Aspergillosis

Medical Advocates
Aspergillosis

Clinical Management

Guidelines
General Management
Cardiac Asp
CNS Asp
Cerebral Asp
Cutaneous Asp
Intracranial Asp
Invasive Asp

Mandibular Asp
Ophthalmic Asp
Pituitary Asp
Respirator/Pulmonary Asp
Sinus Asp
Genitourinary Asp
Transplantation

Aspergillosis Main Page Main New/Newsworthy Home Page

Last Update: July 10, 2017
Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader

Treatment/Prevention Guidelines

Journal Papers, Abstracts, and Commentaries

Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014.
Blyth CC, Gilroy NM, Guy SD, et al
Intern Med J. 2014 Dec;44(12b):1333-49
Abstract
FULL-TEXT ARTICLE
Treating Opportunistic Infections Among HIV-Infected Adults and Adolescents: Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America
MMWR Dec 17, 2004 / Vol. 53 / No. RR--1
Paper

Clinical Management: General

Journal Papers, Abstracts, and Commentaries

Special Considerations for the Diagnosis and Treatment of Invasive Pulmonary Aspergillosis.
McCarthy MW, Walsh TJ.
Expert Rev Respir Med. 2017 Jun 8.
Abstract

In-host adaptation and acquired triazole resistance in Aspergillus fumigatus: a dilemma for clinical management.
Verweij PE, Zhang J, Debets AJ, et al
Lancet Infect Dis. 2016 Sep 13.
Abstract

Treatment of drug-resistant Aspergillus infection.
Aigner M, Lass-Flörl C.
Expert Opin Pharmacother. 2015 Sep 2:1-4.
Abstract

FULL-TEXT ARTICLE
Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis.
Oliveira-Coelho A, Rodrigues F, et al
Front Microbiol. 2015 May 5;6:411.
Paper

Diagnosis and treatment of pulmonary aspergillosis syndromes.
Patterson KC, Strek ME.
Chest. 2014 Nov 1;146(5):1358-68.
Abstract

FULL-TEXT ARTICLE
Characterization of Specific Immune Responses to Different Aspergillus Antigens during the Course of Invasive Aspergillosis in Hematologic Patients.
Potenza L, Vallerini D, Barozzi P, et al PLoS One. 2013 Sep 4;8(9):e74326
Paper

Directed therapy for fungal infections: focus on aspergillosis.
Barnes RA.
J Antimicrob Chemother. 2013 Jul 9..
Abstract

Current treatment options for invasive aspergillosis.
Batista MV, Costa SF, Shikanai-Yasuda MA, Moss RB.
Drugs Today (Barc). 2013 Mar;49(3):213-26
Abstract

FULL-TEXT ARTICLE
Poststernotomy aspergillosis: successful treatment with voriconazole, surgical debridement and vacuum-assisted closure therapy.
Siciliano RF, Waisberg DR, Samano MN, et al
Clinics (Sao Paulo). 2012;67(3):297-9.
Paper

Aerosol and other novel administrations for prevention and treatment of invasive aspergillosis.
Drew RH.
Med Mycol. 2008 Jul 25:1-7.
Abstract

FULL TEXT ARTICLE
Lessons about the pathogenesis and management of Aspergillosis from studies in chronic granulomatous disease.
Gallin JI, Zarember K.
Trans Am Clin Climatol Assoc. 2007;118:175-85.
Paper

Correlation between high-resolution computed tomography and galactomannan antigenemia in adulthematologic patients at risk for invasive aspergillosis.
Hidalgo A, Parody R, Martino R,et al
Eur J Radiol. 2008 May 9.
Abstract

Evolving strategies in the management of aspergillosis.
Magill SS, Chiller TM, Warnock DW.
Expert Opin Pharmacother. 2008 Feb;9(2):193-209.
Abstract

Economic evaluation of targeted treatments of invasive aspergillosis in adult haematopoietic stem cell transplant recipients in the Netherlands: a modelling
approach.
Ament AJ, Hübben MW, Verweij PE, et al
J Antimicrob Chemother. 2007 Jun 7;
Abstract

