Adherence Contributing Factors

Medical Advocates
ARV/HAART

Contributing Adherence Factors

General Reports                            Smoking
Drug Regimen                                Race
Physician/Patient Relationship      Gender
Community Support                   Age
Mental Health
Cognitive Dysfunction
Patient Perceptions
Alcohol Use/Abuse
Substance Use
High-Risk Behaviors
Fatigue
Sleep

Adherence Main Page Main New/Newsworthy Home Page

Last Update: October 16, 2008
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General Reports

     Journal Papers, Abstracts, and Commentaries

Relationship of race-, sexual orientation-, and HIV-related discrimination with adherence to HIV treatment:
a pilot study.
Boarts JM, Bogart LM, Tabak MA, et al
J Behav Med. 2008 Aug 23.
Abstract

Gender and Other Psychosocial Factors as Predictors of Adherence to Highly Active Antiretroviral
Therapy (HAART) in Adults with Comorbid HIV/AIDS, Psychiatric and Substance-related Disorder.
Applebaum AJ, Richardson MA, Brady SM, et al
AIDS Behav. 2008 Aug 9.
Abstract

Association Between Living With Children and Adherence to Highly Active Antiretroviral Therapy
in the Women's Interagency HIV Study.
Merenstein DJ, Schneider MF, Cox C, et al
Pediatrics. 2008 Apr;121(4):e787-93.
Abstract

Self-reported non-adherence to antiretroviral therapy repeatedly assessed by two questions
predicts treatment failure in virologically suppressed patients.
Glass TR, De Geest S, Hirschel B, et al
Antivir Ther. 2008;13(1):77-85.
Abstract

Influence of Prior Antiretroviral Experience on Adherence and Responses to New Highly
Active Antiretroviral Therapy Regimens.
Horberg M, Silverberg M, Hurley L, et al
AIDS Patient Care STDS. 2008 Mar 13
Abstract

Socioeconomic status (SES) as a determinant of adherence to treatment in HIV infected
patients: a systematic review of the literature.
Falagas ME, Zarkadoulia EA, Pliatsika PA, Panos G.
Retrovirology. 2008 Feb 1;5(1):13
Abstract

Psychosocial predictors of medication adherence among persons living with HIV.
Gauchet A, Tarquinio C, Fischer G.
Int J Behav Med. 2007;14(3):141-50
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
FULL TEXT ARTICLE
Patient and regimen characteristics associated with self-reported nonadherence to
antiretroviral therapy
Sullivan PS, Campsmith ML, Nakamura GV, et al
PLoS ONE. 2007 Jun 20;2:e552.
Paper

The phenomenon of missing doses in a cohort of HIV patients with good adherence to highly
active antiretroviral therapy.
Lee SS, Ma K, Chu EK, Wong KH.
Int J STD AIDS. 2007 Mar;18(3):167-70.
Abstract

HIV Treatment Adherence and Sexual Functioning.
Miguez-Burbano MJ, Espinoza L, Lewis JE.
AIDS Behav. 2007 Feb 13;
Abstract

Factors Associated with Suboptimal Antiretroviral Therapy Adherence to Dose, Schedule,
and Dietary Instructions.
Nilsson Schonnesson L, Williams ML, Ross MW, et al
AIDS Behav. 2006 Aug 23;
Abstract

Correlates and predictors of adherence to highly active antiretroviral therapy: overview of
published literature.
Ammassari A, Trotta MP, Murri R
J Acquir Immune Defic Syndr 2002 Dec 15;31 Suppl 3:S123-7
Abstract

Factors predicting lack of adherence to highly active antiretroviral treatment
Martin-Sanchez V, Ortega-Valin L, Perez-Simon Mdel R, et al
Enferm Infecc Microbiol Clin 2002 Dec;20(10):491-7
Abstract
A prospective study of predictors of adherence to combination antiretroviral medication.
Golin CE, Liu H, Hays RD, et al.
J Gen Intern Med 2002 Oct;17(10):756-65
Abstract
Human immunodeficiency virus infection unresponsive to highly active antiretroviral
therapy: denial of poor medication adherence or recalcitrant infection?
Miller LG, Chang ES.
AIDS Patient Care STDS 2002 Aug;16(8):355-9
Abstract
Detection and documentation of actual and potential medication adherence problems in
patients receiving combination therapies.
van Servellen G, Johiro AK, Tichacek MJ.
Assoc Nurses AIDS Care 2002 Jul-Aug;13(4):64-77
Abstract
Individual and system level factors associated with treatment nonadherence
in human immunodeficiency virus-infected men and women.
van Servellen G, Chang B, Garcia L, Lombardi E.
AIDS Patient Care STDS 2002 Jun;16(6):269-81
Abstract
Understanding the psychodynamics of non-adherence to medical treatment in
persons with HIV infetion.
Ricart F, Cohen MA, Alfonso CA, et al
Gen Hosp Psychiatry 2002 May-Jun;24(3):176-80
Abstract

