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Atazanavir (Reyataz)
 
Journal Citations: Efficacy Studies

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Last updated:  September 14, 2017
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Protective Effect of Atazanavir Sulphate Against Pulmonary Fibrosis In Vivo and In Vitro.
Song S, Ji Y, Zhang G, Zhang X,

Basic Clin Pharmacol Toxicol
. 2017 Aug 16.
Abstract

Dual therapy with a combination of unboosted atazanavir and lamivudine as maintenance treatment in virologically suppressed HIV-1-infected patients
Rigo F, Cucchetto G, Lanzafame M, et al 
HIV Med. 2017 May 15.
Abstract

Efficacy and safety of atazanavir/ritonavir-based antiretroviral therapy for HIV-1 infected subjects: a systematic review and meta-analysis.
Menshawy A, Ismail A, Abushouk AI, et al

Arch Virol
. 2017 Mar 30
Abstract

Efficacy, safety and pharmacokinetics of atazanavir (200mg twice daily) plus raltegravir (400mg twice daily) dual regimen in the clinical setting.
Marinaro L, Calcagno A, Ripamonti D,  et al

J Clin Virol
. 2016 Dec 1;87:30-36. doi:
Abstract

Atazanavir plus Cobicistat: Week 48 and Week 144 Subgroup Analyses of a Phase 3, Randomized, Double-Blind, Active-Controlled Trial.
Gallant JE, Moyle G, Berenguer J,  et al  

 Curr HIV Res
. 2016 Oct 21
Abstract

Efficacy and safety of once-daily ritonavir-boosted atazanavir or darunavir in combination with a dual nucleos(t)ide analogue backbone in HIV-1-infected combined ART (cART)-naive patients with severe immunosuppression: a 48 week, non-comparative, randomized, multicentre trial (IMEA 040 DATA trial).
Slama L, Landman R, Assoumou L, et al

J Antimicrob Chemother
. 2016 Apr 10
Abstract

Evaluating the role of atazanavir/cobicistat and darunavir/cobicistat fixed-dose combinations for the treatment of HIV-1 infection.
Crutchley RD, Guduru RC, Cheng AM.

HIV
AIDS (Auckl)
. 2016 Mar 9;8:47-65.
Abstract

Atazanavir/ritonavir monotherapy: 96 week efficacy, safety and bone mineral density from the MODAt randomized trial.
Galli L, Spagnuolo V, Bigoloni A, D'Arminio Monforte A,  et al

J Antimicrob Chemother
. 2016 Mar
Abstract

Long-Term Efficacy, Tolerability, and Renal Safety of Atazanavir/Ritonavir-based Antiretroviral Therapy in a Cohort of Treatment-Naïve Patients with HIV-1 Infection: the REMAIN Study.
Teófilo E, Rocha-Pereira N, Kuhlmann B,
HIV Clin Trials. 2016 Jan;17(1):17-28.
Abstract

FULL-TEXT PDF ARTICLE
Treatment response to unboosted atazanavir in combination with tenofovir disoproxil fumarate and lamivudine in human immunodeficiency virus-1-infected patients who have achieved virological suppression: A therapeutic drug monitoring and pharmacogenetic study.
Tsai MS, Chang SY, Lin SW,
J Microbiol Immunol Infect. 2016 Jan 11. pii: S1684-1182(16)00014-1.
Paper

Use of efavirenz or atazanavir/ritonavir is associated with better clinical outcomes of HAART compared to other protease inhibitors: routine evidence from the Italian MASTER Cohort.
Postorino MC, Prosperi M, Quiros-Roldan E, et al
Clin Microbiol Infect
. 2014 Nov 11.
Abstract

A randomized trial in healthy subjects to assess the bioequivalence of an atazanavir/cobicistat fixed-dose combination tablet versus administration as separate agents.
Sevinsky H, Tao X, Wang R,  et al.

