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Abacavir/Lamivudine
(Epzicom/Kivexa)
 
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Last Updated:  November 13, 2011
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New and Noteworthy
     

November 2011
 

Journal Abstracts, Papers, Commentaries
     

 
A WEEK-IN-REVIEW FEATURED REPORT
FULL-TEXT ARTICLE

Predictors of Limb Fat Gain in HIV Positive Patients Following a Change to Tenofovir-Emtricitabine or Abacavir-Lamivudine.
Martin A, Amin J, Emery S,  et al
PLoS One. 2011;6(10):e26885
Paper

A WEEK-IN-REVIEW FEATURED REPORT
Abacavir/Lamivudine Versus Tenofovir DF/Emtricitabine as Part of Combination Regimens for
Initial Treatment of HIV: Final Results.
Sax PE, Tierney C, Collier AC,  et al  
J Infect Dis
. 2011 Oct;204(8):1191-1201.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Abacavir and lamivudine for the treatment of human immunodeficiency virus.
Rizzardini G, Zucchi P.
Expert Opin Pharmacother. 2011 Sep;12(13):2129-38
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Comparison of abacavir/lamivudine and tenofovir/emtricitabine among treatment-naïve
HIV-infected patients initiating therapy.
Tan DH, Chan K, Raboud J, Cooper C, et al
J Acquir Immune Defic Syndr
. 2011 Jun 24.
Abstract

Peripheral and Central Fat Changes in Subjects Randomized to Abacavir-Lamivudine or
Tenofovir-Emtricitabine With Atazanavir-Ritonavir or Efavirenz: ACTG Study A5224s.
McComsey GA, Kitch D, Sax PE, et al 
Clin Infect Dis
. 2011 Jul;53(2):185-96.
Abstract

Bone Mineral Density and Fractures in Antiretroviral-Naive Persons Randomized to Receive
Abacavir-Lamivudine or Tenofovir Disoproxil Fumarate-Emtricitabine Along With Efavirenz or
Atazanavir-Ritonavir: AIDS Clinical Trials Group A5224s, a Substudy of ACTG A5202.
McComsey GA, Kitch D, Daar ES,  et al
J Infect Dis. 2011 Jun;203(12):1791-801.
Abstract

Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen
comparing ritonavir-boosted atazanavir to efavirenz with fixed-dose abacavir and Lamivudine.
Honda M, Ishisaka M, Ishizuka N,  et al
Intern Med. 2011;50(7):699-705.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and
abacavir in HIV type-1-infected Ugandan children in the ARROW Trial.
Musiime V, Kendall L, Bakeera-Kitaka S,  et al
Antivir Ther
. 2010;15(8):1115-1124.

Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Comparison of Changes in Bone Density and Turnover with Abacavir-Lamivudine versus
Tenofovir-Emtricitabine in HIV-Infected Adults: 48-Week Results from the ASSERT Study.
Stellbrink HJ, Orkin C, Arribas JR, et al
Clin Infect Dis. 2010 Sep
Abstract

A  WEEK-IN-REVIEW FEATURED REPORT
Randomized Comparison of Renal Effects, Efficacy, and Safety With Once-Daily
Abacavir/Lamivudine Versus Tenofovir/Emtricitabine, Administered With Efavirenz,
in Antiretroviral-Naive, HIV-1-Infected Adults: 48-Week Results From the ASSERT
Study.
Post FA, Moyle GJ, Stellbrink HJ,  et al
J Acquir Immune Defic Syndr. 2010 Apr 24
Abstract

Abacavir-Lamivudine versus Tenofovir-Emtricitabine for Initial HIV-1 Therapy.
Sax PE, Tierney C, Collier AC,  et al 
N Engl J Med
. 2009 Dec 3;361(23):2230-2240.
Abstract

Abacavir and lamivudine combination.
Somboonwit C, Kurtyka D, Paula Velez A.
Expert Opin Drug Metab Toxicol
. 2009 Dec;5(12):1599-606.