     Conference Reports, Abstracts, and Posters

Influence of the frequency in the medication collection on adherence to antiretroviral
therapy of HIV+ patients
J A Mu�oz-Moreno, C R Fumaz, et al
(15IAC)
Abstract

Effect of life style and medical contraindications on viral load, CD4 count and adherence
RM Grimes, L Lal, RM Grimes
(15IAC)
Abstract

Drug Regimen



General

     Journal Papers, Abstracts, and Commentaries

The Relationship Between Resistance and Adherence in Drug-Naive Individuals Initiating HAART Is
Specific to Individual Drug Classes
Tam LW, Chui CK, Brumme CJ, et al
J Acquir Immune Defic Syndr. 2008 Oct 3
Abstract

Fixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis.
Bangalore S, Kamalakkannan G, Parkar S, Messerli FH.
Am J Med. 2007 Aug;120(8):713-719.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
FULL TEXT ARTICLE
Patient and regimen characteristics associated with self-reported nonadherence to
antiretroviral therapy
Sullivan PS, Campsmith ML, Nakamura GV, et al
PLoS ONE. 2007 Jun 20;2:e552.
Paper

Treatment-related factors and highly active antiretroviral therapy adherence.
Trotta MP, Ammassari A, Melzi S, et al
J Acquir Immune Defic Syndr 2002 Dec 15;31 Suppl 3:S128-31
Abstract

Medication adherence among HIV+ adults: effects of cognitive dysfunction and regimen
complexity.
Hinkin CH, Castellon SA, Durvasula RS, et al
Neurology 2002 Dec 24;59(12):1944-50
Abstract

Simpler regimens may enhance adherence to antiretrovirals in HIV-infected patients.
Maggiolo F, Ripamonti D, Arici C, Gregis G, et al
HIV Clin Trials 2002 Sep-Oct;3(5):371-8
Abstract

Adherence to antiretroviral therapy measured by pill count and drug serum
concentrations. Variables associated with a bad adherence
Riera M, La Fuente Ld L, Castanyer B, et al.
Med Clin (Barc) 2002 Sep 14;119(8):286-92
Abstract

HIV resistance and tolerability issues in antiretroviral therapy.
Idemyor V.
J Natl Med Assoc 2001 Apr;93(4):151-3
Abstract

Protease Inhibitor Regimens
     Journal Papers, Abstracts, and Commentaries

Regimen-dependent variations in adherence to therapy and virological suppression in
patients initiating protease inhibitor-based highly active antiretroviral therapy.
Moore DM, Hogg RS, Yip B, et al
HIV Med. 2006 Jul;7(5):311-6.
Abstract

Simplification

     Conference Reports, Abstracts, and Posters

Improved treatment adherence associated with treatment simplification
Baker D, Vale R, Doong N, et al
(4th IAS Conference)
Abstract

Once Daily Regimens

     Conference Reports, Abstracts, and Posters

Impact of a once-daily antiretroviral regimen on quality of life and adherence to treatment
of HIV infected patients with viral load suppression
JA Mu�oz-Moreno, C R Fumaz
(15IAC)
Abstract

Efficacy, safety, adherence and pharmacokinetics of the simplification to a once daily
regimen with NNRTIs in patients previously receiving antiretroviral therapy twice daily.
L Casado, J Moya, A Marin, et al
(15IAC)
Abstract

Physician/Patient Relationship



          Journal Papers, Abstracts, and Commentaries

Gender differences in factors associated with adherence to antiretroviral therapy.
Berg KM, Demas PA, Howard AA, et al
J Gen Intern Med. 2004 Nov;19(11):1111-7.
Abstract

     Conference Reports, Abstracts, and Posters

Paradoxical effects of provider emphasis on adherence to highly active antiretroviral therapy
(HAART)
T Tugenberg, M A Wyatt, N C Ware, et al
(15IAC)
Abstract