Antivir Ther
. 2014 Oct 31.
Abstract

Efficacy of a reduced dose of darunavir/ritonavir in a cohort of antiretroviral-naive and -experienced HIV-infected patients: a medium-term follow-up.
Lanzafame M, Lattuada E, Rigo F, et al
J Antimicrob Chemother. 2014 Oct 8.
Abstract

Efficacy and Tolerability of 3 Nonnucleoside Reverse Transcriptase Inhibitor-Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1: A Randomized, Controlled Equivalence Trial.
Lennox JL, Landovitz RJ, Ribaudo HJ,  et al

Ann Intern Med
. 2014 Oct 7;161(7):461-71.
Abstract

Efficacy, Tolerability and Virological Consequences of Long-term Use of Unboosted Atazanavir plus 2 NRTIs in HIV-infected Patients.
Bonora S, Calcagno A, Vigano O,  et al

 Curr HIV Res
. 2014 Aug 7
Abstract

Virologic and immunologic responses in treatment-naive patients to ritonavir-boosted atazanavir or efavirenz with a common backbone.
Wang Q, Young J, Bernasconi E, Vernazza P, et al

HIV Clin Trials
. 2014 May-Jun;15(3):92-103.
Abstract

Interpreting the reasons for the choice and changing of two drug regimens in an observational cohort: comparison of a ritonavir-boosted protease inhibitor-based versus a nonnucleoside reverse transcriptase inhibitor-based first-line regimen.
Jarrin I, Hernández-Novoa B, Alejos B, et al
HIV Med
. 2014 Mar 24.
Abstract

A meta-analysis of the efficacy and safety of unboosted atazanavir compared with ritonavir-boosted protease inhibitor maintenance therapy in HIV-infected adults with established virological suppression after induction.
Baril J, Conway B, Giguère P,  et al
HIV Med. 2013 Dec 9.
Abstract

Outcomes by Sex following Treatment Initiation with Atazanavir plus Ritonavir or Efavirenz with Abacavir/Lamivudine or Tenofovir/Emtricitabine.
Smith KY, Tierney C, Mollan K, et al

Clin Infect Dis
. 2013 Nov 18.
Abstract

Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study.
Dolling DI, Dunn DT, Sutherland KA,  et al

J Antimicrob Chemother
. 2013 May 27.
Abstract

An unusual case of HIV virologic failure during treatment with boosted atazanavir.
Duncan A, Mills J.
AIDS. 2013 May 15;27(8):1361-2.
Abstract

A Maintenance Dose of Atazanavir/Ritonavir 200/100 mg Once Daily Is Effective in Virologically Suppressed HIV-1-Infected Patients.
Lanzafame M, Lattuada E, Rigo F, Vento S.

J Acquir Immune Defic Syndr
. 2013 Jun 1;63(2):e81-2.
Abstract

Cobicistat Versus Ritonavir as a Pharmacoenhancer of Atazanavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-Naive HIV Type 1-Infected Patients: Week 48 Results.
Gallant JE, Koenig E, Andrade-Villanueva J,  et a
J Infect Dis. 2013 Apr 19.
Abstract

Long-Term Gender-Based Outcomes for Atazanavir/Ritonavir (ATV/r) - Containing Regimens in Treatment-Experienced Patients with HIV.
Svedhem-Johansson V, Pugliese P,  et al

Curr HIV Res
. 2013 Apr 12.
Abstract

Lopinavir/ritonavir, atazanavir/ritonavir, and efavirenz in antiretroviral-naïve HIV-1-infected individuals over 144 weeks: An open-label randomized controlled trial.
Andersson LM, Vesterbacka J, Blaxhult A,  et al
Scand J Infect Dis
. 2013 Jan
Abstract

Impact of UGT1A1 Gilbert Variant on Discontinuation of Ritonavir-boosted Atazanavir in AIDS Clinical Trials Group Study A5202.
Ribald HJ, Daar ES, Tierney C,  et al
J Infect Dis
. 2012 Nov 12.
Abstract

ARIES 144 Week Results: Durable Virologic Suppression in HIV-Infected Patients Simplified to Unboosted Atazanavir/Abacavir/Lamivudine.
Squires KE, Young B, Dejesus E,  et al
HIV
Clin Trials
. 2012 Sep-Oct;13(5):233-44
Abstract

Virological efficacy and safety of antiretroviral therapy-switch to atazanavir-based regimen:
a review of the literature.

Stephan C.
Expert Opin Pharmacother
. 2012 Nov;13(16):2355-67.
Abstract

Long-Term Efficacy and Safety of Atazanavir/Ritonavir Treatment in a Real-Life Cohort of Treatment-Experienced Patients
with HIV-1 Infection.

