HAART Adverse Events

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HAART/ART

		Adverse Events
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Last Update: August 14, 2008
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General/Miscellaneous Reports

Journal Papers, Abstracts, and Commentaries

CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection.
Baker JV, Peng G, Rapkin J, et al
AIDS. 2008 Apr 23;22(7):841-8.
Abstract

Ethnicity, Race, and Gender: Differences in Serious Adverse Events Among Participants in an
Antiretroviral Initiation Trial: Results of CPCRA 058 (FIRST Study).
Tedaldi EM , Absalon J, Thomas AJ , et al
JAIDS 47(4):441-448, April 1, 2008.
Abstract

Syncope as a probable side effect to combination antiretroviral therapy initiated during primary
HIV-1 infection.
Lybaek D, Larsen CS.
Sex Health. 2008 Mar;5(1):69-71.
Abstract

Mild-to-Moderate Symptoms during the First Year of Antiretroviral Therapy Worsen Quality of Life
in HIV-Infected Individuals.
Mannheimer SB, Wold N, Gardner EM, et al
Clin Infect Dis. 2008 Feb 15
Abstract

Adverse events to antiretrovirals in the Swiss HIV Cohort Study: effect on mortality and
treatment modification.
Keiser O, Fellay J, Opravil M, et al.
Antivir Ther. 2007;12(8):1157-64.
Abstract

Ethnicity, Race, and Gender: Differences in Serious Adverse Events Among Participants
in an Antiretroviral Initiation Trial: Results of CPCRA 058 (FIRST Study).
Tedaldi EM, Absalon J, Thomas AJ, et al
J Acquir Immune Defic Syndr. 2007 Dec 20
Abstract

Side effects of HIV therapy.
Esser S, Helbig D, Hillen U, et al
J Dtsch Dermatol Ges. 2007 Sep;5(9):745-754.
Abstract

FULL TEXT PDF ARTICLE
Complications of HIV Disease and Therapy.
Currier JS, Havlir DV.
Top HIV Med. 2007 Apr-May;15(2):40-7.
Paper

Coping with HIV Treatment Side Effects: Conceptualization, Measurement, and Linkages.
Johnson MO, Neilands TB.
AIDS Behav. 2007 Apr 11;
Abstract

Immune Reconstitution Inflammatory Syndrome Presenting as Sinusitis with Inflammatory
Pseudotumor in an HIV-Infected Patient: A Case Report and Review of the Literature.
Chan-Tack KM, Chengappa KS, Wolf JS, et al
AIDS Patient Care STDS. 2006 Dec;20(12):823-8.
Abstract

Impact of Antiretroviral Treatment-Related Toxicities on Hospital Admissions in HIV-Infected
Patients.[Spain}
Nunez MJ, Martin-Carbonero L, Moreno V, et al
AIDS Res Hum Retroviruses. 2006 Sep;22(9):825-9
Abstract

Gender and long-term metabolic toxicities from antiretroviral therapy in HIV-1 infected persons.
Boulassel MR, Morales R, Murphy T, et al
J Med Virol. 2006 Jul 17;78(9):1158-1163
Abstract

High incidence of adverse reactions to initial antiretroviral therapy in Brazil.
Menezes de Padua CA, Cesar CC, et al
Braz J Med Biol Res. 2006 Apr;39(4):495-505.
Abstract

Antiretroviral therapy affects the composition of weight loss in HIV infection: Implications
or clinical nutrition.
Maia BS, Engelson ES, Wang J, Kotler DP.
Clin Nutr. 2005 Aug 9;
Abstract

Identification, management, and prevention of adverse effects associated with
highly active antiretroviral therapy.
Schiller DS.
Am J Health Syst Pharm. 2004 Dec 1;61(23):2507-22.
Abstract

Frequent Reactivation of Herpes Simplex Virus among HIV-1-Infected
Patients Treated with Highly Active Antiretroviral Therapy.
Posavad CM, Wald A, Kuntz S, et al
J Infect Dis. 2004 Aug 15;190(4):693-6.
Abstract

FULL-TEXT PDF ARTICLE
Complications of Antiretroviral Therapies and HIV
Keruly JK
The Hopkins HIV Report, March 2004 Vol 16. No 2
Paper

Adverse effects of antiretroviral therapy for HIV infection.
Montessori V, Press N, Harris M, et al.
CMAJ. 2004 Jan 20; 170(2): 229-38
Abstract

Antiretroviral Therapy-associated Serious and Life-threatening Toxicities.
Pau AK.
Curr Infect Dis Rep. 2003 Oct;5(5):429-438.
Abstract

Conference Reports, Abstracts, and Posters

Is older age a risk factor for antiretroviral toxicities?
C A Sabin, C J Smith, T Hill, et al
(8th Int Congress on Drug Therapy in HIV Infection)
Abstract