Community Support



     Conference Reports, Abstracts, and Posters

Social network approaches to HIV prevention and ARV adherence intervention: Social
contextual considerations for more effective community-based intervention
A R Knowlton, C A Latkin
(15IAC)
Abstract

The role of social support in adherence services: The client's perspective
L Weiss, M Waters, J Netherland, et al
(15IAC)
Abstract

Mental Health



     Journal Papers, Abstracts, and Commentaries

Anxiety and Depression Symptoms as Risk Factors for Non-adherence to Antiretroviral Therapy
in Brazil.
Campos LN, Guimar�es MD, Remien RH.
AIDS Behav. 2008 Jul 22.
Abstract

The Relationship of Post-traumatic Stress Disorder and Depression to Antiretroviral Medication
Adherence in Persons with HIV.
Vranceanu AM, Safren SA, Lu M, et al
AIDS Patient Care STDS. 2008 Mar 13
Abstract

Life Stress and Adherence to Antiretroviral Therapy among HIV-Positive Individuals: A
Preliminary Investigation.
Bottonari KA, Roberts JE, Ciesla JA, Hewitt RG.
AIDS Patient Care STDS. 2005 Nov;19(11):719-27.
Abstract

Depressive Symptoms, Neurocognitive Impairment, and Adherence to Highly Active
Antiretroviral Therapy Among HIV-Infected Persons.
Ammassari A, Antinori A, Aloisi MS, et al
Psychosomatics. 2004 Sep-Oct;45(5):394-402.
Abstract

Posttraumatic stress disorder symptoms, salivary cortisol, medication adherence,
and CD4 levels in HIV-positive individuals.
L Delahanty D, M Bogart L, L Figler J.
AIDS Care. 2004 Apr;16(2):247-60.
Abstract

The impact of psychiatric symptoms, drug use, and medication regimen on
non-adherence to HIV treatment.
Ingersoll K.
AIDS Care. 2004 Apr;16(2):199-211.
Abstract

Substance use and mental health correlates of nonadherence to antiretroviral
medications in a sample of patients with human immunodeficiency virus infection.
Tucker JS, Burnam MA, Sherbourne CD, et al.
Am J Med 2003 May;114(7):573-80
Abstract

Depression is a risk factor for suboptimal adherence to highly active antiretroviral
therapy.
Starace F, Ammassari A, Trotta MP, et al
J Acquir Immune Defic Syndr 2002 Dec 15;31 Suppl 3:S136-9
Abstract

Psychiatric morbidity and adherence to antiretroviral medication in patients with
HIV/AIDS.
Sternhell PS, Corr MJ.
Aust N Z J Psychiatry 2002 Aug;36(4):528-33
Abstract

         Conference Reports, Abstracts, and Posters

Depression, non-adherence and clinical progression in HIV infected drug
users treated with Highly Active Antiretroviral therapy
A D Bouhnik, M P Carrieri, E Vincent, et al
(15IAC)
Abstract

Cognitive Dysfunction



     Journal Papers, Abstracts, and Commentaries

Medication adherence among HIV+ adults: effects of cognitive dysfunction and regimen
complexity.
Hinkin CH, Castellon SA, Durvasula RS, et al
Neurology 2002 Dec 24;59(12):1944-50
Abstract

Alcohol Use/Abuse



     Journal Papers, Abstracts, and Commentaries

Adjusting Alcohol Quantity for Mean Consumption and Intoxication Threshold Improves Prediction of Nonadherence in
HIV Patients and HIV-Negative Controls.
Braithwaite RS, Conigliaro J, McGinnis KA, et al
Alcohol Clin Exp Res. 2008 Jun 20.
Abstract

Alcohol Consumption and Antiretroviral Adherence Among HIV-Infected Persons
With Alcohol Problems.
Samet JH, Horton NJ, Meli S, et al
Alcohol Clin Exp Res. 2004 Apr;28(4):572-577
Abstract

Substance Use



     Journal Papers, Abstracts, and Commentaries

The impact of illicit drug use and substance abuse treatment on adherence to HAART.
Hicks PL, Mulvey KP, Chander G, et al
AIDS Care. 2007 Oct;19(9):1134-40.
Abstract