Jansen K, Sonnerborg PA, Brockmeyer N,  et al
AIDS Res Hum Retroviruses. 2012 Sep 27.
Abstract

FULL-TEXT ARTICLE
Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in
Diverse Multinational Settings.
Campbell TB, Smeaton LM, Kumarasamy N,  et al
PLoS Med
. 2012 Aug;9(8):e1001290.
Paper

Unboosted Atazanavir for Treatment of HIV Infection: Rationale and Recommendations for Use.
Focà E, Ripamonti D, Motta D, Torti C.

Drugs
. 2012 May 31.
Abstract

Efficacy and safety of a switch to unboosted atazanavir in combination with nucleoside analogues in
HIV-1-infected patients with virological suppression under antiretroviral therapy.
Pavie J, Porcher R, Torti C, Medrano J,  et al

J Antimicrob Chemother
. 2011 Aug 5.
Abstract

Treatment of advanced HIV disease in antiretroviral-naïve HIV-1-infected patients receiving once-daily
atazanavir/ritonavir or twice-daily lopinavir/ritonavir, each in combination with tenofovir disoproxil
fumarate and emtricitabine.
Uy J, Yang R, Wirtz V, et al  
AIDS Care
. 2011 Jul 7.
Abstract

Nevirapine versus atazanavir/ritonavir, each combined with tenofovir disoproxil fumarate/emtricitabine,
in antiretroviral-naive HIV-1 patients: the ARTEN Trial.
Soriano V, Arastéh K, Migrone H,  et al
Antivir Ther
. 2011;16(3):339-48.
Abstract

Atazanavir/ritonavir-based combination antiretroviral therapy for treatment of HIV-1 infection in adults.
Achenbach CJ, Darin KM, Murphy RL, Katlama C.
Future Virol. 2011 Feb;6(2):157-177.
Abstract

FULL-TEXT ARTICLE
Atazanavir Plus Ritonavir or Efavirenz as Part of a 3-Drug Regimen for Initial Treatment
of HIV Type-1: A Randomized Trial.

Daar ES, Tierney C, Fischl MA,  et al
Ann Intern Med.
2011 Feb 14
Paper
 

 


Comparative gender analysis of the efficacy and safety of atazanavir/ritonavir and
lopinavir/ritonavir at 96 weeks in the CASTLE study.
Squires KE, Johnson M, Yang R, et al
J Antimicrob Chemother
. 2010 Dec 9.
Abstract

Unboosted atazanavir-based therapy maintains control of HIV type-1 replication as effectively
as a ritonavir-boosted regimen.
Ghosn J, Carosi G, Moreno S, Pokrovsky V,  et al
Antivir Ther
. 2010;15(7):993-1002
Abstract

Similar efficacy and tolerability of atazanavir compared with atazanavir/ritonavir, each with
abacavir/lamivudine after initial suppression with abacavir/lamivudine plus ritonavir-boosted
atazanavir in HIV-infected patients.
Squires KE, Young B, Dejesus E, et al
AIDS
. 2010 Jul 5
Abstract

Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or
fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive
HIV-infected patients.
Ross LL, Weinberg WG, DeJesus E,  et al 
AIDS Res Hum Retroviruses
. 2010 Apr;26(4):407-17.
Abstract

Efficacy and Safety of Unboosted Atazanavir in Combination with Lamivudine and
Didanosine in Naive HIV Type 1 Patients in Senegal.
Landman R, Diallo MB, Gueye NF,  et al
AIDS Res Hum Retroviruses
.
2010 May 10.
Abstract

96-week efficacy and safety of atazanavir, with and without ritonavir, in a HAART
regimen in treatment-naive patients.
Malan DR, Krantz E, David N,  et al
J Int Assoc Physicians AIDS
Care
Jan-Feb;9(1):34-42.
Abstract

Effect of Nevirapine on the Steady-State Trough Concentrations of
Atazanavir in HIV-Infected Patients Receiving Atazanavir/Ritonavir.
Moltó J, Deig E, Valle M
Ther Drug Monit
. 2009 Dec 19
Abstract

Once-Daily Atazanavir/Ritonavir Compared With Twice-Daily Lopinavir/Ritonavir,
Each in Combination With Tenofovir and Emtricitabine, for Management of
Antiretroviral-Naive HIV-1-Infected Patients: 96-Week Efficacy and Safety Results
of the CASTLE Study.
Molina JM, Andrade-Villanueva J, Echevarria J, et al
J Acquir Immune Defic Syndr
. 2009 Dec 23.
Abstract

