Medical Advocates

Pegylated Interferon Alfa-2a
(Pegasys)
  HIV/HCV Indications

General Reports
Viral Dynamics
Adverse Events
Efficacy




 
 

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Last Update:  January 03, 2018
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General Reports
     

     Journal Papers, Abstracts, and Commentaries
 
 
Pegylated IFN-α and ribavirin: emerging data in the treatment of special populations.
Walzer N, Flamm SL.
Expert Rev Clin Pharmacol
. 2009 Jan;2(1):67-76.
Abstract

Pharmacodynamics of PEG-IFN alpha-2a and HCV response as a function of IL28B
polymorphism in HIV/HCV co-infected patients.
d
e Araújo ES, Dahari H, Cotler SJ, et al
J Acquir Immune Defic Syndr
. 2010 Dec 13
Abstract

Pharmacodynamics of PEG-IFN-alpha-2a in HIV/HCV co-infected patients:
Implications for treatment outcomes.
Dahari H, Affonso de Araujo ES,  et al

J Hepatol
. 2010 May 27.
Abstract
 

Peg-interferon alfa-2a and highly active antiretroviral drug therapy on hepatitis C patients
with AIDS.

Zhang RF, Sun HQ, Huang Q, et al 
Zhonghua Gan Zang Bing Za Zhi.
2007 Oct;15(10):734-7
Abstract

Nanomedicines in the treatment of patients with hepatitis C co-infected with HIV--focus on
pegylated interferon-alpha.

Zoller H, Vogel W.
Int J Nanomedicine. 2006;1(4):399-409
Abstract
 


Viral Dynamics
     

     Journal Papers, Abstracts, and Commentaries
 
 

Impact of the peginterferon-α 2a and ribavirin plasma levels on viral kinetics and sustained virological response in genotype 1 HCV/HIV-co-infected patients with the unfavourable non-CC IL28B genotypes.
T
orres-Cornejo A, Ruiz-Valderas R, Jimenez-Jimenez L, et al
J Viral Hepat
. 2014 Mar;21(3):178-88.
Abstract

Revisiting predictors of virologic response to PEGIFN + RBV therapy in HIV-/HCV-coinfected patients: the role of metabolic factors and elevated GGT levels.
Mandorfer M, Reiberger T, Payer BA,  et al
J Viral Hepat
. 2014 Jan;21(1):33-41
Abstract

FULL-TEXT ARTICLE
Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV/HCV Genotype 3 Patients.
Rivero-Juárez A, Lopez-Cortes LF, Camacho A,  et al
PLoS One
. 2012;7(11):e48959.
Paper

       Conference Reports, Abstracts, and Posters 
 
 
Distinct hepatitis C virus kinetics in HIV-infected patients treated with ribavirin plus either pegylated
interferon -2a or -2b

E. Vispo, P. Barreiro, S. Rodriguez-Novoa, et al 
(XVII International AIDS Conference)
Abstract
 
Hepatitis C viral kinetics during treatment with weekly versus twice weekly peg IFN-alpha-2a
in HIV/HCV co-infected patients

Polis M, Sachau W, O'Shea M, et al
(4th IAS Conference)
Abstract

Histological response to peginterferon alfa-2a (40KD) (PEGASYS®) plus
ribavirin (COPEGUS®) in HIV-HCV co-infected patients with bridging fibrosis
or cirrhosis in the AIDS PEGASYS Ribavirin International Co-infection Trial (APRICOT)

Lissen E., Clumeck N., Sola R., et al
(3rd IAS)
Abstract

Predictability of Virologic Response at Week 4 and 12 of Peginterferon Alfa-2a (40KD) Plus Ribavirin
(RBV) Therapy in HIV-HCV Co-Infection: AIDS PEGASYS Ribavirin International Co-Infection Trial
(APRICOT)
F.J. TORRIANI, M. RODRIGUEZ-TORRES , E. LISSEN , et al 
(45 ICAAC)

Abstract

Adverse Events
 

     Journal Papers, Abstracts, and Commentaries
 
 
Pegylated IFN-α-induced NK cell activation is associated with HIV-1 DNA decline in ART-treated HIV-1/HCV co-infected patients.
Hua S, Vigano S, Tse S, Zhengyu O,  et al 
Clin Infect Dis
. 2017 Dec 20.
Abstract

Incidence of anaemia and impact on sustained virological response in HIV/HCV-coinfected patients
treated with pegylated interferon plus ribavirin.
Núñez M, Ocampo A, Aguirrebengoa K, et al
J Viral Hepat. 2007 Dec 21
Abstract

Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type
1-coinfected subjects.

