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HAART/ART/cART
 
HAART/ART Failure

General Reports
Virological Failure
 Immunological Failure
Mortality/Risk Factors


 
 
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Last Update:  January 11, 2018  
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General Reports
 
     Journal Papers, Abstracts, and Commentaries
 
 
The Role of HIV-1 Drug-Resistant Minority Variants in Treatment Failure.
Stella-Ascariz N, Arribas JR, Paredes R, Li JZ.
 J Infect Dis. 2017 Dec 1;216(suppl_9):S847-
 Abstract

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults.
 Bisson GP, Ramchandani R, Miyahara S,  et al
 AIDS. 2017 Jul 24
 Abstract

Predicting the Need for Third-Line Antiretroviral Therapy by Identifying Patients at High Risk for Failing Second-Line Antiretroviral Therapy in South Africa
 Onoya D, Nattey C, Budgell E, et al
AIDS Patient Care STDS. 2017 Apr 26
 Abstract

All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up.
Anderegg N, Johnson LF, Zaniewski E,
AIDS. 2017 Apr;31 Suppl 1:S31-S40. .
 Abstract

Effects of unplanned treatment interruptions on HIV treatment failure- results from TAHOD.
 Jiamsakul A, Kerr SJ, Ng OT,  et al
 Trop Med Int Health. 2016 Mar 7
 Abstract

Self-reported nonadherence to antiretroviral therapy as a predictor of viral failure and mortality.
Glass TR, Sterne JA, Schneider MP, et al;  
AIDS. 2015 Oct 23;29(16):2195-2200.
 Abstract

FULL-TEXT ARTICLE
 Severe morbidity after antiretroviral (ART) initiation: active surveillance in HIV care programs, the IeDEA West Africa collaboration.
Abo Y, Zannou Djimon M, Messou E, et al
 BMC Infect Dis. 2015 Apr 9;15(1):176.
 Paper

CD4 criteria improves the sensitivity of a clinical algorithm developed to identify viral failure in HIV-positive patients on antiretroviral therapy.
Evans DH, Fox MP, Maskew M,  et al
J Int AIDS Soc. 2014 Sep 15;17:19139. .
 Abstract

Long-term mortality in HIV positive individuals virally suppressed for more than three years with incomplete CD4 recovery
Engsig FN, Zangerle R, Katsarou O,  et al
Clin Infect Dis. 2014 Jan 22.
Abstract

High Rate of HIV Re-suppression After Viral Failure on First Line Antiretroviral Therapy in the Absence of Switch to Second Line.
Gupta RK, Goodall RL, Ranopa M,  et al
Clin Infect Dis. 2013 Dec 18.
 Abstract

On the role of resonance in drug failure under HIV treatment interruption.
 Oņa L, Kouyos RD, Lachmann M, Bonhoeffer S.
Theor Biol Med Model. 2013 Jul 11;10(1):44.
 Abstract

The parametric g-formula to estimate the effect of highly active antiretroviral therapy
on incident AIDS or death.
Westreich D, Cole SR, Young JG,  et al
Stat Med. 2012 Apr 11.
Abstract

Calendar time trends in the incidence and prevalence of triple-class virologic failure in antiretroviral drug
experienced people with HIV in Europe.
Nakagawa F.|
 J Acquir Immune Defic Syndr. 2011 Nov 11
 Abstract

Pre-existing minority drug-resistant HIV-1 variants, adherence, and risk of
antiretroviral treatment failure.
 Paredes R, Lalama CM, Ribaudo HJ, et al
J Infect Dis. 2010 Mar;201(5):662-71.
 Abstract

Evolution of HIV-1 in a patient population failing multiple-drug therapy.
Hong S, Cao J, Tu YT.
 Microbiol Immunol. 2009 Sep;53(9):535-9.
 Abstract

Better than nothing: keeping pts on failing regimen has benefits.
Winslow DL.
 AIDS Alert. 2009 Apr;24(4):44-5.
 Abstract

FULL-TEXT ARTICLE
 Overestimates of Survival after HAART: Implications for Global Scale-Up Efforts.
Bisson GP, Gaolathe T, Gross R, et al 
PLoS ONE. 2008 Mar 5;3(3)
 Paper
 
Virological Failure
     

      Journal Papers, Abstracts, and Commentaries

 
Early virological response to HIV treatment: can we predict who is likely to experience subsequent treatment failure? Results from an observational cohort study, London, UK.
 Brima N, Lampe FC, Copas A, et al  
J Int AIDS Soc. 2017;20(1).
Abstract

FULL-TEXT ARTICLE
Virological failure and all-cause mortality in HIV-positive adults with low-level viremia during antiretroviral treatment
Elvstam O, Medstrand P, Yilmaz A,
PLoS One. 2017 Jul 6;12(7):e0180761
 Paper

Elevated CD8 T-cell counts and virological failure in HIV-infected patients after combination antiretroviral therapy.
 Ku NS, Jiamsakul A, Ng OT, Yunihastuti E,  et al
Medicine (Baltimore). 2016 Aug;95(32):e4570.
Abstract

