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ARV/HAART
  Adherence
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Last Update:  May 15, 2012
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New and Noteworthy
     
May 2012
 
General Reports
    
           Journal Papers, Abstracts, and Commentaries
 
 
Correlates of Antiretroviral and Antidepressant Adherence Among Depressed HIV-Infected Patients.
 Bottonari KA, Tripathi SP, Fortney JC, et al
AIDS Patient Care STDS. 2012 May;26(5):265-73
 Abstract

The clinical interpretation of viral blips in HIV patients receiving antiviral treatment: are we ready
to infer poor adherence?
 Chun-Hai Fung I, Gambhir M, van Sighem A,  et al
J Acquir Immune Defic Syndr. 2012 Jan 19.
 Abstract

Problems taking pills: understanding HIV medication adherence from a new perspective.
 Okonsky JG.
AIDS Care. 2011 Jun 28.
 Abstract

Levels of Adherence Required for Virologic Suppression Among Newer Antiretroviral
Medications (March).
 Kobin AB, Sheth NU.
 Ann Pharmacother. 2011 Mar 8
 Abstract

Antiretroviral adherence program in HIV patients: a feasibility study in the
Swiss HIV Cohort Study.
 Krummenacher I, Cavassini M, Bugnon O,  et al
Pharm World Sci. 2010 Sep 23
 Abstract

FULL-TEXT ARTICLE
 Early Adherence to Antiretroviral Medication as a Predictor of Long-Term HIV
Virological Suppression: Five-Year Follow Up of an Observational Cohort.
Ford N, Darder M, Spelman T,  et al
PLoS One. 2010 May 5;5(5):e10460.
 Paper

Adherence to Antiretroviral Therapy and HIV Transmission Risks:
Implications for Test-and-Treat Approaches to HIV Prevention.
Kalichman SC, Cherry C, Amaral CM, et al
AIDS Patient Care STDS. 2010 May 3.
 Abstract

Standard Care Impact on Effects of Highly Active Antiretroviral Therapy
Adherence Interventions: A Meta-analysis of Randomized Controlled Trials.
 de Bruin M, Viechtbauer W, Schaalma HP, et al 
Arch Intern Med. 2010 Feb 8;
 Abstract

FULL-TEXT PDF ARTICLE
 Modelling imperfect adherence to HIV induction therapy
Miran RE.Smith RJ
BMC Infectious Diseases 2010, 10:6
 Paper

FULL-TEXT ARTICLE
 The risk of virologic failure decreases with duration of HIV suppression, at greater than 50%
adherence to antiretroviral therapy.
 Rosenblum M, Deeks SG, van der Laan M, Bangsberg DR.
PLoS One. 2009 Sep 29;4(9):e7196
 Paper

Simplification and First Validation of a Short Battery of Patient Questionnaires for Clinical Management
of HIV-Infected Patients: The HIV-SQUAD (Symptom Quality of life Adherence) Questionnaire(R).
 Spire, Arnould, Barbier, Durant, Gilquin, Landman, et al
HIV Clin Trials. 2009 Jul-Aug;10(4):215-32.
 Abstract

An alternative methodology for the prediction of adherence to anti HIV treatment.
Thompson IR, Bidgood P, Petroczi A, et al 
AIDS Res Ther. 2009 Jun 1;6(1):9.
 Abstract

Development and Efficacy of an Intervention to Enhance Readiness for Adherence among Adults
Who Had Previously Failed HIV Treatment.
 Enriquez M, Cheng AL, McKinsey DS, Stanford J.
AIDS Patient Care STDS. 2009 Feb 3.
Abstract

Relationship between Adherence Level, Type of the Antiretroviral Regimen, and Plasma HIV Type 1
RNA Viral Load: A Prospective Cohort Study.
Martin M, Del Cacho E, Codina C, et al
AIDS Res Hum Retroviruses. 2008 Oct 6.
 Abstract
 
FULL TEXT ARTICLE
 Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults
on antiretroviral therapy.
Bisson GP, Gross R, Bellamy S, et al
PLoS Med. 2008 May 20;5(5):e109.
Paper
 
Self-Reported Sexual Dysfunction Is Frequent Among HIV-Infected Persons and Is Associated
with Suboptimal Adherence to Antiretrovirals.
Trotta MP, Ammassari A, Murri R, et al
AIDS Patient Care STDS. 2008 Apr;22(4):291-299.
 Abstract
 
