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Last Updated:  February 09, 2018
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New and Noteworthy

February  2018

Journal Abstracts, Papers, Commentaries

.Abacavir/Lamivudine and Tenofovir/Emtricitabine in Pregnant Women with Hiv: Laboratory and Clinical Outcomes in an Observational National Study.
Floridia M, Pinnetti C, Ravizza M, et al
J Acquir Immune Defic Syndr
. 2018 Feb 5.

Bone density, microarchitecture and tissue quality following long-term treatment with tenofovir/emtricitabine or abacavir/lamivudine.
Güerri-Fernández R, Molina-Morant D, et al 
J Acquir Immune Defic Syndr
. 2017 Apr 7.

Evaluation of the Lipid Concentrations after Switching from Antiretroviral Drug Tenofovir Disoproxil Fumarate/Emtricitabine to Abacavir Sulfate/Lamivudine in Virologically-suppressed Human Immunodeficiency Virus-infected Patients.
Arae H, Tateyama M, Nakamura H,  
Intern Med. 2016;55(23):3435-3440

Abacavir/Lamivudine plus Rilpivirine Is an Effective and Safe Strategy for HIV-1 Suppressed Patients: 48 Week Results of the SIMRIKI Retrospective Study.
Troya J, Ryan P, Ribera E, et al
PLoS One. 2016 Oct 11;11(10):e0164455.


Long-term efficacy and toxicity of abacavir/lamivudine/nevirapine compared to the most prescribed ARV regimens before 2013 in a French Nationwide Cohort Study.
de Boissieu P, Dramé M, Raffi F, et al
Medicine (Baltimore). 2016 Sep;95(37):e4890.

Effectiveness and safety of an abacavir/lamivudine + rilpivirine regimen for the treatment of HIV-1 infection in naive patients.
Curran A, Rojas J, Cabello A, Troya J, et al
J Antimicrob Chemother
. 2016 Sep 2.

Virologic Effectiveness of Abacavir/Lamivudine with Darunavir/Ritonavir Versus Other Protease Inhibitors in Treatment-Experienced HIV-Infected Patients in Clinical Practice.
Lackey P, Mills A, Carpio F, et al
Clin Drug Investig. 2016 Sep 1.

Exploratory Analysis for the Evaluation of Estimated Glomerular Filtration Rate, Cholesterol and Triglycerides after Switching from Tenofovir/Emtricitabine plus Atazanavir/Ritonavir (ATV/r) to Abacavir/Lamivudine plus ATV/r in Patients with Preserved Renal Function.
Postorino MC, Quiros-Roldan E, Maggiolo F, et al
. 2016 Jul 15;10:136-43.

An Indirect Comparison of Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate and Abacavir/Lamivudine + Dolutegravir in Initial Therapy.
M Llibre J, Raffi F, Moyle G, et al
PLoS One
. 2016 May 19;11(5):e0155406.

Comparative risk of failure of ABC/3TC or TDF/FTC based first-line regimens in patients with a high viral load.
Flandre P, Pugliese P, Allavena C,  et al 
HIV Med. 2016 May;17(5):380-4.

Changes in Serum Markers of Inflammation and Endothelial Activation in HIV-Infected Antiretroviral Naive Patients Starting A Treatment with Abacavir-Lamivudine or Tenofovir-Emtricitabine Plus Efavirenz.
Calza L, Magistrelli E, Danese I,   et al
Curr HIV Res. 2016;14(1):61-70.

Backbone switch to abacavir/lamivudine fixed-dose combination: implications for antiretroviral therapy optimization.
Fantauzzi A, Floridia M, Falasca F, et al
New Microbiol
. 2015 Oct 20;38(4).

Abacavir/Dolutegravir/Lamivudine Single-Tablet Regimen: A Review of Its Use in HIV-1 Infection.
Greig SL, Deeks ED.
. 2015 Feb 20.

