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Tenofovir Disoproxil Fumarate
(Viread)
   
Pediatric Data

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Last Update:  December 19, 2008
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New and Noteworthy
     

November 2008
 

Journal Papers, Abstracts, and Commentaries
       

Efficacy
 

 
Tenofovir Disoproxil Fumarate and an Optimized Background Regimen of Antiretroviral
Agents as Salvage Therapy: Impact on Bone Mineral Density in HIV-Infected Children.
Gafni RI, Hazra R, Reynolds JC, Maldarelli F, et al
 
Pediatrics
. 2006 Aug 21;
Abstract
 
Tenofovir Disoproxil Fumarate and an Optimized Background Regimen of Antiretroviral Agents
as Salvage Therapy for Pediatric HIV Infection.
Hazra R, Gafni RI, Maldarelli F, et al
Pediatrics. 2005 Nov 15
Abstract

Single-dose and steady-state pharmacokinetics of tenofovir disoproxil fumarate in human
immunodeficiency virus-infected children.
Hazra R, Balis FM, Tullio AN, et al.
Antimicrob Agents Chemother. 2004 Jan;48(1):124-9.
Abstract
 

Adverse Events
 
 
Decreased bone mineral density with off-label use of tenofovir in children and adolescents
infected with human immunodeficiency virus.

Purdy JB, Gafni RI, Reynolds JC
J Pediatr. 2008 Apr;152(4):582-4.
Abstract
 
Increased beta-2 Microglobulinuria in HIV-1-Infected Children and Adolescents Treated with
Tenofovir

Papaleo A, Warszawski J, Salomon R, et al 
Pediatr Infect Dis J.
2007 Oct;26(10):949-951
.
Abstract
 
Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir.
Hussain S, Khayat A, Tolaymat A, Rathore MH.  

Pediatr Nephrol.
2006 May 16;
Abstract

A 12-Month Treatment With Tenofovir Does Not Impair Bone Mineral Accrual in HIV-Infected
Children.
Giacomet V, Mora S, Martelli L, et al

J Acquir Immune Defic Syndr.
2005 Dec 1;40(4):448-450.
Abstract


Conference Reports, Abstracts, and Posters
       

 
Tenofovir toxicity in children: two clinical cases
Bengleil AS, Kambraki M, Al Fituri, et al 
(Ninth International Congress on Drug Therapy in HIV Infection)
Abstract

 
Impact on bone mineral density of tenofovir-containing HAART in HIV-1 infected children and adolescents:
a report from 5 years of clinical experience

Rosso R, Di Biagio A, Parodi A, et al
(Ninth International Congress on Drug Therapy in HIV Infection)
Abstract
 
Renal safety of tenofovir in antiretroviral-experienced children: issue related to predicting GFR by
different equations

Martelli L., Giacomet V., Borgonovo S., et al
(XVI  International AIDS Conference )
Abstract

 
Experience with tenofovir disoproxil fumarate (TDF) in heavily pretreated HIV-infected children
J T Ramos, M I Gonzalez Tome, P Rojo, et al
(15IAC)
Abstract
 
POSTER
Pharmacokinetics of Tenofovir DF Oral Suspension in HIV-1-infected Children between
2 and 8 Years of Age
BP Kearney, J Abadi, M Rosenberg. et al
 
(11 CROI)
PDF Poster       Abstract

Safety, Tolerability, and Clinical Responses to Tenofovir DF in Combination with other
Antiretrovirals in Heavily Treatment-experienced HIV-infected Children: Data through 48 Weeks
R Hazra, R Gafni, F Maldarelli,
et al
(11 CROI)
Abstract


FDA Updates
       

  NEWS RELEASE
FDA Approves New Pediatric Dosing Recommendations for a New 75 mg Prezista Tablet

US FDA
December 18. 2008
News

 


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