Differential adherence to combination antiretroviral therapy is associated with virological
failure with resistance.
 Gardner EM, Sharma S, Peng G, et al
AIDS. 2008 Jan 2;22(1):75-82
 Abstract
 
Experiences and perceptions of patients with 100% adherence to highly active antiretroviral
therapy: a qualitative study.
 Sidat M, Fairley C, Grierson J
AIDS Patient Care STDS. 2007 Jul;21(7):509-20
 Abstract
 
The Role of Adherence to Antiretroviral Therapy in the Management of HIV Infection.
 Conway B.
J Acquir Immune Defic Syndr. 2007 Jun 1;45 Suppl 1:S14-8.
 Abstract
 
Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic
outcomes.
 Nachega JB, Hislop M, Dowdy DW, et al
Ann Intern Med. 2007 Apr 17;146(8):564-73
 74 Abstract
 
Adherence and plasma drug concentrations are predictors of confirmed virologic response after
24-week salvage highly active antiretroviral therapy.
Quiros-Roldan E, Torti C, et al
AIDS Patient Care STDS. 2007 Feb;21(2):92-9.
 Abstract
 
Outcomes of a Multifaceted Medication Adherence Intervention for HIV-Positive Patients.
 Dieckhaus KD, Odesina V
AIDS Patient Care STDS. 2007 Feb;21(2):81-91.
 Abstract
 
Optimal drug treatment regimens for HIV depend on adherence.
Krakovska O, Wahl LM.
J Theor Biol. 2007 Jan 23;
Abstract
 
Medication Adherence and Sexual Risk Behavior among HIV-Infected Adults: Implications
for Transmission of Resistant Virus.
 Remien RH, Exner TM, Morin SF, et al 
AIDS Behav. 2007 Jan 23;
 Abstract
 
The Elusive Gold Standard: Future Perspectives for HIV Adherence Assessment and
Intervention.
 Chesney MA.  
J Acquir Immune Defic Syndr. 2006 Dec;43 Suppl 1:S149-55.
 Abstract
 
Moving From Theory to Research to Practice: Implementing an Effective Dyadic Intervention
to Improve Antiretroviral Adherence for Clinic Patients.
 Remien RH, Stirratt MJ, Dognin J, et al
J Acquir Immune Defic Syndr. 2006 Dec 1;43 Suppl 1:S69-S78
Abstract
 
Self-Report Measures of Antiretroviral Therapy Adherence: A Review with Recommendations
for HIV Research and Clinical Management.
 Simoni JM, Kurth AE, Pearson CR, et al 
AIDS Behav. 2006 Jun 3;
 Abstract
 
Becoming a "Treatment Success": What Helps and What Hinders Patients from Achieving
and Sustaining Undetectable Viral Loads.
 Alfonso V, Geller J, Bermbach N, et al
AIDS Patient Care STDS. 2006 May;20(5):326-334.
 Abstract
 
Paradoxical Effects of Clinician Emphasis on Adherence to Combination Antiretroviral
Therapy for HIV/AIDS.
 Tugenberg T, Ware NC, Wyatt MA. 
AIDS Patient Care STDS. 2006 Apr;20(4):269-74
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
FULL-TEXT ARTICLE
 Adherence to Antiretroviral Therapy: Merging the Clinical and Social Course of AIDS
 Castro A 
PLoS Medicine  Vol 2, Issue 11,Nov 2005 
Paper
 
Modelling the association between adherence and viral load in HIV-infected patients.
 Vrijens B, Goetghebeur E, de Klerk E, et al 
Stat Med. 2005 Aug 24;24(17):2719-2731
Abstract
 
Similar adherence rates favor different virologic outcomes for patients treated with
nonnucleoside analogues or protease inhibitors.
 Maggiolo F, Ravasio L, Ripamonti D, et al 
Clin Infect Dis. 2005 Jan 1;40(1):158-63.
 Abstract
 
British HIV Association (BHIVA)/British Association for Sexual Health and HIV (BASHH)
guidelines on provision of adherence support to individuals receiving antiretroviral therapy
(2003).
 Poppa A, Davidson O, Deutsch J, et al 
HIV Med. 2004 Jul;5 Suppl 2:46-60
 Abstract
 
