Emtricitabine

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Emtricitabine(Emtriva)

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Tenofovir Disoproxil Fumarate/Emtricitabine (Truvada)
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Last Update: March 18, 2017
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New and Noteworthy

March 2017

Efficacy and safety of emtricitabine/tenofovir alafenamide (FTC/TAF) vs. emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) as a backbone for treatment of HIV-1 infection in virologically suppressed adults: subgroup analysis by third agent of a randomized, double-blind, active-controlled phase 3 trial<sup/>.
Post FA, Yazdanpanah Y, Schembri G, et al HIV Clin Trials. 2017 Mar 17:1-6.

February 2017

Emtricitabine + tenofovir alafenamide for the treatment of HIV.
Corado KC, Daar ES.Expert Opin Pharmacother. 2017 Feb 2.

Pediatric Indications

Pharmacokinetics

          Journal Papers, Abstracts, and Commentaries

Long-term Safety and Efficacy of a Once-Daily Regimen of Emtricitabine, Didanosine,
and Efavirenz in HIV-Infected, Therapy-Naive Children and Adolescents: Pediatric AIDS
Clinical Trials Group Protocol P1021.
McKinney RE, Rodman J, Hu C
Pediatrics. 2007 Jul 23;
Abstract

Pharmacokinetics and Safety of Single Oral Doses of Emtricitabine in Human
Immunodeficiency Virus-Infected Children.
Wang LH, Wiznia AA, Rathore MH, et al.
Antimicrob Agents Chemother. 2004 Jan;48(1):183-191
Abstract

Efficacy

          Journal Papers, Abstracts, and Commentaries

Long-term Safety and Efficacy Results of Once-Daily Emtricitabine-Based Highly Active
Antiretroviral Therapy Regimens in Human Immunodeficiency Virus-Infected Pediatric Subjects.
Saez-Llorens X, Violari A, Ndiweni D, et al
Pediatrics. 2008 Mar 10
Abstract

Long-term Safety and Efficacy of a Once-Daily Regimen of Emtricitabine, Didanosine, and
Efavirenz in HIV-Infected, Therapy-Naive Children and Adolescents: Pediatric AIDS Clinical
Trials Group Protocol P1021.
McKinney RE, Rodman J, Hu C
Pediatrics. 2007 Jul 23;
Abstract

Perinatal Indications

          Journal Papers, Abstracts, and Commentaries

Effect of pregnancy on emtricitabine pharmacokinetics.
Stek A, Best B, Luo M.
HIV Med. 2011 Nov 30.
Abstract
Very high active intracellular phosphorylated emtricitabine in neonates (ANRS 12109 - Step 2).
Hirt D, Pruvost A, Ekou�vi DK, et al
Antimicrob Agents Chemother. 2011 Apr 4.
Abstract

Population Pharmacokinetics of Emtricitabine in HIV-1 infected Pregnant Women and their neonates
(ANRS 12109).
Hirt D, Urien S, Rey E, Arriv� E, et al
Antimicrob Agents Chemother. 2008 Dec 22
Abstract

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