The relation between treatment outcome and efavirenz, atazanavir or lopinavir
exposure in the NORTHIV trial of treatment-naïve HIV-1 infected patients.
Josephson F, Andersson MC, Flamholc L, et al 
Eur J Clin Pharmacol
. 2009 Dec 5.
Abstract

Change to atazanavir/ritonavir treatment improves lipids but not endothelial function
in patients on stable antiretroviral therapy.
Murphy RL, Berzins B, Zala C,et al
AIDS. 2009 Nov 30.  
Abstract

Clinical pharmacology, efficacy and safety of atazanavir: a review.
Bentué-Ferrer D, Arvieux C, Tribut O, et al 
Expert Opin Drug Metab Toxicol
. 2009 Nov;5(11):1455-68.
Abstract

Efficacy and safety of atazanavir-ritonavir plus abacavir-lamivudine or tenofovir-emtricitabine
in patients with hyperlipidaemia switched from a stable protease inhibitor-based regimen
including one thymidine analogue.
Calza L, Manfredi R, Colangeli V, et al
AIDS Patient Care STDS. 2009 Sep;23(9):691-7
Abstract

Efficacy and safety of boosted and unboosted atazanavir-containing antiretroviral
regimens in real life: results from a multicentre cohort study.
Giuntini R, Martinelli C, Ricci E,  et al  
HIV Med
. 2009 Aug 3.
Abstract

Atazanavir: new indication. First-line treatment: fewer gastrointestinal disorders but more
cases of jaundice and a risk of torsades de pointes.
[
No authors listed] 
Prescrire Int. 2009 Jun;18(101):104
Abstract

Atazanavir: A Review of its Use in the Management of HIV-1 Infection.
Croom KF, Dhillon S, Keam SJ.
Drugs. 2009 Jun 4;69(8):1107-1140.
Abstract
 

Efficacy and Safety of Switching From Boosted Lopinavir to Boosted Atazanavir in Patients With
Virological Suppression Receiving a LPV/r-Containing HAART: The ATAZIP Study.
Mallolas J, Podzamczer D, Milinkovic A, et al
J Acquir Immune Defic Synd
r
. 2009 May;51(1):29-36.
Abstract

Efficacy and Safety of Ritonavir-Boosted and Unboosted Atazanavir Among Antiretroviral-Naïve Patients.
Horberg M, Klein D, Hurley L,  et al
HIV Clin Trials
. 2008 Jan 1;9(6):367-374
Abstract
 

Maintaining reduced viral fitness and CD4 response in HIV-infected patients with viremia receiving a
boosted protease inhibitor.
Grant P, Taylor J, Cain P, Short W, et al
Clin Infect Dis 2009 Mar 1;48(5):680-2.
Abstract
 
A pilot study on the efficacy, pharmacokinetics and safety of atazanavir in patients with
end-stage liver disease.
Guaraldi G, Cocchi S, Motta A ,et al
J Antimicrob Chemother. 2008 Sep 5.
Abstract
 
Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination
with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients:
48 week efficacy and safety results of the CASTLE study.
Molina JM, Andrade-Villanueva J, Echevarria J, et al
Lancet.
2008 Aug 23;372(9639):646-55.
Abstract
 
Evaluation of Efficacy, Safety, Pharmacokinetics, and Adherence in HIV-1-Infected, Antiretroviral Naïve
Patients Treated with Ritonavir-Boosted Atazanavir Plus Fixed-Dose Tenofovir DF/Emtricitabine Given
Once Daily.
Elion R, Cohen C, Ward D, 
HIV Clin Trials
. 2008 Jul 1;9(4):213-224.
Abstract
 
Atazanavir in Patients with Persistent Viral Replication Despite HAART:
Results from the French Prospective NADIS Cohort.
Cuzin, Flandr,Pugliese, et al
HIV Clin Trials.
2008 May-June 1;9(3):147-151.
Abstract
 
Atazanavir/ritonavir: A review of its use in HIV therapy.
von Hentig N.
Drugs Today (Barc). 2008 Feb;44(2):103-32.
Abstract
 
Fosamprenavir or atazanavir once daily boosted with ritonavir 100mg, plus
tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT

Smith KY, Weinberg WG, Dejesus E, et al   
AIDS Res Ther
. 2008 Mar 28;5(1):5
Paper
 
Viro-Immunologic Response to Ritonavir-Boosted or Unboosted Atazanavir in a Large
Cohort of Multiply Treated Patients: The CARe Study.
Santoro MM, Bertoli A, Lorenzini P, et al
AIDS Patient Care STDS
. 2007 Dec 20
Abstract
 
Efficacy and safety of replacing lopinavir with atazanavir in HIV-infected patients with
undetectable plasma viraemia: final results of the SLOAT trial.

