Medical Advocates
Tenofovir Disoproxil Fumarate (Viread)
   
Journal Citations: Adverse Events

Cellular Disorders
Blood Disorders
Cutaneous Disorders
Metabolic Disorders
 Mitochondrial Toxicity
Musculoskeletal Disorders
Pancreatic Disorders
Renal Disorders

 
Tenofovir Main Page Main New/Newsworthy Home Page      
Last Update:  December 30, 2008
 Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader
Cellular Disorders
 
 

Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other
nucleoside reverse transcriptase inhibitors.
Cihlar T, Birkus G, Greenwalt DE, Hitchcock MJ.  et al. 
 Antiviral Res 2002 Apr;54(1):37-45
 Abstract
 
FULL-TEXT ARTICLE
 Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir:
Comparison with Other Nucleoside Reverse Transcriptase Inhibitors.
Birkus G, Hitchcock MJ, Cihlar T. et al.
Antimicrob Agents Chemother 2002 Mar;46(3):716-723
Paper

Blood Disorders
 
 
Minor changes in calculated creatinine clearance and anion-gap are associated with
tenofovir disoproxil fumarate-containing highly active antiretroviral therapy.
 Winston A, Amin J, Mallon P, Marriott D, et al
HIV Med. 2006 Mar;7(2):105-111.
 Abstract
 
Evaluation of hypophosphataemia in tenofovir disoproxil fumarate (TDF)-exposed and TDF-unexposed
HIV-infected out-patients receiving highly active antiretroviral therapy.
Buchacz K, Brooks JT, Tong T, et al 
HIV Med. 2006 Oct;7(7):451-6.
Abstract

Hypokalemia in HIV patients on tenofovir.
Cirino CM, Kan VL  Kan V
AIDS. 2006 Aug 1;20(12):1671-
 Abstract
Cutaneous Disorders
 
  Cutaneous reactions with tenofovir disoproxil fumarate: a report of nine cases.
Lockhart SM, Rathbun RC, Stephens JR, et al
AIDS. 2007 Jun;21(10):1370-3.
 Abstract
Metabolic Disorders
 
  Metabolic and Anthropometric Changes One Year after Switching from Didanosine/Stavudine
to Tenofovir in HIV-infected Patients.
Claas GJ, Julg B, Goebel FD, Bogner JR.
Eur J Med Res. 2007 Feb 26;12(2):54-60.
 Abstract
Mitochondrial Toxicity
       
  Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with
additional nucleoside reverse transcriptase inhibitors.
Venhoff N, Setzer B, Melkaoui K, Walker UA.
 Antivir Ther. 2007;12(7):1075-85.
 Abstract
Musculoskeletal Disorders
 
 

A WEEK-IN-REVIEW FEATURED REPORT
 The development of hypophosphataemic osteomalacia with myopathy in two patients with
HIV infection receiving tenofovir therapy.
Parsonage MJ, Wilkins E, Snowden N, et al
HIV Med. 2005 Sep;6(5):341-6.
Abstract
Pancreatic Disorders
 
 
Acute Onset of Pancreatitis with Concomitant Use of Tenofovir and Didanosine.A
Kirian MA, Higginson RT, Fulco PP.
 Ann Pharmacother. 2004 Aug 31
 Abstract
 
Pancreatitis treated with didanosine and tenofovir disoproxil fumarate.
Blanchard JN, Wohlfeiler M, Canas A, et al 
Clin Infect Dis. 2003 Sep 1;37(5):e57-62.
 Abstract
Renal Disorders
 
 
Glomerular filtration rates in HIV-infected patients treated with and without tenofovir:
a prospective, observational study.
Guaraldi G, Roverato A, Giovanardi C, et al
 J Antimicrob Chemother. 2008 Dec 17.
Abstract
 
A WEEK IN REVIEW FEATURED REPORT
A case of acute renal failure involving high amounts of tenofovir after HAART start
Yoshimoto E, Konishi M, Uno K, et al 
Kansenshogaku Zasshi. 2008 Nov;82(6):650-3.
 Abstract
 
Renal Dysfunction and Tenofovir Toxicity in HIV-infected Patients.
Szczech LA
Top HIV Med. 2008 Oct-Nov;16(4):122-6.
 Abstract
 
Rosiglitazone reverses tenofovir-induced nephrotoxicity.
Libório AB, Andrade L, Pereira LV, et al
Kidney Int. 2008 Jun 18
 Abstract
 
FULL-TEXT PDF ARTICLE
 Acute renal failure in an AIDS patient on tenofovir: a case report.
 Kapitsinou PP, Ansari N 
J Med Case Reports. 2008 Mar 31;2(1):94
Paper
 
Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system.
Gupta SK. 
AIDS Patient Care STDS. 2008 Feb;22(2):99-103.
Abstract
 
Tenofovir use is associated with a reduction in calculated glomerular filtration rates in the
Swiss HIV Cohort Study.
Fux CA, Simcock M, Wolbers M, et al 
Antivir Ther. 2007;12(8):1165-73.
 Abstract
 
Greater Tenofovir-Associated Renal Function Decline with Protease Inhibitor-Based versus
Nonnucleoside Reverse-Transcriptase Inhibitor-Based Therapy.
Goicoechea M, Liu S, Best B, et al 
J Infect Dis. 2008 Jan 1;197(1):102-108.
 Abstract
 
Acute renal failure after initiation of tenofovir disoproxil fumarate.
Hynes P, Urbina A, McMeeking A, et al 
Ren Fail. 2007;29(8):1063-6.
 Abstract
 
Early onset of tenofovir-induced renal failure: case report and review of the literature.
Patel SM, Zembower TR, Palella F, et al
ScientificWorldJournal. 2007 Jul 27;7:1140-8
 Abstract
 
