Medical Advocates

Efavirenz
(Sustiva/Strocrin)
 
Journal Citations: Adult/
Adolescent Treatment

General; Reports
Quality of Life
CNS Benefits
Efficacy
Switching Therapy
Salvage Therapy
Treatment Strategies
Drug Failure
Drug Comparison Studies
 

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Last Update:  November 04, 2008
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General Reports
           

 
A WEEK IN REVIEW FEATURED REPORT
Efavirenz - Still First-line King?
Best BM, Goicoechea M. 
Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):965-972.

Abstract
 
Successful use of reduced-dose efavirenz in a patient with human immunodeficiency virus infection:
case repor tand review of the literature.
Torno MS, Witt MD, Saitoh A, Fletcher CV.  
Pharmacotherapy.
2008 Jun;28(6):782-7.
Abstract
 
Response to Efavirenz-Containing Regimens in Previously Antiretroviral-Naive HIV-Positive
Patients: The Role of Gender.

Smith CJ, Sabin CA, Youle MS, et al 
J Acquir Immune Defic Syndr. 2007 Jul 19;
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Efavirenz.
Maggiolo F
Expert Opin Pharmacother.
2007 Jun;8(8):1137-45.
Abstract

Tolerance and acceptability of an efavirenz-based regimen in 740 adults (predominantly women)
in West Africa.
Danel C, Moh R, Anzian A, Abo Y, et al   
J Acquir Immune Defic Syndr.
2006 May;42(1):29-35.

Abstract


Quality of Life Studies
           

  Quality of Life, Emotional Status, and Adherence of HIV-1–Infected Patients Treated With Efavirenz.
Fumaz CR, Tuldra A, Ferrer MJ,
et al.  
J Acquir Immune Defic Syndr 2002 Mar1;29(3):244-53
Abstract

Central Nervous System Benefits
 

  Therapeutic effects of nonnucleoside reverse transcriptase inhibitors on the central nervous
system in HIV-1-infected patients.
von Giesen HJ, Koller H, Theisen A, Arendt G.
J Acquir Immune Defic Syndr 2002 Apr 1;29(4):363-7
Abstract
 

Efficacy
General Studies                    HIV/TB

General  HIV Studies

 
Efavirenz versus nevirapine-based initial treatment of HIV infection: clinical and virological outcomes
in Southern African adults.
Nachega JB, Hislop M, Dowdy DW, et al   
AIDS
. 2008 Oct 18;22(16):2117-25.
Abstract
 
A WEEK IN REVIEW FEATURED REPORT
Efavirenz-based regimens in treatment-naive patients with a range of pretreatment HIV-1 RNA
levels and CD4 cell counts.

Ribaudo HJ, Kuritzkes DR, Lalama CM, et al
J Infect Dis.
2008 Apr 1;197(7):1006-10
Abstract
 
Efavirenz versus indinavir among HIV-1 naive patients in Abidjan (Ivory Coast).
Tanon AK, Eholié SP, Polneau S, et a
Med Mal Infect. 2008 Apr 3
Abstract
 
A WEEK IN REVIEW FEATURED REPORT
First-line antiretroviral therapy with efavirenz or lopinavir/ritonavir plus two nucleoside
analogues: the SUSKA study, a non-randomized comparison from the VACH cohort.

Domingo P, Suárez-Lozano I, Torres F, et al
J Antimicrob Chemother. 2008 Mar 20
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and tolerability of long-term efavirenz plus nucleoside reverse transcriptase
inhibitors for HIV-1 infection.

Tashima K, Staszewski S, Nelson M, et al
AIDS
. 2008 Jan 11;22(2):275-279.
Abstract
 
Efficacy and Safety of a Once Daily Regimen with Efavirenz, Lamivudine, and Didanosine, with
and without Food, as Initial Therapy for HIV Infection: The ELADI Study.

Sánchez-Conde M, Palacios R, Sanz J, et al
AIDS Res Hum Retroviruses. 2007 Oct;23(10):1237-1241.
Abstract
 
Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination
with efavirenz: results of a systematic overview.

