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Last Update:  August 14, 2008
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New and Noteworthy
 
August 2008
 
July 2008
 
General/Miscellaneous Reports
 
     Journal Papers, Abstracts, and Commentaries
 
 
Perceived stress and norepinephrine predict the effectiveness of response to protease inhibitors in HIV.
Ironson G, Balbin E, Stieren E, et al
Int J Behav Med. 2008;15(3):221-6.
 Abstract
 
Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontičres.
Pujades-Rodríguez M, O'Brien D, 
AIDS. 2008 Jul 11;22(11):1305-12.
Abstract
 
Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for
Combating Drug Resistance.
Ghosh AK, Chapsal BD, Weber IT, Mitsuya H.
Acc Chem Res. 2007 Aug 28;
Abstract
 
Efficacy of boosted protease inhibitor monotherapy in patients with complex medical problems.
Garrett NJ, Matin N, Edwards SG, Miller RF.
AIDS. 2007 Aug 20;21(13):1821-3
 Abstract
 
HIV Protease Inhibitors Enhance the Efficacy of Irradiation.
Cuneo KC, Tu T, Geng L, et al 
Cancer Res. 2007 May 15;67(10):4886-93.
 Abstract
 
HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis
nduced by combined treatment TNF-alpha+TSA.
Vandergeeten C, Quivy V, Moutschen M, et al 
Biochem Pharmacol. 2007 Feb 24;
 Abstract
 
Flying in the Face of Resistance: Antiviral-independent Benefit of HIV Protease Inhibitors
on T-cell Survival.
Vlahakis SR, Bren GD, Algeciras-Schimnich A, et al 
Clin Pharmacol Ther. 2007 Mar 14;
 Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Variability in non-nucleoside reverse transcriptase and protease inhibitors concentrations among
HIV-infected adults in routine clinical practice.
Molto J, Blanco A, Miranda C, Miranda J, et al
Br J Clin Pharmacol. 2007 Jan 12;
 Abstract
 
Acid suppressive therapy and the effects on protease inhibitors.
Fulco PP, Vora UB, Bearman GM. 
Ann Pharmacother. 2006 Nov;40(11):1974-83.
 Abstract
 
Initial highly-active antiretroviral therapy with a protease inhibitor versus a non-nucleoside
reverse transcriptase inhibitor: discrepancies between direct and indirect meta-analyses.
 Chou R, Fu R, Huffman LH, Korthuis PT.
Lancet. 2006 Oct 28;368(9546):1503-15.
 Abstract
 
Susceptibility to protease inhibitors in HIV-2 primary isolates from patients failing
antiretroviral therapy.
Rodes B, Sheldon J, Toro C,  et al
J Antimicrob Chemother. 2006 Feb
Abstract
 
Postprandial response to a physiologic caloric load in HIV-positive patients receiving
protease inhibitor-based or nonnucleoside reverse transcriptase inhibitor-based antiretroviral
therapy.
Thomas-Geevarghese A, Raghavan S, Minolfo R, et al   
Am J Clin Nutr. 2005 Jul;82(1):146-54.
 Abstract
 
Prescribing of Contraindicated Protease Inhibitor and Statin Combinations Among
HIV-Infected Persons.
Hulgan T, Sterling TR, Daugherty J, et al 
J Acquir Immune Defic Syndr. 2005 Mar 1;38(3):277-282.
Abstract
 
FULL-TEXT PDF ARTICLE
 The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART)
on health-related quality of life.
 Eriksson LE, Bratt GA, Sandstrom E, Nordstrom G.
 Health Qual Life Outcomes. 2005 May 4;3(1):32
 Paper
 
The impact of HIV-protease inhibitors on opportunistic parasites.
Pozio E, Morales MA. et al    
Trends Parasitol. 2005 Feb;21(2):58-63.
 Abstract

Tolerability and Safety of HIV Protease Inhibitors in Adults.
Sax PE, Kumar P.  
J Acquir Immune Defic Syndr. 2004 Sep 1;37(1):1111-1124
 Abstract
 