The impact of psychiatric symptoms, drug use, and medication regimen on non-adherence
to HIV treatment.
Ingersoll K.
AIDS Care. 2004 Apr;16(2):199-211.
Abstract

Substance use and mental health correlates of nonadherence to antiretroviral
medications in a sample of patients with human immunodeficiency virus infection.
Tucker JS, Burnam MA, Sherbourne CD, et al.
Am J Med 2003 May;114(7):573-80
Abstract

Association of social stress, illicit drug use, and health beliefs with nonadherence to
antiretroviral therapy.
Gebo KA, Keruly J, Moore RD.
J Gen Intern Med 2003 Feb;18(2):104-11
Abstract

Smoking



     Journal Papers, Abstracts, and Commentaries

A WEEK IN REVIEW FEATURED REPORT
Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals
receiving highly active antiretroviral therapy.
Shuter J, Bernstein SL.
Nicotine Tob Res. 2008 Apr;10(4):731-6.
Abstract

Patient Perceptions



     Journal Papers, Abstracts, and Commentaries

Factors Influencing Medication Adherence Beliefs and Self-Efficacy in Persons Naive to
Antiretroviral Therapy: A Multicenter, Cross-Sectional Study.
Reynolds NR, Testa MA, Marc LG, et al
AIDS Behav. 2004 Jun;8(2):141-150.
Abstract

     Conference Reports, Abstracts, and Posters

Subjective beliefs about health status and health care providers significantly predict adherence
to anti-retroviral medications
R L Wald, L R Temoshok
(15IAC)
Abstract

High-Risk Behaviors



           Journal Papers, Abstracts, and Commentaries

Use of and Adherence to Antiretroviral Therapy Is Associated With Decreased Sexual Risk
Behavior in HIV Clinic Patients.
Diamond C, Richardson JL, Milam J, et al
J Acquir Immune Defic Syndr. 2005 Jun 1;39(2):211-218
Abstract

HIV treatment adherence and unprotected sex practices in people receiving antiretroviral
therapy.
Kalichman SC, Rompa D.
Sex Transm Infect 2003 Feb;79(1):59-61
Abstract

    Conference Reports, Abstracts, and Poster

Risky sexual behaviors and non-adherence to HAART: evidence from a large
representative sample of outpatients attending French hospitals (VESPA/
ANRS 2003)
P M Peretti-Watel, B Spire, et al
(15IAC)
Abstract

POSTER
Association between Unprotected Sex and Antiretroviral Use and Adherence in HIV Clinic
Patients
C Diamond, JL Richardson, J Milam, et al
{11 CROI}
PDF Poster       Abstract

Fatigue



     Conference Reports, Abstracts, and Poster

Impact of fatigue on daily activites and adherence to ARV medications
G Voss, I B Corless, P K Nicholas, et al
(15IAC)
Abstract

Sleep



     Journal Papers, Abstracts, and Commentaries

Sleep Disturbance and Depression as Barriers to Adherence.
Phillips KD, Moneyham L, Murdaugh C, et al
Clin Nurs Res. 2005 Aug;14(3):273-293.
Abstract

Age



     Journal Papers, Abstracts, and Commentaries

Young HIV-infected adults are at greater risk for medication nonadherence.
Becker SL, Dezii CM, Burtcel B, et al
MedGenMed 2002 Jul 30;4(3):21
Abstract

     Conference Reports, Abstracts, and Poster

The impact of age on medication adherence in HIV infection: A longitudinal
investigation
T R Barclay, S A Castellon, D Hardy, et al
(15IAC)
Abstract

Race



     Journal Papers, Abstracts, and Commentaries

Patient-perceived barriers to antiretroviral adherence: associations with race.
Ferguson TF, Stewart KE, Funkhouser E, et al.
AIDS Care 2002 Oct;14(5):607-17
Abstract

Gender



          Journal Papers, Abstracts, and Commentaries

Gender differences in factors associated with adherence to antiretroviral therapy.
Berg KM, Demas PA, Howard AA, et al
J Gen Intern Med. 2004 Nov;19(11):1111-7.
Abstract

Home Visits

Journal Papers, Abstracts, and Commentaries

Home Visits to Improve Adherence to Highly Active Antiretroviral Therapy: A Randomized
Controlled Trial.
Williams AB, Fennie KP, Bova CA
J Acquir Immune Defic Syndr. 2006 Jun 7;
Abstract

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Adherence: Contributing Factors