Medical Advocates

HIV Protease Inhibitors
  Resistance/Cross Resistance

Resistance: General Reports
Cross Resistance


Protease Inhibitors Main Page   Main New/Newsworthy Home    

Last Update:  April 04, 2017
Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader


     Journal Papers, Abstracts, and Commentaries
Lack of protease inhibitor resistance following treatment failure - too good to be true?
Bartlett JA.
J Clin Invest
. 2013 Aug 27:1-2.

Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance.
Rabi SA, Laird GM, Durand CM,  et al
J Clin Invest. 2013 Aug 27

Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance
Babrzadeh F, Varghese V, Pacold M, et al

J Antimicrob Chemother
. 2012 Oct 19

Mutational patterns in the frameshift-regulating site of HIV-1 selected by protease inhibitors.
Knops E, Brakier-Gingras L, Schülter E, et al

Med Microbiol Immunol
. 2011 Dec 27

Multiple independent origins of a protease inhibitor resistance mutation in salvage therapy

Kapoor A, Shapiro B, Shafer RW,et al
Retrovirology. 2008 Jan 25;5(1):7

Effect of Adherence to HAART on Virologic Outcome and on the Selection of Resistance-
Conferring Mutations in NNRTI- or PI-Treated Patients.
Maggiolo F, Airoldi M, Kleinloog HD, et al
HIV Clin Trials. 2007 Sep-Oct;8(5):282-92

Increasing prevalence of HIV-1 protease inhibitor-associated mutations correlates with long-term
on-suppressive protease inhibitor treatment.

Kagan RM, Cheung PK, Huard TK, Lewinski MA. 

Antiviral Res.
2006 Mar 23;

  Mutation Patterns and Structural Correlates in Human Immunodeficiency Virus Type 1
Protease following Different Protease Inhibitor Treatments.

Wu TD, Schiffer CA, Gonzales MJ, et al.

J Virol
2003 Apr 15;77(8):4836-4847


Resistance: General Reports

     Journal Papers, Abstracts, and Commentaries


Computational Prediction of HIV-1 Resistance to Protease Inhibitors.
Hosseini A, Alibés A, Noguera-Julian M, Gil VA, et al  

J Chem Inf Model
. 2016 Apr 15

Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.
Rossouw TM, Feucht UD, Melikian G, et al
PLoS One
. 2015 Jul 21;10(7):e0133452.

Resistance to Protease Inhibitors in a Model of HIV-1 Infection with Impulsive Drug Effects.
Miron RE, Smith RJ.

Bull Math Biol
. 2013 Nov 5.

Resistance to the most recent protease and non-nucleoside reverse transcriptase inhibitors across HIV-1 non-B subtypes.
Anta L, Blanco JL, Llibre JM, García F,et al

J Antimicrob Chemother
. 2013 Apr 29

Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1-pyrrolidinone or P2-tris-THF.
Agniswamy J, Shen CH, Wang YF,  et al
J Med Chem. 2013 Apr 16

Molecular Basis for Drug Resistance in HIV-1 Protease.
Ali A, Bandaranayake RM, Cai Y, et al

. 2010 Nov;2(11):2509-2535.

The impact of individual HIV-1 protease mutations on drug susceptibility is highly
influenced by complex interactions with the background protease sequence.
Van Marck H, Dierynck I, Kraus G, et al

J Virol
. 2009 Jul 8

Gag Determinants of Fitness and Drug Susceptibility in Protease Inhibitor Resistant HIV-1.
Parry CM, Kohli A, Boinett CJ, Tet al 
J Virol. 2009 Jul 8

Effect of Human Immunodeficiency Virus Type 1 Protease Inhibitor Therapy and Subtype on
Development of Resistance in Subtypes B and G.
Palma AC, Abecasis AB, Vercauteren J,
et al
Infect Genet Evol
. 2009 Jul 1.