A Randomized Comparative Trial of Continued Abacavir/Lamivudine plus Efavirenz or Replacement with Efavirenz/Emtricitabine/Tenofovir DF in Hypercholesterolemic HIV-1 Infected Individuals.
Moyle GJ, Orkin C, Fisher M,  et al
PLoS One
. 2015 Feb 6;10(2):e0116297.


Correction: Simplification to Abacavir/Lamivudine + Atazanavir Maintains Viral Suppression and Improves Bone and Renal Biomarkers in ASSURE, a Randomized, Open Label, Non-Inferiority Trial.
PLoS One
. 2014 Jul 23;9(7):e103925.


Abacavir/lamivudine plus darunavir/ritonavir in routine clinical practice: a multicentre experience in antiretroviral therapy-naive and -experienced patients.
Podzamczer D, Imaz A, Perez I, et al
J Antimicrob Chemother
. 2014 May 15.

Simplification to Abacavir/Lamivudine + Atazanavir Maintains Viral Suppression and Improves Bone and Renal Biomarkers in ASSURE, a Randomized, Open Label, Non-Inferiority Trial.

Wohl DA, Bhatti L, Small CB,  et al
PLoS One. 2014 May 13;9(5):e96187.

Safety analysis of Epzicom® (lamivudine/abacavir sulfate) in post-marketing surveillance in Japan.
Kurita T, Kitaichi T, Nagao T,  et al
Pharmacoepidemiol Drug Saf. 2014 Mar 3.

Early Virologic Response to Abacavir/Lamivudine and Tenofovir/Emtricitabine During ACTG A5202.
Grant PM, Tierney C, Budhathoki C,  et al
HIV Clin Trials
. 2013 Nov-Dec;14(6):284-91.

96-Week results of abacavir/lamivudine versus tenofovir/emtricitabine, plus efavirenz, in antiretroviral-naive, HIV-1-infected adults: ASSERT study.
Moyle GJ, Stellbrink HJ, Compston J, et al
Antivir Ther
. 2013 Jul 31.


Pharmacokinetic interactions between lersivirine and zidovudine, tenofovir disoproxil fumarate/emtricitabine and abacavir/lamivudine.
Vourvahis M, Davis J, Langdon G,  et al
Antivir Ther. 2013 Apr 4.

Once-daily darunavir/ritonavir and abacavir/lamivudine versus tenofovir/emtricitabine for treatment-naïve patients with a baseline viral load of more than 100 000 copies/ml.
Nishijima T, Komatsu H, Teruya K,  et al
AIDS. 2013 Mar 13;27(5):839-42

Abacavir/Lamivudine versus Tenofovir/Emtricitabine with Atazanavir/Ritonavir for Treatment-naive Japanese Patients
with HIV-1 Infection: A Randomized Multicenter Trial.
Nishijima T, Takano M, Ishisaka M,  et al
|Intern Med. 2013;52(7):735-44

Novel Kivexa-based regimens in early courses of treatment for HIV infection.
Conway B, Alenezi O, Wong L,  et al
J Int AIDS Soc. 2012 Nov 11;15(6):18283.

Effectiveness and tolerability of abacavir-lamivudine-nevirapine (ABC/3TC/NVP) in a multicenter cohort of HIV-infected ARV-experienced patients.
Podzamczer D, Ferrer E, Llibre J, et al
J Int AIDS Soc
. 2
012 Nov 11;15(6):18343


Changes in Fat Mitochondrial DNA and Function in Subjects Randomized to Abacavir/Lamivudine or Tenofovir DF/Emtricitabine with Atazanavir/Ritonavir or Efavirenz: AIDS Clinical Trials Group Study A5224s, substudy of A5202.
McComsey GA, Daar ES, O'Riordan , et al
J Infect Dis. 2012 Nov 29.