Bartlett JA, Chen SS, Quinn JB. 
HIV Clin Trials
. 2007 Jul-Aug;8(4):221-6.
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Comparative efficacy of nucleoside/nucleotide reverse transcriptase inhibitors in combination
with efavirenz: results of a systematic overview.

Bartlett JA, Chen SS, Quinn JB. 
HIV Clin Trials
. 2007 Jul-Aug;8(4):221-6.
Abstract
 
Comparison of the effectiveness of initial combined antiretroviral therapy with nelfinavir or
efavirenz at a university-based outpatient service in Brazil.

Vanni T, Morejón KM, Santana RC, et al 
Braz J Med Biol Res.
2007 Jul;40(7):963-9.

Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Plasma HIV-1 RNA Dynamics in Antiretroviral-Naive Subjects Receiving either Triple-Nucleoside
or Efavirenz-Containing Regimens: ACTG A5166s
Kuritzkes DR, Ribaudo HJ, Squires KE, et al
J Infect Dis.
2007 Apr 15;195(8):1169-76.
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line
therapy for all?

Goicoechea M, Best B.
Expert Opin Pharmacother. 2007 Feb;8(3):371-82
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
A Comparison between Abacavir and Efavirenz as the Third Drug Used in Combination with a
Background Therapy Regimen of 2 Nucleoside Reverse-Transcriptase Inhibitors in Patients with
Initially Suppressed Viral Loads.

Cozzi-Lepri A, Luca AD, Phillips AN, et al 
J Infect Dis. 2006 Jul 1;194(1):20-8.
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and safety of an anti-retroviral combination regimen including either efavirenz or
lopinavir-ritonavir with a backbone of two nucleoside reverse transcriptase inhibitors.
Panagopoulos P, Tsiodras S, Antoniadou A, et al
Clin Microbiol Infect.
2006 May;12(5):486-9.
Abstract
 
Comparison of efavirenz and nevirapine in HIV-infected patients (NEEF Cohort).
Harmann M, Witte S, Brust J, et al
Int J STD AIDS. 2005 Jun;16(6):404-9

Abstract
 
The effect of baseline CD4 cell count and HIV-1 viral load on the efficacy and safety of
nevirapine or efavirenz-based first-line HAART.
van Leth F, Andrews S, Grinsztejn B, Wilkins E
AIDS. 2005 Mar 25;19(5):463-471
Abstract
 
Plasma HIV-1 RNA Decline Within the First Two Weeks of Treatment Is Comparable
for Nevirapine, Efavirenz, or Both Drugs Combined and Is Not Predictive of Long-Term
Virologic Efficacy: A 2NN Substudy.
van Leth F, Huisamen CB, Badaro R, et al
J
Acquir Immune Defic Syndr. 2005 Mar 1;38(3):296-300.
Abstract
 
First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy for
naive patients.
Manfredi R, Calza L, Chiodo F.
AIDS. 2004 Nov 19;18(17):2331-3.
Abstract
 
Clinical, Virologic, and Immunologic Response to Efavirenz-or Protease Inhibitor-Based
Highly Active Antiretroviral Therapy in a Cohort of Antiretroviral-Naive Patients With Advanced
HIV Infection (EfaVIP 2 Study).
The EfaVIP Cohort Study Group.
J Acquir Immune Defic Syndr.
2004 Apr 20;35(4):343-350.
Abstract
 
Efavirenz Versus Nevirapine in Current Clinical Practice: A Prospective, Open-Label
Observational Study.
Manfredi R, Calza L, Chiodo F. 
J Acquir Immune Defic Syndr.
2004 Mar 15;35(5):492-502.
Abstract
 
FULL-TEXT ARTICLE
Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral-Therapy-Naive
Patients Infected with HIV-1

van Leth F , Phanuphak P Stroes  E , et al  
PLoS Medicine
Vol 1, No 1
Paper
 
Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of
HIV-1 infection.
Gulick RM, Ribaudo HJ, Shikuma CM  
N
Engl J Med. 2004 Apr 29;350(18):1850-61.
Abstract
 
Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or
both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study.
Van Leth F, Phanuphak P, Ruxrungtham K, et al.  
Lancet. 2004 Apr 17;363(9417):1253-1263.
Abstract
 