Dynamics of HIV replication in lymphocytes and the efficacy of protease inhibitors.
Bermejo M, Sanchez-Palomino S, Usan L, Alcami J. 
J Med Virol. 2004 Aug;73(4):502-7.
Abstract
 
Protease inhibitor-sparing simplified maintenance therapy: a need for perspective.
Bucher HC, Young J, Battegay M.  
J Antimicrob Chemother. 2004 Jul 21
 Abstract
 
Transport of HIV Protease Inhibitors Through the Blood-Brain Barrier and Interactions With
the Efflux Proteins, P-Glycoprotein and Multidrug Resistance Proteins.
Gimenez F, Fernandez C, Mabondzo A.
J Acquir Immune Defic Syndr. 2004 Jun 1;36(2):649-658
 Abstract
 
Effectiveness of antiretroviral therapy after protease inhibitor failure: an analytic overview.
Losina E, Islam R, Pollock AC, et al  
 Clin Infect Dis. 2004 Jun 1;38(11):1613-22.
 Abstract
 
Attitudes toward HIV protease inhibitors and medication adherence in an inner city
HIV population.
Demmer C.
AIDS Patient Care STDS. 2003 Nov;17(11):575-80.
 Abstract
 
FULL-TEXT PDF PUBLICATION
The HIV Protease Inhibitors
 The Drug Advisor Volume 2. No 8 August 2003
 Paper

Simplification of antiretroviral treatment--how to sustain success, reduce toxicity
and ensure adherence avoiding PI use.
 Barreiro P, Garcia-Benayas T, Soriano V, Gallant
J. AIDS Rev 2002 Oct-Dec;4(4):233-41
 Abstract

Therapeutic drug monitoring of HIV-protease inhibitors to assess noncompliance.
 Hugen PW, Burger DM, Aarnoutse RE,et al|
 Ther Drug Monit 2002 Oct;24(5):579-87
 Abstract

Factors associated with mortality in human immunodeficiency virus type  1-infected
adults initiating protease inhibitor-containing therapy: role of education level and of
early transaminase level elevation (APROCO-ANRS EP11 study).
The Antiproteases Cohorte Agence Nationale de Recherches sur
le SIDA EP 11 study.Lewden C, Raffi F, Cuzin L, et al
J Infect Dis 2002 Sep 1;186(5):710-4
 Abstract
 
HIV-1 Protease Inhibitors- A Review for Clinicians.
Deeks, SG, Smith M, Holodniy M et al.
JAMA 1997; 277(2): 145-53.
Abstract
 

 
     Conference Reports, Abstracts, and Posters
 
 
Tolerability of boosted protease inhibitor therapy in clinical practice
 DV Condoluci, M Andrews, PD Slowinski, et al
(8th Int Congress on Drug Therapy in HIV Infection)
 Abstract
 
Lipid profile using of the new protease inhibitors in antiretroviral treated HIV-infected patients
 E Negredo, P Echeverria, J Puig,  et al
 (8th Int Congress on Drug Therapy in HIV Infection)
 Abstract
 
A randomized, prospective comparison of three hypoglycemic agents in HIV-infected patients
receiving protease inhibitors, who developed insulin resistance and glucose intolerance
 L Calza
 (8th Int Congress on Drug Therapy in HIV Infection)
 Abstract
 
Comparison of single and boosted-protease-inhibitor (PI) versus non-nucleoside reverse
transcriptase inhibitor (NNRTI) containing regimens in previously antiretroviral naive patients
 A Mocroft, O Kirk, A Horban
 (8th Int Congress on Drug Therapy in HIV Infection)
 Abstract
 
HIV Protease Inhibitor Blocks gp120-induced CD4 T-cell Death by Preventing Mitochondrial
Destabilization
S Vlahakis, G Bren, S Trushin, et al
(13 CROI)
 Abstract
 