Early Clinical Toxicity to Nonnucleoside Reverse Transcriptase Inhibitor-based HAART in a
Home-based AIDS Care Program in Rural Uganda
F Forna, C Liechty, P Solberg, et al
(13 CROI)
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
POSTER
Differences in Adverse Event Profiles in Antiretroviral-Naive Subjects Starting Antiretroviral
Therapy with CD4 Counts <50 Cells/mm³ vs. >200 Cells/mm³:Does Immune Reconstitution
Inflammatory Syndrome (IRIS) Play a Role?
C Fichtenbaum, WC Woodward, T Bykov, et al
(10th EACS)
PDF Poster

Women

Conference Reports, Abstracts, and Posters

Low-grade Symptoms Worsen Quality of Life for HIV-infected Individuals in
Antiretroviral Therapy Clinical Trials
S Mannheimer, J Matts, C Child, et al
(11 CROI)
Abstract

Dyslipidemia, Osteopenia, and Changes in Body Habitus in HIV-infected
Women
ESchoenbaum
(11 CROI)
Abstract

Blood Disorders

Hyperbilirubinemia

Journal Papers, Abstracts, and Commentaries

Gilbert syndrome and the development of antiretroviral therapy-associated
hyperbilirubinemia.
Rotger M, Taffe P, Bleiber G, et al
J Infect Dis. 2005 Oct 15;192(8):1381-6.
Abstract

Hypergammaglobulinaemia

Journal Papers, Abstracts, and Commentaries

The effect of combination antiretroviral therapy on CD5 B- cells, B-cell
activation and hypergammaglobulinaemia in HIV-1-infected patients.
Redgrave BE, Stone SF, French MA, et al
HIV Med. 2005 Sep;6(5):307-12
Abstract

Leukemia

Journal Papers, Abstracts, and Commentaries

Advanced acute myelogenous leukaemia (AML) during HAART-treated HIV disease,
manifesting initially as a thyroid mass.
Manfredi R, Sabbatani S, Chiodo F. et al
Scand J Infect Dis. 2005 Oct;37(10):781-783.
Abstract

Central/Peripheral Nervous System Disorders

Journal Papers, Abstracts, and Commentaries

Fulminant inflammatory leukoencephalopathy associated with HAART-induced
immune restoration in AIDS-related progressive multifocal leukoencephalopathy.
Vendrely A, Bienvenu B, Gasnault J, et al
Acta Neuropathol (Berl). 2005 Mar 1;
Abstract

Cutaneous Disorders

Mycoses
Journal Papers, Abstracts, and Commentaries
	Increased incidence of cutaneous mycoses after HAART initiation: a benign form of immune reconstitution disease? Nacher M, Vantilcke V, Mahamat A, et al AIDS. 2007 Oct;21(16):2248-2250. Abstract

Breast Disorders

Breast Abscess

Journal Papers, Abstracts, and Commentaries

Cryptococcal breast abscess in an HIV-positive patient: Arguments for reviewing the definition
of immune reconstitution inflammatory syndrome.
Haddow LJ, Sahid F, Moosa MY.
J Infect. 2008 Feb 26
Abstract

Gynecomastia

Journal Papers, Abstracts, and Commentaries

Bilateral lipomastia in men: a side effect of highly active antiretroviral therapy.
Deonarain J, Ramdial PK, Singh B.
Int J Surg Pathol. 2008 Apr;16(2):171-5.
Abstract

Gynecomastia in HIV-infected patients receiving antiretroviral therapy.
Garcia-Benayas T, Blanco F, Martin-Carbonero L, et al
AIDS Res Hum Retroviruses. 2003 Sep;19(9):739-41
Abstract

Breast enlargement in 13 men who were seropositive for human
immunodeficiency virus.
Evans DL, Pantanowitz L, Dezube BJ, Aboulafia DM.
Clin Infect Dis. 2002 Nov 1;35(9):1113-9
Abstract

Toxiderma

Journal Papers, Abstracts, and Commentaries

Antiretroviral-induced toxiderma in HIV-infected patients
Caumes E, Bossi P, Katlama C, Bricaire F.
Presse Med. 2003 Sep;32(28):1325-1333.
Abstract

Endocrine Disorders

Thyroid Disorders

Journal Papers, Abstracts, and Commentaries

Thyroid function in human immunodeficiency virus patients treated with highly active
antiretroviral therapy (HAART): a longitudinal study.
Madeddu G, Spanu A, Chessa F, et al
Clin Endocrinol (Oxf). 2006 Apr;64(4):375-83.
Abstract

Sexual Dysfunction

Journal Papers, Abstracts, and Commentaries

Sexual dysfunction in the highly active antiretroviral therapy era.
Collazos J.
AIDS Rev. 2007 Oct-Dec;9(4):237-45.
Abstract