Abacavir/lamivudine vs tenofovir/emtricitabine in virologically suppressed patients switching from ritonavir-boosted protease inhibitors to raltegravir.
Martinez E, D'Albuquerque PM, Perez I,  et al
AIDS Res Hum Retroviruses
. 2012 Aug 23

Changes in Bone Turnover and Bone Loss in HIV-Infected Patients Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine.
Haskelberg H, Hoy JF, Amin J, et al
PLoS One. 2012;7(6):e38377

Inflammation markers after randomization to abacavir/lamivudine or tenofovir/emtricitabine with efavirenz or
atazanavir/ritonavir: ACTG A5224 s, A5202 substudy.
McComsey GA, Kitch D, Daar ES, et al
. 2012 Apr 26

Effects of highly active antiretroviral therapy on platelet activating factor metabolism in naive HIV-infected patients:
ii) study of the abacavir/lamivudine/efavirenz HAART regimen.
Chini M, Tsoupras AB, Mangafas N, et al
Int J Immunopathol Pharmacol. 2012 Jan-Mar;25(1):247-58.

Changes in body composition and mitochondrial DNA in HIV-1-infected patients switching
to fixed-dose abacavir/lamivudine or tenofovir/emtricitabine: a substudy of the BICOMBO Trial.
Curran A, Martinez E, Podzamczer D, et al
Antivir Ther
. 2012 Feb 28. 

Predictors of Limb Fat Gain in HIV Positive Patients Following a Change to Tenofovir-Emtricitabine or Abacavir-Lamivudine.
Martin A, Amin J, Emery S,  et al
PLoS One. 2011;6(10):e26885

Abacavir/Lamivudine Versus Tenofovir DF/Emtricitabine as Part of Combination Regimens for
Initial Treatment of HIV: Final Results.
Sax PE, Tierney C, Collier AC,  et al  
J Infect Dis
. 2011 Oct;204(8):1191-1201.

Abacavir and lamivudine for the treatment of human immunodeficiency virus.
Rizzardini G, Zucchi P.
Expert Opin Pharmacother. 2011 Sep;12(13):2129-38
Comparison of abacavir/lamiv
udine and tenofovir/emtricitabine among treatment-naïve

HIV-infected patients initiating therapy.
Tan DH, Chan K, Raboud J, Cooper C, et al
J Acquir Immune Defic Syndr
. 2011 Jun 24.

Peripheral and Central Fat Changes in Subjects Randomized to Abacavir-Lamivudine or
Tenofovir-Emtricitabine With Atazanavir-Ritonavir or Efavirenz: ACTG Study A5224s.
McComsey GA, Kitch D, Sax PE, et al 
Clin Infect Dis
. 2011 Jul;53(2):185-96.

Bone Mineral Density and Fractures in Antiretroviral-Naive Persons Randomized to Receive
Abacavir-Lamivudine or Tenofovir Disoproxil Fumarate-Emtricitabine Along With Efavirenz or
Atazanavir-Ritonavir: AIDS Clinical Trials Group A5224s, a Substudy of ACTG A5202.
McComsey GA, Kitch D, Daar ES,  et al
J Infect Dis. 2011 Jun;203(12):1791-801.
Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen
comparing ritonavir-boosted atazanavir to efavirenz with fixed-dose abacavir and Lamivudine.
Honda M, Ishisaka M, Ishizuka N,  et al
Intern Med
. 2011;50(7):699-705.
Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and
abacavir in HIV type-1-infected Ugandan children in the ARROW Trial.
Musiime V, Kendall L, Bakeera-Kitaka S,  et al
Antivir Ther. 2010;15(8):1115-1124.
Comparison of Changes in Bone Density and Turnover with Abacavir-Lamivudine versus
Tenofovir-Emtricitabine in HIV-Infected Adults: 48-Week Results from the ASSERT Study.
Stellbrink HJ, Orkin C, Arribas JR, et al
Clin Infect Dis. 2010 Sep
Randomized Comparison of Renal Effects, Efficacy, and Safety With Once-Daily
Abacavir/Lamivudine Versus Tenofovir/Emtricitabine, Administered With Efavirenz,
in Antiretroviral-Naive, HIV-1-Infected Adults: 48-Week Results From the ASSERT
Post FA, Moyle GJ, Stellbrink HJ,  et al
J Acquir Immune Defic Syndr. 2010 Apr 24

Abacavir-Lamivudine versus Tenofovir-Emtricitabine for Initial HIV-1 Therapy.
Sax PE, Tierney C, Collier AC,  et al 
N Engl J Med
. 2009 Dec 3;361(23):2230-2240.
Abacavir and lamivudine combination.
Somboonwit C, Kurtyka D, Paula Velez A.
Expert Opin Drug Metab Toxicol
. 2009 Dec;5(12):1599-606.

