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Nevirapine (Viramune)
 
Perinatal/Neonate Efficacy Data

Monotherapy
 NVP vs ZDV
 NVP/ZDV
 NVP/TNF/EMT
 NVP vs 3TC/ZDV
 NVP vs ZDV/NVP
 NVP-Based HAART
 National Studies




 
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Last Update:  June 06, 2008
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Monotherapy
 

          Journal Papers, Abstracts, and Commentaries  

 
Independent effects of nevirapine prophylaxis and HIV-1 RNA suppression in breast milk on
early perinatal HIV-1 transmission.
 Chung MH, Kiarie JN, Richardson BA, et al 
J Acquir Immune Defic Syndr. 2007 Dec 1;46(4):472-8
 Abstract
 
Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine.
 Lockman S, Shapiro RL, Smeaton LM, et al 
N Engl J Med. 2007 Jan 11;356(2):135-147.
 Abstract
 
Intrapartum Transmission After Mucosal Exposure to HIV Was Not Observed With Single-Dose
Nevirapine for Mother and Child.
 Kunz A, Mugenyi K, Karcher H, et al 
J Acquir Immune Defic Syndr. 2006 Dec 21;
 Abstract
 
Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent
mother-to-child HIV transmission in Botswana.
 Shapiro RL, Thior I, Gilbert PB, Lockman S 
AIDS. 2006 Jun 12;20(9):1281-1288.
 Abstract

Timing of maternal and neonatal dosing of nevirapine and the risk of mother-to-child transmission
of HIV-1: HIVNET 024*
 Chi BH, Wang L, Read JS, et al;  
AIDS. 2005 Nov 4;19(16):1857-1864.
 Abstract

Comparison of Mother-to-Child Transmission Rates in Ugandan Women With Subtype
A Versus D HIV-1 Who Received Single-Dose Nevirapine Prophylaxis: HIV Network for
Prevention Trials 012.
 Eshleman SH, Guay LA, Mwatha A, et al 
J Acquir Immune Defic Syndr. 2005 Aug 15;39(5):593-597.
 Abstract
 
A randomized trial of two postexposure prophylaxis regimens to reduce mother-to-child
HIV-1 transmission in infants of untreated mothers.
 Gray GE, Urban M, Chersich MF, et al 
AIDS. 2005 Aug 12;19(12):1289-97.
 Abstract
 
Nevirapine and zidovudine at birth to reduce perinatal transmission of HIV in an African
setting: a randomized controlled trial.
 Taha TE, Kumwenda NI, Hoover DR et al 
JAMA. 2004 Jul 14;292(2):202-9.
 Abstract

Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting
of intrapartum and neonatal single-dose nevirapine.
Stringer JS, Sinkala M, Chapman V, et al.
AIDS. 2003 Jul 25;17(11):1659-1665.
Abstract

Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine
regimen: association with timing of maternal intrapartum nevirapine dose.
Mirochnick M, Dorenbaum A, Blanchard S
Acquir Immune Defic Syndr. 2003 Jun 1;33(2):153-6.
Abstract

Comparison of Two Strategies for Administering Nevirapine to Prevent Perinatal HIV
Transmission in High-Prevalence, Resource-Poor Settings.
Stringer JS, Sinkala M, Stout JP, et al. 
J Acquir Immune Defic Syndr 2003 Apr 15;32(5):506-513
 Abstract

Survival of Ugandan Infants with Subtype A and D HIV-1 Infection (HIVNET 012).
 Eshleman SH, Guay LA, Fleming T, et al.  
J Acquir Immune Defic Syndr 2002 Nov 1;31(3):327-30
 Abstract
 
Impact of human immunodeficiency virus type 1 (hiv-1) subtype on women receiving
single-dose nevirapine prophylaxis to prevent hiv-1 vertical transmission (hiv network
for prevention trials 012 study).
Eshleman SH, Becker-Pergola G, Deseyve M, et al.
J Infect Dis 2001 Oct 1;184(7):914-917
 Abstract
 
Impact of Human Immunodeficiency Virus Type 1 (HIV-1) Subtype on Women Receiving
Single-Dose Nevirapine Prophylaxis to Prevent HIV-1 Vertical Transmission
Eshleman SH, Becker-Pergola G, Deseyve M, et al
J Infect Dis 2001 Aug 13;184(7)
 Abstract
 
Nevirapine: a review of its use in the prevention and treatment of paediatric
HIV infection.
 Bardsley-Elliot A, Perry CM
Paediatr Drugs 2000 Sep-Oct;2(5):373-407  
Abstract

        Conference Reports, Abstracts, and Posters

  Short-course Zidovudine and Lamivudine or single-dose Nevirapine-containing PMTCT
Compromises 12-Month Response to HAART in African Women, Abidjan, Côte d’Ivoire
(2003-2006)
 P Coffie, D Ekouevi, M L Chaix. et al
 (14 CROI)
 Abstract
 
