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Lopinavir/Ritonavir (Kaletra/Aluvia)
 
Perinatal Data

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Last Update:  August 08, 2008
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New and Noteworthy
       
February 2008
 
 
Guidelines
       
United States

     Internet Documents

  PDF DOCUMENT
Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs
in Pregnant HIV-Infected Women for Maternal Health and Interventions to Reduce
Perinatal HIV  Transmission in the United States.
Perinatal HIV Guidelines Working Group.
November 2, 2007

 
  PDF DOCUMENT
Safety and Toxicity of Individual Antiretroviral Agents in Pregnancy
 Perinatal HIV Guidelines Working Group.
November 2, 2007
Guidelines
General Reports
 
       Journal Papers, Abstracts, and Commentaries
 
 
Reduced lopinavir exposure during pregnancy.
Stek AM, Mirochnick M, Capparelli E, et al 
AIDS. 2006 Oct 3;20(15):1931-1939.
 Abstract

Placental transfer of lopinavir/ritonavir in the ex vivo human cotyledon perfusion model.
Gavard L, Gil S, Peytavin G, et al   
Am J Obstet Gynecol. 2006 May 4;
 Abstract
 
      Conference Reports, Abstracts, and Posters 
 
  Plasma lopinavir levels in a group of pregnant women on lopinavir, ritonavir, zidovudine, and
lamivudine
 K Manavi, A McDonald, Al Al-Sharqui
(8th Int Congress on Drug Therapy in HIV Infection)
 Abstract
Animal Studies
       
       Journal Papers, Abstracts, and Commentaries
 
 
Effects of lopinavir-ritonavir combined therapy during the rat pregnancy
Morphological and biochemical aspects.
Cunha AM, Hagemann CC, Simoes RS, et al   
Eur J Obstet Gynecol Reprod Biol. 2006 Sep 18;
 Abstract
Pharmacokinetics
       
       Journal Papers, Abstracts, and Commentaries
 
  Placental transfer and pharmacokinetics of lopinavir and other protease inhibitors in combination
with nevirapine at delivery.
Gingelmaier A, Kurowski M, Kastner R, et al 
AIDS. 2006 Aug 22;20(13):1737-1743
 Abstract
 
      Conference Reports, Abstracts, and Posters 
 
 
ial" f Lopinavir Population Pharmacokinetics on HIV-infected Pregnant Women
 M Bouillon Pichault, V Jullien, E Azria, et al
 (13 CROI)
 Abstract

POSTER
Adequate Lopinavir Exposure Achieved with a Higher Dose during the Third Trimester of
Pregnancy
M Mirochnick, A Stek, E Capparelli, et al
 (13 CROI)
 PDF Poster     Abstract

Adequate Trough Lopinavir Levels with Standard Dosing in Pregnancy
 F Lyons, M Lechelt, V Magaya, et al
 (13 CROI)
Abstract
 
Reduced lopinavir exposure during pregnancy: preliminary pharmacokinetic
results from PACTG 1026
A Stek, M Mirochnick, E Capparelli,  et al
(15IAC)
Abstract
Efficacy
       
       Journal Papers, Abstracts, and Commentaries
 
  Plasma lopinavir trough levels in a group of pregnant women on lopinavir, ritonavir,
zidovudine,and lamivudine.
Manavi K, McDonald A, Al-Sharqui A. 
AIDS. 2007 Mar 12;21(5):643-5.
Abstracts
 
      Conference Reports, Abstracts, and Posters 
 
 
PDF POSTER
Lopinavir/ritonavir (LPV/r) in Pregnancy
SS Roberts, M Martinez, DL.Covington, et al 
(17IAC)
 Abstract

High-dose Lopinavir and Standard-dose Emtricitabine Pharmacokinetics during Pregnancy
and Postpartum
 B Best, A Stek, C Hu, et al
 (15 CROI)
 Abstract
 
Pharmacokinetics and 24-Week Efficacy and Safety of Lopinavir/Ritonavir in HIV-1-infected
Infants <6 Weeks of Age
J Pinto, B Robbins, J Chen, et al
 (14 CROI)
 Abstract
 
Reduced Lopinavir Exposure during Pregnancy: A Case Control Study
G Peytavin, S Pierre-François, B Cassard, et
(14 CROI)
 Abstract
 
Different rates of early viral load reduction with nevirapine or lopinavir/ritonavir-based combination
antiretroviral therapies in pregnant women
 C Bell, N Desmond, GP Taylor
(8th Int Congress on Drug Therapy in HIV Infection)
 Abstract

Lopinavir/ritonavir during the pregnancy of HIV-infected women
Sovric M., Gingelmaier A., Kaestner R., et al
(XVI  International AIDS Conference)
 Abstract
Monitoring
       
      Conference Reports, Abstracts, and Posters 
 
 
Lopinavir Drug Monitoring in 36 Pregnant Women
Marie-Aude Khuong-Josses, A Boussaïri, C Palette, D Méchali
 (14 CROI)
 Abstract
 
Therapeutic Drug Monitoring of Lopinavir/ritonavir (LPV/r) Containing Regimen in
Pregnant HIV-infected Women
 Cassard B, Rouault A, Damond F, et al
 (3rd IAS Conference)
Abstract

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