects of tipranavir/r (500/200 or 500/100 mg BID) in comparison with lopinavir/r
(400/100 mg BID) on changes in body composition and metabolic parameters in ARV-naïve
patients over 48 weeks

Carr A, Zajdenverg R, Workman C, et al
Abstract
 
 

Analysis of cleavage site evolution following virological rebound on a tipranavir-based regimen
Tremblay S, Bourgon L, Hall D, et al
Abstract

  Tipranavir/ritonavir (500/200 mg bid) demonstrated potent and durable virologic responses
and a favourable safety profile in HIV-1 positive women participating in RESIST
Walmsley S, Squires K, Kraft M, et al
Abstract
 
  Usefulness of the genotypic inhibitory quotient in HIV patients treated with tipranavir
Morello J , García-Gascó P, Rodríguez-Novoa S , et al
Abstract
 
  Co-administering tipranavir/r (500/200 mg BID) and enfuvirtide (ENF) in the RESIST studies
resulted in superior virological outcomes and a comparable safety profile compared to regimens
containing tipranavir/r without enfuvirtide

Raffi F, Battegay M, Rusconi S, et al
Abstract

14th Conference on Retroviruses and
Opportunistic Infections

  Predicted Risk of Coronary Heart Disease with Tipranavir Exposure Compared to Conventional PI in
the RESIST Trial

N Friis-Møller, M Kraft, H Valdez, et al
Abstract
 
  POSTER
Predictors of Response to TPV/r in Pediatric Patients: Results of PACTG1051/BI1182.14
JC Salazar, P Cahn, M Della Negra, et al
PDF Poster     Abstract

 
  Mutations Associated with Response to Boosted Tipranavir in HIV-1-infected PI-experienced Patients
AG Marcelin, B Masquelier, D Descamps, et al
Abstract
 
  POSTER
Effects of Tipranavir/Ritonavir on the Activity of Hepatic and Intestinal Cytochrome P450 3A4/5
and P-glycoprotein: Implications for Drug Interactions

M Vourvahis, J Dumond, K Patterson, et al
PDF Poster
     Abstract
 
  POSTER
Phenotypic Susceptibility in vitro to Amprenavir, Atazanavir, Darunavir, Lopinavir, and Tipranavir of
HIV-2 Clinical Isolates from the French ANRS HIV-2 Cohort

t> D Desbois, G Peytavin, S Matheron, et al
PDF Poster
     Abstract

XVI International AIDS Conference
 

 
Efficacy and safety results of 48 weeks of treatment with APTIVUS oral solution co-administered
with low dose ritonavir (APTIVUS/r) in children and teenagers (phase I/IIa study)

J. Salazar, P. Cahn, M. Della Negra, et al
Abstract
 
  The non-peptidic HIV inhibitor tipranavir modulates pneumocystis in vitro growth
Mazza F., Tronconi E., Valerio A., et al
Abstract

Impact of prior PI usage on week 48 responses to tipranavir boosted with ritonavir (TPV/r)
Pollard R.B., Staszewski S., LeBlanc R., et al 
Abstract
 
  Tipranavir/ritonavir is more effective against protease inhibitor (PI)-resistant strains than
other ritonavir-boosted PI in heavily antiretroviral-experienced HIV-infected patients
de Mendoza C., Ribera E., Barreiro P., et al 
Abstract

 
  Success of rescue therapy with TMC114 in HIV-infected patients who failed multiple
ritonavir-boosted protease inhibitor-based regimens

E. Poveda, F. Blanco, P. García-Gasco, A
Abstract

13th Conference on Retroviruses and
Opportunistic Infections

POSTER
Unexpected Drug-Drug Interaction between Tipranavir/Ritonavir and Enfuvirtide
D Gonzalez De Requena, A Calcagno, S Bonora, et al

PDF Poster
     Abstract 
 

  POSTER
Viologic Response to Tipranavir Based on Plasma Concentration and Baseline Resistance
Parameters

L Naeger, J Zheng, K Struble, et al

PDF Poster     Abstract
 
  POSTER
Significant Decrease in TMC125 Exposures when Co-administered with Tipranavir Boosted
with Ritonavir in Healthy Subjects

M Schöller, M Kraf, R Hoetelman, et al
PDF Poster     Abstract
 
  POSTER
Effect of Lopinavir and Ritonavir Dose Adjustments on the Pharmacokinetic Interaction between
LPV/RTV and Tipranavir

M Harris, S Ramirez, R Joy, et al

PDF Poster     Abstract
 
  Therapeutic Drug Monitoring of Boosted Tipranavir with and without Combination to Lopinavir
or Fosamprenavir

 Peytavin, A Marcelin, A Rouault,  et al
Abstract