Behler CM, Vittinghoff E, Lin F, et al

Clin Infect Dis. 2007 May 15;44(10):1375-83.
Abstract
 

       Conference Reports, Abstracts, and Posters 
 
 

Predictors of insulin resistance (IR) in HIV/HCV co-infected patients treated with pegylated
interferon alpha 2-a (Peg/IFN) and ribavirin (RBV)

Matti A, Nasta P, Borghi F, et al
(4th IAS Conference)
Abstract

Neuropsychological disturbances (NPS) predict a lower rate of rapid virologic response (RVR)
and early virologic response (EVR) in HIV/HCV co-infected patients treated with pegylated
interferon alpha 2-a (Peg/IFN) and ribavirin (RBV)

Nasta P, Antonelli S, Compostella S, et al
(4th IAS Conference)
Abstract


Efficacy
 

Peg Interferon alfa-2a Monotherapy
 
     Journal Papers, Abstracts, and Commentaries
 
  Peginterferon-alfa mono-therapy in the treatment of acute hepatitis C in HIV-infection.
Boesecke C, van Assen S, Stellbrink HJ, Baumgarten A, et al
J Viral Hepat. 2014 Jul 9}
Abstract

Efficacy and safety of pegylated interferon alpha-2a therapy for chronic hepatitis C
in HIV-infected patients with haemophilia.
Zhang RF, Sun HQ, Huang Q,  et al
Haemophilia
. 2009 Dec 20

Abstract

Peg Interferon alfa-2a vs Peg Interferon alfa-2a/Ribavirin
 

     Journal Papers, Abstracts, and Commentaries
 
 
Peginterferon alfa-2a Plus Ribavirin for HIV-HCV Genotype 1 Coinfected Patients: A Randomized International Trial.
Rodriguez-Torres M, Slim J,  et al
HIV Clin Trials
. 2012 May-Jun;13(3):142-52.
Abstract

The Dose-Response Relationship of Peginterferon Alfa-2a and Ribavirin in the Treatment of Patients
Coinfected with HIV-HCV.
Opravil M, Rodriguez-Torres M, Rockstroh J, et al

HIV Clin Trials
. 2012 Jan-Feb;13(1):33-45.
Abstract

FULL-TEXT ARTICLE
Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment,
re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation.

Hartwell D, Jones J, Baxter L, Shepherd J.
Health Technol Assess. 2011 Apr;15(17):1-210
Paper

      Conference Reports, Abstracts, and Posters 

 
HCV relapses upon completion of peg-interferon plus ribavirin in HIV-infected patients: rate, timing
and predictors

P. Barreiro, M. Nuñez, I. Santos, et al 
(XVII International AIDS Conference)
Abstract

Comparison of Pegylated Interferons Alfa-2a and Alfa-2b in HCV/HIV-1 Co-Infected Patients
J. SLIM, J.P. FALLON, N. SCANGARELLO, S.M. SMITH; 
(45 ICAAC)

Abstract
 

Peg Interferon alfa-2a/Ribavirin

     Journal Papers, Abstracts, and Commentaries

 
OPERA: use of pegylated interferon plus ribavirin for treating hepatitis C/HIV co-infection in interferon-naive patients.
Carosi G, Bruno R, Cariti G,  et al
Antivir Ther
. 2014 Feb 28
Abstract

Addition of Nitazoxanide to PEG-IFN and Ribavirin to Improve HCV Treatment Response in HIV-1 and HCV Genotype 1 Coinfected Persons Naïve to HCV Therapy: Results of the ACTG A5269 Trial.
Amorosa VK, Luetkemeyer A, Kang M, ry al
HIV Clin Trials. 2013 Nov-Dec;14(6):274-83
Abstract

The effects of a maintenance therapy with peg-interferon alpha-2a on liver fibrosis in HIV/HCV co-infected patients: a randomized controlled trial.
Chapplain JM, Bellissant E, Guyader D,  et al
J Infect. 2013 Jun 22
Abstract

Clinical evaluation of peginterferon α plus ribavirin for patients co-infected with HIV and HCV at
Nagoya Medical Center.
Tsuzuki T, Iwase H, Shimada M,  et a;  
Nihon Shokakibyo Gakkai Zasshi
. 2012;109(7):1186-96.
Abstract

Effect of an induction period of pegylated interferon-α2a and ribavirin on early virological response i
n HIV-HCV-coinfected patients: results from the CORAL-2 study.

