Protease Inhibitors Adverse Cardiovascular Events

Medical Advocates
Protease Inhibitors

Adverse Cardiovascular Events

General Reports
Atherosclerosis
Arteriosclerosis
Coronary Artery Disease
Carotid Artery Disease
Myocardial Infarct
Neuropathy

PI Adverse Events Main Page Main New/Newsworthy Home Page

Last Update: October 18, 2008
Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader

General Reports

Journal Papers, Abstracts, and Commentaries

Protease inhibitors and cardiovascular disease: analysis of the Los Angeles County adult
spectrum of disease cohort.
Vaughn G, Detels R.
AIDS Care. 2007 Apr;19(4):492-9.
Abstract

Intermittent viremia during first-line, protease inhibitors-containing therapy: significance and
relationship with drug resistance.
Masquelier B, Pereira E, Peytavin G, et al
J Clin Virol. 2005 May;33(1):75-8
Abstract

Protease inhibitor exposure and increased risk of cardiovascular disease in HIV-infected
patients.
Iloeje U, Yuan Y, L'italien G, et al
HIV Med. 2005 Jan;6(1):37-44.
Abstract

Protease inhibitors and cardiovascular outcomes in patients with HIV-1.
Holmberg SD, Moorman AC, Williamson JM,
Lancet 2002 Nov 30;360(9347):1747-8
Abstract

Do protease inhibitors increase the risk for coronary heart disease n patients with HIV-1
infection?
Klein D, Hurley LB, Quesenberry CP Jr, Sidney S.
J Acquir Immune Defic Syndr 2002 Aug 15;30(5):471-7
Abstract

Acute coronary syndromes in patients treated with HIV protease inhibitors
Barthelemy O, Escaut L, Vayre F, et al
Presse Med 2002 Mar 2;31(8):343-8
Abstract

Conference Reports, Abstracts, and Posters

Do Different Protease Inhibitors Used for Human Immunodeficiency Virus Have Varying
Effects on Coronary Heart Disease Risk?
E.L. GILLESPIE, C. M. WHITE, C. I. COLEMAN
(45 ICAAC)
Abstract

Protease Inhibitors May be Associated with Oxidative Stress in HIV-Infected Patients
S. PADILLA , E. BERNAL, M. MASI�, et al
(45 ICAAC)
Abstract

Women's Intragency HIV Study (WIHS): cardiovascular outcomes in women on PI therapy
M Daftary, AP Dutta, Z Xue, et al
(15IAC)
Abstract

POSTER
Protease Inhibitor Exposure Time and Risk of Cardiovascular Disease in HIV-infected
Patients
U Iloeje, Y Yuan, G L'Italien, et al
(11 CROI)

PDF Poster Abstract

Atherosclerosis

Journal Papers, Abstracts, and Commentaries

HIV positive patients treated with protease inhibitors have vascular changes resembling those
observed in atherosclerotic cardiovascular disease.
Lekakis J, Tsiodras S, Ikonomidis I, et al
Clin Sci (Lond). 2008 Feb 5 ,
Abstract

How HIV protease inhibitors promote atherosclerotic lesion formation.
Thomas CM, Smart EJ.
Curr Opin Lipidol. 2007 Oct;18(5):561-5.
Abstract

Estrogen receptor-alpha mediated gender differences in atherosclerosis induced by HIV
protease inhibitors.
Allred KF, Smart EJ, Wilson ME.
J Biol Chem. 2005 Nov 18;
Abstract

Cellular mechanisms of insulin resistance, lipodystrophy and atheroscleosis
induced by HIV protease inhibitors.
Rudich A, Ben-Romano R, Etzion S, Bashan N.
Acta Physiol Scand. 2005 Jan;183(1):75-88.
Abstract

FULL-TEXT ARTICLE
IV protease inhibitors promote atherosclerotic lesion formation independent of
dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in
macrophages.
Dressman J, Kincer J, Matveev SV, et al.
J Clin Invest 2003 Feb;111(3):389-97
Paper

Arteriosclerosis

Journal Papers, Abstracts, and Commentaries

Impact of Treatment With Protease Inhibitors on Aortic Stiffness in Adult Patients
With Human Immunodeficiency Virus Infection.
Schillaci G, De Socio GV, Pirro M, et al;
Arterioscler Thromb Vasc Biol. 2005 Aug 25;
Abstract

Carotid Artery Disease

Journal Papers, Abstracts, and Commentaries

3-year Follow-up of Carotid Intima-media Thickness in HIV-infected and Uninfected Adults:
ACTG 5078
J Currier, M Kendall, K Henry, et al
(13 CROI)
Abstract

Journal Papers, Abstracts, and Commentaries

Coronary Artery Disease

Coronary artery calcification, atherogenic lipid changes, and increased erythrocyte
volume in black injection drug users infected with human immunodeficiency virus-1
treated with protease inhibitors.
Meng Q, Lima JA, Lai H, Vlahov D, et al
Am Heart J 2002 Oct;144(4):642-8
Abstract

Stent Implantation for Acute Left Main Coronary Artery Occlusion in an HIV-Infected
Patient on Protease Inhibitors.
Boccara F, Teiger E, Cohen A.
J Invasive Cardiol 2002 Jun;14(6):343-6
Abstract

Myocardial Infarct

Acute myocardial infarct in HIV-positive patients in treatment with protease inhibitors
Gurgo AM, Massino Ferri F, et al
Ital Heart J 2001 Nov;2(11 Suppl):1236-9|
Abstract

Conference Reports, Abstracts, and Posters

Exposure to PI and NNRTI and Risk of Myocardial Infarction: Results from the D:A:D Study
N Friis-M�ller, P Reis, W El-Sadr, et al
(13 CROI)
Abstract

Neuropathy|

Journal Papers, Abstracts, and Commentaries

Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency
syndrome patients: Protease inhibitor-mediated neurotoxicity.
Pettersen JA, Jones G, Worthington C, et al
Ann Neurol. 2006 Apr 21;59(5):816-824
Abstract

PI Adverse Events Main Page

Main New/Newsworthy

Home Page

Protease Inhibitors Adverse Cardiovascular Events