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Tenofovir 300mg/Emtricitabine 200mg (Truvada)
 
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HIV Indications
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Last Update:  December 30, 2011
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HIV Indications
     

 
Penetration of Tenofovir and Emtricitabine in Mucosal Tissues: Implications for Prevention of HIV-1 Transmission.
Patterson KB, Prince HA, Kraft E, et al
Sci Transl Med. 2011 Dec 7;3(112):112re4
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
FULL-TEXT ARTICLE

Predictors of Limb Fat Gain in HIV Positive Patients Following a Change to Tenofovir-Emtricitabine or
Abacavir-Lamivudine.
Martin A, Amin J, Emery S,  et al
PLoS One. 2011;6(10):e26885
Paper

A randomized, pilot trial to evaluate glomerular filtration rate by creatinine or cystatin C in naïve
HIV-infected patients after tenofovir/emtricitabine in combination with atazanavir/ritonavir or efavirenz.
Albini L, Cesana BM, Motta D, et al
J Acquir Immune Defic Syndr
. 2011 Oct 11
Abstract

Once-daily antiretroviral therapy among treatment-experienced Muslim patients fasting for the month of Ramadan.
Yakasai AM, Muhammad H, Babashani M, et al
Trop Doct
. 2011 Sep 13
Abstract

Abacavir/Lamivudine Versus Tenofovir DF/Emtricitabine as Part of Combination Regimens for Initial Treatment of HIV: Final Results.
Sax PE, Tierney C, Collier AC,  et al
J Infect Dis
. 2011 Oct;204(8):1191-1201.

Abstract

Comparison of Abacavir/Lamivudine and Tenofovir/Emtricitabine Among Treatment-Naive
HIV-Infected Patients Initiating Therapy.

Tan DH, Chan K, Raboud J,  et al
J Acquir Immune Defic Syndr
. 2011 Sep 1;58(1):38-46.
Abstract

Randomized comparison of renal effects, efficacy, and safety with once-daily abacavir/lamivudine versus
tenofovir/emtricitabine, administered with efavirenz, in antiretroviral-naive, HIV-1-infected adults: 48-week
results from the ASSERT study.
Post FA, Moyle GJ, Stellbrink HJ, et al
J Acquir Immune Defic Syndr. 2010 Sep;55(1):49-57.
Abstract

Prevalence of low-level HIV-1 variants with reverse transcriptase mutation K65R and the effect of antiretroviral
drug exposure on variant levels.
Kozal MJ, Chiarella J, St John EP,  et al
Antivir Ther
. 2011;16(6):925-9.

Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Comparison of abacavir/lamivudine and tenofovir/emtricitabine among treatment-naïve
HIV-infected patients initiating therapy.
Tan DH, Chan K, Raboud J, Cooper C, et al
J Acquir Immune Defic Syndr
. 2011 Jun 24.
Abstract

Peripheral and Central Fat Changes in Subjects Randomized to Abacavir-Lamivudine or Tenofovir-Emtricitabine
With Atazanavir-Ritonavir or Efavirenz: ACTG Study A5224s.
McComsey GA, Kitch D, Sax PE, et al
Clin Infect Dis
. 2011 Jul;53(2):185-96.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Protection against Rectal Transmission of an Emtricitabine (FTC)-Resistant SHIV162p3M184V
Mutant by Intermittent Prophylaxis with Truvada.
Cong ME, Youngpairoj AS, Zheng Q,  et al
J Virol
. 2011 Jun 1.
Abstract

Bone Mineral Density and Fractures in Antiretroviral-Naive Persons Randomized to Receive
Abacavir-Lamivudine or Tenofovir Disoproxil Fumarate-Emtricitabine Along With Efavirenz or
Atazanavir-Ritonavir: AIDS Clinical Trials Group A5224s, a Substudy of ACTG A5202.
McComsey GA, Kitch D, Daar ES,  et al
J Infect Dis
. 2011 Jun;203(12):1791-801.
Abstract

Beliefs about antiretroviral therapy, treatment adherence and quality of life in a 48-week randomised
study of continuation of zidovudine/lamivudine or switch to tenofovir DF/emtricitabine, each with efavirenz.
Cooper V, Moyle GJ, Fisher M,  et al
AIDS Care. 2011 Apr 5:1-9.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection.
Anderson PL, Kiser JJ, Gardner EM, et al
J Antimicrob Chemother
. 2010 Nov 30.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Concomitant Administration of BILR 355/r with Emtricitabine/Tenofovir Disoproxil Fumarate
Increases Exposure to Emtricitabine and Tenofovir: A Randomized, Open-Label, Prospective Study.
Huang F, Scholl P, Huang DB,  et al
Basic Clin Pharmacol Toxicol
. 2010 Oct 27.
Abstract

