Medical Advocates
HIV Infection/Disease
  Progressive Multifocal
Leukoencephalopathy

General Reports             
Epidemiology 
 Diagnosis      
Clinical Management
Drugs
Case Studies



 
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Last Update: December 09, 2008
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General Reports
       
           Journal Papers, Abstracts, and Commentaries
 
 
Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated
dendritic cells from patients with progressive multifocal leukoencephalopathy.
Marzocchetti A, Lima M, Tompkins T, et al  
Virology. 2008 Dec 4.
 Abstract
 
Immune Reconstitution Associated With Progressive Multifocal Leukoencephalopathy in Human
Immunodeficiency Virus: A Case Discussion and Review of the Literature.
Travis J, Varma A, Duplessis D, 
Neurologist. 2008 Sep;14(5):321-326.
 Abstract
 
Spinal cord lesions of progressive multifocal leukoencephalopathy in an acquired
immunodeficiency syndrome patient
Bernal-Cano F, Joseph JT, Koralnik IJ.
J Neurovirol. 2007 Sep;13(5):474-476.
 Abstract
 
Longitudinal study of two cases of progressive multifocal leukoencephalopathy with a clinical
benign evolution.
Delbue S, Marchioni E, Sotgiu G, et al 
J Neurovirol. 2007 Jun;13(3):268-73.
 Abstract
 
Progressive multifocal leukoencephalopathy--epidemiology, clinical pictures, diagnosis
and therapy
Kishida S.
 Brain Nerve. 2007 Feb;59(2):125-37.
 Abstract
 
Frequency and phenotype of JC Virus-specific CD8+ T lymphocytes in the peripheral blood
of patients with Progressive Multifocal Leukoencephalopathy.
Lima MA, Marzocchetti A, Autissier P, et al
J Virol. 2007 Jan 17;
 Abstract
 
New trends in progressive multifocal leukoencephalopathy.
Gasnault J, Taoufik Y  .
 Rev Neurol (Paris). 2006 Jan;162(1):43-56
 Abstract
 
Changes in the natural history of progressive multifocal leukoencephalopathy in HIV-negative
lymphoproliferative disorders: Impact of novel therapies.
Garcia-Suarez J, de Miguel D, Krsnik I, Banas H,
Am J Hematol. 2005 Nov 28;80(4):271-281
Abstract
 
Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune
restoration in AIDS-related progressive multifocal leukoencephalopathy.
 Vendrely A, Bienvenu B, Gasnault J, et al 
Acta Neuropathol (Berl). 2005 Mar 1;
Abstract
 
Progressive Multifocal Leukencephalopathy in Patients on Highly Active Antiretroviral
Therapy: Survival and Risk Factors of Death.
Wyen C, Hoffmann C, Schmeier N 
J Acquir Immune Defic Syndr. 2004 Oct 1;37(2):1263-1268.
Abstract

New insights into progressive multifocal leukoencephalopathy.
Koralnik IJ
Curr Opin Neurol. 2004 Jun;17(3):365-70.
Abstract

The evolving face of human immunodeficiency virus-related progressive
multifocal leukoencephalopathy: Defining a consensus terminology.
Cinque P, Koralnik IJ, Clifford DB.
J Neurovirol 2003 Apr;9 Suppl 1:88-92
Abstract

Unusual viral infections (progressive multifocal leukoencephalopathy and
cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell  
rescue and peritransplantation rituximab.
Goldberg SL, Pecora AL, Alter RS , et al.
Blood 2002 Feb 15;99(4):1486-8
 Abstract

Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy
patients with a CTL responsespecific for a commonly recognized JC virus epitope
Koralnik IJ, Du Pasquier RA, Kuroda MJ
J Immunol 2002 Jan 1;168(1):499-504
 Abstract

JCV-specific cellular immune response correlates with a favorable clinical outcome in
HIV-infected individuals with progressive multifocal leukoencephalopathy.
Du Pasquier RA, Clark KW, Smith PS et al.
J Neurovirol 2001 Aug;7(4):318-22
 Abstract

  

          Conference Reports, Abstracts, and Posters

 
Frequent Infection of Granule Cell Neurons by JC Virus in HIV+ Progressive Multifocal
Leukoencephalopathy Patients
C Wuthrich J Cheng, J Joseph, et al
(15th CROI)
 Abstract
 