Adherence to Antiretroviral Therapy and Virologic Failure: A Meta-Analysis.
Bezabhe WM, Chalmers L, Bereznicki LR, Peterson GM.
Medicine (Baltimore). 2016 Apr;95(15):e3361.
 Abstract

Impact of low-level viraemia on virological failure in HIV-1-infected patients with stable antiretroviral treatment.
 Navarro J, Caballero E,Curran A, ET AL
Antivir Ther. 2016 Jan 12.
Abstract

FULL-TEXT ARTICLE
 Factors Associated with Low-Level Viraemia and Virological Failure: Results from the Austrian HIV Cohort Study.
Leierer G, Grabmeier-Pfistershammer K, Steuer A
PLoS One 2015 Nov 13;10(11):e0142923. .
 Paper

Evolution of HIV-1 tropism at quasispecies level after 5 years of combination antiretroviral therapy in patients always suppressed or experiencing episodes of virological failure.
 Rozera G, Abbate I, Giombini E,  et al
J Antimicrob Chemother. 2014 Jul 10.
Abstract

Ultrasensitive assessment of residual low-level HIV viremia in HAART-treated patients and r
isk of virological failure.
Maggiolo F, Callegaro A, Cologni G, et al
 J Acquir Immune Defic Syndr. 2012 Apr 4.
 Abstract

Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure
of drugs from three antiretroviral drug classes: a cohort study.
The Pursuing Later Treatment Option II (PLATO II) project team for the Collaboration of Observational
HIV Epidemiological Research Europe (COHERE) Group
 Lancet Infect Dis. 2011 Oct 7.
 Abstract

FULL-TEXT PDF ARTICLE
 A Prognostic Model for Estimating the Time to Virologic Failure in HIV-1 Infected Patients
Undergoing a New Combination Antiretroviral Therapy Regimen.
Prosperi MC, Di Giambenedetto S, Fanti I, et al
BMC Med Inform Decis Mak. 2011 Jun 14;11(1):40. .
 Paper

Triple-Class Virologic Failure in HIV-Infected Patients Undergoing Antiretroviral
Therapy for Up to 10 Years.
The Pursuing Later Treatment Options II (PLATO II) Project Team for the Collaboration
| of Observational HIV Epidemiological Research Europe (COHERE).
Arch Intern M
ed. 2010 Mar 8;170(5):410-419.
 Abstract
     Conference Reports, Abstracts, and Posters
 
  Strategy to identify individuals with virologic failure before nucleic acid testing to increase the relative efficiency in resource-limited settings
R. Mendizabal-Burastero, A. Giron-Callejas, E. Yax. et al
 (XX International AIDS Conference)
 Abstract
Poor Immunological Response/Immunological
Failure
     Journal Papers, Abstracts, and Commentaries
 
  FULL-TEXT ARTICLE
 KIR-HLA Genotypes in HIV-Infected Patients Lacking Immunological Recovery despite
Effective Antiretroviral Therapy.
Soria A, Guerini FR, Bandera A, et al
PLoS One. 2011;6(11):e27349
 Paper

Immunologic failure despite suppressive antiretroviral therapy is related to activation and
turnover of memory CD4 cells.
Lederman MM, Calabrese L, Funderburg NT, et al
J Infect Dis. 2011 Oct;204(8):1217-26.
 Abstract
 
Mortality/Risk Factors
     
     Journal Papers, Abstracts, and Commentaries
 
 
FULL-TEXT ARTICLE
 Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy.
 Grund B, Baker JV, Deeks SG, et al
PLoS One. 2016 May 12;11(5):e0155100
 Paper

FULL-TEXT ARTICLE
 Relationship between Body Mass Index and Mortality in HIV-Infected HAART Users in the Women's Interagency HIV Study.
 Sharma A, Hoover DR, Shi Q,  et al 
PLoS One. 2015 Dec 23;10(12):e0143740
 Paper

FULL-TEXT ARTICLE
 Mortality in Patients with HIV-1 Infection Starting Antiretroviral Therapy in South Africa, Europe, or North America: A Collaborative Analysis of Prospective Studies.
Boulle A, Schomaker M, May MT,  et al
 PLoS Med. 2014 Sep 9;
 Paper

Factors associated with mortality among persistently viraemic triple-antiretroviral-class-experienced patients receiving antiretroviral therapy in the HIV Outpatient Study (HOPS).
Palella FJ Jr, Armon C, Buchacz K, er al.
 J Antimicrob Chemother. 2014 Jun 16
 Abstract

Causes of Death in HIV-1-Infected Patients Treated with Antiretroviral Therapy,
1996-2006: Collaborative Analysis of 13 HIV Cohort Studies.
[No authors listed]
Clin Infect Dis. 2010 Mar 26.
 Abstract

Racial disparities in HIV virologic failure: do missed visits matter?
Mugavero MJ, Lin HY, Allison JJ, et al 
J Acquir Immune Defic Syndr. 2009 Jan 1;50(1):100-8.
 Abstract
 

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HAART/ART Failure