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Medical Advocates

Nevirapine
(Viramune)
 
Journal Citations: Adverse Events

General Reports

Cardiovascular Disorders
Cutaneous Disorders
Hepatic Disorders
Hypersensitivity
Mental Disorders
Meningoencephalitis
Metabolic Disorders
Renal Disorders

Oral Disorders
Stevens-Johnson Syndrome/Toxic Epidermal Necrosis 
 

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Last Update:  August 25, 2017
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General Reports
       

 
Nevirapine induced mitochondrial dysfunction in HepG2 cells.
Paemanee A, Sornjai W, Kittisenachai S,  et al
Sci Rep. 2017 Aug 23;7(1):9194.
Abstract

Nelfinavir inhibits proliferation and induces DNA damage in thyroid cancer cells.
Jensen K, Bikas AD, Patel A,  et al
Endocr Relat Cancer
. 2017 Jan 30.
Abstract

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions.
Marinho AT, Rodrigues PM, Caixas U,  et al  J
 Antimicrob Chemother
. 2014 Feb;69(2):476-82.
Abstract

Residual viremia in patients on antiretroviral therapy incorporating nevirapine is not associated with the gag-specific cellular immune response.
McIlroy D, Allavena C, Rodallec A,  et al
J Med Viro
l
. 2013 Sep 23.
Abstract

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions.
Marinho AT, Rodrigues PM, Caixas U,  et al 
J Antimicrob Chemother
. 2013 Sep 19
Abstract

FULL-TEXT ARTICLE
DRESS Syndrome due to Nevirapine Treated with Methylprednisolone.
Pott Junior H, Gosuen GC, Gales AC.
Case Rep Med
. 2013;2013:269501
Paper

Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis.
Shubber Z, Calmy A, Andrieux-Meyer I, et al 
AIDS
. 2013 Jan 22. [
Abstract

Long-term therapy with nevirapine and tropism.
Moling O, Andreis S, Bressan S,et al
J Int AIDS Soc
. 2012 Nov 11;15(6):18157
Abstract

Pharmacogenetics of Toxicity, Plasma Trough Concentration and Treatment Outcome with Nevirapine-Containing Regimen in Anti-Retroviral-Naïve HIV-Infected Adults: an Exploratory Study of the TRIANON ANRS 081 Trial.
Gozalo C, Gérard L, Loiseau P,  et al 
Basic Clin Pharmacol Toxicol
. 2011 Aug 9.
Abstract

Nevirapine-associated toxicity in clinical practice in Buenos Aires, Argentina.
Bottaro EG, Huberman MJ, Iannella Mdel C, et al
J Int Assoc Physicians AIDS Care
2010 Sep-Oct;9(5):306-12.
Abstract

Amino Acid Adduct Formation by the Nevirapine Metabolite, 12-Hydroxynevirapine
A Possible Factor in Nevirapine Toxicity.
Antunes AM, Godinho AL, Martins IL,  et al
Chem Res Toxicol
. 2010 Apr 14.
Abstract

Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing
antiretroviral therapy.

Kesselring AM, Wit FW, Sabin CA, et al
AIDS
. 2009 May 29.
Abstract

Nevirapine Toxicity in Non-HIV Cancer Patients.
Landriscina M, Fabiano A, Lombardi V, et al 
Chemotherapy.
2008 Oct 2;54(6):475-478.
Abstract
 

Analysis of Severe Hepatic Events Associated with Nevirapine-Containing Regimens : CD4+ T-Cell Count and Gender in Hepatitis C Seropositive and Seronegative Patients.
Torti C, Costarelli S, De Silv
Abstract
 
Nevirapine-associated toxicity in HIV-infected Thai men and women, including pregnant
women.
Phanuphak N, Apornpong T, Teeratakulpisarn S, et al
HIV Med. 2007 Sep;8(6):357-66.
Abstract
 
Predisposing factors for nevirapine toxicity among AIDS patients with low baseline CD4
count.
Tansuphaswadikul S, Aung SE, Phonrat B, et al
Asian Pac J Allergy Immunol. 2007 Jun-Sep;25(2-3):147-54.
Abstract

Nevirapine toxicity.
Taiwo BO.
Int J STD AIDS. 2006 Jun;17(6):364-70.
Abstract


Cardiovascular Disorders
       

 
Nevirapine and cardiovascular risk.
Parienti JJ, Verdon R.  
Med Mal Infect
. 2010 Apr 28.
Abstract

FULL-TEXT ARTICLE
Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral-Therapy-Naive Patients Infected with HIV-1
van Leth F, Phanuphak P, Stroes E, et al
PLOS Vol2 Issue 9 Sep 2005

Paper


Cutaneous
       

 
Incidence and risk factors of skin rashes and hepatotoxicity in HIV-infected patients receiving nevirapine-containing combination antiretroviral therapy in Taiwan.
Tseng YT, Yang CJ, Chang SY, et al
Int J Infect Dis. 2014 Oct 10
Abstract