  Maternal immune response and clinical outcomes on NNRTI-based antiretroviral therapy (ART)
following exposure to single-dose nevirapine (NVP) for prevention of mother-to-child HIV
transmission (PMTCT)
 Chi B., Sinkala M., Levy J., et al    
 (XVI International AIDS Conference)
 Abstract
 
  Infant Nevirapine Dosing for the Prevention of Mother-to-Child Transmission in
Association with Timing of Maternal Intrapartum Nevirapine Dose: Initiatives of
the United States Pharmacopeia Drug Quality and Information Program (USP DQI)
Seyoum D., Primo-Carpenter J.
 (3rd IAS)
Abstract
 
  NNRTI-resistant mutations in HIV-1 infected infants following single dose
Nevirapine (Sd-NVP) are reduced by the addition of short course zidovudine
and 3TC.
Gray G., McIntyre J., Hopley M., et al
 (3rd IAS)
Abstract
 
  Frequency of nevirapine resistance (NVPR) after single dose nevirapine (sdNVP)
use to prevent HIV-1 vertical transmission: a meta-analysis
Arrivé E., Dabis F., Newell M.-L.,, et al
 (3rd IAS)
Abstract
 
  Timing of maternal and infant nevirapine and the risk of mother-to-child transmission
of HIV-1: HIVNET 024
 Chi B.H., Wang L., Read J.S., et al
 (3rd IAS)
 Abstract
 
  6-month immunological response with HAART containing Nevirapine in HIV infected
women post exposure to single dose of Nevirapine for PMTCT. The MTCT-Plus Initiative
in Abidjan, Côte d’Ivoire (2003-2005).
 G Bedikou,  I Viho,  B Tonwe-Gold, et al 
(3rd IAS)
Abstract
 
  Effectiveness of Single-dose Nevirapine in a Second Pregnancy
 N Martinson, L Pumla, L Morris, et al
 (12 CROI)
 Abstract
 
  Sensitive Real-Time PCR Quantification of 103N Resistance Mutants
following Single-dose Treatment with Nevirapine
 S Loubser, P Balfe, G Sherman, et al
 (12 CROI)
 Abstract
 
  Effect of Nevirapine (NVP) for Perinatal HIV Prevention Appears Greatest Among
Women with Most Advanced Disease: Subgroup Analyses of HIVNET 012
MG. Fowler, A. Mwatha LA Guay, et al.
(9 CROI)
 Abstract
 
  Effect of Nevirapine (NVP) for perinatal HIV prevention appears strong among women with
advanced disease: Subgroup analyses of HIVNET 012
C Nakabiito, L A Guay, P Musoke, et al(
 (14IAC)
 Abstract
 
          Internet Documents
 
  FULL-TEXT DOCUMENT
 WHO reconfirms its support for the use of nevirapine to prevent mother-to-child
transmission of HIV.
WHO Web Site July 2003
 Report
 
         Journal Papers, Abstracts, and Commentaries
 
 
Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing
HIVNET 012 nevirapine versus short-course zidovudine.
 Chung MH, Kiarie JN, Richardson BA, et al  
 AIDS. 2005 Sep 2;19(13):1415-1422.
Abstract

Safety and trough concentrations of nevirapine prophylaxis given daily, twice weekly,
or weekly in breast-feeding infants from birth to 6 months.
 Shetty AK, Coovadia HM, Mirochnick MM, et al  
 J Acquir Immune Defic Syndr. 2003 Dec 15;34(5):482-90.
 Abstract

        Conference Reports, Abstracts, and Posters

  Modeling the Effectiveness of Nevirapine(NVP), HIV Vaccine and HIV-Specific Monoclonal
Antibody(HIV-Ab) on Mother to Child Transmission of HIV from Intrapartum and Breast-Feeding
MTCT) and Cost Effectiveness Analysis of those Interventions
M S Sim, W J Cumberland, N Duan, Y J Bryson
 (15IAC)
 Abstract
 
  Detection of HIV-1 RNA in breast milk from Subtype C HIV-1 infected women after single dose
Nevirapine (SD-NVP)
E Lee, D A Katzenstein, L Tanimoto, et al
 (15IAC)
 Abstract
 
Suppression of HIV-1 RNA levels in breast milk after randomization to perinatal nevirapine vs.
AZT
M H Chung, D Lehman, J Kiarie, et al
 (15IAC)
 Abstract
 
  Effectiveness of Nevirapine in reducing mother-to-child transmission of HIV in formula-fed infants
L Rivera, M Pena, E Perez-Then, M Tavarez-Rojas
 (15IAC)
 Abstract
 
GROWTH OF BREAST AND FORMULA FED BABIES BORN TO NEVIRAPINE TREATED
HIV-1 POSITIVE MOTHERS IN YAOUNDE, CAMEROON
G. Tene, M. Tejiokem, F. Tietche, et al
 (2nd IAS)
 Abstract
 
Uptake of interventions to reduce mother-to-child HIV transmission: nevirapine and
exclusive breastfeeding in the Zambia exclusive breastfeeding study (ZEBS)
L Kuhn, P Kasonde, C Vwalika,  et al
 (14IAC)
 Abstract
NVP vs ZDV
 