Perspectives on Adherence and Simplicity for HIV-Infected Patients on Antiretroviral
Therapy: Self-Report of the Relative Importance of Multiple Attributes of Highly Active
Antiretroviral Therapy (HAART) Regimens in Predicting Adherence.
Stone VE, Jordan J, Tolson J, Miller R, Pilon T.
J Acquir Immune Defic Syndr. 2004 Jul 1;36(3):808-816.
 Abstract
 
The Impact of Adherence on CD4 Cell Count Responses Among HIV-Infected Patients.
 Wood E, Hogg RS, Yip B, et al 
J Acquir Immune Defic Syndr. 2004 Apr 12;35(3):261-268.
 Abstract
 
No Evidence of an Association between Transient HIV Viremia ("Blips") and Lower
Adherence  to the Antiretroviral Medication Regimen.
 Miller LG, Golin CE, Liu H, et al 
Infect Dis. 2004 Apr 15;189(8):1487-96.
 Abstract
 
FULL-TEXT ARTICLE
 Effect of Medication Adherence on Survival of HIV-Infected Adults Who Start Highly Active
Antiretroviral Therapy When the CD4+ Cell Count Is 0.200 to 0.350 x 109 cells/L.
 Wood E, Hogg RS, Yip B, Harrigan PR, et al 
Ann Intern Med. 2003 Nov 18;139(10):810-6.
Abstract

Adherence to Antiretroviral Therapy and Persistence of HIV RNA in Semen.
 Barroso PF, Schechter M, Gupta P, et al.
J Acquir Immune Defic Syndr 2003 Apr 1;32(4):435-40
 Abstract

HIV/AIDS medication adherence factors: inner-city clinic patient's self-reports.
 Graney MJ, Bunting SM, Russell CK.
Tenn Med 2003 Feb;96(2):73-8
Abstract

Chronic disease self-management and adherence to HIV medications.
 Gifford AL, Groessl EJ.
 J Acquir Immune Defic Syndr 2002 Dec 15;31 Suppl 3:S163-6
 Abstract
 
Adherence to antiretroviral therapy among patients with HIV: a critical link between
behavioral and biomedical sciences.
 Ickovics JR, Meade CS.
J Acquir Immune Defic Syndr 2002 Dec 15;31 Suppl 3:S98-102
 Abstract
 
Adherence, resistance, and timing: current issues in the use of new therapies.
 Volberding P.
 AIDS Read 2002 Aug;12(8):349-50, 356-7, 368
 Abstract
 
Adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients:
from a predictive to a dynamic approach.
 Spire B, Duran S, Souville M, et al.
 Soc Sci Med 2002 May;54(10):1481-96
 Abstract
 
Impact of adherence on duration of virological suppression among patients receiving
combination antiretroviral therapy.
Raboud JM, Harris M, Rae S, Montaner JS.
 HIV Med 2002 Apr;3(2):118-24
 Abstract
 
Adherence to antiretroviral therapy by human immunodeficiency virus-infected patients.
Turner BJ.
 J Infect Dis 2002 May 15;185 Suppl 2:S143-51
 Abstract
 
Nonadherence to highly active antiretroviral therapy: clinically relevant patient categorization
based on electronic event monitoring.
Van Wijngaerden E, De Saar V, De Graeve V, et al
 AIDS Res Hum Retroviruses 2002 Mar 20;18(5):327-30
 Abstract
 
Patient adherence to HIV medication regimens: a review of published and abstract reports.
 Fogarty L, Roter D, Larson S, et al
 Patient Educ Couns 2002 Feb;46(2):93-108
 Abstract
 
Correlates of adherence to combination antiretroviral therapy among members of HIV-
positive mixed status couples.
 Wagner GJ, Remien RH, Carballo-Dieguez A, Dolezal C.
 AIDS Care 2002 Feb;14(1):105-9
 Abstract
 

 
         Conference Reports, Abstracts, and Posters
 
 
POSTER
 The Risk of Virologic Failure Decreases with Duration of Continuous Viral Suppression, for
Adherence Levels >50%
M Rosenblum, S Deeks, M Van Der Laan,  D Bangsberg 
(16 CROI)
PDF Poster     Abstract
 
POSTER
 Analysis of the Relationship between Antiretroviral Medication Adherence and Class-specific
Resistance in a Large Prospective Randomized Clinical Trial
 E Gardner, G Pen, E Telzak, et al
(15th CROI)
 PDF Poster    Abstract
 