Morbidity During the 5 Years Following Initiation of Protease Inhibitor Therapy in HIV-Infected
Patients
V. LE MOING,  G. CHĘNE , L. CUZIN ,  et al 
 (45 ICAAC)
 Abstract
 
CD14+/CD16+ Monocytes Are Enriched in Cerebrospinal Fluid of HIV-1-infected
Individuals on Protease Inhibitors
JK Neuenburg, N Lollo, R Price,  R Grant
(12 CROI)
Abstract
 
Pharmacokinetics Data
 

     Journal Papers, Abstracts, and Commentaries

 
HIV Protease Inhibitors Activate the Unfolded Protein Response and Disrupt Lipid Metabolism in
Primary Hepatocytes.
Zhou H, Gurley EC, Jarujaron S ,et al
Am J Physiol Gastrointest Liver Physiol. 2006 Jul 20;
 Abstract
 
The management of HIV-1 protease inhibitor pharmacokinetic interactions.
Winston A, Boffito M.
J Antimicrob Chemother. 2005 Jun 7;
 Abstract
 
The pharmacokinetics of HIV protease inhibitor combinations.
Boffito M, Maitland D, Samarasinghe Y, Pozniak A. 
Curr Opin Infect Dis. 2005 Feb;18(1):1-7.
 Abstract

HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome:
A potential mechanism for protease inhibitor-induced hyperlipidemia.
 Liang JS, Distler O, Cooper DA, et al.
Nat Med 2001 Dec;7(12):1327-31
 Abstract

  

     Conference Reports, Abstracts, and Posters

 
Human immunodeficiency virus protease inhibitors accumulate into cultured human
adipocytes and alter expression of adipocytokines
 CV Vernochet, S Azoulay, D Duval, et al
 (15IAC)
 Abstract
Database of ARV Drug Interactions
Drug Interactions Data|
 

     Journal Papers, Abstracts, and Commentaries

 
Pharmacokinetics and Pharmacodynamics of Sildenafil in a Patient Treated With Human
Immunodeficiency Virus Protease Inhibitors.
Aschmann YZ, Kummer O, Linka A, et al 
Ther Drug Monit. 2008 Feb;30(1):130-134.
 Abstract  
 
Drug Interactions between HIV Protease Inhibitors and Acid-Reducing Agents.
Falcon RW, Kakuda TN.
Clin Pharmacokinet. 2008;47(2):75-89.
 Abstract  
 
Quantitative Assessment of HIV-1 Protease Inhibitor Interactions with Drug Efflux Transporters
in the Blood-Brain Barrier.
Bachmeier CJ, Spitzenberger TJ, Elmquist WF, Miller DW. 
Pharm Res. 2005 Aug;22(8):1259-68
 Abstract  

Drug interactions between HIV protease inhibitors based on physiologically-based
pharmacokinetic model.
 Shibata N, Gao W, Okamoto H, et al.
J Pharm Sci 2002 Mar;91(3):680-9
Abstract  

 
Viral Dynamics Data
Viral Dynamics
 

     Journal Papers, Abstracts, and Commentaries

 
Review: Immunologic Response to Protease Inhibitor-Based Highly Active Antiretroviral
Therapy: A Review.
Wainberg MA, Clotet B.
AIDS Patient Care STDS. 2007 Sep;21(9):609-620.
 Abstract
 
Virological and immunological outcomes at 3 years after starting antiretroviral therapy with
regimens containing non-nucleoside reverse transcriptase inhibitor, protease inhibitor, or
both in NITIO: open-label randomised trial.INITIO Trial
International Co-ordinating Committee; Yeni P, Cooper DA, Aboulker JP, et al 
Lancet. 2006 Jul 22;368(9532):287-98
 Abstract

Mechanisms of early virologic failure in antiretroviral-naive patients starting protease
inhibitor-containing regimens: the APROVIR Study
 Masquelier B, Peytavin G, Leport C, et al
 J Infect Dis 2002 Nov 15;186(10):1503-7
 Abstract
 