Tolerability of HIV postexposure prophylaxis with tenofovir/emtricitabine and
lopinavir/ritonavir tablet formulation.
Tosini W, Muller P, Prazuck T,  et al 
AIDS
. 2010 Aug 19
Abstract

Pharmacokinetics and Bioavailability of an Integrase and Novel Pharmacoenhancer-
Containing Single-Tablet Fixed-Dose Combination Regimen for the Treatment of HIV.
German P, Warren D, West S, Hui J, Kearney BP.
J Acquir Immune Defic Syndr
. 2010 Jul 30.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Randomized Comparison of Renal Effects, Efficacy, and Safety With Once-Daily
Abacavir/Lamivudine Versus Tenofovir/Emtricitabine, Administered With Efavirenz,
in Antiretroviral-Naive, HIV-1-Infected Adults: 48-Week Results From the ASSERT
Study.
Post FA, Moyle GJ, Stellbrink HJ,  et al  
J Acquir Immune Defic Syndr
. 2010 Apr 24
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Impact of Low Abundance HIV Variants on Response to Ritonavir-Boosted
Atazanavir or Fosamprenavir Given Once Daily with Tenofovir/Emtricitabine
in Antiretroviral-Naive HIV-Infected Patients.
Ross LL, Weinberg WG, Dejesus E, et al  
AIDS Res Hum Retroviruses
. 2010 Apr 9
Abstract

Does choice of combination antiretroviral therapy (cART) alter changes in
cerebral function testing after 48 weeks in treatment-naive, HIV-1-infected
individuals commencing cART? A randomized, controlled study.
Winston A, Duncombe C, Li PC,  et al
Clin Infect Dis
. 2010 Mar 15;50(6):920-9.
Abstract

Safety and efficacy of tenofovir/emtricitabine plus nevirapine in HIV-infected patients.
Labarga P, Medrano J, Seclen E, et al
AIDS
. 2010 Feb 15.
Abstract

Emerging mutations at virological failure of HAART combinations containing
tenofovir and lamivudine or emtricitabine.
Maserati R, De Silvestri A, Uglietti A,  et al

AIDS
. 2010 Jan 30.
Abstract

A WEEK-IN REVIEW FESTERED REPORT
Switching the nucleoside reverse transcriptase inhibitor backbone to
reverse transcriptase inhibitor backbone to tenofovir disoproxil fumarate +
emtricitabine promptly improves triglycerides and low-density lipoprotein
cholesterol in dyslipidaemic patients.
Valantin MA, Bittar R, de Truchis P, et al
J Antimicrob Chemother
. 2010 Jan 6
Abstract
 

Simplification of Antiretroviral Therapy with Tenofovir-Emtricitabine or Abacavir-Lamivudine:
A Randomized, 96-Week Trial.
Martin A, Bloch M, Amin J, et al
 
Clin Infect Dis
. 2009 Nov 15;49(10):1591-1601
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Viral Load Decay in Antiretroviral-Naïve Patients Receiving Once-Daily Tenofovir and Emtricitabine
plus Twice-Daily Nevirapine.
Amoroso A, Gilliam BL, Talwani R,
et al
HIV Clin Trials
. 2009 Sep-Oct;10(5):320-3.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Lower limb high arterial flow induced by tenofovir and emtricitabine treatment.
Periard D, Yerly P, Hayoz D, et al 
Antivir Ther. 2009;14(6):865-7.
Abstract

Tenofovir-Emtricitabine-Efavirenz in HIV-1-Infected Adults in Senegal: A 96-Week Pilot Trial in
Treatment-Naive Patients.
Landman R, Poupard M, Diallo M, et al
 
J Int Assoc Physicians AIDS Care
 
2009 Sep 15.
Abstract

Complete Protection from Repeated Vaginal SHIV Exposures in Macaques by a
Topical Gel Containing Tenofovir Alone or with Emtricitabine.
Parikh UM, Dobard C, Sharma S, et al 

J Virol
. 2009 Aug 5.
Abstract

A WEEK-IN-REVIEW-FEATURED REPORT
Development of HIV-1 Drug Resistance Through 144 Weeks in Antiretroviral-
Naïve Subjects on Emtricitabine, Tenofovir Disoproxil Fumarate, and Efavirenz
Compared With Lamivudine/Zidovudine and Efavirenz in Study GS-01-934.
Margot NA, Enejosa J, Cheng AK, et al