Antiretroviral (ART) adherence (adh) evaluation in large populations: is it necessary to assess
adherence using more than one method?
Elias L, Pérez Elías MJ, Rodriguez Sagrado MA, et al
(4th IAS Conference)
 Abstract
 
Travelling with ART (Antiretroviral Therapy
 CC Smith
[8th Int Congress on Drug Therapy in HIV Infection]
 Abstract
 
Adherence to HAART assessed by pharmacy refill data: influence in virological and
immunological response
 AC Ventura, JB Pires, A Madalena , et al
 [8th Int Congress on Drug Therapy in HIV Infection]
 Abstract
 
Adults with perinatally acquired HIV-1 infection: adherence, resistance and disease monitoring
 C Foster, S Portsmouth, S McDonald, et al
 [8th Int Congress on Drug Therapy in HIV Infection]
 Abstract

Use of Bilirubin as a Surrogate Marker of Medication Adherence to Atazanavir-based ART
 K Petersen, B Hale, L Jones, et al
 (12 CROI)
 Abstract

Pharmacodynamics of Antiretroviral Agents in HIV-1-infected Patients Using Viral
Dynamic Models with Consideration of Drug Susceptibility and Adherence
 H Wu, Y Huang, E Acosta, et al
 (12 CROI)
 Abstract
 
  Sustained benefit from a long-term antiretroviral (AR) adherence intervention:
Results of a large randomized clinical trial
S Mannheimer, E Morse, J Matts, et al
 (15IAC)
 Abstract
 
Longer term impact of a short term adherence intervention for highly active antiretroviral
therapy (HAART)
L R Hirschhorn, L Ruhlmann, P B Lawrence, et al
 (15IAC)
 Abstract
 
Which adherence measures predict clinical markers?
W L Holzemer, R M Grimes, C J Portillo, et al
 (15IAC)
 Abstract
 
Maintenance of medication adherence over time
J R J Gray
 (15IAC)
 Abstract
Measuring Adherence
    
          Journal Papers, Abstracts, and Commentaries
 
  Practical and conceptual challenges in measuring antiretroviral adherence.
 Berg KM, Arnsten JH.  
J Acquir Immune Defic Syndr. 2006 Dec;43 Suppl 1:S79-87.
 Abstract
 
A Practical Method to Calibrate Self-Reported Adherence to Antiretroviral Therapy.
 Liu H, Miller LG, Hays RD. et al  
J Acquir Immune Defic Syndr. 2006 Dec 1;43 Suppl 1:S104-S112.
 Abstract
 
          Conference Reports, Abstracts, and Posters
 
 
A comparison between AACTG Adherence Questionnaire and the 9-item Morisky Medication
Adherence Scale in HIV-patients
 B Södergård, M Halvarsson, J Brännström, et al
 [8th Int Congress on Drug Therapy in HIV Infection]
 Abstract
 
Diagnostic value of the 2-item Swiss HIV Cohort Study Adherence Questionnaire
 AE Deschamps, S De Geest, A-Mi Vandamme, et al
 [8th Int Congress on Drug Therapy in HIV Infection]
 Abstract

Measuring adherence to antiretroviral therapy in a diverse population using a visual
analogue scale (VAS)
TP Giordano, D Guzman, R Clark, et al
 (15IAC)
 Abstract

Adherence and Drug Resistance
    
           Journal Papers, Abstracts, and Commentaries
 
 
Effect of Adherence to HAART on Virologic Outcome and on the Selection of Resistance-
Conferring Mutations in NNRTI- or PI-Treated Patients.
 Maggiolo F, Airoldi M, Kleinloog HD, et al
HIV Clin Trials. 2007 Sep-Oct;8(5):282-92
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Adherence to antiretroviral HIV drugs: how many doses can you miss before resistance
emerges?
 Smith RJ. 
Proc Biol Sci. 2006 Mar 7;273(1586):617-24.
 Abstract
 
Adherence and resistance
 Klimkait T, Vernazza P.
Ther Umsch. 2004 Oct;61(10):631-4
 Abstract
 
Resistance profiles and adherence at primary virological failure in three different highly
active antiretroviral therapy regimens: analysis of failure rates in a randomized study.
 Roge B, Barfod T, Kirk O, et al
 HIV Med. 2004 Sep;5(5):344-351.
 Abstract
 