Combination antifungal therapy for invasive aspergillosis - Is it indicated?
Steinbach WJ.
Med Mycol. 2006 Sep;44 Suppl:373-82.
Abstract

Diagnosis and treatment of aspergillosis in the patients with chronic granulomatous disease
Kurenko-Deptuch M, Wolska-Kusnierz B, Heropolitanska-Pliszka E, et al
Przegl Epidemiol. 2006;60(1):43-7
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Current Approaches to Diagnosis and Treatment of Invasive Aspergillosis.
Segal BH, Walsh TJ.
Am J Respir Crit Care Med. 2005 Dec 30;
Abstract

Initial CT manifestations of invasive pulmonary aspergillosis in 45 non-HIV immunocompromised patients: association with patient outcome?
Horger M, Hebart H, Einsele H, et al
Eur J Radiol. 2005 Sep;55(3):437-44
Abstract

Salvage therapy with voriconazole for invasive fungal infections in patients failing or intolerant to standard antifungal therapy.
Baden LR, Katz JT, Fishman JA, et al
Transplantation. 2003 Dec 15; 76(11): 1632-7.
Abstract

Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis.
Steinbach WJ, Stevens DA.
Clin Infect Dis. 2003 Oct 1;37 Suppl 3:S157-87.
Abstract

Invasive aspergillosis treated with adjunctive hyperbaric oxygenation: a retrospective clinical series at a single institution.
Garcia-Covarrubias L, Barratt DM, Bartlett R, et al
South Med J 2002 Apr;95(4):450-6
Abstract

Cardiovascular Aspergillosis

Diagnostics

Journal Papers, Abstracts, and Commentaries

Polymerase chain reaction aids in the diagnosis of an unusual case of Aspergillus niger endocarditis in a patient with acute myeloid leukaemia.
McCracken D, Barnes R, Poynton C, et al
J Infect. 2003 Nov;47(4):344-7
Abstract

Case Studies

Journal Papers, Abstracts, and Commentaries

Endovascular Repair As A Bridge To Open Repair Of A Ruptured Descending Thoracic Aspergilus Aortitis.
Tresson P, Roussel A, Mordant P, et al
Ann Thorac Surg. 2017 May 9.
Abstract
Successful surgical management of invasive aspergillosis of the pulmonary arteries
Zanotti G, Nicolardi S, Morsolini M, et al
Ann Thorac Surg. 2008 Aug;86(2):655-7.
Abstract

Rapidly advancing invasive endomyocardial aspergillosis.
Davutoglu V, Soydinc S, Aydin A, Karakok M.
Am Soc Echocardiogr. 2005 Feb;18(2):185-187.
Abstract

Cardiac aspergillosis in patients with acquired immunodeficiency syndrome: a case report
and review of the literature.
Xie L, Gebre W, Szabo K, Lin JH. et al
Arch Pathol Lab Med. 2005 Apr;129(4):511-5.
Abstract

Cerebral Aspergillosis

Diagnosis

            Journal Papers, Abstracts, and Commentaries

Early diagnosis of cerebral aspergillosis with various methods: a case report.
Sav H, Atalay MA, Demir G, et al
Infez Med. 2013 Jun 1;21(2):134-8.
Abstract

Treatment

            Journal Papers, Abstracts, and Commentaries

Rhino-orbital-cerebral mucormycosis and aspergillosis: differential diagnosis and treatment.
Arndt S, Aschendorff A, Echternach M, et al
Eur Arch Otorhinolaryngol. 2008 May 10.
bstract

Successful treatment of brain aspergillosis with voriconazole.
Tattevin P, Bruneel F, Lellouche F, et al.
Clin Microbiol Infect. 2004 Oct;10(10):928-31.
Abstract

Case Studies

            Journal Papers, Abstracts, and Commentaries

FULL-TEXT ARTICLE
Cerebral Aspergillus arteritis with bland infarcts: A report of two patients with poor outcome.
Uppin MS, Challa S, Uppin SG, et al
Neurol India. 2007 Jul-Aug;55(3):298-300.
Paper