  
 

Predictors of virological rebound in HIV-1-infected patients initiating a protease
inhibitor-containing regimen.
Le Moing V, Chene G, Carrieri MP , et al.
 AIDS 2002 Jan 4;16(1):21-29 
Abstract

Impact of discontinuation of initial protease inhibitor therapy on further virological
response in a cohort of human immunodeficiency virus-infected patients.
 Le Moing V, Chene G, Leport C, et al.
Clin Infect Dis 2002 Jan 15;34(2):239-47
 Abstract 

 

     Conference Reports, Abstracts, and Posters

  POSTER
 The effect of antiretroviral protease inhibitors on P-gp expression in CD4 and CD8
subpopulations of lymphocytes.
Ford J, Chandler B, Khoo SH, Back DJ , et al.
(4th Pharmacology Workshop)
 PDF Poster

     Conference Reports, Abstracts, and Posters

  MDR1 Genotype May Influence CD4+ T-cell P-glycoprotein Activity in HIV-1-infected
Persons Receiving Protease Inhibitors
 T Hulgan, J Donahue, R Kim,et al
(11 CROI)
 Abstract
 
Distinct cross-resistance profiles of the new protease inhibitors (PI) Amprenavir,
Lopinavir, and Atazanavir in a panel of clinical samples
 B Schmid, T Schnell , G Moschik, et al
(1st European HIV Drug Resistance Workshop)
 Abstract
 
Protease inhibitors cross-resistance
F Maggiolo, A Callegaro, D Ripamonti, et al.
(1st European HIV Drug Resistance Workshop)
 Abstract
 
Adherence
 

     Journal Papers, Abstracts, and Commentaries

 
Effect of Adherence to HAART on Virologic Outcome and on the Selection of Resistance-Conferring
Mutations in NNRTI- or PI-Treated Patients.
 Maggiolo F, Airoldi M, Kleinloog HD, et al
 HIV Clin Trials. 2007 Sep-Oct;8(5):282-92
 Abstract
 
Regimen-dependent variations in adherence to therapy and virological suppression in
patients initiating protease inhibitor-based highly active antiretroviral therapy.
 Moore DM, Hogg RS, Yip B, et al
HIV Med. 2006 Jul;7(5):311-6.
 Abstract
 
The social realities of adherence to protease inhibitor regimens: substance use, health care
and psychological States.
 Halkitis PN, Kutnick AH, Slater S. et al
J Health Psychol. 2005 Jul;10(4):545-58.
Abstract  
 
Treatment Strategies
 

     Journal Papers, Abstracts, and Commentaries

 
Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontičres.
Pujades-Rodríguez M, O'Brien D, Humblet P, Calmy A.
AIDS. 2008 Jul 11;22(11):1305-12.
 Abstract
 
Ezetimibe Combined with Low-Dose Statin Effectively Lowers LDL in Protease Inhibitor
Treated Patients.
Berg-Wolf MV, Klibanov OM, Gaughan JP, Tedaldi EM.
AIDS Patient Care STDS. 2008 Ma
 Abstract
 
Overview of boosted protease inhibitors in treatment-experienced HIV-infected patients.
Youle M. 
J Antimicrob Chemother. 2007 Sep 25;
Abstract
 
Superior virological response to boosted protease inhibitor-based highly active antiretroviral
therapy in an observational treatment programme.
Wood E, Hogg R, Yip B, Moore D, et al
HIV Med. 2007 Mar;8(2):80-5.
 Abstract
 
A WEEK IN REVIEW FEATURED REPORT
Three-year follow-up of protease inhibitor-based regimen simplification in HIV-infected patients.
Martinez E, Arnaiz JA, Podzamczer D, et al 
AIDS. 2007 Jan 30;21(3):367-369.
 Abstract
 