POSTER
 Early Brainstem Damage Is Predictive of Poor Survival in HIV-infected Patients with
Progressive Multifocal Leukoencephalopathy
J Gasnault, M G de Goer de Hervé, J Rahoiljaon,  et al
(11 CROI)
 PDF Poster    Abstract
 
POSTER
Macrophage Chemotactic Protein Levels in Cerebrospinal Fluid of Patients with AIDS-
associated PML Treated with HAART Favorably Correlate with Patients Survival
A Marzocchetti, A Cingolani, S Di Giambenedetto, et al
(11 CROI)
PDF Poster      Abstract
Epidemiology
       
           Journal Papers, Abstracts, and Commentaries
 
  Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome:
Explaining the high incidence and disproportionate frequency of the illness relative to other
immunosuppressive conditions.
Berger JR.   
Neurovirol 2003 Apr;9 Suppl 1:38-41
 Abstract

Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era
of highly active antiretroviral therapy:Data from the Italian Registry Investigative Neuro AIDS
(IRINA).
Antinori A, Cingolani A, Lorenzini P, et al.
J Neurovirol 2003 Apr;9 Suppl 1:47-53
 Abstract

Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is
there a biological explanation?
Shankar S, Satishchandra P, Mahadevan A et al J
Neurovirol 2003 Apr;9(Supplement 1):59-67
Abstract

  
Diagnosis
       
            Journal Papers, Abstracts, and Commentaries
 
 
Progressive Multifocal Leukoencephalopathy: Serial High-b-Value Diffusion-Weighted MR
Imaging and Apparent Diffusion Coefficient Measurements to Assess Response to Highly
Active Antiretroviral Therapy.
Usiskin SI, Bainbridge A, Miller RF, Jager HRl 
AJNR Am J Neuroradiol. 2007 Feb;28(2):285-6.
 Abstract
 
Prognostic Significance of JC Virus DNA Levels in Cerebrospinal Fluid of Patients
with HIV-Associated Progressive Multifocal Leukoencephalopathy.
Bossolasco S, Calori G, Moretti F, et al
Clin Infect Dis. 2005 Mar 1;40(5):738-44.
Abstract

Correlation between clinical diagnostic test and neuropathological findings in patients
with AIDS
Akova-Ozturk E, Evers S, Colak-Ekici R, et al
Nervenarzt. 2004 Apr 28
 Abstract
Clinical Management
       
            Journal Papers, Abstracts, and Commentaries
 
 
Incidence, Clinical Presentation, and Outcome of Progressive Multifocal Leukoencephalopathy in
HIV-Infected Patients during the Highly Active Antiretroviral Therapy Era: A Nationwide Cohort Study.
Engsig FN, Hansen AB, Omland LH,et al  
J Infect Dis. 2008 Nov 13.
Abstract
 
Remission of progressive multifocal leukoencephalopathy and primary central nervous system
lymphoma in an HIV-infected patient.
 Lima MA, Katz-Brull R, Lenkinski RE, et al
Eur J Neurol. 2007 Jun;14(6):598-602.
Abstract
 
Changes in the natural history of progressive multifocal leukoencephalopathy in HIV-negative
lymphoproliferative disorders: Impact of novel therapies.
Garcia-Suarez J, de Miguel D, Krsnik I, Banas H,
Am J Hematol. 2005 Nov 28;80(4):271-281
Abstract
 
AIDS-Related Progressive Multifocal Leukoencephalopathy in the Era of HAART:
Report of Two Cases and Review of the Literature.
Wyen C, Lehmann C, Fatkenheuer G, Hoffmann C.
AIDS Patient Care STDS. 2005 Aug;19(8):486-94.
Abstract

The effect of highly active antiretroviral therapy-induced immune reconstitution on
development and outcome of progressive multifocal leukoencephalopathy: Study of 43
cases with review of the literature.
Cinque P, Bossolasco S, Brambilla AM, et al
J Neurovirol 2003 Apr;9 Suppl 1:73-80
Abstract

Inflammatory reaction in progressive multifocal leukoencephalopathy:Harmful or
beneficial?
Pasquier RA, Koralnik IJ.
J Neurovirol 2003 Apr;9 Suppl 1:25-31
Abstract