FULL-TEXT ARTICLE
Cerebral aspergillosis due to Aspergillus fumigatus in AIDS patient: first culture - |proven case reported in Brazil.
Vidal JE, Dauar RF, Melhem MS, Szeszs W, et al
Rev Inst Med Trop Sao Paulo. 2005 Jun;47(3):161-165.
Paper

Cerebral aspergillosis in the critically ill: two cases of successful medical treatment.
Ehrmann S, Bastides F, Gissot V, et al
Intensive Care Med. 2005 Mar 22;
Abstract

Two Cases of Cerebral Aspergillosis Successfully Treated with Voriconazole.
De Lastours V, Lefort A, Zappa M, et al.
Eur J Clin Microbiol Infect Dis 2003 May 10;
Abstract

Case Reports. Chronic and acute Aspergillus meningitis.
Moling O, Lass-Floerl C, Verweij PE, et al.
Mycoses 2002 Dec;45(11-12):504-511
Abstract

CNS Aspergillosis

Cerebral Aspergillosis

            Journal Papers, Abstracts, and Commentaries

Successful multimodal therapy of invasive pulmonary and central nervous system aspergillosis in a neutropenic surgical patient: case report and review of the literature.
Kaffarnik M, Utzolino S, Blaich A, Hopt UT.
Mycoses. 2008 Jan;51(1):74-8.
Abstract

Central nervous system aspergillosis in patients with human immunodeficiency virus infection. Report of 6 cases and review.
Mylonakis E, Paliou M, Sax PE, et al
Medicine (Baltimore) 2000 Jul;79(4):269-80
Abstract

Cutaneous Aspergillosis

            Journal Papers, Abstracts, and Commentaries

Severe primary cutaneous aspergillosis refractory to amphotericin B and the successful treatment with systemic voriconazole in two premature infants with extremely low birth
weight.
Frankenbusch K, Eifinger F, Kribs A, et al
J Perinatol. 2006 Aug;26(8):511-4.
Abstract

Human immunodeficiency virus-related primary cutaneous aspergillosis.
Stanford D, Boyle M, Gillespie R.,
Australas J Dermatol 2000 May;41(2):112-6
Abstract

Intracranial Aspergillosis

            Journal Papers, Abstracts, and Commentaries

Invasive intracranial aspergillosis: the management dilemmas.
Mohindra S, Mukherjee KK, Chhabra R, et al
Surg Neurol. 2008 May;69(5):496-505.
Abstract

Intracranial invasive aspergillosis originating in the sphenoid sinus: a successful treatment with high-dose itraconazole in three cases
Yamanoi T, Shibano K, Soeda T, et al
Tohoku J Exp Med. 2004 Jun;203(2):133-9.
Abstract

Invasive Aspergillosis

            Journal Papers, Abstracts, and Commentaries

Long-term follow up of invasive aspergillosis in allogeneic stem cell transplantation recipients and leukemia patients: Differences in risk factors and outcomes.
Bonnet S, Duléry R, Regany K, et al
Curr Res Transl Med. 2017 Jul 5
Abstract
A CONSORT analysis of randomised controlled trials for the treatment of invasive aspergillosis.
Jones BL, Richardson MD, Ingram PM, Agrawal SG.
Med Mycol. 2016 Dec 3.
Abstract

Invasive Aspergillosis: Current Strategies for Diagnosis and Management.
Cadena J, Thompson GR 3rd, Patterson TF.
Infect Dis Clin North Am. 2016 Mar;30(1):125-42.
Abstract

Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014.
Blyth CC, Gilroy NM, Guy SD, et al
Intern Med J. 2014 Dec;44(12b):1333-49
Abstract

FULL-TEXT ARTICLE
Invasive aspergillosis in kidney transplant recipients: a cohort study.
Pérez-Sáez MJ, Mir M, Montero MM, et al
Exp Clin Transplant. 2014 Apr;12(2):101-5
Paper