Abstract

Simplification of Antiretroviral Therapy with Tenofovir-Emtricitabine or Abacavir-Lamivudine:
A Randomized, 96-Week Trial.
Martin A, Bloch M, Amin J, et al   
Clin Infect Dis. 2009 Nov 15;49(10):1591-1601
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or
tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment.
Smith KY, Patel P, Fine D, et al
AIDS. 2009 Jun 17.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Virologic response and safety of the abacavir/lamivudine fixed-dose formulation as part of highly active
antiretroviral therapy: analyses of six clinical studies.
Ha B, Liao QM, Dix LP, Pappa KA.
HIV Clin Trials
. 2009 Mar-Apr;10(2):65-75
Abstract

A Simplification Trial Switching From Nucleoside Reverse Transcriptase Inhibitors to Once-Daily
Fixed-Dose Abacavir/Lamivudine or Tenofovir/Emtricitabine in HIV-1-Infected Patients With Virological
Suppression.

Martínez E, Arranz JA, Podzamczer D, et al
J Acquir Immune Defic Syndr
. 2009 Apr 24.
Abstract

Two novel fixed formulations of nucleoside analogues (tenofovir-emtricitabine, and
abacavir-lamivudine). Prospective, open study on clinical practice and therapeutic
perspectives, in patients naïve and in subjects pre-treated with antiretrovirals
Manfredi R, Calza L.
Recenti Prog Med. 2008 Oct;99(10):492-501
Abstract

Switching from twice-daily abacavir and lamivudine to the once-daily fixed-dose combination tablet of
abacavir and lamivudine improves patient adherence and satisfaction with therapy.

Maitland D, Jackson A, Osorio J, et al 
HIV Med
. 2008 Oct;9(8):667-72.
Abstract
 

A WEEK IN REVIEW FEATURED REPORT
Short-term Safety and Tolerability of a Once-Daily Fixed-Dose Abacavir-Lamivudine Combination
versus Twice-Daily Dosing of Abacavir and Lamivudine as Separate Components: Findings from the
ALOHA Study.

Cohen CJ, Kubota M, Brachman PS, et al 
Pharmacotherapy. 2008 Mar;28(3):314-322.
Abstract
 
A WEEK IN REVIEW FEATURED REPORT
Recent Availability of Two Novel, Fixed Formulations of Antiretroviral Nucleoside Analogues:
A 12-Month Prospective, Open-Label Survey of Their Practical Use and Therapeutic Perspectives
in Antiretroviral-Naive and -Experienced Patients.
Manfredi R, Calza L.
AIDS Patient Care
STDS. 2008 Feb 21
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Abacavir/lamivudine combination in the treatment of HIV-1 infection: a review.
Waters L, Moyle G.
Expert Opin Pharmacothe
r. 2006 Dec;7(18):2571-2580.
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and safety of a once-daily fixed-dose combination of abacavir/lamivudine compared with
abacavir twice daily and lamivudine once daily as separate entities in antiretroviral-experienced
HIV-1-infected patients (CAL30001 Study).

Lamarca A, Clumeck N, Plettenberg A, et al
J Acquir Immune Defic Syndr. 2006 Apr 15;41(5):598-606.
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Fixed dose combination abacavir/lamivudine in the treatment of HIV-1 infection.
Anderson AM, Bartlett JA. 
Expert Rev Anti Infect Ther. 2005 Dec;3(6):871-83
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
Abacavir and Lamivudine Fixed-Dose Combination Tablet Once Daily Compared With Abacavir
and Lamivudine Twice Daily in HIV-Infected Patients Over 48 Weeks (ESS30008, SEAL).
Sosa N, Hill-Zabala C, Dejesus E, et al 
J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):422-427
Abstract
 
Two-once-daily fixed-dose NRTI combinations for HIV.
[
No authors listed]  
Med Lett Drugs Ther
. 2005 Feb 28;47(1203):19-20
Abstract

Abacavir plus Lamivudine: A Review of their Combined Use in the Management of HIV Infection.
Dando TM, Scott LJ. 
Drugs. 2005;65(2):285-302
Abstract


Pediatric Indications
     

Conference Citations
 
  POSTER
Pharmacokinetic Study of Once- vs Twice-daily Abacavir and Lamivudine as Part of Combination ART in Children
with HIV-1 Infection aged 3 to 36 months: Pediatric European Network for Treatment of AIDS 15 and ANRS 133

E Jacqz-Aigrain, L Farrelly, A Compagnucci, et al
(
16 CROI)
PDF Poster     Abstract 


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