Simplification of Antiretroviral Therapy with Tenofovir-Emtricitabine or Abacavir-Lamivudine:
A Randomized, 96-Week Trial.
Martin A, Bloch M, Amin J, et al   
Clin Infect Dis
. 2009 Nov 15;49(10):1591-1601

Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or
tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment.
Smith KY, Patel P, Fine D, et al
AIDS 2009 Jun 17.
Virologic response and safety of the abacavir/lamivudine fixed-dose formulation as part of highly active
antiretroviral therapy: analyses of six clinical studies.
Ha B, Liao QM, Dix LP, Pappa KA.
HIV Clin Trials. 2009 Mar-Apr;10(2):65-75
A Simplification Trial Switching From Nucleoside Reverse Transcriptase Inhibitors to Once-Daily
Fixed-Dose Abacavir/Lamivudine or Tenofovir/Emtricitabine in HIV-1-Infected Patients With Virological

Martínez E, Arranz JA, Podzamczer D, et al
J Acquir Immune Defic Syndr. 2009 Apr 24.
Two novel fixed formulations of nucleoside analogues (tenofovir-emtricitabine, and
abacavir-lamivudine). Prospective, open study on clinical practice and therapeutic
perspectives, in patients naïve and in subjects pre-treated with antiretrovirals
Manfred R, Calza L.
Recenti Prog Med. 2008 Oct;99(10):492-501

Switching from twice-daily abacavir and lamivudine to the once-daily fixed-dose combination tablet of
abacavir and lamivudine improves patient adherence and satisfaction with therapy.

Maitland D, Jackson A, Osorio J, et al 
. 2008 Oct;9(8):667-72.

Recent Availability of Two Novel, Fixed Formulations of Antiretroviral Nucleoside Analogues:
A 12-Month Prospective, Open-Label Survey of Their Practical Use and Therapeutic Perspectives
in Antiretroviral-Naive and -Experienced Patients.
Manfredi R, Calza L.
AIDS Patient Care
STDS. 2008 Feb 21
Abacavir/lamivudine combination in the treatment of HIV-1 infection: a review.
Waters L, Moyle G.
Expert Opin Pharmacothe
r. 2006 Dec;7(18):2571-2580.
Efficacy and safety of a once-daily fixed-dose combination of abacavir/lamivudine compared with
abacavir twice daily and lamivudine once daily as separate entities in antiretroviral-experienced
HIV-1-infected patients (CAL30001 Study).

Lamarca A, Clumeck N, Plettenberg A, et al
J Acquir Immune Defic Syndr. 2006 Apr 15;41(5):598-606.
Fixed dose combination abacavir/lamivudine in the treatment of HIV-1 infection.
Anderson AM, Bartlett JA. 
Expert Rev Anti Infect Ther. 2005 Dec;3(6):871-83
Abacavir and Lamivudine Fixed-Dose Combination Tablet Once Daily Compared With Abacavir
and Lamivudine Twice Daily in HIV-Infected Patients Over 48 Weeks (ESS30008, SEAL).
Sosa N, Hill-Zabala C, Dejesus E, et al 
J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):422-427
Two-once-daily fixed-dose NRTI combinations for HIV.
No authors listed]  
Med Lett Drugs Ther
. 2005 Feb 28;47(1203):19-20

Abacavir plus Lamivudine: A Review of their Combined Use in the Management of HIV Infection.
Dando TM, Scott LJ. 
Drugs. 2005;65(2):285-302

Pediatric Indications

  Once versus twice daily abacavir and lamivudine in African children: The randomised controlled ARROW Trial.
Musiime V, Kasirye P, Naidoo-James B, et al
AIDS. 2016 Apr 8.

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