Paradoxes of adherence and drug resistance to HIV antiretroviral therapy.
 Bangsberg DR, Moss AR, Deeks SG
J Antimicrob Chemother. 2004 May;53(5):696-9
 Abstract
.
Association between Adherence to Antiretroviral Therapy and Human Immunodeficiency
Virus Drug Resistance.
Sethi AK, Celentano DD, Gange SJ ,et al
 Clin Infect Dis. 2003 Oct 15;37(8):1112-1118.
 Abstract
 
High levels of adherence do not prevent accumulation of HIV drug resistance mutations.
Bangsberg DR, Charlebois ED, Grant RM 
AIDS. 2003 Sep 5;17(13):1925-32.
 Abstract
 
 
    Conference Reports, Abstracts, and Posters
 
  95% Adherence Is Not Necessary for Viral Suppression to Less than 400 Copies/mL in the
Majority of Individuals on NNRTI Regimens     
D  Bangsberg , S Weiser, D Guzman, E Rile
 (12 CROI)
 Abstract
Therapeutic Drug Monitoring
    
          Journal Papers, Abstracts, and Commentaries
 
 
Preventing HIV antiretroviral resistance through better monitoring of treatment adherence.
Bangsberg DR.
J Infect Dis. 2008 May 15;197 Suppl
Abstract

Therapeutic drug monitoring of indinavir and nelfinavir to assess adherence
to therapy in human immunodeficiency virus-infected children.
van Rossum AM, Bergshoeff AS, Fraaij PL, et al.
Pediatr Infect Dis J 2002 Aug;21(8):743-7
 Abstract

  
Provider Challenges
    
         Journal Papers, Abstracts, and Commentaries
 
 
The impact of HIV clinical pharmacists on HIV treatment outcomes: a systematic review.
 Saberi P, Dong BJ, Johnson MO, et al
Patient Prefer Adherence. 2012;6:297-322.
 Abstract

The importance of the patient-clinician relationship in adherence to antiretroviral
medication.
Molassiotis A, Morris K, Trueman
Int J Nurs Pract. 2007 Dec;13(6):370-6.
 Abstract
 
Is the quality of the patient-provider relationship associated with better adherence
and health outcomes for patients with HIV?
 Beach MC, Keruly J, Moore RD.
 J Gen Intern Med. 2006 Jun;21(6):661-5.
 Abstract

Better Physician-Patient Relationships Are Associated with Higher Reported Adherence
to Antiretroviral Therapy in Patients with HIV Infection.
 Schneider J, Kaplan SH, Greenfield S, et al 
J Gen Intern Med. 2004 Nov;19(11):1096-0
 Abstract
 
Patient-reported and Physician-estimated Adherence to HAART.
 Murri R, Ammassari A, Trotta MP, et al  
J Gen Intern Med. 2004 Nov;19(11):1104-10.
 Abstract
 
FULL-TEXT PDF ARTICLE
 The patient-provider relationship and adherence to highly active antiretroviral therapy.
 Russell J, Krantz S, Neville S. et al
 Paper

Provider inaccuracy in assessing adherence and outcomes with newly initiated
antiretroviral therapy.
Gross R, Bilker WB, Friedman HM, et al.
AIDS 2002 Sep 6;16(13):1835-7
 Abstract

How well do clinicians estimate patients' adherence to combination antiretroviral
therapy?
Miller LG, Liu H, Hays RD, et al
J Gen Intern Med 2002 Jan;17(1):1-11
 Abstract

Physician-patient relationships, patient satisfaction, and antiretroviral medication
Adherence among HIV-infected adults attending a public health clinic.
Roberts KJ.
AIDS Patient Care STDS 2002 Jan;16(1):43-50
 Abstract

  
Economic Studies
    
          Journal Papers, Abstracts, and Commentaries
 
 
Cost-Effectiveness of an Intervention to Improve Adherence to Antiretroviral Therapy in
HIV-Infected Patients.
 Freedberg KA, Hirschhorn LR, Schackman BR, et al  
J Acquir Immune Defic Syndr. 2006 Dec 1;43 Suppl 1:S113-S118
 Abstract

Projecting the cost-effectiveness of adherence interventions in persons with human
immunodeficiency virus infection.
 Goldie SJ, Paltiel AD, Weinstein MC  
 Am J Med. 2003 Dec 1;115(8):632-41.
 Abstract

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