Bone disease and pathologic fractures in a patient with tenofovir-induced Fanconi syndrome.
Brim NM, Cu-Uvin S, Hu SL, O'Bell JW.
AIDS Read. 2007 Jun;17(6):322-8, C3.
 Abstract
 
Tenofovir renal safety in HIV-infected patients: Results from the SCOLTA Project.
Madeddu G, Bonfanti P, De Socio GV, et al
Biomed Pharmacother. 2007 May 29;
 Abstract
 
Renal Function in Tenofovir-Exposed and Tenofovir-Unexposed Patients Receiving Highly Active
Antiretroviral Therapy in the HIV Outpatient Study.
Young B, Buchacz K, Baker RK, et al
J Int Assoc Physicians AIDS Care 2007 Jun 19
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy
in a retrospective analysis of kidney biopsies.
Schmid S, Opravil M, Moddel M, et al
Virchows Arch. 2007 Apr 27;
 Abstract
 
Tenofovir-induced kidney injury.
Gitman MD, Hirschwerk D, Baskin CH, Singhal PC.
Expert Opin Drug Saf. 2007 Mar;6(2):155-164.
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Association between ABCC2 Gene Haplotypes and Tenofovir-Induced Proximal Tubulopathy.
Izzedine H, Hulot JS, Villard E, et al
J Infect Dis. 2006 Dec 1;194(11):1481-91.
Abstract

Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions.
Zimmermann AE, Pizzoferrato T, Bedford J, et al
 Clin Infect Dis. 2006 Jan 15;42(2):283-90.
 Abstract

Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions.
 Zimmermann AE, Pizzoferrato T, Bedford J, et al  
 Clin Infect Dis. 2006 Jan 15;42(2):283-90.
 Abstract
 
Is tenofovir involved in hypophosphatemia and decrease of tubular phosphate reabsorption in
HIV-positive adults?
Badiou S, Merle De Boever C, Terrier N, et al 
J Infect. 2005 Sep 19;
 Abstract
 
Low frequency of renal function impairment during one-year of therapy with tenofovir-containing
regimens in the real-world: a case-control study.
Padilla S, Gutierrez F, Masia M, Canovas VC, Orozco C. 
AIDS Patient Care STDS. 2005 Jul;19(7):421-4.
 Abstract
 
 
Fanconi syndrome associated with use of tenofovir in HIV-infected patients: a case report
and review of the literature.
Quimby D, Brito MO. 
AIDS Read. 2005 Jul;15(7):357-64.
 Abstract
 
Acute renal failure and Fanconi syndrome in an AIDS patient on tenofovir treatment-case
report and review of literature.
Malik A, Abraham P, Malik N.
J Infect. 2005 Aug;51(2):E61-5.
Abstract
 
Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort study.
Antoniou T, Raboud J, Chirhin S, et al 
HIV Med. 2005 Jul;6(4):284-90
 Abstract
 
Risk factors for CD4 lymphopenia in patients treated with a tenofovir/didanosine high dose-
containing highly active antiretroviral therapy regimen.
 Lacombe K, Pacanowski J, Meynard JL 
AIDS. 2005 Jul 1;19(10):1107-1108.
 Abstract
 
Antiretroviral therapy with tenofovir is associated with mild renal dysfunction.
Mauss S; Berger F, et al  
AIDS. 19(1):93-95, January 3, 2005.
 Abstract
 
Renal Dysfunction With Tenofovir Disoproxil Fumarate-Containing Highly Active Antiretroviral
Therapy Regimens Is Not Observed More Frequently: A Cohort and Case-Control Study.
Jones R, Stebbing J, Nelson M, et al 
J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1489-1495.
Abstract
 
Fatal lactic acidosis associated with coadministration of didanosine and tenofovir disoproxil
fumarate.
Guo Y, Fung HB.  
Pharmacotherapy. 2004 Aug;24(8):1089-9
 Abstract
 
Nephrolithiasis and hydronephrosis in an HIV-infected man receiving tenofovir.
Cicconi P, Bongiovanni M, Melzi S, et al 
Int J Antimicrob Agents. 2004 Sep;24(3):284-5.
Abstract
 
Pancreatic toxic effects associated with co-administration of didanosine and tenofovir
in HIV-infected adults.
 Martinez E, Milinkovic A, De Lazzari E, et al 
Lancet. 2004 Jul 3;364(9428):65-67.
 Abstract
 
Renal Tubular Dysfunction Associated With Tenofovir Therapy: Report of 7 Cases.
Peyriere H, Reynes J, Rouanet I, et al 
J Acquir Immune Defic Syndr. 2004 Apr 12;35(3):293-300.
 Abstract
 
Tenofovir-related nephrotoxicity: case report and review of the literature.
James CW, Steinhaus MC, Szabo S, Dressier RM.  
Pharmacotherapy. 2004 Mar;24(3):415-8.
Abstract
 
Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three
cases of renal failure, fanconi syndrome, and nephrogenic diabetes insipidus.
Karras A, Lafaurie M, Furco A,  et al.
Clin Infect Dis 2003 Apr 15;36(8):1070-3
 Abstract
 
Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral
 regimen containing Didanosine.
Murphy MD, O'Hearn M, Chou , et al.
Clin Infect Dis 2003 Apr 15;36(8):1082-5
 Abstract
 
Fanconi syndrome and renal failure induced by tenofovir: a first case report.
Verhelst D, Monge M, Meynard JL, et al. 
Am J Kidney Dis 2002 Dec;40(6):1331-3
 Abstract
 

Tenofovir Main Page Main New/Newsworthy Home Page      

Tenofovir Journal Citations
Adverse Events