Antiretroviral therapy is associated with sexual dysfunction and with increased
serum oestradiol levels in men.
Lamba H, Goldmeier D, Mackie NE, Scullard G.et al
Int J STD AIDS. 2004 Apr;15(4):234-7.
Abstract

Eye Disorders

Journal Papers, Abstracts, and Commentaries

Emergence of multiple drug-resistant human cytomegalovirus variants in 2
patients with human immunodeficiency virus infection unresponsive to
highly active antiretroviral therapy.
Baldanti F,Paolucci S, Parisi A
Clin Infect Dis 2002 Apr 15;34(8):1146-9
Abstract

Conference Reports, Abstracts, and Posters

CMV-Specific CD4+T Lymphocyte Function in Long-Term Survivors of CMV
Retinitis (CMVR) Receiving HAART.
MA Jacobson, R Schrier, JM McCune, et al.
(8 CROI)
Abstract

Immune Reconstitution Inflammatory Syndrome(IRIS)

Journal Papers, Abstracts, and Commentaries

Immune reconstitution inflammatory syndrome (IRIS).
Wagner AD.
Z Rheumatol. 2008 May 16.
Abstract

Oral manifestations after immune reconstitution in HIV patients on HAART.
Ortega KL, Ceballos-Salobreña A, Gaitán-Cepeda LA, Magalhães MG
Int J STD AIDS. 2008 May;19(5):305-8.
Abstract

Organizing Pneumonia as a Manifestation of Pneumocystis jiroveci Immune Reconstitution
Syndrome in HIV-positive Patients: Report of 2 Cases.
Godoy MC, Silva CI, Ellis J, et al
J Thorac Imaging. 2008 Feb;23(1):39-43
Abstract

Acute Cytomegalovirus Colitis Presenting during Primary HIV Infection: An Unusual Case of an
Immune Reconstitution Inflammatory Syndrome.
Both UV, Laffer R, Grube C, et al
Clin Infect Dis. 2008 Jan 16
Abstract

Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients Receiving Antiretroviral
Therapy : Pathogenesis, Clinical Manifestations and Management.
Dhasmana DJ, Dheda K, Ravn P, et al
Drugs. 2008;68(2):191-208.
Abstract

Immune reconstitution inflammatory syndrome: risk factors and treatment implications.
Manabe YC, Campbell JD, Sydnor E, Moore RD.
J Acquir Immune Defic Syndr. 2007 Dec 1;46(4):456-62.
Abstract

Liver Enzymes Elevation and Immune Reconstitution Among Treatment-Naïve
HIV-Infected Patients Instituting Antiretroviral Therapy.
Ofotokun I, Smithson SE, Lu C, et al
Am J Med Sci. 2007 Nov;334(5):334-341
Abstract

FULL TEXT PDF ARTICLE
Oral cavity lymphoma as secondary AIDS-defining neoplasm in a patient on HAART
with immune reconstitution.
Corti M, Solari R, Cangelosi D, De Carolis L, et al
Rev Soc Bras Med Trop. 2007 Oct;40(5):582-584.
Paper

Thoracic Manifestations of Immune Restoration Syndromes in AIDS.
Haramati LB, Jenny-Avital ER, Alterman DD.
J Thorac Imaging. 2007 Aug;22(3):213-220
Abstract

Case report: immune reconstitution inflammatory syndrome associated with disseminated
mycobacterial infection in patients with AIDS.
Tuon FF, Mulatti GC, Pinto WP,et akl
AIDS Patient Care STDS. 2007 Aug;21(8):527-32
Abstract

Herpes zoster infection as an immune reconstitution inflammatory syndrome in
HIV-seropositive subjects: A review.
Feller L, Wood NH, Lemmer J.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jun 27;
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
FULL-TEXT PDF ARTICLE
Immune reconstitution inflammatory syndrome (IRIS): Review of common infectious
manifestations and treatment options.
Murdoch DM, Venter WD, Van Rie A, Feldman C.
AIDS Res Ther. 2007 May 8;4(1):9
Paper

Immune reconstitution syndrome in a patient with AIDS with paradoxically deteriorating
brain tuberculoma.
Lee CH, Lui CC, Liu JW.
AIDS Patient Care STDS. 2007 Apr;21(4):234-9.
Abstract

Disorders of Immune Reconstitution in Patients with HIV Infection Responding to
Antiretroviral Therapy
French MA.
Curr HIV/AIDS Rep. 2007 Feb;4(1):16-21.
Abstract

A case of tuberculosis showing immune reconstitution syndrome after the initiation of
antiretroviral therapy for HIV infection
Taniguchi H, Izumi S.
Kekkaku. 2007 Jan;82(1):27-31.
Abstract