Invasive aspergillosis: diagnosis, prophylaxis and treatment.
Del Bono V, Mikulska M, Viscoli C.
Curr Opin Hematol. 2008 Nov;15(6):586-93
Abstract

Successful management of invasive aspergillosis presenting as pericarditis in an adult patient with chronic granulomatous disease.
Mortensen KL, Knudsen JB, Jensen-Fangel S, et al
Mycoses. 2009 Dec 23
Abstract

Successful management of invasive aspergillosis presenting as pericarditis in an adult patient with chronic granulomatous disease.
Mortensen KL, Knudsen JB, Jensen-Fangel S, et al
Mycoses. 2009 Dec 23.
Abstract

FULL-TEXT ARTICLE
Management of invasive aspergillosis in patients with COPD: rational use of voriconazole.
Ader F, Bienvenu AL, Rammaert B, Nseir S
Int J Chron Obstruct Pulmon Dis. 2009;4(2):279-87
Paper

Mandibular Aspergillosis

            Journal Papers, Abstracts, and Commentaries

Aspergillosis: a rare case of secondary delayed mandibular involvement.
Sandhu S, Kaur T.
Quintessence Int 2003 Feb;34(2):139-42
Abstract

Ophthalmic Aspergillosis

            Journal Papers, Abstracts, and Commentaries

FULL-TEXT ARTICLE
Orbital aspergillosis: voriconazole - the new standard treatment?
Ohlstein DH, Hooten C, Perez J, et al
Case Report Ophthalmol. 2012 Jan;3(1):46-53.
Paper
Different presentations of ophthalmic aspergillosis.
Willermain F, Bradstreet C, Kampouridis S, et al
Eur J Ophthalmol. 2008 Sep-Oct;18(5):827-30
Abstract

Role of 0.02% polyhexamethylene biguanide and 1% povidone iodine in experimental Aspergillus keratitis.
Panda A, Ahuja R, Biswas NR
Cornea 2003 Mar;22(2):138-41
Abstract

Pituitary Aspergillosis

            Journal Papers, Abstracts, and Commentaries

Aspergillus pituitary abscess.
Iplikcioglu AC, Bek S, Bikmaz K, Ceylan D, Gokduman CA.
Acta Neurochir (Wien). 2004 May;146(5):521-4
Abstract

Genitourinary Aspergillosis

Prostatic

            Journal Papers, Abstracts, and Commentaries

Prostatic and renal aspergillosis due to Aspergillus fumigatus in a patient receiving alemtuzumab for chronic lymphocytic leukaemia.
Roux C, Thyss A, Gari-Toussaint M.
J Mycol Med. 2013 Nov 6
Abstract

Renal

         Journal Papers, Abstracts, and Commentaries

Prostatic and renal aspergillosis due to Aspergillus fumigatus in a patient receiving alemtuzumab for chronic lymphocytic leukaemia.
Roux C, Thyss A, Gari-Toussaint M.
J Mycol Med. 2013 Nov 6
Abstract
Primary bilateral parenchymal renal Aspergillus infection.
Lisson SW, Hellinger WC, Parra RO.
Urology 2002 Aug;60(2):345
Abstract
Bilateral Renal Aspergillosis in a Patient with AIDS: A Case Report and Review of Reported Cases
Oosten AW, Sprenger HG, van Leeuwen JT, et al
AIDS Patient Care STDS. 2007 Dec 20
Abstract

Isolated renal Aspergillus abscess in an AIDS patient with a normalCD4+ cell count on highly active antiretroviral therapy.
Rey D, de Mautort E, Saussine C, et al.
Eur J Clin Microbiol Infect Dis 1999 Feb;18(2):137-41
Abstract

Sinus Aspergillosis

            Journal Papers, Abstracts, and Commentaries

Surgical treatment of Aspergillus mycetomas of the maxillary sinus: review of the literature.
Costa F, Polini F, Zerman N, et al
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jun;103(6):e23-9.
Abstract