Nevirapine- versus efavirenz-based highly active antiretroviral therapy regimens in
antiretroviral-naive patients with advanced HIV infection.
Manosuthi W, Sungkanuparph S, Vibhagool A, et al
HIV Med.
2004 Mar;5(2):105-9.
Abstract
 
FULL-TEXT ARTICLE
Virological and immunological outcomes in HIV-1-infected Chinese patients treated with a
combination of Efavirenz and Indinavir for 48 weeks.
Li L, Wei FL, Mei S, et al
Chin Med J (Engl). 2004 Mar;117(3):347-52
Abstract
 
Intrapatient Variability of Efavirenz Concentrations as a Predictor of Virologic
Response to Antiretroviral Therapy.
Brundage RC, Yong FH, Fenton T, et al
Antimicrob Agents Chemother. 2004 Mar;48(3):979-984
Abstract

.
Treatment of primary HIV-1 infection with nonnucleoside reverse transcriptase inhibitor-based therapy
is effective and well tolerated.
Portsmouth S, Imami N, Pires A, et al  
HIV Med. 2004 Jan; 5(1): 26-9.
Abstract
 
A Randomized Trial of 2 Different 4-Drug Antiretroviral Regimens versus a 3-Drug
Regimen, in Advanced Human Immunodeficiency Virus Disease.
Fischl MA, Ribaudo HJ, Collier AC, et al

J Infect Dis. 2003 Sep 1;188(5):625-34.
Abstract
 
 
 

A prospective comparison of the two main indications of efavirenz in 2001 highly active
antiretroviral therapy (HAART) regimens: first-line versus salvage use.
Manfredi R, Calza L, Chiodo F.
J Antimicrob Chemother 2002 May;49(5):723-9

Abstract

Evaluation of an efavirenz-containing regimen: an open-label, multicenter study.
Hartmann M, Rump A, Brust J, et al
HIV Clin Trials 2001 Sep-Oct;2(5):421-8

Abstract

Efavirenz as a substitute for protease inhibitors in hiv-1-infected patients with undetectable
plasma viral load on haart: a median follow-up of 64 weeks. 
Rey D, Schmitt MP, Partisani M, et al.
J Acquir Immune Defic Syndr 2001 Aug 15;27(5):459-62

Abstract

Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection.
Albrecht MA,  Bosch RJ, Hammer SM, et al;
N Engl J Med 2001  Aug 9;345(6):398-407

Abstract

Response to first protease inhibitor- and efavirenz-containing antiretroviral combination therapy
The Swiss HIV Cohort Study.
Friedl AC, Ledergerber B, Flepp M, et al
AIDS 2001 Sep 28;15(14):1793-1800
Abstract

Comparison of initial combination antiretroviral therapy with a single protease inhibitor, ritonavir
and saquinavir, or efavirenz.
Lucas GM, Chaisson RE, Moore RD.
AIDS 2001 Sep 7;15(13):1679-1686

Abstract

 

 
HIV/HCV Studies
 
  Effect of Treatment With Efavirenz on Neuropsychiatric Adverse Events of Interferon in HIV/HCV-Coinfected Patients.
Quereda C, Corral I, Moreno A, Pérez-Elías MJ,
J Acquir Immune Defic Syndr
. 2008 Jul 23.
Abstract
 
HIV/TB Studies
 
 
A WEEK-IN-REVIEW FEATURED REPORT
Efavirenz 600 mg/day versus efavirenz 800 mg/day in HIV-infected patients with tuberculosis receiving
rifampicin: 48 weeks results.
Manosuthi W, Kiertiburanakul S, Sungkanuparph S, et al 
AIDS. 2006 Jan 2;20(1):131-132.
Abstract

Efavirenz levels and 24-week efficacy in HIV-infected patients with tuberculosis receiving
|highly active antiretroviral therapy and rifampicin.
Manosuthi W, Sungkanuparph S, Thakkinstian A, et al
AIDS. 2005 Sep 23;19(14):1481-6.
Abstract


Switching Therapy
 

 
A WEEK IN REVIEW FEATURED REPORT
Switch to Efavirenz (EFV) after Protease-inhibitor (PI) - Failure: Explorative Analysis of Outcome by Baseline Viral VS
Tolerability Failure.