Soriano V, García-Gasco P, Vispo E, Ruiz-Sancho A, et al 
J Antimicrob Chemother.
2007 Nov 13

Abstract
 

Efficacy and Safety of Atazanavir, With or Without Ritonavir, as Part of Once-Daily Highly
Active Antiretroviral Therapy Regimens in Antiretroviral-Naive Patients.
Malan DR, Krantz E, David N, et al 
J Acquir Immune Defic Syndr
. 2007 Oct 25;
Abstract
 
Efficacy and safety of atazanavir-based highly active antiretroviral therapy in patients with
virologic suppression switched from a stable, boosted or unboosted protease inhibitor

treatment regimen: the SWAN Study (AI424-097) 48-week results.
Gatell J, Salmon-Ceron D, Lazzarin A, Van Wijngaerden E, et al 
Clin Infect Dis.
2007 Jun 1;44(11):1484-92.
Abstract
 
Successful treatment with atazanavir and lopinavir/ritonavir combination therapy in protease
inhibitor-susceptible and protease inhibitor-resistant HIV-infected patients.

Gilliam BL, Chan-Tack KM, Qaqish RB, et al
AIDS Patient Care STDS. 2006 Nov;20(11):745-59
Abstract|
 
Influence of atazanavir 200 mg on the intracellular and plasma pharmacokinetics of saquinavir
and ritonavir 1600/100 mg administered once daily in HIV-infected patients.
Ford J, Boffito M, Maitland D, et al 
J Antimicrob Chemother. 2006 Sep 19;
Abstract

 
Clinical Outcomes Associated with Concomitant Use of Atazanavir and Proton Pump Inhibitors
(October).
Sahloff EG, Duggan JM.  
Ann Pharmacother. 2006 Sep 12;
Abstract
 
  Atazanavir and lopinavir/ritonavir: pharmacokinetics, safety and efficacy of a promising
double-boosted protease inhibitor regimen.
Ribera E, Azuaje C, Lopez RM, et al
AIDS
. 2006 May 12;20(8):1131-1139.
Abstract
 
  A single centre cohort experience with a new once daily antiretroviral drug.
Stebbing J, Bower M, Holmes P, et al 
Postgrad Med J. 2006 May;82(967):343-6.
Abstract
 
  Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing
multiple virological failures.
Johnson M, Grinsztejn B, Rodriguez C,
AIDS.
2005 Apr 29;19(7):685-694.
Abstract
 
  Long-Term Efficacy and Safety of Atazanavir With Stavudine and Lamivudine in Patients
Previously Treated With Nelfinavir or Atazanavir.
Wood R, Phanuphak P, Cahn P, et al 
J Acquir Immune Defic Syndr. 2004 Jun 1;36(2):684-692.
Abstract
 
  Therapy with atazanavir plus saquinavir in patients failing highly active antiretroviral therapy:
a randomized comparative pilot trial.

Haas DW, Zala C, Schrader S, 
AIDS. 2003 Jun 13;17(9):1339-1349.
Abstract
 
  Activities of Atazanavir (BMS-232632) against a Large Panel of Human Immunodeficiency
Virus Type 1 Clinical Isolates Resistant to One or More Approved Protease Inhibitors.

Colonno RJ, Thiry A, Limoli K, Parkin N.
Antimicrob Agents Chemothe
r 2003 Apr;47(4):1324-33

Abstract
 
  Results of a Phase 2 Clinical Trial at 48 Weeks (AI424-007): A Dose-Ranging, Safety,
and Efficacy Comparative Trial of Atazanavir at Three Doses in Combination with
Didanosine and Stavudine in Antiretroviral-Naive Subjects.

Sanne I, Piliero P, Squires K . et al.
J Infect 2003 Jan;46(1):70-1

Abstract


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