Tural C, Solà R, Alvarez NP,  et al
Antivir Ther. 2011;16(6):833-841
Abstract

Effect of Baseline CD4 Cell Count on the Efficacy and Safety of Peginterferon Alfa-2a (40KD)
Plus Ribavirin in Patients With HIV/Hepatitis C Virus Coinfection.

Opravil M, Sasadeusz J, Cooper DA, et al
J Acquir Immune Defic Syndr.
2008 Jan 1;47(1):36-49.
Abstract
 

      Conference Reports, Abstracts, and Posters 

 
Efficacy of the treatment with peginterferon alfa-2a or peginterferon alfa-2b in co-infected patients treated at
the reference center for AIDS in Santos, SP, Brazil

M. Caseiro, S.O. Costa, M.H. Ventura, et al
(XVII International AIDS Conference)
Abstract
 
Pegylated interferon alfa-2a (PEG-IFN) + ribavirin (RBV) in HIV infected individuals within the
Australian Trial of Acute Hepatitis C (ATAHC) achieves end of treatment response (ETR) in over
80% of individuals

Matthews G, Hellard M, Sasadeusz J, et al
(4th IAS Conference)
Abstract
 
A phase II open-label pilot trial of the antiretroviral activity, safety, and tolerability of
pegylated interferon-α-2a (40KD) (PegIFN) in HIV-1 infected subjects - ACTG 5192

Asmuth D, Chan E, Cai T , et al
(4th IAS Conference)
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
16 or 24 weeks of peginterferon alfa-2a (40kd) (pegasys®) plus ribavirin (rbv) (copegus®) in
patients with hcv genotype 2 or 3 and bridging fibrosis or cirrhosis: results from a large, randomised
multinational study (accelerate)

Zeuzem S., Pappas S., Nyberg L., et al 
(12th International Symposium on Viral Hepatitis and
Liver Disease)
Abstract
 
Baseline HCV Genotype 1 RNA Concentration: Relationships with Sustained Virologic
Response to Peginterferon alfa-2a Plus Ribavirin and with Demographic Characteristics
J. TICEHURST, J. RAKELA , H. BODENHEIMER, et al 
(45 ICAAC)

Abstract
 
Treatment Exposure and Sustained Virologic Response (SVR) in Genotype 1 Patients Treated with
Peginterferon alfa-2a (40KD) (PEG IFNα2a)+ Ribavirin (RBV) in APRICOT (AIDS PEGASYS Ribavirin
International Co-Infection Trial)
M. OPRAVIL, F. TORRIANI , J. SASADEUSZ,  et al
(45 ICAAC)

Abstract
 
Determinants of Early Anti-HIV Effect of Pegylated interferon alfa 2a (PegINF)
and Ribavirin (RBV) in Antiretroviral Therapy (ART)-Free Coinfected HIV/HCV Patients
L. VERONESE, D. AGUILAR, D. GONZALEZ DE REQUENA, et al  
(45 ICAAC)

Abstract
 
Impact of Growth Factors (GF) on Treatment Outcomes in Patients with HIV-HCV Co-Infection in
the AIDS PEGASYS Ribavirin (RBV) International Co-Infection Trial (APRICOT)
M. SULKOWSKI, N. BRÄU , F. J. TORRIANI , et al 
(45 ICAAC)

Abstract
 
Treatment Exposure and Sustained Virologic Response (SVR) in Genotype 1 Patients Treated with
Peginterferon alfa-2a (40KD) (PEG IFNα2a)+ Ribavirin (RBV) in APRICOT (AIDS PEGASYS Ribavirin
International Co-Infection Trial)
M. OPRAVIL, F. TORRIANI , J. SASADEUSZ,  et al  
(45 ICAAC)