Khaykin P, Postel N, Reeb I, Staszewski S
Eur J Med Res. 2008 Apr 30;13(4):169-72.

Abstract
 

Is it safe to switch between efavirenz and nevirapine in the event of toxicity?
Mehta U, Maartens G.
Lancet Infect Dis. 2007 Nov;7(11):733-8.
Abstract
 

A WEEK-IN-REVIEW FEATURED REPORT
Comparative biological and clinical outcomes after a switch from a virologically unsuccessful
first protease inhibitor-containing antiretroviral combination to a 3-drug regimen containing
efavirenz, nevirapine, or abacavir.

Abgrall S, Yeni PG, Bouchaud O, et al
Clin Infect Dis
. 2007 Jan 1;44(1):120-7.
Abstract

 
Switch from a first virologically effective protease inhibitor-containing regimen to a
regimen containing efavirenz, nevirapine or abacavir.

Abgrall S, Yeni PG, Bouchaud O, et al 
AIDS. 2006 Oct 24;20(16):2099-106.
Abstract
 
Metabolic benefits 24 months after replacing a protease inhibitor with abacavir, efavirenz or nevirapine.
F
isac C, Fumero E, Crespo M, et al
AIDS. 2005 Jun 10;19(9):917-925
Abstract

Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.
Saah AJ, Haas DW, DiNubile MJ, et al.
J Infect Dis 2003 Apr 1;187(7):1157-62
Abstract

  Switching from protease inhibitors to efavirenz: differences in efficacy and tolerance among risk
groups:a case-control study from the Swiss HIV Cohort,

Hirschel B, Flepp M, Bucher HC, et al .

AIDS 2002 Feb 15;16(3):381-385
Abstract
  Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine
or to
 efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression.
Negredo E, Cruz L, Paredes R, Ruiz L, et al.
Clin Infect Dis 2002 Feb 15;34(4):504-10
Abstract
  Switch to efavirenz in a protease inhibitor-containing regimen.
Knechten H, Sturner KH, Hohn C, Braun P.
HIV Clin Trials 2001 May-Jun;2(3):200-4
Abstract

Salvage Therapy
 

 
Genotypic resistance profile in treatment-experienced HIV-infected individuals after abacavir and
efavirenz salvage regimen.
Vallejo A, Olivera M, Rubio A, et al.
Antiviral Res.
2004 Feb;61(2):129-32

Abstract

Modulation of Human Immunodeficiency Virus (HIV)-Specific Immune Response by Using Efavirenz,
Nelfinavir, and Stavudine in a Rescue Therapy Regimen for HIV-Infected, Drug-Experienced Patients.
Trabattoni D, Lo Caputo S, Biasin M, et al.

Clin Diagn Lab Immunol 2002 Sep;9(5):1114-8
Abstract

Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after
nevirapine failure.
Antinori A, Zaccarelli M, Cingolani A, et al.
AIDS Res Hum Retroviruses 2002 Aug 10;18(12):835-8
Abstract

 

Drug Failure
       

 
How Long Is the Window of Opportunity Between Adherence Failure and Virologic Failure on Efavirenz-Based
HAART?
Gross R, Bilker WB, Wang H, Chapman J.
HIV Clin Trials.
2008 May-June 1;9(3):202-206.

Abstract

Drug Comparison Studies
       

 
Virologic, Immunologic, Clinical, Safety, and Resistance Outcomes from a Long-Term
Comparison of Efavirenz-Based Versus Nevirapine-Based Antiretroviral Regimens as Initial
Therapy in HIV-1-Infected Persons.
van den Berg-Wolf M, Hullsiek KH, Peng G, et al
HIV Clin Trials. 2008 Jan 1;9(5):324-336
Abstract
 
Efavirenz versus indinavir among HIV-1 naive patients in Abidjan (Ivory Coast).
Tanon AK, Eholié SP, Polneau S, et al
Med Mal Infect.
2008 Apr 3

Abstract


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