A comparison of three highly active antiretroviral treatment strategies consisting of
non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the
presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 058
FIRST Study): a long-term randomised trial.
 MacArthur RD, Novak RM, Peng G, et al 
Lancet. 2006 Dec 16;368(9553):2107-9.
Abstract
 
Effects of discontinuing Stavudine or protease inhibitor therapy on human immunodeficiency
virus-related fat redistribution evaluated by dual-energy x-ray absorptiometry.
 Tavassoli N, Bagheri H, Sommet A, et al
Pharmacotherapy. 2006 Feb;26(2):154-61
 Abstract
 
Quadruple-2 protease inhibitors (PI)-therapy does not accelerate viral decay and suppression
in PI-naive HIV-1 infected patients with severe immunosuppression and high viral load as
compared with standard triple therapy.
Portilla J, Boix V, Garcia-Henarejos JA, et al;
Int J STD AIDS. 2005 Dec;16(12):807-810.
Abstract
 
Superiority of protease inhibitors over nonnucleoside reverse-transcriptase inhibitors when highly
active antiretroviral therapy is resumed after treatment interruption.
Barreiro P, de Mendoza C, Gonzalez-Lahoz J, Soriano V.
Clin Infect Dis. 2005 Sep 15;41(6):897-900.
 Abstract
 
FULL-TEXT ARTICLE
 Clinical efficacy of antiretroviral combination therapy based on protease inhibitors or
non-nucleoside analogue reverse transcriptase inhibitors: indirect comparison of
controlled trials.
Yazdanpanah Y, Sissoko D, Egger M, et al
BMJ  2004;328:249 
 Paper
 
Meta-analysis of randomized controlled trials of simplified versus continued protease
inhibitor-based antiretroviral therapy in HIV-1-infected patients.
Bucher HC, Kofler A, Nuesch R,et al
AIDS. 2003 Nov 21;17(17):2451-9.
 Abstract
 
Increased use of lipid-lowering therapy in patients receiving human immunodeficiency  
virus protease inhibitors.
Stein JH, Wu Y, Kawabata H, Iloeje UH.
Am J Cardiol. 2003 Aug 1;92(3):270-4.
Abstract

Effect of simultaneous versus staggered dosing on pharmacokinetic interactions of
protease inhibitors.
 Washington CB, Flexner C, Sheiner  LB, et al.
Clin Pharmacol Ther 2003 May;73(5):406-16
 Abstract
 
 
The role of pharmacological enhancement in protease inhibitor-based highly active
antiretroviral therapy.
 Becker SL
 Expert Opin Investig Drugs 2003 Mar;12(3):401-12
 Abstract
 
Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a
randomized trial.
 Hammer SM, Vaida F, Bennett KK , et al.
JAMA 2002 Jul 10;288(2):169-80
 Abstract
 
 

 

 

 
     Conference Reports, Abstracts, and Posters
 
 
Pharmacokinetic of protease inhibitors based regimens in 6 liver transplantation
HIV-infected patients
Tavio M., Baccarani U., Londero A., Pea F., et al
(XVI International AIDS Conference)
 Abstract
 
A Randomized Trial of 1 or 2 Protease Inhibitors in Combination with a Non-nucleoside
Reverse Transcriptase Inhibitor and Background Therapy in Patients with Virologic Failure
on an Initial Protease-inhibitor Containing Regimen
 J Kostman, B Grund, R Leduc, et al
(11 CROI)
 Abstract
Diagnostics/Monitoring
 
     Journal Papers, Abstracts, and Commentaries
 
  An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase
inhibitor and protease inhibitor concentrations in human plasma.
 Weller DR, Brundage RC, Balfour HH Jr, Vezina HE. et al
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Oct 31;
Abstract
Non-HIV Indications
 
     Journal Papers, Abstracts, and Commentaries
 
  Antileishmanial activity of HIV protease inhibitors.
Savoia D, Allice T, Tovo PA.
Int J Antimicrob Agents. 2005 Jun 12;
Abstract

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