Novel mechanisms of HIV protease inhibitor resistance.
Nijhuis M, van Maarseveen NM, Verheyen J, Boucher CA.
Curr Opin HIV AIDS. 2008 Nov;3(6):627-32

Approaches to the design of HIV protease inhibitors with improved resistance profiles.
Gulnik SV, Eissenstat M.
Curr Opin HIV AIDS. 2008 Nov;3(6):633-41.

New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid
drug resistance and discover robust inhibitors.
Nalam MN, Schiffer CA.
Curr Opin HIV AIDS. 2008 Nov;3(6):642-6.

Population trends in the prevalence and patterns of protease resistance related to exposure to
unboosted and boosted protease inhibitors.
Dunn D, Geretti AM, Green H, et al  

Antivir Ther.

Increased Resilience to the Development of Drug Resistance with Modern Boosted Protease Inhibitor-Based
Highly Active Antiretroviral Therapy.
Lima VD, Gill VS, Yip B, et al 
J Infect Dis. 2008 May 22.
Protease inhibitor resistance update: where are we now?
Kim R, Baxter JD.
AIDS Patient Care STDS. 2008 Apr;22(4):267-77.
HIV-1 protease inhibitors: effects on HIV-2 replication and resistance.
Menéndez-Arias L, Tözsér J.
Trends Pharmacol Sci. 2007 Dec 2
Protease inhibitor resistance in HIV-infected patients: Molecular and clinical perspectives.
Martinez-Cajas JL, Wainberg MA
Antiviral Res.
2007 Jul 16;
Impact of HIV protease inhibitor resistance in treatment-naive populations in the united states.
Hicks C. 

AIDS Read.
2005 Dec;15(12):683-6,
Comparison of HIV Type 1 Protease Inhibitor Susceptibility Results in Viral Samples
Analyzed by Phenotypic Drug Resistance Assays and by Six Resistance Algorithms:
An Analysis of a Subpopulation of the CHORUS Cohort.
Ross L, Boulme R, Fusco G, et al
AIDS Res Hum Retroviruses. 2005 Aug;21(8):696-701.

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in
patients who are chronically infected with human immunodeficiency virus type 1.
Martinez-Picado J, Wrin T, et al 
J Virol.
2005 May;79(10):5907-13.


Intermittent viremia during first-line, protease inhibitors-containing therapy: significance and
relationship with drug resistance.
Masquelier B, Pereira E, Peytavin G, et al 
J Clin Virol. 2005 May;33(1):75-8
Determining and Overcoming Resistance to HIV Protease Inhibitors.
Prejdova J, Soucek M, Konvalinka J.
Curr Drug Targets Infect Disord. 2004 Jun;4(2):137-52.
Selection of high-level resistance to human immunodeficiency virus type 1 protease inhibitors.
Watkins T, Resch W, Irlbeck D, Swanstrom R.
Antimicrob Agents Chemother
2003 Feb;47(2):759-69

CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients
who remain viremic despite long-term treatment with protease inhibitor-based therapy.
Deeks SG, Hoh R, Grant RM, et al.
J Infect Dis 2002 Feb 1;185(3):315-23

Development and significance of resistance to protease inhibitors in HIV-1-infected adults under
triple-drug therapy in clinical practice.
Romano L, Venturi G, Giomi S, et al.
J Med Virol 2002 Feb;66(2):143-50

Computational study of protein specificity: the molecular basis of HIV-1 protease
drug resistance.
Wang W, Kollman PA.
Proc Natl Acad Sci U S A 2001 Dec 18;98(26):14937-42



Cross Resistance

     Journal Papers, Abstracts, and Commentaries
HIV-1 Protease Mutations and Protease Inhibitor Cross Resistance.
Rhee SY, Taylor J, Fessel WJ,  et al

Antimicrob Agents Chemother
. 2010 Jul 26

Molecular Basis for Increased Susceptibility of Isolates with Atazanavir Resistance-
Conferring Substitution I50L to Other Protease Inhibitors.
Yanchunas J Jr, Langley DR, et al   
Antimicrob Agents Chemother.
2005 Sep;49(9):3825-32.


Protease Inhibitors Main Page   Main New/Newsworthy Home    

Protease Inhibitors Resistance/Cross Resistance