      Journal Papers, Abstracts, and Commentaries

 
Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-
to-child transmission of HIV in Africa?
 Leroy V, Sakarovitch C, Cortina-Borja M,
AIDS. 2005 Nov 4;19(16):1865-1875.
Abstract
 
Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing
HIVNET 012 nevirapine versus short-course zidovudine.
 Chung MH, Kiarie JN, Richardson BA, et al  
AIDS. 2005 Sep 2;19(13):1415-1422.
Abstract
 
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for
prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month
follow-up of the HIVNET 012 randomised trial.
 Jackson JB, Musoke P, Fleming T, et al  
 Lancet. 2003 Sep 13;362(9387):859-68
 Abstract

Intrapartum and Neonatal Single-Dose Nevirapine Compared with Zidovudine for
Prevention of Mother-to-Child Transmission of HIV-1 in Kampala, Uganda:
Randomized Trial (HIVNET 012)
Guay LA, Musoke P, Fleming T, et al.
Lancet 1999 Sep 4;354(9181):795-802  
Abstract

        Conference Reports, Abstracts, and Posters

 
Routine use of combined zidovudine and nevirapine regimen in MTCT-Plus program
 O Marcy,  A Mafoua , G Halembokaka
(3rd IAS)
 Abstract

Immunologic and virologic responses to generic highly active antiretroviral therapy of patients
with single dose nevirapine or short course AZT pre-exposure
L S Zijenah, G Kadzirange, O Tobaiwa, et al
 (15IAC)
 Abstract
 
Suppression of HIV-1 RNA levels in breast milk after randomization to perinatal nevirapine vs.
AZT
MH Chung, D Lehman, J Kiarie, et al
 (15IAC)
Abstract
 
Prevention of vertical HIV-1 transmission by Zidovudine and Nevirapine
SN Kurle, SP Tripathy, PL Joshi, et al
 (15IAC)
 Abstract
NVP/ZDV

          Journal Papers, Abstracts, and Commentaries

 
A randomized, double-blind, placebo-controlled trial of combined nevirapine and zidovudine
compared with nevirapine alone in the prevention of perinatal transmission of HIV in Zimbabwe.
 Thistle P, Spitzer RF, Glazier RH, et al
Clin Infect Dis. 2007 Jan 1;44(1):111-9
 Abstract
 
Nevirapine and zidovudine at birth to reduce perinatal transmission of HIV in an African
setting: a randomized controlled trial.
 Taha TE, Kumwenda NI, Hoover DR et al 
JAMA. 2004 Jul 14;292(2):202-9.
 Abstract
 
FULL-TEXT ARTICLE
 Single-Dose Perinatal Nevirapine plus Standard Zidovudine to Prevent Mother-to-Child
Transmission of HIV-1 in Thailand.
 Lallemant M, Jourdain G, Le Coeur S, et al
N Engl J Med. 2004 Jul 9
Paper
 
Short postexposure prophylaxis in newborn babies to reduce mother-to-child transmission
of HIV-1: NVAZ randomised clinical trial.
 Taha TE, Kumwenda NI, Gibbons A, et al.
Lancet. 2003 Oct 11;362(9391):1171-7.
Abstract

Intrapartum and Neonatal Single-Dose Nevirapine Compared with Zidovudine for
Prevention of Mother-to-Child Transmission of HIV-1 in Kampala, Uganda:
Randomized Trial (HIVNET 012)
Guay LA, Musoke P, Fleming T, et al.
Lancet 1999 Sep 4;354(9181):795-802  
Abstract

 

          Conference Reports, Abstracts, and Posters

 
Efficacy of Peripartum Nevirapine to Prevent Mother to Child HIV Transmission in
Women Presenting Late for Antenatal Care in Thailand
 G Jourdain, S Le Coeur, N Ngo-Giang-Huong, et al
 (12 CROI)
 Abstract
 
Maternal Single-dose Nevirapine May Not Be Needed to Reduce Mother-to-Child HIV
Transmission in the Setting of Maternal and Infant Zidovudine and Infant Single-dose
Nevirapine: Results of a Randomized Clinical Trial in Botswana
 R Shapiro, I Thior, P Gilbert, et al
(12 CROI)
Abstract
 
Duration of nevirapine (NVP) postpartum exposure in women who received single
dose NVP during labor in addition to standard zidovudine (ZDV) prophylaxis for the
prevention of mother-to-child transmission of HIV-1 in Thailand
T R Cressey, S Kunkeaw, P N Ruttana-Aroongorn., et al
 (15IAC)
 Abstract
 
Multicentre, Randomized Controlled Trial, Assessing the Safety and Efficacy of Nevirapine
in Addition to Zidovudine for the Prevention of Perinatal HIV In Thailand: PHPT-2 Update
 M Lallemant, G Jourdain, S Le Coeur, et al.
(2nd IAS)
 Abstract
 
Genotypic resistance analysis following single-dose administration of nevirapine to HIV-infected
women and their infants receiving short-course zidovudine
W Leelawiwat, P Wirachsilp, R Sutthent,et al
 (14IAC)
 Abstract