J Acquir Immune Defic Syndr
. 2009 Jul 29
Abstract

A Randomized Comparative Trial of Continued Zidovudine/Lamivudine or Replacement
With Tenofovir Disoproxil Fumarate/Emtricitabine in Efavirenz-Treated HIV-1-Infected
Individuals.
Fisher M, Moyle GJ, Shahmanesh M, et al

J Acquir Immune Defic Syndr
. 2009 Jun 25
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or
tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment.
Smith KY, Patel P, Fine D, et al

AIDS
. 2009 Jun 17.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Switch from a ZDV/3TC-based Regimen to a Completely Once Daily (QD) Regimen of
Emtricitabine/Tenofovir DF Fixed Dose Combination plus a Third QD Agent (sonett).
Arasteh K, Weitner L, Fenske S, et al
Eur J Med Res. 2009 May 14;14(5):195-9.
Abstract

A WEEK IN REVIEW FEATURED REPORT
Emtricitabine/Tenofovir Disoproxil Fumarate: In Combination with a Protease Inhibitor in HIV-1 Infection.
Perry CM.

Drugs
. 2009;69(7):843-57.
Abstract

A Simplification Trial Switching From Nucleoside Reverse Transcriptase Inhibitors to Once-Daily
Fixed-Dose Abacavir/Lamivudine or Tenofovir/Emtricitabine in HIV-1-Infected Patients With Virological
Suppression.
Martínez E, Arranz JA, Podzamczer D, et al

 J Acquir Immune Defic Syndr
. 2009 Apr 24.
Abstract

Combination of Tenofovir and Emtricitabine plus Efavirenz: In Vitro Modulation of ABC transporter and
Intracellular Drug Accumulation.
Bousquet L, Pruvost A, Guyot AC, et al

Antimicrob Agents Chemother
. 2008 Dec 15
Abstract

Pharmacokinetics of emtricitabine/tenofovir disoproxil fumarate and tacrolimus at steady state
when administered alone or in combination.
Chittick GE, Zong J, Begley JA,. et al 
 Int J Clin Pharmacol Ther. 2008 Dec;46(12):627-36
Abstract
 

Two novel fixed formulations of nucleoside analogues (tenofovir-emtricitabine, and
abacavir-lamivudine). Prospective, open study on clinical practice and therapeutic
perspectives, in patients naïve and in subjects pre-treated with antiretrovirals
Manfredi R, Calza L.
Recenti Prog Med. 2008 Oct;99(10):492-501
Abstract
 
A WEEK IN REVIEW FEATURED REPORT
Effectiveness and safety of simplification from tenofovir-lamivudine (TDF-3TC) to tenofovir-emtricitabine (TDF-FTC)
co-formulation (Truvada) in virologically suppressed HIV-infected patients on HAART.

Palacios R, Hidalgo C, Ríos MJ, et al

Eur J Clin Microbiol Infect Dis.
2008 Oct 8.
Abstract
 
Drug-Susceptible HIV-1 Infection Despite Intermittent Fixed-Dose Combination Tenofovir/Emtricitabine as Prophylaxis Is
Associated With Low-Level Viremia, Delayed Seroconversion, and an Attenuated Clinical Course.

Prada N, Davis B, Jean-Pierre P, Roche ML, et al
 
J Acquir Immune Defic Syndr.
2008 Sep 2.
Abstract
 
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination
of tenofovir and emtricitabine in human plasma and its application to a bioequivalence study.
Gomes NA, Vaidya VV, Pudage A, et al
J Pharm Biomed Anal. 2008 Aug
Abstract
 
A WEEK IN REVIEW FEATURED REPORT
Impact of Switching Virologically Suppressed, HIV-1-Infected Patients from Twice-Daily Fixed-Dose
Zidovudine/Lamivudine to Once-Daily Fixed-Dose Tenofovir Disoproxil Fumarate/Emtricitabine.
Wright D, Rodriguez A, Godofsky E,et al

HIV Clin Trials
. 2008 Mar-Apr;9(2):103-14.
Abstract
 
Cost-effectiveness analysis of emtricitabine/tenofovir versus lamivudine/zidovudine, in
combination with efavirenz, in antiretroviral-naive, HIV-1-infected patients.

Sánchez-de la Rosa R, Herrera L, Moreno S.
Clin Ther. 2008 Feb;30(2):372-81.
Abstract
 
Recent Availability of Two Novel, Fixed Formulations of Antiretroviral Nucleoside Analogues:
A 12-Month Prospective, Open-Label Survey of Their Practical Use and Therapeutic Perspectives
in Antiretroviral-Naive and -Experienced Patients.
Manfredi R, Calza L.