Montelukast in the treatment of HIV associated immune reconstitution disease.
Hardwick C, White D, Morris E, et al
Sex Transm Infect. 2006 Dec;82(6):513-4.
Abstract

Immune reconstitution inflammatory syndrome associated with PML in AIDS: a
treatable disorder
Martinez JV, Mazziotti JV, Efron ED. et al
Neurology. 2006 Nov 14;67(9):1692-4
Abstract

Immune Reconstitution Syndrome in HIV: Validating a Case Definition and Identifying
Clinical Predictors in Persons Initiating Antiretroviral Therapy.
Robertson J, Meier M, Wall J, Ying J, Fichtenbaum CJ.
Clin Infect Dis. 2006 Jun 1;42(11):1639-4
Abstract

Immune reconstitution inflammatory syndromes: what's new?
Crum-Cianflone NF.
S Read. 2006 Apr;16(4):199-206, 213,
Abstract

Disseminate and fatal cytomegalovirus disease with thymitis in a naive HIV-patient
after early initiation of HAART: Immune restoration disease?
Gutierrez S, Alconchel S, Ruiz-Mateos E, et al
Clin Virol. 2006 Feb 13;
Abstract

Immune reconstitution inflammatory syndrome in HIV.
Lipman M, Breen R.
Curr Opin Infect Dis. 2006 Feb;19(1):20-5.
Abstract

Immune reconstitution inflammatory syndrome: more answers, more questions.
Shelburne SA, Montes M, Hamill RJ.
J Antimicrob Chemother. 2005 Dec 14;
Abstract

Tegumentary leishmaniasis as a manifestation of immune reconstitution inflammatory
syndrome in 2 patients with AIDS.
Posada-Vergara MP, Lindoso JA, Tolezano JE
J Infect Dis. 2005 Nov 15;192(10):1819-22.
Abstract

Recrudescent Kaposi's sarcoma after initiation of HAART: a manifestation of immune
reconstitution syndrome.
Leidner RS, Aboulafia DM.
AIDS Patient Care STDS. 2005 Oct;19(10):635-44.
Abstract

Dermatologic manifestations associated with immune reconstitution syndrome in HIV+
patients starting HAART: a retrospective study in French Guiana
Sarazin E, Nacher M, Toure Y, et al
Bull Soc Pathol Exot. 2005 Sep;98(3):187-92
Abstract

Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma.
Bower M, Nelson M, Young AM, Thirlwell C
J Clin Oncol. 2005 Aug 1;23(22):5224-8.
Abstract

Chronic vulval ulceration--another immune reconstitution inflammatory syndrome?
Reddy V, Luzzi GA.
Int J STD AIDS. 2005 Jun;16(6):454-5.
Abstract

Raised intracranial pressure complicating cryptococcal meningitis: immune reconstitution
inflammatory syndrome or recurrent cryptococcal disease?
York J, Bodi I, Reeves I, Riordan-Eva P, Easterbrook PJ.
J Infect. 2005 Aug;51(2):165-71.
Abstract

Incidence and risk factors of immune reconstitution inflammatory syndrome complicating
HIV-associated cryptococcosis in France.
Lortholary O, Fontanet A, Memain N
AIDS. 2005 Jul 1;19(10):1043-9.
Abstract

Immune reconstitution syndromes secondary to effective antiretroviral therapy
Knysz B, Rogowska-Szadkowska D, Gasiorowski J, Gladysz A.
Postepy Hig Med Dosw (Online). 2005 May 6;59:180-7.
Abstract

Clinical characteristics of IRIS syndrome in patients with HIV and tuberculosis.
Michailidis C, Pozniak AL, Mandalia S, et al
Antivir Ther. 2005;10(3):417-22.
Abstract

Incidence and risk factors for immune reconstitution inflammatory syndrome during highly
active antiretroviral therapy.
Shelburne SA, Visnegarwala F, Darcourt J,
AIDS. 2005 Mar 4;19(4):399-406.
Abstract

Immune reconstitution syndrome.
Cheonis N.
BETA. 2005 Winter;17(2):12-5.
Abstract

Illness of Immune Reconstitution: Recognition and Management
Gardner EM, Connick E.
Curr Infect Dis Rep. 2004 Dec;6(6):483-493.
Abstract

Adverse events of desirable gain in immunocompetence: the Immune Restoration
Inflammatory Syndromes
Stoll M, Schmidt RE.
Autoimmun Rev. 2004 Jun;3(4):243-9.
Abstract

Immune Restoration Inflammatory Syndromes: The Dark Side of Successful
Antiretroviral Treatment.
Stoll M, Schmidt RE.
Curr Infect Dis Rep 2003 Jun;5(3):266-276
Abstract

Mental Health Disorders

Journal Papers, Abstracts, and Commentaries