FULL-TEXT ARTICLE
Nevirapine induced toxic epidermal necrolysis and non-Hodgkin lymphoma in a Human Immunodeficiency Virus positive patient.
Budamakuntla L, Loganathan E, Suryanarayan S, et al
Indian Dermatol Online J. 2014 Apr;5(2):179-81
Paper

Rash and hepatitis within days of starting a new antiretroviral regimen: Nevirapine hypersensitivity, secondary syphilis or both?
Saxon CJ, Helbert MR, Komolafe AJ, Higgins SP.
Int J STD AIDS. 2013 Aug 8.
Abstract

Identification of ‘Danger’ Signals in Nevirapine-Induced Skin Rash.
Zhang X, Sharma AM, Uetrecht J.
Chem Res Toxicol
. 2013 Aug 15
Abstract

FULL-TEXT PDF ARTICLE
Association of Nevirapine Levels with Rash or Hepatotoxicity Among HIV-Infected Thai Women.
Ratanasuwan W, Jariyasethpong T, Anekthananon T,  et al
Open AIDS J. 2012;6:266-73. 
Paper

FULL-TEXT DOCUMENT
HLA involvement in nevirapine-induced dermatological reaction in antiretroviral-treated HIV-1 patients.
Umapathy S, Pawar A, Bajpai S,
J Pharmacol Pharmacother. 2011 Apr;2(2):114-5.
Letter

Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent.
Yuan J, Guo S, Hall D, et al
AIDS
. 2011 Apr 18.
Abstract

HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients.
Likanonsakul S, Rattanatham T, Feangvad S,  et al 
AIDS Res Ther. 2009 Oct 21;6(1):22.
Abstract

A Model and Risk Score for Predicting Nevirapine-Associated Rash among HIV-infected Patients: In Settings of Low CD4 Cell Counts and Resource Limitation.
Kiertiburanakul S, Sungkanuparph S, Malathum K 
Open AIDS J. 2009 Jul 8;3:24-30.
Abstract

HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in
HIV-infected Thai patients.
Chantarangsu S, Mushiroda T, Mahasirimongkol S, et al  
Pharmacogenet Genomic
s
. 2009 Dec 19
Abstract
 

HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz.
Vitezica ZG, Milpied B, Lonjou C, et al 
AIDS.
2008 Feb 19;22(4):540-1.
Abstract
 
Incidence and risk factors of nevirapine-associated skin rashes among HIV-infected patients with CD4 cell counts <250 cells/muL.
Manosuthi W, Sungkanuparph S, Tansuphaswadikul S, et al 
Int J STD AIDS
. 2007 Nov;18(11):782-786.
Abstract
 
Nevirapine-related adverse events in a patient receiving a fixed-drug combination pill.
Daniel OJ, Krain AB, Ogun SA, Odusoga OL, Boyle BA.  
J Natl Med Assoc
. 2005 Dec;97(12):1719-21.
Abstract
 
Case reports: treatment of nevirapine-associated dress syndrome with intravenous immune globulin (IVIG).
Fields KS, Petersen MJ, Chiao E, Tristani-Firouzi P.
J Drugs Dermatol.
2005 Jul-Aug;4(4):510-3
Abstract
 
Rashes in HIV-infected patients undergoing therapy with nevirapine or efavirenz.
H
artmann M, Brust J, Schuster D, et al 
Hautarzt. 2005 Feb 23
Abstract
 
Incidence and risk factors for rash in Thai patients randomized to regimens with nevirapine, efavirenz or both drugs.
Ananworanich J, Moor Z, Siangphoe U, et a;
AIDS. 2005 Jan 28;19(2):185-19
2
Abstract
 
Nevirapine-induced toxic epidermal necrolysis and toxic hepatitis treated successfully with a combination of intravenous immunoglobulins and N-acetylcysteine.
Claes P, Wintzen M, Allard S, 
Eur J Intern Med.
2004 Jul;15(4):255-258.
Abstract
 
Assessment of cetirizine, an antihistamine, to prevent cutaneous reactions to nevirapine therapy:results of the viramune-zyrtec double-blind, placebo-controlled trial.
Launay O, Roudiere L, Boukli N, et al   
Clin Infect Dis.
2004 Apr 15;38(8):e66-7|
Abstract
 
Serious Adverse Cutaneous and Hepatic Toxicities Associated With Nevirapine Use by Non-HIV-Infected Individuals.
Patel SM, Johnson S, Belknap SM, et al 
J Acquir Immune Defic Syndr.
2004 Feb 1; 35(2): 120-125
Abstract
 
Incidence and risk factors for nevirapine-associated rash.
De Maat MM, Ter Heine R, Mulder JW, et al.

Eur J Clin Pharmacol. 2003 Aug 12
Abstract

Failure of a Short-Term Prednisone Regimen to Prevent Nevirapine-Associated Rash: A Double-Blind Placebo-Controlled Trial: The GESIDA 09/99 Study.
Knobel H, Miro JM, Domingo P, et al
J Acquir Immune Defic Syndr. 2001 Sep 1;28(1):14-18.
Abstract