AIDS Patient Care
STDS. 2008 Feb 21
Abstract
 
FULL TEXT ARTICLE
Review of tenofovir-emtricitabine.
Masho SW, Wang CL, Nixon DE.
Ther Clin Risk Manag. 2007 Dec;3(6):1097-104.
Paper
 
Tenofovir DF Plus Lamivudine or Emtricitabine for Nonoccupational Postexposure
Prophylaxis (NPEP) in a Boston Community Health Center.
Mayer KH, Mimiaga MJ, Cohen D,et al
J Acquir Immune Defic Syndr. 2007 Dec 20
Abstract
 
Tenofovir Disoproxil Fumarate, Emtricitabine, and Efavirenz Compared With Zidovudine/Lamivudine
and Efavirenz in Treatment-Naive Patients: 144-Week Analysis.

Arribas JR, Pozniak AL, Gallant JE
J Acquir Immune Defic Syn
dr. 2007 Oct 25;
Abstract
 
Characterization of a novel drug-resistance pattern associated with the mutations K70G and
M184V in HIV-1 reverse transcriptase.
Bradshaw D, Malik S, Booth C, et al

Antimicrob Agents Chemother
. 2007 Sep 17;
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Bone disease and pathologic fractures in a patient with tenofovir-induced Fanconi syndrome.
Brim NM, Cu-Uvin S, Hu SL, O'Bell JW.

AIDS Read.
2007 Jun;17(6):322-8, C3.
Abstract
 
Tenofovir disoproxil fumarate-emtricitabine coformulation for once-daily dual NRTI backbone.
Munoz de Benito RM, Arribas Lopez JR.
Expert Rev Anti Infect Ther. 2006 Aug;4(4):523-535.
Abstract
 
In Vitro HIV-1 Resistance Selections with Combinations of Tenofovir and Emtricitabine or Abacavir
and Lamivudine.
Margot NA, Waters JM, Miller MD.  
Antimicrob Agents Chemother.
2006 Sep 18;
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Use of tenofovir disoproxil fumarate and emtricitabine combination in HIV-infected patients.
Gazzard BG.
Expert Opin Pharmacother. 2006 Apr;7(6):793-802
Abstract
 
Two-once-daily fixed-dose NRTI combinations for HIV.
[
No authors listed]  
Med Lett Drugs Ther
. 2005 Feb 28;47(1203):19-20
Abstract
 
Emtricitabine/tenofovir disoproxil fumarate.
Dando TM, Wagstaff AJ.
Drugs. 2004;64(18):2075-82;
Abstract

HBV Indications
     

 
Tenofovir is effective as monotherapy or in combination with emtricitabine in adefovir
treated patients with chronic hepatitis B infection.
Berg T, Marcellin P, Zoulim F, et al  
Gastroenterology
. 2010 Jun 20
Abstract

Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to
respond to an adefovir-containing regimen.
Santos SA, Uriel AJ, Park JS, et al
 
Eur J Gastroenterol Hepatol.
2006 Dec;18(12):1247-53.
Abstract

HIV/HBV Coinfection
     

 
Virologic Outcome of Using Tenofovir/Emtricitabine to Treat Hepatitis B in HIV-Coinfected Patients.
Engell CA, Pham VP, Holzman RS, Aberg JA.I
SRN Gastroenterol
. 2011;2011:405390.
Abstract

Managing hepatitis B/HIV co-infected: adding entecavir to truvada (tenofovir/emtricitabine)
experienced patients.
Ratcliffe L, Beadsworth MB, Pennell A,  et al
AIDS
. 2011 Feb 22.
Abstract

Efficacy of tenofovir disoproxil fumarate/emtricitabine compared with emtricitabine alone
in antiretroviral-naive HIV-HBV coinfection in Thailand.
Avihingsanon A, Lewin SR, Kerr S,  et al
Antivir Ther
. 2010;15(6):917-22.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with
HIV/hepatitis B virus co-infection.

Nüesch R, Ananworanich J, Srasuebkul P, et al 
AIDS. 2008 Jan 2;22(1):152-4.

Abstract


Diagnostics/Monitoring
     

 
Selective Determination of Antiretroviral Agents Tenofovir, Emtricitabine, and Lamivudine in Human Plasma
by a LC-MS-MS Method for a Bioequivalence Study in Healthy Indian Subjects.
Yadav M, Singhal P, Goswami S, Pande UC, Sanyal M, Shrivastav PS.
J Chromatogr Sci
. 2010;48(9):704-13.
Abstract

The simultaneous assay of tenofovir and emtricitabine in plasma using LC/MS/MS and isotopically
labeled internal standards.
Delahunty T, Bushman L, Robbins B, Fletcher CV .

J Chromatogr B Analyt Technol Biomed Life Sci
. 2009 May 21

Abstract

 


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Journal Citations