Endoscopic Surgery for Sinonasal Invasive Aspergillosis in Bone Marrow Transplantation Patients.
Eliashar R, Resnick IB, Goldfarb A, Wohlgelernter J, Gross M.
Laryngoscope. 2006 Nov 28;
Abstract

Primary frontal sinus aspergillosis: an uncommon occurrence.
Panda NK, Ekambar Eshwara Reddy C.
Mycoses. 2005 Jul;48(4):235-7.
Abstract

Localised invasive sino-orbital aspergillosis: characteristic features.
Sivak-Callcott JA, Livesley N, et al
Br J Ophthalmol. 2004 May;88(5):681-687.
Abstract

Sinus cavernous syndrome caused by isolated aspergillosis of the sphenoid sinus
Haegelen C, Godey B, Riffaud L, et al
Rev Neurol (Paris) 2003 Feb;159(2):209-11
Abstract

Transplantation

Journal Papers, Abstracts, and Commentaries

Aspergillosis in hematopoietic stem cell transplant recipients: risk factors, prophylaxis, and treatment.
Avery RK.
Curr Infect Dis Rep. 2009 May;11(3):223-8
Abstract

Breakthrough invasive aspergillosis in allogeneic haematopoietic stem cell transplant recipients treated with caspofungin.
Madureira A, Bergeron A, Lacroix C, et al
Int J Antimicrob Agents. 2007 Oct 26
Abstract

Preemptive Treatment of Fungal Infection Based on Plasma (1 --> 3)beta-D: -Glucan Levels after Liver Transplantation.
Akamatsu N, Sugawara Y, Kaneko J, et al
Infection. 2007 Oct;35(5):346-51.
Abstract

Prognostic factors for death due to invasive aspergillosis after hematopoietic stem cell transplantation: a 1-year retrospective study of consecutive patients at French transplantation
centers.
Cordonnier C, Ribaud P, Herbrecht R, et al
Clin Infect Dis. 2006 Apr 1;42(7):955-63.
Abstract

Prospective Assessment of Platelia Aspergillus Galactomannan Antigen for the Diagnosis of Invasive Aspergillosis in Lung Transplant Recipients.
Husain S, Kwak EJ, Obman A ,et al
Am J Tra Am J Transplant. 2004 May;4(5):796-802
Abstract

Invasive aspergillosis in the setting of cardiac transplantation.
Montoya JG, Chaparro SV, Celis D, et al.
Clin Infect Dis. 2003 Oct 1;37 Suppl 3:S281-92.
Abstract

I nvasive fungal infections in recipients of allogeneic hematopoietic stem cell transplantation after nonmyeloablative conditioning: risks and outcomes.
Fukuda T, Boeckh M, Carter RA, et al.
Blood 2003 Apr 10
Abstract

Invasive aspergillosis in solid-organ transplantation: report of eight cases and review of the literature.
Ergin F, Arslan H, Azap A, et al Transpl Int 2003 Apr;16(4):280-6
Abstract

Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management.
Singh N, Husain S.
J Heart Lung Transplant 2003 Mar;22(3):258-66
Abstract

Aspergillus infection in lung transplant recipients with cystic fibrosis: risk factors and outcomes comparison to other types of transplant recipients.
Helmi M, Love RB, Welter D, et al
Chest 2003 Mar;123(3):800-8
Abstract

Central nervous system aspergillosis in allogeneic stem cell transplant recipients.
Jantunen E, Volin L, Salonen O, et al.
Bone Marrow Transplant 2003 Feb;31(3):191-6
Abstract

Invasive central nervous system aspergillosis in bone marrow transplantation recipients: an overview.
Guermazi A, Gluckman E, Tabti B, Miaux Y.
Eur Radiol 2003 Feb;13(2):377-88
Abstract

Prophylactic administration of liposomal amphotericin B is superior to treatment in a murine model of invasive aspergillosis after hematopoietic cell transplantation.
BitMansour A, Brown JM
Infect Dis 2002 Jul 1;186(1):134-7
Abstract

Aspergillosis Main Page Main New/Newsworthy Home Page

Aspergillosis Clinical Management