Fatal immune restoration disease in human immunodeficiency virus type1-infected
patients with progressive multifocal leukoencephalopathy: impact of antiretroviral
therapy-associated immune reconstitution.
Safdar A, Rubocki RJ, Horvath JA, et al
Clin Infect Dis 2002 Nov 15;35(10):1250-7
Abstract
 

  
          Conference Reports, Abstracts, and Posters
 
  Influence of Immunological, Virological, and Radiological Determinants in the Clinical Outcome
of Patients with Progressive Multifocal Leukoencephalopathy
A Marzocchetti, T Tompkins, D Clifford, et al
(15th CROI)
 Abstract
Drugs
       
ARVs

          Conference Reports, Abstracts, and Posters
 
 
POSTER
Intracerebral Penetrating ART Are More Efficient on Survival of HIV+ Patients with
Progressive Multifocal Leucoencephalopathy (ANRS CO4 - FHDH)
J Gasnault, E Lanoy, M Bentata, et al
 (15 CROI)
 PDF Poster  Abstract

POSTER
 Acceleration of Immune Recovery on Intensified ART Improves Survival in Patients with
AIDS-related Progressive Multifocal Leukoencephalopathy: Preliminary Reports of the
ANRS 125 Trial
J Gasnault, H Hendel Chavez, E Dorofeev et al
 (14 CROI)
 PDF Poster     Abstract
 
The Relationship between Outcome of Progressive Multifocal Leukoencephalopathy and
Type and Response to ART in Previously HAART-untreated Patients
A Pazzi, L Galli, P Costenaro, et al
 (14 CROI)
 Abstract
 
Cidofovir
 		  
          Journal Papers, Abstracts, and Commentaries
 		  
 
A WEEK-IN-REVIEW FEATURED REPORT
Cidofovir in combination with HAART and survival in AIDS-associated progressive multifocal
leukoencephalopathy.
Kraemer C, Evers S, Nolting T, et al
J Neurol. 2008 Jan 18
Abstract 

Prolonged survival in AIDS-related progressive multifocal leukoencephalopathy following
anti-retroviral therapy and cidofovir.
Roberts MT, Carmichael A, Lever AM.
Int J Antimicrob Agents 2003 Apr;21(4):347-9
Abstract 

A pilot study of cidofovir for progressive multifocal leukoencephalopathy in AIDS.
Marra CM, Rajicic N, Barker DE, et al.
AIDS 2002 Sep 6;16(13):1791-1797
 Abstract

Cidofovir in AIDS-associated progressive multifocal leukoencephalopathy: A monocenter
observational study with clinical and JC virus load monitoring.
Gasnault J, Kousignian P, Kahrama et al.
J Neurovirol 2001 Aug;7(4):375-81
 Abstract
 
Interferons

          Conference Reports, Abstracts, and Posters
 
  Interferon-a and -ß Restrict Polyomavirus JC Replication in Primary Human Fetal
Glial Cells: Implications for Progressive Multifocal Leukoencephalopathy Therapy
S Verma, J G Co, L Sumibcay, et al
 (14 CROI)
 Abstract
 
Topotecan

          Journal Papers, Abstracts, and Commentaries
 
  Topotecan in the Treatment of Acquired Immunodeficiency Syndrome-Related
Progressive Multifocal Leukoencephalopathy.
Royal III W, Dupont B, McGuire D, et al
J Neurovirol 2003;9(3):411-419
 Abstract
 
Case Reports/Literature Reviews
       

          Journal Papers, Abstracts, and Commentaries

 
Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable
disorder
Martinez JV, Mazziotti JV, Efron ED. et  al
Neurology. 2006 Nov 14;67(9):1692-4
 Abstract
 
Evolution of purely infratentorial PML under HAART-negative outcome under rapid immune
 reconstitution.
Kastrup O, Wanke I, Esser S, Maschke M    
Clin Neurol Neurosurg. 2005 Oct;107(6):509-13.
Abstract
 
Progressive multifocal leukoencephalopathy with unusual inflammatory response during
antiretroviral treatment.
Hoffmann C, Horst HA, Albrecht H, Schlote W.
 J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1142-4.
 Abstract

Progressive multifocal leukoencephalopathy revealing AIDS in a 13-year-old girl  
Hugonenq C, Lethel V, Chambost H,  et al.
Arch Pediatr 2002 Jan;9(1):32-5
 Abstract

  

       

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HIV -Associated Progressive Multifocal Leukoencephalopathy