Abstract
 
Predictability of Virologic Response at Week 4 and 12 of Peginterferon Alfa-2a (40KD) Plus Ribavirin
(RBV) Therapy in HIV-HCV Co-Infection: AIDS PEGASYS Ribavirin International Co-Infection Trial
(APRICOT)
F.J. TORRIANI, M. RODRIGUEZ-TORRES , E. LISSEN , et al 
(45 ICAAC)

Abstract
 
Impact of Growth Factors (GF) on Treatment Outcomes in Patients with HIV-HCV Co-Infection in
the AIDS PEGASYS Ribavirin (RBV) International Co-Infection Trial (APRICOT)
M. SULKOWSKI, N. BRÄU , F. J. TORRIANI , et al 
(45 ICAAC)

Abstract
 
Nadir CD4% Independently Predicts Immunological Failure in Antiretroviral Therapy (ART)
Free HIV/HCV Coinfected Subjects Treated with Pegylated Interferon alfa (PegINF) and
Ribavirin (RBV)
D. AGUILAR, L. VERONESE, D. GONZALEZ DE REQUENA, et al
(45 ICAAC)

Abstract
 
Determinants of Early Anti-HIV Effect of Pegylated interferon alfa 2a (PegINF)
and Ribavirin (RBV) in Antiretroviral Therapy (ART)-Free Coinfected HIV/HCV Patients
L. VERONESE, D. AGUILAR, D. GONZALEZ DE REQUENA, et al  
(45 ICAAC)

Abstract
 
Patients with HCV/HIV co-infection achieving a sustained virological response following
HCV treatment with peginterferon alfa-2a (Pegasys®) plus ribavirin (Copegus®) have i
mproved health related quality of life

 D T Dieterich, M Rodriguez-Torres, J K Rockstroh, et al

(15IAC)
Abstract
 
  HCV-related factors but not HIV-related factors at baseline predict the response to
treatment with peginterferon alfa-2a (40KD) (Pegasys) plus ribavirin (Copegus) in patients
with HCV/HIV co-infection: Predictor analysis from the APRICOT study

D Cooper, FJ Torriani, M Rodriguez-Torres, et al
(45th ICAAC)
Abstract
 
  Patients with HCV/HIV co-infection achieving a sustained virological response following
HCV treatment with peginterferon alfa-2a (Pegasys®) plus ribavirin (Copegus®) have improved
health related quality of life

DT Dieterich, M Rodriguez-Torres, JK Rockstroh, et al
(45th ICAAC)
Abstract
 
  Moderate dose of PegInterferon alfa-2b in combination with ribavirin in the treatment of HCV
patients with or without HIV

C Sarmento, A Horta, H Coelho, O Vasconcelos, et al.
(45th ICAAC)
Abstract
 
  Safety of peginterferon alfa-2a (PEGASYS) 180 mcg weekly plus ribavirin (RBV) 800 mg daily
in HIV/HCV coinfection compared to HCV monoinfection

N Bräu, FJ Torriani, M Rodriguez-Torres, et al
(45th ICAAC)
Abstract
 
  Predictability of sustained virological response (SVR) in patients with HCV/HIV co-infection during
combination therapy with peginterferon alfa-2A (40KD) (Pegasys®) plus ribavirin (Copegus®) in the
APRICOT trial

M Rodriguez-Torres, FJ Torriani, E Lissen, et al
(45th ICAAC)
Abstract
 
  PegInterferon-alfa2a plus ribavirin in HIV/HCV-coinfected patients: early assessment of response in
the PRESCO trial

M Núñez, P Barreiro, A Ocampo. et al
(45th ICAAC)
Abstract
 
Peg Interferon alfa-2a/Ribavirin vs Interferon alfa-2a/Ribavirin

     Journal Papers, Abstracts, and Commentaries

  Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C
in HIV-coinfected persons.

Chung RT, Andersen J, Volberding P, et al
N Engl J Med. 2004 Jul 29;351(5):451-9.
Abstract
 
       Conference Reports, Abstracts, and Posters 
 
  Histological response to peginterferon alfa-2a (40KD) (PEGASYS®) plus
ribavirin (COPEGUS®) in HIV-HCV co-infected patients with bridging fibrosis
or cirrhosis in the AIDS PEGASYS Ribavirin International Co-infection Trial (APRICOT)

Lissen E., Clumeck N., Sola R., et al
(3rd IAS)
Abstract


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Pegylated Interferon Alfa-2a
HIV/HCV
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